{"id":"https://openalex.org/W2219087065","doi":null,"title":"The use of antidepressants in novel combination therapies.","display_name":"The use of antidepressants in novel combination therapies.","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2219087065","mag":"2219087065","pmid":"https://pubmed.ncbi.nlm.nih.gov/12625794"},"language":"en","primary_location":{"id":"pmid:12625794","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12625794","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical psychiatry","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010294016","display_name":"Richard Charles Shelton","orcid":"https://orcid.org/0000-0002-3806-4208","observed_orcids":["https://orcid.org/0000-0002-3806-4208"]},"institutions":[{"id":"https://openalex.org/I4210096570","display_name":"Vanderbilt Psychiatric Hospital","ror":"https://ror.org/0118bqm57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210096570","https://openalex.org/I4210162197","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard C Shelton","raw_affiliation_strings":["Adult Psychiatry Division, Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37212-8646, USA. richard.shelton@vanderbilt.edu","Adult Psychiatry Division, Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37212-8646, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Adult Psychiatry Division, Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37212-8646, USA. richard.shelton@vanderbilt.edu","institution_ids":["https://openalex.org/I4210096570","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Adult Psychiatry Division, Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37212-8646, USA","institution_ids":["https://openalex.org/I901861585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5010294016"],"corresponding_institution_ids":["https://openalex.org/I4210096570","https://openalex.org/I901861585"],"apc_list":null,"apc_paid":null,"fwci":4.054,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.9367104,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"64 Suppl 2","issue":null,"first_page":"14","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11921","display_name":"Electroconvulsive Therapy Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antidepressants","display_name":"antidepressants","score":0.824999988079071},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8629999756813049},{"id":"https://openalex.org/keywords/treatment-resistant-depression","display_name":"treatment-resistant depression","score":0.8870000243186951},{"id":"https://openalex.org/keywords/lithium-augmentation","display_name":"lithium augmentation","score":0.9330000281333923},{"id":"https://openalex.org/keywords/atypical-antipsychotics","display_name":"atypical antipsychotics","score":0.9769999980926514},{"id":"https://openalex.org/keywords/selective-serotonin-reuptake-inhibitors","display_name":"selective serotonin reuptake inhibitors","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antidepressant-monotherapy","display_name":"antidepressant monotherapy","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.7077523469924927},{"id":"https://openalex.org/C2778541603","wikidata":"https://www.wikidata.org/wiki/Q152763","display_name":"Lithium (medication)","level":2,"score":0.619321346282959},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5331422686576843},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.5259112119674683},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.5243387818336487},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.475027859210968},{"id":"https://openalex.org/C2910584757","wikidata":"https://www.wikidata.org/wiki/Q334477","display_name":"Serotonin Uptake Inhibitors","level":5,"score":0.4340362846851349},{"id":"https://openalex.org/C31487548","wikidata":"https://www.wikidata.org/wiki/Q4859664","display_name":"Reuptake inhibitor","level":4,"score":0.41752588748931885},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.415277898311615},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.35967883467674255},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3480294346809387},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.24396559596061707},{"id":"https://openalex.org/C2776134451","wikidata":"https://www.wikidata.org/wiki/Q422244","display_name":"Fluoxetine","level":4,"score":0.2310624122619629},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17708882689476013},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.14402145147323608},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.06264603137969971},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008094","descriptor_name":"Lithium","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011569","descriptor_name":"Psychiatric Status Rating Scales","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014284","descriptor_name":"Triiodothyronine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015201","descriptor_name":"Meta-Analysis as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015928","descriptor_name":"Cognitive Behavioral Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:12625794","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12625794","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical psychiatry","raw_type":"Journal Article"},{"id":"mag:2219087065","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12625794","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W48930832","https://openalex.org/W130392180","https://openalex.org/W140880789","https://openalex.org/W175575895","https://openalex.org/W1654634226","https://openalex.org/W1731933520","https://openalex.org/W1965532261","https://openalex.org/W1973534109","https://openalex.org/W1988049829","https://openalex.org/W1998541625","https://openalex.org/W2005066505","https://openalex.org/W2012721984","https://openalex.org/W2018065855","https://openalex.org/W2022211890","https://openalex.org/W2032149427","https://openalex.org/W2038883174","https://openalex.org/W2045422537","https://openalex.org/W2050941211","https://openalex.org/W2052626672","https://openalex.org/W2058489875","https://openalex.org/W2070159228","https://openalex.org/W2073585506","https://openalex.org/W2083597120","https://openalex.org/W2083877757","https://openalex.org/W2090368299","https://openalex.org/W2114693958","https://openalex.org/W2114743098","https://openalex.org/W2141398558","https://openalex.org/W2150760153","https://openalex.org/W2155275341","https://openalex.org/W2169741270","https://openalex.org/W2237595605","https://openalex.org/W2294950054","https://openalex.org/W2326556724","https://openalex.org/W2345549584"],"related_works":["https://openalex.org/W2940933484","https://openalex.org/W1965831048","https://openalex.org/W2560129632","https://openalex.org/W2408793302","https://openalex.org/W2026585231","https://openalex.org/W1972602891","https://openalex.org/W4302308359","https://openalex.org/W4253242625","https://openalex.org/W2033924507","https://openalex.org/W2048985936"],"abstract_inverted_index":{"Antidepressant":[0],"monotherapy":[1],"is":[2,48,90,99],"used":[3],"more":[4,97],"often":[5],"than":[6],"other":[7,22],"therapies":[8,29,41],"to":[9,20,33,101],"achieve":[10],"symptom":[11],"remission":[12],"in":[13],"depressed":[14],"patients;":[15],"however,":[16],"for":[17],"patients":[18],"resistant":[19,35],"antidepressants,":[21],"strategies":[23],"are":[24,68],"necessary.":[25],"Many":[26],"novel":[27],"combination":[28,40,78],"have":[30],"been":[31],"proposed":[32],"treat":[34],"depression.":[36],"The":[37],"efficacy":[38],"of":[39,46,54,73,76,79],"such":[42],"as":[43],"lithium":[44],"augmentation":[45],"antidepressants":[47],"supported":[49],"by":[50],"a":[51,91],"large":[52],"amount":[53],"evidence":[55],"including":[56],"data":[57],"from":[58,71],"controlled":[59],"trials.":[60],"Nonetheless,":[61],"anecdotal":[62],"reports":[63],"suggest":[64,87],"that":[65,88],"these":[66,103],"combinations":[67],"underutilized.":[69],"Data":[70],"studies":[72],"the":[74,77],"use":[75],"atypical":[80],"antipsychotics":[81],"and":[82],"selective":[83],"serotonin":[84],"reuptake":[85],"inhibitors":[86],"this":[89],"particularly":[92],"promising":[93],"therapeutic":[94],"avenue.":[95],"However,":[96],"research":[98],"needed":[100],"corroborate":[102],"early":[104],"results.":[105]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
