{"id":"https://openalex.org/W2219225571","doi":"https://doi.org/10.1007/s40262-015-0354-3","title":"Pharmacokinetic/Pharmacodynamic Modelling of Receptor Internalization with CRTH2 Antagonists to Optimize Dose Selection","display_name":"Pharmacokinetic/Pharmacodynamic Modelling of Receptor Internalization with CRTH2 Antagonists to Optimize Dose Selection","publication_year":2015,"publication_date":"2015-12-21","ids":{"openalex":"https://openalex.org/W2219225571","doi":"https://doi.org/10.1007/s40262-015-0354-3","mag":"2219225571","pmid":"https://pubmed.ncbi.nlm.nih.gov/26692193"},"language":"en","primary_location":{"id":"doi:10.1007/s40262-015-0354-3","doi":"https://doi.org/10.1007/s40262-015-0354-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s40262-015-0354-3","pdf_url":null,"source":{"id":"https://openalex.org/S69290020","display_name":"Clinical Pharmacokinetics","issn_l":"0312-5963","issn":["0312-5963","1179-1926"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacokinetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029281314","display_name":"Andreas Krause","orcid":"https://orcid.org/0000-0002-4686-976X","observed_orcids":["https://orcid.org/0000-0002-4686-976X"]},"institutions":[{"id":"https://openalex.org/I95056601","display_name":"Actelion (Switzerland)","ror":"https://ror.org/001yedb91","country_code":"CH","type":"company","lineage":["https://openalex.org/I95056601"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Andreas Krause","raw_affiliation_strings":["Department of Clinical Pharmacology, Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, 4123, Allschwil, Switzerland. andreas.krause@actelion.com","Department of Clinical Pharmacology, Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, 4123, Allschwil, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, 4123, Allschwil, Switzerland. andreas.krause@actelion.com","institution_ids":["https://openalex.org/I95056601"]},{"raw_affiliation_string":"Department of Clinical Pharmacology, Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, 4123, Allschwil, Switzerland","institution_ids":["https://openalex.org/I95056601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060004391","display_name":"Jochen Zisowsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95056601","display_name":"Actelion (Switzerland)","ror":"https://ror.org/001yedb91","country_code":"CH","type":"company","lineage":["https://openalex.org/I95056601"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Jochen Zisowsky","raw_affiliation_strings":["Department of Clinical Pharmacology, Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, 4123, Allschwil, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, 4123, Allschwil, Switzerland","institution_ids":["https://openalex.org/I95056601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049875519","display_name":"Daniel S. Strasser","orcid":"https://orcid.org/0000-0002-0097-1937","observed_orcids":["https://orcid.org/0000-0002-0097-1937"]},"institutions":[{"id":"https://openalex.org/I95056601","display_name":"Actelion (Switzerland)","ror":"https://ror.org/001yedb91","country_code":"CH","type":"company","lineage":["https://openalex.org/I95056601"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Daniel S. Strasser","raw_affiliation_strings":["Department of Translational Science, Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, 4123, Allschwil, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Translational Science, Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, 4123, Allschwil, Switzerland","institution_ids":["https://openalex.org/I95056601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047505892","display_name":"Martine G\u00e9hin","orcid":"https://orcid.org/0000-0003-0780-1073","observed_orcids":["https://orcid.org/0000-0003-0780-1073"]},"institutions":[{"id":"https://openalex.org/I95056601","display_name":"Actelion (Switzerland)","ror":"https://ror.org/001yedb91","country_code":"CH","type":"company","lineage":["https://openalex.org/I95056601"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Martine Gehin","raw_affiliation_strings":["Department of Clinical Pharmacology, Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, 4123, Allschwil, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, 4123, Allschwil, Switzerland","institution_ids":["https://openalex.org/I95056601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085651386","display_name":"Patricia N. Sidharta","orcid":"https://orcid.org/0000-0001-7581-4525","observed_orcids":["https://orcid.org/0000-0001-7581-4525"]},"institutions":[{"id":"https://openalex.org/I95056601","display_name":"Actelion (Switzerland)","ror":"https://ror.org/001yedb91","country_code":"CH","type":"company","lineage":["https://openalex.org/I95056601"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Patricia N. Sidharta","raw_affiliation_strings":["Department of Clinical Pharmacology, Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, 4123, Allschwil, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, 4123, Allschwil, Switzerland","institution_ids":["https://openalex.org/I95056601"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035346090","display_name":"Peter M. A. Groenen","orcid":"https://orcid.org/0000-0002-8172-1752","observed_orcids":["https://orcid.org/0000-0002-8172-1752"]},"institutions":[{"id":"https://openalex.org/I95056601","display_name":"Actelion (Switzerland)","ror":"https://ror.org/001yedb91","country_code":"CH","type":"company","lineage":["https://openalex.org/I95056601"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Peter M. A. Groenen","raw_affiliation_strings":["Department of Translational Science, Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, 4123, Allschwil, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Translational Science, Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, 4123, Allschwil, Switzerland","institution_ids":["https://openalex.org/I95056601"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058093690","display_name":"Jasper Dingemanse","orcid":"https://orcid.org/0000-0002-4083-5817","observed_orcids":["https://orcid.org/0000-0002-4083-5817"]},"institutions":[{"id":"https://openalex.org/I95056601","display_name":"Actelion (Switzerland)","ror":"https://ror.org/001yedb91","country_code":"CH","type":"company","lineage":["https://openalex.org/I95056601"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Jasper Dingemanse","raw_affiliation_strings":["Department of Clinical Pharmacology, Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, 4123, Allschwil, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, 4123, Allschwil, Switzerland","institution_ids":["https://openalex.org/I95056601"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5029281314"],"corresponding_institution_ids":["https://openalex.org/I95056601"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":null,"fwci":1.1087,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.78013042,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"55","issue":"7","first_page":"813","last_page":"821"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.7714999914169312,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.7714999914169312,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.06449999660253525,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.019300000742077827,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crth2-antagonist","display_name":"CRTH2 antagonist","score":0.9850000143051147},{"id":"https://openalex.org/keywords/prostaglandin-d2","display_name":"prostaglandin D2","score":0.8650000095367432},{"id":"https://openalex.org/keywords/receptor-internalization","display_name":"receptor internalization","score":0.8040000200271606},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.8190000057220459},{"id":"https://openalex.org/keywords/eosinophils","display_name":"eosinophils","score":0.8859999775886536},{"id":"https://openalex.org/keywords/pharmacokinetic-pharmacodynamic-modeling","display_name":"pharmacokinetic-pharmacodynamic modeling","score":0.7749999761581421},{"id":"https://openalex.org/keywords/dose-selection","display_name":"dose selection","score":0.7400000095367432},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6669999957084656},{"id":"https://openalex.org/keywords/inflammatory-diseases","display_name":"inflammatory diseases","score":0.5130000114440918},{"id":"https://openalex.org/keywords/population-pharmacokinetics","display_name":"population pharmacokinetics","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.7572619915008545},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6481949687004089},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6457486748695374},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.5052977204322815},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47127053141593933},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.4553036093711853},{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.4466210603713989},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3095897138118744},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21376419067382812},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.14438700675964355},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000085","descriptor_name":"Acetates","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000085","descriptor_name":"Acetates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002227","descriptor_name":"Carbazoles","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D002227","descriptor_name":"Carbazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004804","descriptor_name":"Eosinophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009281","descriptor_name":"Naphthalenes","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D009281","descriptor_name":"Naphthalenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D011982","descriptor_name":"Receptors, Prostaglandin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s40262-015-0354-3","doi":"https://doi.org/10.1007/s40262-015-0354-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s40262-015-0354-3","pdf_url":null,"source":{"id":"https://openalex.org/S69290020","display_name":"Clinical Pharmacokinetics","issn_l":"0312-5963","issn":["0312-5963","1179-1926"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacokinetics","raw_type":"journal-article"},{"id":"pmid:26692193","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26692193","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical pharmacokinetics","raw_type":"Clinical Trial, Phase II"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1843986322","https://openalex.org/W1918931129","https://openalex.org/W1971595233","https://openalex.org/W1980109320","https://openalex.org/W2010306947","https://openalex.org/W2049001074","https://openalex.org/W2078915983","https://openalex.org/W2084624382","https://openalex.org/W2100705331","https://openalex.org/W2122556001","https://openalex.org/W2136248567","https://openalex.org/W2140688081","https://openalex.org/W2142492100","https://openalex.org/W2162617604","https://openalex.org/W2163870925","https://openalex.org/W2169506749","https://openalex.org/W2331980604","https://openalex.org/W2582743722"],"related_works":["https://openalex.org/W2122556001","https://openalex.org/W1535429252","https://openalex.org/W2122749412","https://openalex.org/W4239716202","https://openalex.org/W2010306947","https://openalex.org/W2099886404","https://openalex.org/W2325051397","https://openalex.org/W1994060519","https://openalex.org/W2020695556","https://openalex.org/W2073651858"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
