{"id":"https://openalex.org/W2219684161","doi":"https://doi.org/10.1177/000313480407001203","title":"Impact of Neoadjuvant Therapy on Postoperative Complications in Patients Undergoing Resection for Rectal Adenocarcinoma","display_name":"Impact of Neoadjuvant Therapy on Postoperative Complications in Patients Undergoing Resection for Rectal Adenocarcinoma","publication_year":2004,"publication_date":"2004-12-01","ids":{"openalex":"https://openalex.org/W2219684161","doi":"https://doi.org/10.1177/000313480407001203","mag":"2219684161","pmid":"https://pubmed.ncbi.nlm.nih.gov/15663042"},"language":"en","primary_location":{"id":"doi:10.1177/000313480407001203","doi":"https://doi.org/10.1177/000313480407001203","is_oa":false,"landing_page_url":"https://doi.org/10.1177/000313480407001203","pdf_url":null,"source":{"id":"https://openalex.org/S113474406","display_name":"The American Surgeon","issn_l":"0003-1348","issn":["0003-1348","1555-9823"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Surgeon","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027278759","display_name":"Immanuel I. Turner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Immanuel I. Turner","raw_affiliation_strings":["From the Surgical Oncology Service and the Departments of General Surgery, Radiation Oncology, and Public Health Sciences, Wake Forest University, Winston-Salem, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Surgical Oncology Service and the Departments of General Surgery, Radiation Oncology, and Public Health Sciences, Wake Forest University, Winston-Salem, North Carolina","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024347949","display_name":"Gregory B. Russell","orcid":"https://orcid.org/0000-0003-0270-3618","observed_orcids":["https://orcid.org/0000-0003-0270-3618"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory B. Russell","raw_affiliation_strings":["From the Surgical Oncology Service and the Departments of General Surgery, Radiation Oncology, and Public Health Sciences, Wake Forest University, Winston-Salem, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Surgical Oncology Service and the Departments of General Surgery, Radiation Oncology, and Public Health Sciences, Wake Forest University, Winston-Salem, North Carolina","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032064458","display_name":"A. William Blackstock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. William Blackstock","raw_affiliation_strings":["From the Surgical Oncology Service and the Departments of General Surgery, Radiation Oncology, and Public Health Sciences, Wake Forest University, Winston-Salem, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Surgical Oncology Service and the Departments of General Surgery, Radiation Oncology, and Public Health Sciences, Wake Forest University, Winston-Salem, North Carolina","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040292764","display_name":"Edward Allen Levine","orcid":"https://orcid.org/0000-0002-7683-9502","observed_orcids":["https://orcid.org/0000-0002-7683-9502"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward A. Levine","raw_affiliation_strings":["From the Surgical Oncology Service and the Departments of General Surgery, Radiation Oncology, and Public Health Sciences, Wake Forest University, Winston-Salem, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Surgical Oncology Service and the Departments of General Surgery, Radiation Oncology, and Public Health Sciences, Wake Forest University, Winston-Salem, North Carolina","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.64,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.7081365,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"70","issue":"12","first_page":"1045","last_page":"1049"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13110","display_name":"Colorectal and Anal Carcinomas","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12020","display_name":"Enhanced Recovery After Surgery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rectal-adenocarcinoma","display_name":"rectal adenocarcinoma","score":0.9229999780654907},{"id":"https://openalex.org/keywords/neoadjuvant-therapy","display_name":"neoadjuvant therapy","score":0.8949999809265137},{"id":"https://openalex.org/keywords/postoperative-complications","display_name":"postoperative complications","score":0.9070000052452087},{"id":"https://openalex.org/keywords/abdominoperineal-resection","display_name":"abdominoperineal resection","score":0.9710000157356262},{"id":"https://openalex.org/keywords/neoadjuvant-chemotherapy","display_name":"neoadjuvant chemotherapy","score":0.7450000047683716},{"id":"https://openalex.org/keywords/preoperative-radiotherapy","display_name":"preoperative radiotherapy","score":0.8510000109672546},{"id":"https://openalex.org/keywords/30-day-mortality","display_name":"30-day mortality","score":0.8140000104904175},{"id":"https://openalex.org/keywords/wound-infection","display_name":"wound infection","score":0.5099999904632568},{"id":"https://openalex.org/keywords/anastomotic-leakage","display_name":"anastomotic leakage","score":0.7599999904632568}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9720100164413452},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.7736226320266724},{"id":"https://openalex.org/C2781171867","wikidata":"https://www.wikidata.org/wiki/Q3933360","display_name":"Abdominoperineal resection","level":4,"score":0.7298281192779541},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.6114062070846558},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.582927942276001},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5687124133110046},{"id":"https://openalex.org/C2778292576","wikidata":"https://www.wikidata.org/wiki/Q6991934","display_name":"Neoadjuvant therapy","level":4,"score":0.5009260177612305},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.4642565846443176},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.45922887325286865},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.43303343653678894},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.33368512988090515},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.11590820550918579},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11400601267814636},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D003082","descriptor_name":"Colectomy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012004","descriptor_name":"Rectal Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020360","descriptor_name":"Neoadjuvant Therapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1177/000313480407001203","doi":"https://doi.org/10.1177/000313480407001203","is_oa":false,"landing_page_url":"https://doi.org/10.1177/000313480407001203","pdf_url":null,"source":{"id":"https://openalex.org/S113474406","display_name":"The American Surgeon","issn_l":"0003-1348","issn":["0003-1348","1555-9823"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Surgeon","raw_type":"journal-article"},{"id":"pmid:15663042","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15663042","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American surgeon","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8799999952316284,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1585172067","https://openalex.org/W1963782590","https://openalex.org/W1975570770","https://openalex.org/W1990983711","https://openalex.org/W2007983135","https://openalex.org/W2019669758","https://openalex.org/W2021925080","https://openalex.org/W2027469879","https://openalex.org/W2050020104","https://openalex.org/W2055477207","https://openalex.org/W2057674448","https://openalex.org/W2069793735","https://openalex.org/W2080742741","https://openalex.org/W2081981652","https://openalex.org/W2085735157","https://openalex.org/W2100348520","https://openalex.org/W2107371365","https://openalex.org/W2125452425","https://openalex.org/W2132565869","https://openalex.org/W2156880958","https://openalex.org/W2167972978","https://openalex.org/W2170320291","https://openalex.org/W2919276782","https://openalex.org/W4205231424","https://openalex.org/W4253234031","https://openalex.org/W4293241248"],"related_works":["https://openalex.org/W2081981652","https://openalex.org/W2600471472","https://openalex.org/W1964225865","https://openalex.org/W4382057998","https://openalex.org/W2341464479","https://openalex.org/W1985772694","https://openalex.org/W1994122227","https://openalex.org/W2330135672","https://openalex.org/W2414339826","https://openalex.org/W2358044975"],"abstract_inverted_index":{"Surgical":[0],"resection":[1,56,68,108],"continues":[2],"to":[3,21,42,74,173],"be":[4,22],"the":[5,44,103,157,165,187,209,231,240,245,265],"mainstay":[6],"of":[7,26,38,46,57,62,164,242,267],"treatment":[8],"for":[9,69,133,208],"rectal":[10,58,70],"cancer.":[11,59],"Neoadjuvant":[12],"therapy":[13,48,148,235,269],"(chemotherapy":[14],"and":[15,29,115,135,141,198,228,255,257],"radiation)":[16],"has":[17],"also":[18],"been":[19],"shown":[20],"efficacious.":[23],"The":[24,36,95,146,201],"impact":[25,238],"preoperative":[27,119,147,253,268],"chemotherapy":[28,120,254],"radiation":[30,122,169,256],"on":[31,49,102,152,239],"postoperative":[32,50],"complications":[33,51,153,171],"is":[34,41],"unclear.":[35],"purpose":[37],"this":[39,90,261,271],"study":[40],"evaluate":[43],"relationship":[45],"neoadjuvant":[47,234],"in":[52,177,186,223,270],"patients":[53,64,96,166],"undergoing":[54],"a":[55,250],"A":[60],"total":[61],"325":[63],"who":[65,85,167,179],"underwent":[66],"curative":[67],"cancer":[71],"from":[72],"1984":[73],"2001":[75],"were":[76,92,97],"retrospectively":[77],"reviewed.":[78],"Only":[79],"cases":[80],"with":[81,137,212],"complete":[82],"data":[83],"sets":[84],"had":[86,149,170,236],"undergone":[87],"surgery":[88],"at":[89],"institution":[91],"evaluable":[93],"(257).":[94],"divided":[98],"into":[99],"groups":[100],"based":[101],"operative":[104],"procedure":[105],"performed;":[106],"abdominoperineal":[107],"(APR)":[109],"versus":[110],"sphincter-sparing":[111],"(SS)":[112],"procedures":[113],"(LAR/Transanal)":[114],"whether":[116],"or":[117,121],"not":[118,181,263],"was":[123,126,204,219],"administered.":[124],"There":[125,218],"no":[127,150,213,220,237],"significant":[128,221],"difference":[129,215,222],"between":[130,216,226,252],"complication":[131,224,258],"rates":[132],"APR":[134,227,232],"SS":[136,158,188,246],"19":[138],"per":[139,143,162,175,206],"cent":[140,163,176,207],"14":[142],"cent,":[144],"respectively.":[145],"effect":[151],"after":[154],"APR.":[155],"However,":[156,244,260],"group":[159,189,247],"showed":[160],"21":[161],"received":[168],"compared":[172],"11":[174],"those":[178],"did":[180,248],"(P":[182],"=":[183],"0.087).":[184],"Complications":[185],"included":[190],"leaks,":[191],"wound":[192],"infections,":[193],"abscess,":[194],"embolism,":[195],"cardiac":[196],"dysrhythmias,":[197],"myocardial":[199],"infarctions.":[200],"30-day":[202],"mortality":[203],"1.9":[205],"entire":[210],"cohort":[211],"clear":[214],"groups.":[217],"rate":[225],"SS.":[229],"In":[230],"group,":[233],"incidence":[241],"complications.":[243],"show":[249],"trend":[251],"rate.":[259],"may":[262],"outweigh":[264],"advantages":[266],"setting.":[272]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
