{"id":"https://openalex.org/W2219787372","doi":"https://doi.org/10.13128/ijae-16961","title":"Evaluation of the effects of a dynamic culture on osteogenic differentiation of oral-periosteal cells grown on PLGA sponges","display_name":"Evaluation of the effects of a dynamic culture on osteogenic differentiation of oral-periosteal cells grown on PLGA sponges","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2219787372","doi":"https://doi.org/10.13128/ijae-16961","mag":"2219787372"},"language":"it","primary_location":{"id":"pmh:oai:iris.uniroma1.it:11573/1581920","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11573/1581920","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["crossref","datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11573/1581920","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048453889","display_name":"Gabriele Ceccarelli","orcid":"https://orcid.org/0000-0002-8576-694X","observed_orcids":["https://orcid.org/0000-0002-8576-694X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ceccarelli, Gabriele","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Benedetti, Laura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Benedetti, Laura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034816355","display_name":"Antonio Graziano","orcid":"https://orcid.org/0000-0003-3409-7624","observed_orcids":["https://orcid.org/0000-0003-3409-7624"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Graziano, Antonio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001410968","display_name":"Maurizio Alloni","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alloni, Maurizio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Silvani, Giulia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Silvani, Giulia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080157924","display_name":"Maurilio Sampaolesi","orcid":"https://orcid.org/0000-0002-2422-3757","observed_orcids":["https://orcid.org/0000-0002-2422-3757"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sampaolesi, Maurilio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111097300","display_name":"Piero Micheletti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Micheletti, Piero","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048033563","display_name":"Livia Visai","orcid":"https://orcid.org/0000-0003-1181-3632","observed_orcids":["https://orcid.org/0000-0003-1181-3632"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Visai, Livia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5063579573","display_name":"Maria Gabriella Cusella De Angelis","orcid":"https://orcid.org/0000-0003-2642-3346","observed_orcids":["https://orcid.org/0000-0003-2642-3346"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cusella De Angelis, Maria Gabriella","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"120","issue":"1","first_page":"100","last_page":"100"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10359","display_name":"Dental Implant Techniques and Outcomes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.8740000128746033},{"id":"https://openalex.org/keywords/dynamic-culture","display_name":"dynamic culture","score":0.8709999918937683},{"id":"https://openalex.org/keywords/rotating-bioreactor","display_name":"rotating bioreactor","score":0.9509999752044678},{"id":"https://openalex.org/keywords/bone-tissue-engineering","display_name":"bone tissue engineering","score":0.7699999809265137},{"id":"https://openalex.org/keywords/bmp-2","display_name":"BMP-2","score":0.8059999942779541},{"id":"https://openalex.org/keywords/osteoprotegerin","display_name":"osteoprotegerin","score":0.996999979019165},{"id":"https://openalex.org/keywords/tooth-extraction","display_name":"tooth extraction","score":0.6019999980926514},{"id":"https://openalex.org/keywords/periodontal-defects","display_name":"periodontal defects","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C2910894859","wikidata":"https://www.wikidata.org/wiki/Q267813","display_name":"ALIZARIN RED","level":3,"score":0.7468781471252441},{"id":"https://openalex.org/C2778849931","wikidata":"https://www.wikidata.org/wiki/Q18960","display_name":"Sponge","level":2,"score":0.5920901894569397},{"id":"https://openalex.org/C2777674748","wikidata":"https://www.wikidata.org/wiki/Q367423","display_name":"Periosteum","level":2,"score":0.570266842842102},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.5679323673248291},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.5661452412605286},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5302193760871887},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5193197131156921},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.47129499912261963},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.4636830687522888},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.449833482503891},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4416828751564026},{"id":"https://openalex.org/C2780165375","wikidata":"https://www.wikidata.org/wiki/Q2102907","display_name":"PLGA","level":3,"score":0.43014055490493774},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.4192747473716736},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3522157073020935},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30357229709625244},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2975480854511261},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.24844837188720703},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.195094496011734},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18993332982063293},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16408801078796387},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:iris.uniroma1.it:11573/1581920","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11573/1581920","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"},{"id":"mag:2219787372","doi":null,"is_oa":false,"landing_page_url":"https://iris.unipv.it/handle/11571/1197923","pdf_url":null,"source":{"id":"https://openalex.org/S2754812629","display_name":"Italian Journal of Anatomy and Embryology","issn_l":"0004-0223","issn":["0004-0223","1122-6714","2038-5129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310317633","host_organization_name":"University of Florence","host_organization_lineage":["https://openalex.org/P4310317633"],"host_organization_lineage_names":["University of Florence"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Italian Journal of Anatomy and Embryology","raw_type":null},{"id":"doi:10.13128/ijae-16961","doi":"https://doi.org/10.13128/ijae-16961","is_oa":true,"landing_page_url":"https://doi.org/10.13128/ijae-16961","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.13128/ijae-16961","doi":"https://doi.org/10.13128/ijae-16961","is_oa":false,"landing_page_url":"https://doi.org/10.13128/ijae-16961","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"pmh:oai:iris.uniroma1.it:11573/1581920","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11573/1581920","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"},"sustainable_development_goals":[{"score":0.7246000170707703,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W1988796528"],"related_works":["https://openalex.org/W7135071631","https://openalex.org/W7134931350","https://openalex.org/W7070290146","https://openalex.org/W2057329913","https://openalex.org/W2114990979","https://openalex.org/W3016655499","https://openalex.org/W1990031483","https://openalex.org/W2910129163","https://openalex.org/W1964990227","https://openalex.org/W1511345164"],"abstract_inverted_index":{"Oral-periosteum":[0],"derived":[1,104],"stem":[2,37],"cells":[3,38,103,128,149,176,204,237,261],"represent":[4,263],"an":[5,239],"innovative":[6],"cell":[7],"source":[8],"for":[9,132],"bone":[10,164],"tissue":[11,33,43,269],"engineering":[12,34],"applications":[13,83],"in":[14,32,35,81,123,142,163,177,209,231,267],"terms":[15],"of":[16,42,54,98,148,175,228,236,246,254],"accessibility":[17],"and":[18,40,56,68,135,157,197,258],"self-commitment":[19],"towards":[20],"osteogenic":[21,96,140,173,226,250],"lineage":[22],"[1].":[23],"In":[24,74],"this":[25,111,255],"scenario,":[26],"biomaterials":[27],"play":[28],"a":[29,50,115,120,264],"pivotal":[30],"role":[31],"supporting":[36],"growth":[39],"regeneration":[41],"defects":[44,88],"[2].":[45],"Among":[46],"these":[47,222],"biomaterials,":[48],"Fisiograft\u00ae,":[49],"synthetic":[51],"co-polymer":[52],"composed":[53],"polylactic":[55],"polyglycholic":[57],"acids":[58],"produced":[59],"by":[60,152,158,192,203],"Ghimas":[61],"(Bologna,":[62],"Italy),":[63],"is":[64],"highly":[65,201],"biocom-":[66],"patible":[67],"completely":[69,86],"absorbed":[70],"within":[71],"4-6":[72],"months.":[73],"particular,":[75],"Fisiograft\u00ae":[76,99,130,207,229],"sponges":[77,100,131,170,208,230],"are":[78,200],"normally":[79],"used":[80],"dental":[82,108],"to":[84,183,217,238,243],"fix":[85],"periodontal":[87],"without":[89,138,248],"damage":[90],"Schneider\u2019s":[91],"membrane.":[92],"We":[93],"evaluated":[94,151],"the":[95,143,178,225,233],"potential":[97,227],"on":[101,119,160,206],"oral-periosteal":[102],"from":[105],"patients":[106],"undergoing":[107],"extractions.":[109],"For":[110],"purpose,":[112],"we":[113,125],"created":[114],"dynamic":[116,179,210],"culture":[117,180,211],"based":[118],"rotating":[121],"apparatus":[122],"which":[124],"seeded":[126],"periosteal":[127],"with":[129,181,215],"7,":[133],"14":[134,188,213,244],"21":[136],"days":[137,214,245],"adding":[139],"supplement":[141],"medium.":[144],"Osteoblast":[145],"differen-":[146],"tiation":[147],"was":[150],"Alizarin":[153,193],"Red":[154,194],"S":[155],"staining":[156],"qRT-PCR":[159],"genes":[161,199],"involved":[162],"development.":[165],"Results":[166],"show":[167],"that":[168],"Fisograft\u00ae":[169],"promote":[171],"greater":[172],"differentiation":[174],"respect":[182,216],"standard":[184],"condition":[185],"already":[186],"at":[187,212],"days,":[189],"as":[190],"demonstrated":[191],"staining.":[195],"BMP-2":[196],"Osteoprotegerin":[198],"expressed":[202],"grown":[205],"plastic":[218],"culture.":[219],"Taken":[220],"together,":[221],"results":[223],"confirm":[224],"accelerating":[232],"dif-":[234],"ferentiation":[235],"osteoblast":[240],"phenotype":[241],"(already":[242],"culture)":[247],"any":[249],"induction.":[251],"The":[252],"combination":[253],"PLGA":[256],"biomaterial":[257],"oral-peri-":[259],"osteal":[260],"could":[262],"promising":[265],"bio-complex":[266],"maxillo-facial":[268],"repair.":[270]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2016-06-24T00:00:00"}