{"id":"https://openalex.org/W2220040744","doi":null,"title":"Unravelling the induction and development of intramembranous bones in the chicken eye","display_name":"Unravelling the induction and development of intramembranous bones in the chicken eye","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2220040744","mag":"2220040744"},"language":"en","primary_location":{"id":"pmh:oai:library2.smu.ca:01/23726","doi":null,"is_oa":true,"landing_page_url":"http://library2.smu.ca/xmlui/handle/01/23726","pdf_url":"http://library2.smu.ca/xmlui/handle/01/23726","source":{"id":"https://openalex.org/S4306402189","display_name":"Saint Mary's University Institutional Repository (Saint Mary's University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66890659","host_organization_name":"Saint Mary's University","host_organization_lineage":["https://openalex.org/I66890659"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://library2.smu.ca/xmlui/handle/01/23726","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036253845","display_name":"Kellie Duench","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kellie Duench","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5036253845"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.6201000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.6201000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12989","display_name":"Ocular Disorders and Treatments","score":0.163100004196167,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.11789999902248383,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/scleral-ossicles","display_name":"scleral ossicles","score":0.9139999747276306},{"id":"https://openalex.org/keywords/chicken-eye","display_name":"chicken eye","score":0.9020000100135803},{"id":"https://openalex.org/keywords/scleraxis","display_name":"scleraxis","score":0.6700000166893005},{"id":"https://openalex.org/keywords/patched","display_name":"Patched","score":0.8579999804496765},{"id":"https://openalex.org/keywords/bone-morphogenetic-proteins","display_name":"bone morphogenetic proteins","score":0.9380000233650208},{"id":"https://openalex.org/keywords/sonic-hedgehog","display_name":"Sonic hedgehog","score":0.8410000205039978},{"id":"https://openalex.org/keywords/indian-hedgehog","display_name":"Indian hedgehog","score":0.8700000047683716},{"id":"https://openalex.org/keywords/msx2","display_name":"Msx2","score":0.9919999837875366}],"concepts":[{"id":"https://openalex.org/C188945261","wikidata":"https://www.wikidata.org/wiki/Q10746904","display_name":"Intramembranous ossification","level":2,"score":0.960195004940033},{"id":"https://openalex.org/C2778514029","wikidata":"https://www.wikidata.org/wiki/Q816052","display_name":"Ossicles","level":3,"score":0.8548887968063354},{"id":"https://openalex.org/C17938293","wikidata":"https://www.wikidata.org/wiki/Q3312710","display_name":"Endochondral ossification","level":3,"score":0.8153480887413025},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6036689877510071},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.5602338314056396},{"id":"https://openalex.org/C2776637008","wikidata":"https://www.wikidata.org/wiki/Q14860072","display_name":"Sonic hedgehog","level":3,"score":0.5331726670265198},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44623053073883057},{"id":"https://openalex.org/C2777846895","wikidata":"https://www.wikidata.org/wiki/Q501553","display_name":"Middle ear","level":2,"score":0.13877993822097778},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.12075883150100708},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.094572514295578}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:library2.smu.ca:01/23726","doi":null,"is_oa":true,"landing_page_url":"http://library2.smu.ca/xmlui/handle/01/23726","pdf_url":"http://library2.smu.ca/xmlui/handle/01/23726","source":{"id":"https://openalex.org/S4306402189","display_name":"Saint Mary's University Institutional Repository (Saint Mary's University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66890659","host_organization_name":"Saint Mary's University","host_organization_lineage":["https://openalex.org/I66890659"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"mag:2220040744","doi":null,"is_oa":false,"landing_page_url":"https://library2.smu.ca/bitstream/01/23726/2/duench_kellie_masters_2010.PDF","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:library2.smu.ca:01/23726","doi":null,"is_oa":true,"landing_page_url":"http://library2.smu.ca/xmlui/handle/01/23726","pdf_url":"http://library2.smu.ca/xmlui/handle/01/23726","source":{"id":"https://openalex.org/S4306402189","display_name":"Saint Mary's University Institutional Repository (Saint Mary's University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66890659","host_organization_name":"Saint Mary's University","host_organization_lineage":["https://openalex.org/I66890659"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320313015","display_name":"Mount Saint Vincent University","ror":"https://ror.org/03g3p3b82"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2220040744.pdf","grobid_xml":"https://content.openalex.org/works/W2220040744.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W56952916","https://openalex.org/W1482347863","https://openalex.org/W1963757127","https://openalex.org/W1972649530","https://openalex.org/W1973021296","https://openalex.org/W1984288177","https://openalex.org/W1991941177","https://openalex.org/W1995789564","https://openalex.org/W2003289937","https://openalex.org/W2024215958","https://openalex.org/W2026201824","https://openalex.org/W2030245679","https://openalex.org/W2030583109","https://openalex.org/W2039523697","https://openalex.org/W2039871960","https://openalex.org/W2041632453","https://openalex.org/W2042860502","https://openalex.org/W2044384686","https://openalex.org/W2045670456","https://openalex.org/W2046409391","https://openalex.org/W2046865142","https://openalex.org/W2053362902","https://openalex.org/W2055283372","https://openalex.org/W2061042922","https://openalex.org/W2061135487","https://openalex.org/W2065340908","https://openalex.org/W2070703107","https://openalex.org/W2075639475","https://openalex.org/W2076155657","https://openalex.org/W2087321947","https://openalex.org/W2088174138","https://openalex.org/W2101958327","https://openalex.org/W2104852357","https://openalex.org/W2119434944","https://openalex.org/W2121894190","https://openalex.org/W2124354752","https://openalex.org/W2128051624","https://openalex.org/W2131823580","https://openalex.org/W2140034535","https://openalex.org/W2155343233","https://openalex.org/W2161282017","https://openalex.org/W2163591231","https://openalex.org/W2171958860","https://openalex.org/W2182792048","https://openalex.org/W2589107153","https://openalex.org/W2748693789","https://openalex.org/W4300045476"],"related_works":["https://openalex.org/W18760785","https://openalex.org/W2313125968","https://openalex.org/W7028878774","https://openalex.org/W2794217560","https://openalex.org/W4389028658","https://openalex.org/W2915327749","https://openalex.org/W2117306665","https://openalex.org/W2061936913","https://openalex.org/W2404637315","https://openalex.org/W2468235691"],"abstract_inverted_index":{"Bone":[0],"development":[1,17,78,102,132],"is":[2],"a":[3],"complex":[4],"process,":[5],"involving":[6],"multiple":[7],"tissues":[8],"and":[9,57,67,73,113,130,136],"hierarchical":[10],"inductive":[11],"interactions.":[12],"The":[13],"study":[14,119],"of":[15,44,70,79,93,103,133,143],"skeletal":[16],"has":[18,120,137],"focused":[19],"on":[20],"endochondral":[21],"bones":[22,25],"while":[23],"intramembranous":[24,144],"(e.g.":[26],"scleral":[27,45,80,104,134],"ossicles)":[28],"have":[29,61],"received":[30],"less":[31],"attention.":[32],"Although,":[33],"sonic":[34],"hedgehog":[35,112],"was":[36,108],"recently":[37],"demonstrated":[38,62],"to":[39,97,122,139],"be":[40,98],"present":[41],"during":[42,76,127],"induction":[43,129],"ossicles,":[46],"other":[47],"signalling":[48],"molecules":[49],"are":[50,115],"still":[51],"unknown.":[52],"Using":[53],"in":[54,100],"situ":[55],"hybridization":[56],"bead":[58],"implantation":[59],"I":[60],"the":[63,68,77,87,101,124,128,140],"presence":[64],"or":[65],"absence":[66],"involvement":[69],"candidate":[71],"genes":[72],"gene":[74],"families":[75],"ossicles.":[81,105],"Scleraxis,":[82],"patched,":[83],"as":[84,86],"well":[85],"bone":[88,145],"morphogenetic":[89],"protein":[90],"(BMP)":[91],"family":[92],"genes,":[94],"were":[95],"found":[96],"involved":[99,126],"Conversely,":[106],"it":[107],"determined":[109],"that":[110],"indian":[111],"msx2":[114],"not":[116],"present.":[117],"This":[118],"contributed":[121,138],"unravelling":[123],"signals":[125],"subsequent":[131],"ossicles":[135],"current":[141],"understanding":[142],"development.":[146]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2016-06-24T00:00:00"}