{"id":"https://openalex.org/W2220046640","doi":"https://doi.org/10.1242/dev.128.22.4405","title":"Increase of cGMP, cADP-ribose and inositol 1,4,5-trisphosphate preceding Ca2+ transients in fertilization of sea urchin eggs","display_name":"Increase of cGMP, cADP-ribose and inositol 1,4,5-trisphosphate preceding Ca2+ transients in fertilization of sea urchin eggs","publication_year":2001,"publication_date":"2001-11-15","ids":{"openalex":"https://openalex.org/W2220046640","doi":"https://doi.org/10.1242/dev.128.22.4405","mag":"2220046640","pmid":"https://pubmed.ncbi.nlm.nih.gov/11714667"},"language":"en","primary_location":{"id":"doi:10.1242/dev.128.22.4405","doi":"https://doi.org/10.1242/dev.128.22.4405","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.128.22.4405","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103386118","display_name":"Ritsu Kuroda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42766147","display_name":"University of Toyama","ror":"https://ror.org/0445phv87","country_code":"JP","type":"education","lineage":["https://openalex.org/I42766147"]},{"id":"https://openalex.org/I53888640","display_name":"National Defense Medical College","ror":"https://ror.org/02e4qbj88","country_code":"JP","type":"education","lineage":["https://openalex.org/I53888640"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ritsu Kuroda","raw_affiliation_strings":["Department of Environmental Biology and Chemistry, Faculty of Science, Toyama University, 3190 Gofuku, Toyama 930-8555, Japan","Present address: Department of Pharmacology, National Defense Medical College, Namiki, Tokorozawa 359-8513, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Biology and Chemistry, Faculty of Science, Toyama University, 3190 Gofuku, Toyama 930-8555, Japan","institution_ids":["https://openalex.org/I42766147"]},{"raw_affiliation_string":"Present address: Department of Pharmacology, National Defense Medical College, Namiki, Tokorozawa 359-8513, Japan","institution_ids":["https://openalex.org/I53888640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083578860","display_name":"Kenji Kontani","orcid":"https://orcid.org/0000-0001-7122-0877","observed_orcids":["https://orcid.org/0000-0001-7122-0877"]},"institutions":[{"id":"https://openalex.org/I53888640","display_name":"National Defense Medical College","ror":"https://ror.org/02e4qbj88","country_code":"JP","type":"education","lineage":["https://openalex.org/I53888640"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Kontani","raw_affiliation_strings":["Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, 3-7-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan","Present address: Department of Pharmacology, National Defense Medical College, Namiki, Tokorozawa 359-8513, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, 3-7-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Present address: Department of Pharmacology, National Defense Medical College, Namiki, Tokorozawa 359-8513, Japan","institution_ids":["https://openalex.org/I53888640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028592309","display_name":"Yasunari Kanda","orcid":"https://orcid.org/0000-0003-2527-3526","observed_orcids":["https://orcid.org/0000-0003-2527-3526"]},"institutions":[{"id":"https://openalex.org/I53888640","display_name":"National Defense Medical College","ror":"https://ror.org/02e4qbj88","country_code":"JP","type":"education","lineage":["https://openalex.org/I53888640"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasunari Kanda","raw_affiliation_strings":["Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, 3-7-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan","Present address: Department of Pharmacology, National Defense Medical College, Namiki, Tokorozawa 359-8513, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, 3-7-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Present address: Department of Pharmacology, National Defense Medical College, Namiki, Tokorozawa 359-8513, Japan","institution_ids":["https://openalex.org/I53888640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029324365","display_name":"Toshiaki Katada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53888640","display_name":"National Defense Medical College","ror":"https://ror.org/02e4qbj88","country_code":"JP","type":"education","lineage":["https://openalex.org/I53888640"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiaki Katada","raw_affiliation_strings":["Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, 3-7-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan","Present address: Department of Pharmacology, National Defense Medical College, Namiki, Tokorozawa 359-8513, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, 3-7-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Present address: Department of Pharmacology, National Defense Medical College, Namiki, Tokorozawa 359-8513, Japan","institution_ids":["https://openalex.org/I53888640"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Takashi Nakano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42766147","display_name":"University of Toyama","ror":"https://ror.org/0445phv87","country_code":"JP","type":"education","lineage":["https://openalex.org/I42766147"]},{"id":"https://openalex.org/I53888640","display_name":"National Defense Medical College","ror":"https://ror.org/02e4qbj88","country_code":"JP","type":"education","lineage":["https://openalex.org/I53888640"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Nakano","raw_affiliation_strings":["Department of Environmental Biology and Chemistry, Faculty of Science, Toyama University, 3190 Gofuku, Toyama 930-8555, Japan","Present address: Department of Pharmacology, National Defense Medical College, Namiki, Tokorozawa 359-8513, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Biology and Chemistry, Faculty of Science, Toyama University, 3190 Gofuku, Toyama 930-8555, Japan","institution_ids":["https://openalex.org/I42766147"]},{"raw_affiliation_string":"Present address: Department of Pharmacology, National Defense Medical College, Namiki, Tokorozawa 359-8513, Japan","institution_ids":["https://openalex.org/I53888640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001136287","display_name":"Yu-ichi Satoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]},{"id":"https://openalex.org/I53888640","display_name":"National Defense Medical College","ror":"https://ror.org/02e4qbj88","country_code":"JP","type":"education","lineage":["https://openalex.org/I53888640"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yu-ichi Satoh","raw_affiliation_strings":["Division of Biological Sciences, Graduate School of Science, Hokkaido University, Kita-ku, Kita 10-jyo, Nishi 8-chome, Sapporo 060-0810, Japan","Present address: Department of Pharmacology, National Defense Medical College, Namiki, Tokorozawa 359-8513, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biological Sciences, Graduate School of Science, Hokkaido University, Kita-ku, Kita 10-jyo, Nishi 8-chome, Sapporo 060-0810, Japan","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"Present address: Department of Pharmacology, National Defense Medical College, Namiki, Tokorozawa 359-8513, Japan","institution_ids":["https://openalex.org/I53888640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105696331","display_name":"Norio Suzuki","orcid":"https://orcid.org/0000-0001-6100-3350","observed_orcids":["https://orcid.org/0000-0001-6100-3350"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]},{"id":"https://openalex.org/I53888640","display_name":"National Defense Medical College","ror":"https://ror.org/02e4qbj88","country_code":"JP","type":"education","lineage":["https://openalex.org/I53888640"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Norio Suzuki","raw_affiliation_strings":["Division of Biological Sciences, Graduate School of Science, Hokkaido University, Kita-ku, Kita 10-jyo, Nishi 8-chome, Sapporo 060-0810, Japan","Present address: Department of Pharmacology, National Defense Medical College, Namiki, Tokorozawa 359-8513, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biological Sciences, Graduate School of Science, Hokkaido University, Kita-ku, Kita 10-jyo, Nishi 8-chome, Sapporo 060-0810, Japan","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"Present address: Department of Pharmacology, National Defense Medical College, Namiki, Tokorozawa 359-8513, Japan","institution_ids":["https://openalex.org/I53888640"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111899715","display_name":"Hideyo Kuroda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42766147","display_name":"University of Toyama","ror":"https://ror.org/0445phv87","country_code":"JP","type":"education","lineage":["https://openalex.org/I42766147"]},{"id":"https://openalex.org/I53888640","display_name":"National Defense Medical College","ror":"https://ror.org/02e4qbj88","country_code":"JP","type":"education","lineage":["https://openalex.org/I53888640"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideyo Kuroda","raw_affiliation_strings":["Department of Environmental Biology and Chemistry, Faculty of Science, Toyama University, 3190 Gofuku, Toyama 930-8555, Japan","Present address: Department of Pharmacology, National Defense Medical College, Namiki, Tokorozawa 359-8513, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Biology and Chemistry, Faculty of Science, Toyama University, 3190 Gofuku, Toyama 930-8555, Japan","institution_ids":["https://openalex.org/I42766147"]},{"raw_affiliation_string":"Present address: Department of Pharmacology, National Defense Medical College, Namiki, Tokorozawa 359-8513, Japan","institution_ids":["https://openalex.org/I53888640"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1815,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.8540107,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"128","issue":"22","first_page":"4405","last_page":"4414"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.011500000022351742,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fertilisation-biology","display_name":"fertilisation (biology)","score":0.7749999761581421},{"id":"https://openalex.org/keywords/sea-urchin-eggs","display_name":"sea urchin eggs","score":0.9760000109672546},{"id":"https://openalex.org/keywords/calcium-transients","display_name":"calcium transients","score":0.9070000052452087},{"id":"https://openalex.org/keywords/cgmp","display_name":"cyclic GMP","score":0.8199999928474426},{"id":"https://openalex.org/keywords/cyclic-adp-ribose","display_name":"cyclic ADP-ribose","score":0.9879999756813049},{"id":"https://openalex.org/keywords/inositol-1-4-5-trisphosphate","display_name":"inositol 1,4,5-trisphosphate","score":0.9990000128746033},{"id":"https://openalex.org/keywords/soluble-guanylate-cyclase","display_name":"soluble guanylate cyclase","score":0.8519999980926514},{"id":"https://openalex.org/keywords/ryanodine-receptor","display_name":"ryanodine receptor","score":0.984000027179718},{"id":"https://openalex.org/keywords/ip3-receptor","display_name":"IP3 receptor","score":0.8820000290870667},{"id":"https://openalex.org/keywords/intracellular-calcium-stores","display_name":"intracellular calcium stores","score":0.7789999842643738},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.7860000133514404},{"id":"https://openalex.org/keywords/second-messengers","display_name":"second messengers","score":0.7760000228881836}],"concepts":[{"id":"https://openalex.org/C2776908312","wikidata":"https://www.wikidata.org/wiki/Q83483","display_name":"Sea urchin","level":2,"score":0.8214868903160095},{"id":"https://openalex.org/C2777427919","wikidata":"https://www.wikidata.org/wiki/Q407997","display_name":"Inositol","level":3,"score":0.7863869667053223},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7079058289527893},{"id":"https://openalex.org/C163235415","wikidata":"https://www.wikidata.org/wiki/Q899814","display_name":"Second messenger system","level":3,"score":0.6921561360359192},{"id":"https://openalex.org/C113217602","wikidata":"https://www.wikidata.org/wiki/Q416781","display_name":"Ryanodine receptor","level":3,"score":0.6842238306999207},{"id":"https://openalex.org/C152624196","wikidata":"https://www.wikidata.org/wiki/Q418917","display_name":"Inositol trisphosphate receptor","level":4,"score":0.6423658728599548},{"id":"https://openalex.org/C2781387506","wikidata":"https://www.wikidata.org/wiki/Q138145","display_name":"Inositol trisphosphate","level":4,"score":0.5777110457420349},{"id":"https://openalex.org/C88972607","wikidata":"https://www.wikidata.org/wiki/Q2666904","display_name":"Human fertilization","level":2,"score":0.5273146033287048},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.517913281917572},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5050039887428284},{"id":"https://openalex.org/C2777336126","wikidata":"https://www.wikidata.org/wiki/Q2467043","display_name":"Cyclic ADP-ribose","level":5,"score":0.4658903181552887},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3710578680038452},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.34819328784942627},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.312669575214386},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28226906061172485},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.11325287818908691},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06750929355621338},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.0},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.0},{"id":"https://openalex.org/C159912055","wikidata":"https://www.wikidata.org/wiki/Q14885119","display_name":"CD38","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000246","descriptor_name":"Adenosine Diphosphate Ribose","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000246","descriptor_name":"Adenosine Diphosphate Ribose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005306","descriptor_name":"Fertilization","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006162","descriptor_name":"Guanylate Cyclase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D006162","descriptor_name":"Guanylate Cyclase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006162","descriptor_name":"Guanylate Cyclase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009712","descriptor_name":"Nucleotides, Cyclic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010063","descriptor_name":"Ovum","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012617","descriptor_name":"Sea Urchins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015290","descriptor_name":"Second Messenger Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015544","descriptor_name":"Inositol 1,4,5-Trisphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D036563","descriptor_name":"Cyclic ADP-Ribose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1242/dev.128.22.4405","doi":"https://doi.org/10.1242/dev.128.22.4405","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.128.22.4405","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},{"id":"pmid:11714667","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11714667","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development (Cambridge, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W25999916","https://openalex.org/W1488869774","https://openalex.org/W1499398296","https://openalex.org/W1534119359","https://openalex.org/W1561270317","https://openalex.org/W1562338683","https://openalex.org/W1597778600","https://openalex.org/W1623412780","https://openalex.org/W1964639762","https://openalex.org/W1980148057","https://openalex.org/W1980166477","https://openalex.org/W1986605032","https://openalex.org/W1991123763","https://openalex.org/W1991692667","https://openalex.org/W1992526945","https://openalex.org/W2000587392","https://openalex.org/W2004773321","https://openalex.org/W2006265135","https://openalex.org/W2007278837","https://openalex.org/W2019237376","https://openalex.org/W2023071085","https://openalex.org/W2026403098","https://openalex.org/W2026452617","https://openalex.org/W2026571586","https://openalex.org/W2033620401","https://openalex.org/W2040593177","https://openalex.org/W2044342274","https://openalex.org/W2047204395","https://openalex.org/W2048614780","https://openalex.org/W2056768252","https://openalex.org/W2058790454","https://openalex.org/W2058982726","https://openalex.org/W2070533233","https://openalex.org/W2072104542","https://openalex.org/W2075068003","https://openalex.org/W2075203851","https://openalex.org/W2083510764","https://openalex.org/W2090611949","https://openalex.org/W2091763212","https://openalex.org/W2129032725","https://openalex.org/W2138270253","https://openalex.org/W2141260882","https://openalex.org/W2154690445","https://openalex.org/W2155993370","https://openalex.org/W2160021227","https://openalex.org/W2164715751","https://openalex.org/W2167947042","https://openalex.org/W2186033591","https://openalex.org/W2394776735","https://openalex.org/W2486082984","https://openalex.org/W4231716452","https://openalex.org/W4249424055"],"related_works":["https://openalex.org/W2072104542","https://openalex.org/W2417490733","https://openalex.org/W1974728143","https://openalex.org/W298220864","https://openalex.org/W2083510764","https://openalex.org/W2028478845","https://openalex.org/W2006265135","https://openalex.org/W3080340810","https://openalex.org/W1987603536","https://openalex.org/W2070533233"],"abstract_inverted_index":{"Transient":[0],"increases,":[1],"or":[2,61,123],"oscillations,":[3],"of":[4,13,71,87,103,111,125,159,163,183,198,215,219,223,228,240,276],"cytoplasmic":[5],"free":[6],"Ca(2+)":[7,23,89,171,200,241,268],"concentration,":[8],"[Ca(2+)](i),":[9,184],"occur":[10],"during":[11,77,107,274],"fertilization":[12,80,112,275],"animal":[14],"egg":[15],"cells.":[16],"In":[17],"sea":[18,78,104,277],"urchin":[19,79,105,278],"eggs,":[20,216],"the":[21,30,46,52,72,88,95,108,117,121,156,164,170,180,186,199,203,211,226,234,238,249,261,267],"increased":[22],"is":[24,57,191,256],"derived":[25],"from":[26],"intracellular":[27],"stores,":[28],"but":[29,264],"principal":[31],"signaling":[32,90],"and":[33,51,98,113,149,217,231,233,254],"release":[34],"system":[35],"involved":[36],"has":[37],"not":[38,257],"yet":[39],"been":[40],"agreed":[41],"upon.":[42],"Possible":[43],"candidates":[44,76],"are":[45],"inositol":[47,99],"1,4,5-trisphosphate":[48,100],"receptor/channel":[49,54],"(IP(3)R)":[50],"ryanodine":[53],"(RyR)":[55],"which":[56],"activated":[58],"by":[59,147,179,210,270],"cGMP":[60,140,207,253],"cyclic":[62],"ADP-ribose":[63],"(cADPR).":[64],"Thus,":[65],"it":[66],"seemed":[67],"that":[68,248],"direct":[69],"measurements":[70],"likely":[73],"second":[74],"messenger":[75],"would":[81],"be":[82,177],"essential":[83],"to":[84,143,266],"an":[85,126],"understanding":[86],"pathway.":[91],"We":[92,132],"therefore":[93],"measured":[94,204],"cGMP,":[96],"cADPR":[97,148,230,255],"(IP(3))":[101],"contents":[102],"eggs":[106,224],"early":[109],"stages":[110],"compared":[114],"these":[115,245],"with":[116],"[Ca(2+)](i)":[118,235],"rise":[119,144,165],"in":[120,166,189,206],"presence":[122],"absence":[124],"inhibitor":[127],"against":[128],"soluble":[129,212,220],"guanylate":[130,213,221],"cyclase.":[131],"obtained":[133],"three":[134],"major":[135],"experimental":[136],"results:":[137],"(1)":[138],"cytosolic":[139],"levels":[141],"began":[142],"first,":[145],"followed":[146],"IP(3)":[150,167,173,190,232,272],"levels,":[151],"all":[152],"almost":[153],"doubling":[154],"before":[155],"explosive":[157],"increase":[158,188,205,236],"[Ca(2+)](i);":[160],"(2)":[161],"most":[162],"occurred":[168],"after":[169],"peak;":[172],"production":[174,227,273],"could":[175],"also":[176],"induced":[178],"artificial":[181],"elevation":[182],"suggesting":[185],"large":[187],"a":[192,196],"consequence,":[193],"rather":[194],"than":[195],"cause,":[197],"transient;":[201],"(3)":[202],"was":[208],"produced":[209],"cyclase":[214,222],"inhibition":[218],"diminished":[225],"both":[229],"without":[237],"delay":[239],"transients.":[242],"Taken":[243],"together,":[244],"results":[246],"suggest":[247],"RyR":[250],"pathway":[251],"involving":[252],"solely":[258],"responsible":[259],"for":[260],"initiating":[262],"event,":[263],"contributes":[265],"transients":[269],"stimulating":[271],"eggs.":[279]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}