{"id":"https://openalex.org/W2220072621","doi":"https://doi.org/10.1152/ajpregu.2001.281.1.r176","title":"Effect of a myocardial volume overload on lactate transport in skeletal muscle sarcolemmal vesicles","display_name":"Effect of a myocardial volume overload on lactate transport in skeletal muscle sarcolemmal vesicles","publication_year":2001,"publication_date":"2001-07-01","ids":{"openalex":"https://openalex.org/W2220072621","doi":"https://doi.org/10.1152/ajpregu.2001.281.1.r176","mag":"2220072621","pmid":"https://pubmed.ncbi.nlm.nih.gov/11404292"},"language":"en","primary_location":{"id":"doi:10.1152/ajpregu.2001.281.1.r176","doi":"https://doi.org/10.1152/ajpregu.2001.281.1.r176","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpregu.2001.281.1.r176","pdf_url":null,"source":{"id":"https://openalex.org/S59702976","display_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","issn_l":"0363-6119","issn":["0363-6119","1522-1490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080176195","display_name":"William G. Aschenbach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I82497590","display_name":"Auburn University","ror":"https://ror.org/02v80fc35","country_code":"US","type":"education","lineage":["https://openalex.org/I82497590"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William G. Aschenbach","raw_affiliation_strings":["Department of Health and Human Performance, Auburn University and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health and Human Performance, Auburn University and","institution_ids":["https://openalex.org/I82497590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085323143","display_name":"Gregory L. Brower","orcid":"https://orcid.org/0000-0003-4764-1844","observed_orcids":["https://orcid.org/0000-0003-4764-1844"]},"institutions":[{"id":"https://openalex.org/I82497590","display_name":"Auburn University","ror":"https://ror.org/02v80fc35","country_code":"US","type":"education","lineage":["https://openalex.org/I82497590"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory L. Brower","raw_affiliation_strings":["Department of Anatomy, Physiology, and Pharmacology, Auburn University College of Veterinary Medicine, Auburn, Alabama 36849; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Physiology, and Pharmacology, Auburn University College of Veterinary Medicine, Auburn, Alabama 36849; and","institution_ids":["https://openalex.org/I82497590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042661935","display_name":"Robert J. Talmadge","orcid":"https://orcid.org/0000-0002-8792-3312","observed_orcids":["https://orcid.org/0000-0002-8792-3312"]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. Talmadge","raw_affiliation_strings":["Department of Human Nutrition, Foods, and Exercise Science, Virginia Tech, Blacksburg, Virginia 24061"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Nutrition, Foods, and Exercise Science, Virginia Tech, Blacksburg, Virginia 24061","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023242706","display_name":"John L. Dobson","orcid":"https://orcid.org/0000-0003-1154-5623","observed_orcids":["https://orcid.org/0000-0003-1154-5623"]},"institutions":[{"id":"https://openalex.org/I82497590","display_name":"Auburn University","ror":"https://ror.org/02v80fc35","country_code":"US","type":"education","lineage":["https://openalex.org/I82497590"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John L. Dobson","raw_affiliation_strings":["Department of Health and Human Performance, Auburn University and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health and Human Performance, Auburn University and","institution_ids":["https://openalex.org/I82497590"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086956465","display_name":"L. Bruce Gladden","orcid":"https://orcid.org/0000-0001-5193-7440","observed_orcids":["https://orcid.org/0000-0001-5193-7440"]},"institutions":[{"id":"https://openalex.org/I82497590","display_name":"Auburn University","ror":"https://ror.org/02v80fc35","country_code":"US","type":"education","lineage":["https://openalex.org/I82497590"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Bruce Gladden","raw_affiliation_strings":["Department of Health and Human Performance, Auburn University and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health and Human Performance, Auburn University and","institution_ids":["https://openalex.org/I82497590"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7051,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.89400074,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"281","issue":"1","first_page":"R176","last_page":"R186"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.7842000126838684,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.7842000126838684,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.02800000086426735,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.026100000366568565,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lactate-transport","display_name":"lactate transport","score":0.9290000200271606},{"id":"https://openalex.org/keywords/monocarboxylate-transporters","display_name":"monocarboxylate transporters","score":0.9070000052452087},{"id":"https://openalex.org/keywords/carrier-mediated-transport","display_name":"carrier-mediated transport","score":0.5440000295639038},{"id":"https://openalex.org/keywords/left-ventricular-function","display_name":"left ventricular function","score":0.628000020980835},{"id":"https://openalex.org/keywords/soleus-muscle","display_name":"soleus muscle","score":0.6600000262260437},{"id":"https://openalex.org/keywords/plantaris","display_name":"plantaris","score":0.8240000009536743},{"id":"https://openalex.org/keywords/cardiorespiratory-fitness","display_name":"cardiorespiratory fitness","score":0.328000009059906}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6524838209152222},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6024259328842163},{"id":"https://openalex.org/C7301908","wikidata":"https://www.wikidata.org/wiki/Q318623","display_name":"Myofibril","level":2,"score":0.5833829641342163},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.5504419207572937},{"id":"https://openalex.org/C199096232","wikidata":"https://www.wikidata.org/wiki/Q1545001","display_name":"Sarcolemma","level":3,"score":0.5475521683692932},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.5342786312103271},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.5192349553108215},{"id":"https://openalex.org/C111133373","wikidata":"https://www.wikidata.org/wiki/Q21132608","display_name":"Citrate synthase","level":3,"score":0.5098687410354614},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.48929092288017273},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3085136413574219},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23801428079605103},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16145527362823486},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10984870791435242},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.09955653548240662}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002306","descriptor_name":"Cardiac Volume","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002950","descriptor_name":"Citrate (si)-Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007811","descriptor_name":"Lanthanum","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009210","descriptor_name":"Myofibrils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012519","descriptor_name":"Sarcoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012519","descriptor_name":"Sarcoplasmic Reticulum","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D016277","descriptor_name":"Ventricular Function, Left","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018995","descriptor_name":"Myosin Heavy Chains","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D027501","descriptor_name":"Monocarboxylic Acid Transporters","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpregu.2001.281.1.r176","doi":"https://doi.org/10.1152/ajpregu.2001.281.1.r176","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpregu.2001.281.1.r176","pdf_url":null,"source":{"id":"https://openalex.org/S59702976","display_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","issn_l":"0363-6119","issn":["0363-6119","1522-1490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","raw_type":"journal-article"},{"id":"pmid:11404292","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11404292","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Regulatory, integrative and comparative physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G503289898","display_name":null,"funder_award_id":"1RO1-AR-40342","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G5750475721","display_name":"REGULATION OF LACTATE TRANSPORT AND METABOLISM","funder_award_id":"5r01ar040342-07","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W137976010","https://openalex.org/W954944586","https://openalex.org/W1255683091","https://openalex.org/W1852969178","https://openalex.org/W1896658134","https://openalex.org/W1910297960","https://openalex.org/W1962076835","https://openalex.org/W1970800813","https://openalex.org/W1980301450","https://openalex.org/W1982851358","https://openalex.org/W1991928071","https://openalex.org/W1996140321","https://openalex.org/W1996845220","https://openalex.org/W2001176512","https://openalex.org/W2006684869","https://openalex.org/W2020001555","https://openalex.org/W2041791381","https://openalex.org/W2042284908","https://openalex.org/W2050598500","https://openalex.org/W2064856771","https://openalex.org/W2066707051","https://openalex.org/W2067704925","https://openalex.org/W2073208146","https://openalex.org/W2085640002","https://openalex.org/W2092195115","https://openalex.org/W2092224927","https://openalex.org/W2093561976","https://openalex.org/W2100837269","https://openalex.org/W2114101618","https://openalex.org/W2128635872","https://openalex.org/W2128652538","https://openalex.org/W2138540535","https://openalex.org/W2146644604","https://openalex.org/W2148522618","https://openalex.org/W2149622570","https://openalex.org/W2166850289","https://openalex.org/W2175991112","https://openalex.org/W2199693306","https://openalex.org/W2233040893","https://openalex.org/W2259100771","https://openalex.org/W2276563167","https://openalex.org/W2281704869","https://openalex.org/W2410910724","https://openalex.org/W2412819927","https://openalex.org/W2416316334","https://openalex.org/W2432034884","https://openalex.org/W4321000909"],"related_works":["https://openalex.org/W2099343002","https://openalex.org/W2188790462","https://openalex.org/W2199693306","https://openalex.org/W2021841009","https://openalex.org/W2283222809","https://openalex.org/W2006050240","https://openalex.org/W1995291844","https://openalex.org/W2189501148","https://openalex.org/W2136555704","https://openalex.org/W2189290421"],"abstract_inverted_index":{"This":[0],"study":[1],"sought":[2],"to":[3,86,219],"determine":[4],"the":[5,20,105,129,145],"effect":[6],"of":[7,23,43,59],"a":[8,37,78,132,139,220,228],"myocardial":[9],"volume":[10],"overload":[11],"(MVO)":[12],"on":[13],"sarcolemmal":[14],"(SL)":[15],"lactate":[16],"(La(-))":[17],"transport":[18,73,236],"and":[19,90,95,131,180,187,198,215,249],"aerobic":[21],"profile":[22],"skeletal":[24],"muscle.":[25,169],"SL":[26,174,251],"vesicles":[27,175],"were":[28,53,75,98,147,165],"obtained":[29],"from":[30],"female":[31],"rats":[32],"10":[33],"wk":[34],"after":[35],"either":[36],"MVO":[38,106,150,181,230],"was":[39,62,111,176,211,217,241],"induced":[40],"by":[41],"creation":[42],"an":[44,82],"infrarenal":[45],"fistula":[46],"(n":[47,55],"=":[48,56,136,183,194],"10),":[49],"or":[50,159,237],"sham":[51,179],"surgeries":[52],"performed":[54],"11).":[57],"Influx":[58],"(14)C-labeled":[60],"L(+)-La(-)":[61],"measured":[63],"at":[64,208],"various":[65],"unlabeled":[66],"La(-)":[67,72,171,235],"concentrations":[68],"under":[69],"zero-trans":[70],"conditions.":[71],"kinetics":[74],"determined":[76],"using":[77],"Michaelis-Menten":[79],"equation":[80],"with":[81,243],"added":[83],"linear":[84],"component":[85],"discriminate":[87],"between":[88,178],"carrier-mediated":[89],"diffusional":[91],"transport.":[92],"Although":[93],"heart":[94],"lung":[96],"weights":[97],"significantly":[99],"increased":[100],"(P":[101,115,135],"<":[102,116],"0.0001)":[103],"in":[104,121,128,144,149,155,167,213,223,246],"group,":[107],"left":[108],"ventricular":[109],"function":[110],"only":[112],"modestly":[113],"altered":[114],"0.05).":[117],"A":[118],"significant":[119],"reduction":[120,222],"type":[122,141],"I":[123],"myosin":[124],"heavy":[125],"chain":[126],"(MHC)":[127],"soleus":[130],"strong":[133],"trend":[134],"0.06)":[137],"for":[138],"reduced":[140],"IIx":[142],"MHC":[143],"plantaris":[146],"observed":[148],"rats,":[151],"but":[152,240],"no":[153],"differences":[154],"citrate":[156],"synthase":[157],"activity":[158],"monocarboxylate":[160],"transporter":[161],"proteins":[162,248],"(MCT)-1":[163],"expression":[164,239],"noted":[166],"any":[168],"Carrier-mediated":[170],"influx":[172,207],"into":[173],"similar":[177],"(K(m)":[182],"12":[184],"+/-":[185,189,196,200],"1":[186],"18":[188],"3":[190],"mM;":[191],"apparent":[192],"V(max)":[193],"772":[195],"99":[197],"827":[199],"80":[201],"nmol.":[202],"mg(-1).":[203],"min(-1),":[204],"respectively).":[205],"Total":[206],"100":[209],"mM":[210],"lower":[212],"MVO,":[214],"this":[216],"due":[218],"30%":[221],"membrane":[224],"diffusion.":[225],"In":[226],"conclusion,":[227],"10-wk":[229],"did":[231],"not":[232],"alter":[233],"MCT-mediated":[234],"protein":[238],"associated":[242],"modest":[244],"changes":[245],"myofibrillar":[247],"impaired":[250],"diffusive":[252],"properties.":[253]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
