{"id":"https://openalex.org/W2218878479","doi":"https://doi.org/10.1088/1478-3975/12/5/054001","title":"Scaling law characterizing the dynamics of the transition of HIV-1 to error catastrophe","display_name":"Scaling law characterizing the dynamics of the transition of HIV-1 to error catastrophe","publication_year":2015,"publication_date":"2015-09-02","ids":{"openalex":"https://openalex.org/W2218878479","doi":"https://doi.org/10.1088/1478-3975/12/5/054001","mag":"2218878479","pmid":"https://pubmed.ncbi.nlm.nih.gov/26331636"},"language":"en","primary_location":{"id":"doi:10.1088/1478-3975/12/5/054001","doi":"https://doi.org/10.1088/1478-3975/12/5/054001","is_oa":true,"landing_page_url":"https://doi.org/10.1088/1478-3975/12/5/054001","pdf_url":"https://iopscience.iop.org/article/10.1088/1478-3975/12/5/054001/pdf","source":{"id":"https://openalex.org/S728652","display_name":"Physical Biology","issn_l":"1478-3967","issn":["1478-3967","1478-3975"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physical Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://iopscience.iop.org/article/10.1088/1478-3975/12/5/054001/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Vipul Gupta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vipul Gupta","raw_affiliation_strings":["Department of Chemical Engineering, Indian Institute of Science, Bangalore 560012, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Indian Institute of Science, Bangalore 560012, India","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009087944","display_name":"Narendra M. Dixit","orcid":"https://orcid.org/0000-0002-2145-9828","observed_orcids":["https://orcid.org/0000-0002-2145-9828"]},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Narendra M Dixit","raw_affiliation_strings":["Department of Chemical Engineering, Indian Institute of Science, Bangalore 560012, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Indian Institute of Science, Bangalore 560012, India","institution_ids":["https://openalex.org/I59270414"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5009087944"],"corresponding_institution_ids":["https://openalex.org/I59270414"],"apc_list":{"value":3325,"currency":"USD","value_usd":3325},"apc_paid":{"value":3325,"currency":"USD","value_usd":3325},"fwci":0.8271,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.74009454,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"12","issue":"5","first_page":"054001","last_page":"054001"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.8154000043869019,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.8154000043869019,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10482","display_name":"Mathematical and Theoretical Epidemiology and Ecology Models","score":0.13699999451637268,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.037300001829862595,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.9760000109672546},{"id":"https://openalex.org/keywords/error-catastrophe","display_name":"error catastrophe","score":0.996999979019165},{"id":"https://openalex.org/keywords/mutation-rate","display_name":"mutation rate","score":0.6690000295639038},{"id":"https://openalex.org/keywords/scaling-laws","display_name":"scaling laws","score":0.7400000095367432},{"id":"https://openalex.org/keywords/within-host-viral-evolution","display_name":"within-host viral evolution","score":0.7680000066757202},{"id":"https://openalex.org/keywords/stochastic-dynamics","display_name":"stochastic dynamics","score":0.6629999876022339},{"id":"https://openalex.org/keywords/viral-quasispecies","display_name":"viral quasispecies","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C99844830","wikidata":"https://www.wikidata.org/wiki/Q102441924","display_name":"Scaling","level":2,"score":0.7098006010055542},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.6884019374847412},{"id":"https://openalex.org/C2984125019","wikidata":"https://www.wikidata.org/wiki/Q176737","display_name":"Stochastic dynamics","level":2,"score":0.6264386177062988},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.6263837814331055},{"id":"https://openalex.org/C2988430800","wikidata":"https://www.wikidata.org/wiki/Q428971","display_name":"Scaling law","level":3,"score":0.6043585538864136},{"id":"https://openalex.org/C194232998","wikidata":"https://www.wikidata.org/wiki/Q1606712","display_name":"Transition (genetics)","level":3,"score":0.532617449760437},{"id":"https://openalex.org/C98638677","wikidata":"https://www.wikidata.org/wiki/Q2067051","display_name":"Mutation rate","level":3,"score":0.4982490539550781},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4852142632007599},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.46693745255470276},{"id":"https://openalex.org/C171578705","wikidata":"https://www.wikidata.org/wiki/Q5418700","display_name":"Evolutionary dynamics","level":3,"score":0.4122348129749298},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3632722496986389},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2785675525665283},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.27322524785995483},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21715036034584045},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.1721906065940857},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11922246217727661},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009153","descriptor_name":"Mutagens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059645","descriptor_name":"Mutation Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1088/1478-3975/12/5/054001","doi":"https://doi.org/10.1088/1478-3975/12/5/054001","is_oa":true,"landing_page_url":"https://doi.org/10.1088/1478-3975/12/5/054001","pdf_url":"https://iopscience.iop.org/article/10.1088/1478-3975/12/5/054001/pdf","source":{"id":"https://openalex.org/S728652","display_name":"Physical Biology","issn_l":"1478-3967","issn":["1478-3967","1478-3975"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physical Biology","raw_type":"journal-article"},{"id":"pmid:26331636","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26331636","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physical biology","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.iisc.ac.in:52639","doi":null,"is_oa":false,"landing_page_url":"http://eprints.iisc.ac.in/52639/1/Phy_Bio_12-5_054001_2015.pdf","pdf_url":"http://eprints.iisc.ac.in/52639/1/Phy_Bio_12-5_054001_2015.pdf","source":{"id":"https://openalex.org/S4377196309","display_name":"NOT FOUND REPOSITORY (Indian Institute of Science Bangalore)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I59270414","host_organization_name":"Indian Institute of Science Bangalore","host_organization_lineage":["https://openalex.org/I59270414"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1088/1478-3975/12/5/054001","doi":"https://doi.org/10.1088/1478-3975/12/5/054001","is_oa":true,"landing_page_url":"https://doi.org/10.1088/1478-3975/12/5/054001","pdf_url":"https://iopscience.iop.org/article/10.1088/1478-3975/12/5/054001/pdf","source":{"id":"https://openalex.org/S728652","display_name":"Physical Biology","issn_l":"1478-3967","issn":["1478-3967","1478-3975"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physical Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320717","display_name":"Department of Biotechnology, Ministry of Science and Technology, India","ror":"https://ror.org/03tjsyq23"},{"id":"https://openalex.org/F4320325580","display_name":"The Wellcome Trust DBT India Alliance","ror":"https://ror.org/04reqzt68"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2218878479.pdf","grobid_xml":"https://content.openalex.org/works/W2218878479.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1511276416","https://openalex.org/W1515965744","https://openalex.org/W1965995198","https://openalex.org/W1975592054","https://openalex.org/W1977745444","https://openalex.org/W1981105411","https://openalex.org/W1998502704","https://openalex.org/W2000283702","https://openalex.org/W2003675319","https://openalex.org/W2004180922","https://openalex.org/W2006383247","https://openalex.org/W2007441249","https://openalex.org/W2011309731","https://openalex.org/W2024153114","https://openalex.org/W2043516282","https://openalex.org/W2044373215","https://openalex.org/W2051453551","https://openalex.org/W2052381091","https://openalex.org/W2059296701","https://openalex.org/W2073918065","https://openalex.org/W2075106941","https://openalex.org/W2077778637","https://openalex.org/W2078219342","https://openalex.org/W2087895317","https://openalex.org/W2099219682","https://openalex.org/W2099900753","https://openalex.org/W2130710252","https://openalex.org/W2153918414","https://openalex.org/W2166111767","https://openalex.org/W2166147286","https://openalex.org/W2187165435","https://openalex.org/W2202919481","https://openalex.org/W2318926789","https://openalex.org/W2342351646","https://openalex.org/W2412909330","https://openalex.org/W4236479494","https://openalex.org/W4237038146","https://openalex.org/W4237794778"],"related_works":["https://openalex.org/W2007441249","https://openalex.org/W2318926789","https://openalex.org/W2612457682","https://openalex.org/W2043516282","https://openalex.org/W2020404213","https://openalex.org/W1784386902","https://openalex.org/W2992600873","https://openalex.org/W4413335778","https://openalex.org/W2052207146","https://openalex.org/W2991511456"],"abstract_inverted_index":{"Increasing":[0],"the":[1,35,53,57],"mutation":[2],"rate,":[3],"\u03bc":[4],"of":[5,19,37,56,79,89],"viruses":[6],"above":[7],"a":[8,16,28,49],"threshold,":[9],"\u03bc(c)":[10],"has":[11],"been":[12],"predicted":[13],"to":[14,68],"trigger":[15],"catastrophic":[17],"loss":[18],"viral":[20],"genetic":[21],"information":[22],"and":[23,74],"is":[24,66],"being":[25],"explored":[26],"as":[27],"novel":[29],"intervention":[30],"strategy.":[31],"Here,":[32],"we":[33],"examine":[34],"dynamics":[36],"this":[38],"transition":[39],"using":[40],"stochastic":[41],"simulations":[42],"mimicking":[43],"within-host":[44],"HIV-1":[45,80,95],"evolution.":[46],"We":[47,84],"find":[48],"scaling":[50],"law":[51,65],"governing":[52],"characteristic":[54],"time":[55],"transition:":[58],"\u03c4":[59],"\u2248":[60],"0.6/(\u03bc":[61],"-":[62],"\u03bc(c)).":[63],"The":[64],"robust":[67],"variations":[69],"in":[70],"underlying":[71],"evolutionary":[72],"forces":[73],"presents":[75],"guidelines":[76],"for":[77],"treatment":[78,90],"infection":[81],"with":[82],"mutagens.":[83],"estimate":[85],"that":[86],"many":[87],"years":[88],"would":[91],"be":[92],"required":[93],"before":[94],"can":[96],"suffer":[97],"an":[98],"error":[99],"catastrophe.":[100]},"counts_by_year":[{"year":2021,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}