{"id":"https://openalex.org/W2218326153","doi":"https://doi.org/10.1016/j.jiac.2015.10.009","title":"An exploratory analysis of the ability of a cefepime trough concentration greater than 22 mg/L to predict neurotoxicity","display_name":"An exploratory analysis of the ability of a cefepime trough concentration greater than 22 mg/L to predict neurotoxicity","publication_year":2015,"publication_date":"2015-12-18","ids":{"openalex":"https://openalex.org/W2218326153","doi":"https://doi.org/10.1016/j.jiac.2015.10.009","mag":"2218326153","pmid":"https://pubmed.ncbi.nlm.nih.gov/26712584"},"language":"en","primary_location":{"id":"doi:10.1016/j.jiac.2015.10.009","doi":"https://doi.org/10.1016/j.jiac.2015.10.009","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jiac.2015.10.009","pdf_url":null,"source":{"id":"https://openalex.org/S141781860","display_name":"Journal of Infection and Chemotherapy","issn_l":"1341-321X","issn":["1341-321X","1437-7780"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Infection and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074442044","display_name":"Nathaniel J. Rhodes","orcid":"https://orcid.org/0000-0002-0018-5434","observed_orcids":["https://orcid.org/0000-0002-0018-5434"]},"institutions":[{"id":"https://openalex.org/I128902783","display_name":"Midwestern University","ror":"https://ror.org/046yatd98","country_code":"US","type":"education","lineage":["https://openalex.org/I128902783"]},{"id":"https://openalex.org/I4210089162","display_name":"Northwestern Memorial Hospital","ror":"https://ror.org/009543z50","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210089162","https://openalex.org/I4210147348"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathaniel J. Rhodes","raw_affiliation_strings":["Department of Pharmacy Practice, Midwestern University, Chicago College of Pharmacy, Downers Grove, IL, USA; Department of Pharmacy, Northwestern Memorial Hospital, Chicago, IL, USA","Department of Pharmacy Practice, Midwestern University, Chicago College of Pharmacy, Downers Grove, IL, USA","Department of Pharmacy, Northwestern Memorial Hospital, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy Practice, Midwestern University, Chicago College of Pharmacy, Downers Grove, IL, USA; Department of Pharmacy, Northwestern Memorial Hospital, Chicago, IL, USA","institution_ids":["https://openalex.org/I128902783","https://openalex.org/I4210089162"]},{"raw_affiliation_string":"Department of Pharmacy Practice, Midwestern University, Chicago College of Pharmacy, Downers Grove, IL, USA","institution_ids":["https://openalex.org/I128902783"]},{"raw_affiliation_string":"Department of Pharmacy, Northwestern Memorial Hospital, Chicago, IL, USA","institution_ids":["https://openalex.org/I4210089162"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090657231","display_name":"Joseph L. Kuti","orcid":"https://orcid.org/0000-0002-4464-3126","observed_orcids":["https://orcid.org/0000-0002-4464-3126"]},"institutions":[{"id":"https://openalex.org/I1302163369","display_name":"Hartford Hospital","ror":"https://ror.org/00gt5xe03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302163369"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph L. Kuti","raw_affiliation_strings":["Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT, USA","institution_ids":["https://openalex.org/I1302163369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090740872","display_name":"David P. Nicolau","orcid":"https://orcid.org/0000-0002-4148-0165","observed_orcids":["https://orcid.org/0000-0002-4148-0165"]},"institutions":[{"id":"https://openalex.org/I1302163369","display_name":"Hartford Hospital","ror":"https://ror.org/00gt5xe03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302163369"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David P. Nicolau","raw_affiliation_strings":["Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT, USA","institution_ids":["https://openalex.org/I1302163369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026635936","display_name":"Michael Noel Neely","orcid":"https://orcid.org/0000-0002-1675-8276","observed_orcids":["https://orcid.org/0000-0002-1675-8276"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael N. Neely","raw_affiliation_strings":["University of Southern California, Keck School of Medicine, Los Angeles, CA, USA; Laboratory of Applied Pharmacokinetics and Bioinformatics (LAPKB), Children's Hospital of Los Angeles, Los Angeles, CA, USA","Laboratory of Applied Pharmacokinetics and Bioinformatics (LAPKB), Children's Hospital of Los Angeles, Los Angeles, CA, USA","University of Southern California, Keck School of Medicine, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Southern California, Keck School of Medicine, Los Angeles, CA, USA; Laboratory of Applied Pharmacokinetics and Bioinformatics (LAPKB), Children's Hospital of Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626"]},{"raw_affiliation_string":"Laboratory of Applied Pharmacokinetics and Bioinformatics (LAPKB), Children's Hospital of Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1336910626"]},{"raw_affiliation_string":"University of Southern California, Keck School of Medicine, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091908239","display_name":"Anthony M. Nicasio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I365282","display_name":"Albany College of Pharmacy and Health Sciences","ror":"https://ror.org/014hfaw95","country_code":"US","type":"education","lineage":["https://openalex.org/I365282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony M. Nicasio","raw_affiliation_strings":["Department of Pharmacy Practice, Albany College of Pharmacy and Health Sciences, Albany, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy Practice, Albany College of Pharmacy and Health Sciences, Albany, NY, USA","institution_ids":["https://openalex.org/I365282"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022097782","display_name":"Marc H. Scheetz","orcid":"https://orcid.org/0000-0002-1091-6130","observed_orcids":["https://orcid.org/0000-0002-1091-6130"]},"institutions":[{"id":"https://openalex.org/I128902783","display_name":"Midwestern University","ror":"https://ror.org/046yatd98","country_code":"US","type":"education","lineage":["https://openalex.org/I128902783"]},{"id":"https://openalex.org/I4210089162","display_name":"Northwestern Memorial Hospital","ror":"https://ror.org/009543z50","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210089162","https://openalex.org/I4210147348"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marc H. Scheetz","raw_affiliation_strings":["Department of Pharmacy Practice, Midwestern University, Chicago College of Pharmacy, Downers Grove, IL, USA; Department of Pharmacy, Northwestern Memorial Hospital, Chicago, IL, USA. Electronic address: mscheetz@nm.org","Department of Pharmacy Practice, Midwestern University, Chicago College of Pharmacy, Downers Grove, IL, USA","Department of Pharmacy, Northwestern Memorial Hospital, Chicago, IL, USA"],"raw_orcid":"https://orcid.org/0000-0002-1091-6130","affiliations":[{"raw_affiliation_string":"Department of Pharmacy Practice, Midwestern University, Chicago College of Pharmacy, Downers Grove, IL, USA; Department of Pharmacy, Northwestern Memorial Hospital, Chicago, IL, USA. Electronic address: mscheetz@nm.org","institution_ids":["https://openalex.org/I128902783","https://openalex.org/I4210089162"]},{"raw_affiliation_string":"Department of Pharmacy Practice, Midwestern University, Chicago College of Pharmacy, Downers Grove, IL, USA","institution_ids":["https://openalex.org/I128902783"]},{"raw_affiliation_string":"Department of Pharmacy, Northwestern Memorial Hospital, Chicago, IL, USA","institution_ids":["https://openalex.org/I4210089162"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5022097782"],"corresponding_institution_ids":["https://openalex.org/I128902783","https://openalex.org/I4210089162"],"apc_list":{"value":2650,"currency":"USD","value_usd":2650},"apc_paid":null,"fwci":1.4376,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.80473167,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"22","issue":"2","first_page":"78","last_page":"83"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cefepime","display_name":"cefepime","score":1.0},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.9670000076293945},{"id":"https://openalex.org/keywords/trough-concentration","display_name":"trough concentration","score":0.8849999904632568},{"id":"https://openalex.org/keywords/pharmacokinetic-modeling","display_name":"pharmacokinetic modeling","score":0.6259999871253967},{"id":"https://openalex.org/keywords/febrile-neutropenia","display_name":"febrile neutropenia","score":0.8809999823570251},{"id":"https://openalex.org/keywords/number-needed-to-harm","display_name":"number needed to harm","score":0.7369999885559082},{"id":"https://openalex.org/keywords/creatinine-clearance","display_name":"creatinine clearance","score":0.7829999923706055},{"id":"https://openalex.org/keywords/dose-simulation","display_name":"dose simulation","score":0.5099999904632568}],"concepts":[{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.9165327548980713},{"id":"https://openalex.org/C2777050379","wikidata":"https://www.wikidata.org/wiki/Q2552927","display_name":"Cefepime","level":5,"score":0.7665461301803589},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5744054913520813},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5242959856987},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.45379626750946045},{"id":"https://openalex.org/C2910800852","wikidata":"https://www.wikidata.org/wiki/Q7846541","display_name":"Trough Concentration","level":3,"score":0.44679170846939087},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.425171434879303},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.290870726108551},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2792724668979645},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.1583493947982788},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.07642588019371033},{"id":"https://openalex.org/C2779631663","wikidata":"https://www.wikidata.org/wiki/Q425152","display_name":"Imipenem","level":4,"score":0.0},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077723","descriptor_name":"Cefepime","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002511","descriptor_name":"Cephalosporins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002511","descriptor_name":"Cephalosporins","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002511","descriptor_name":"Cephalosporins","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020258","descriptor_name":"Neurotoxicity Syndromes","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jiac.2015.10.009","doi":"https://doi.org/10.1016/j.jiac.2015.10.009","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jiac.2015.10.009","pdf_url":null,"source":{"id":"https://openalex.org/S141781860","display_name":"Journal of Infection and Chemotherapy","issn_l":"1341-321X","issn":["1341-321X","1437-7780"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Infection and Chemotherapy","raw_type":"journal-article"},{"id":"pmid:26712584","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26712584","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W2021298363","https://openalex.org/W2106307190","https://openalex.org/W2145284269","https://openalex.org/W2153655781","https://openalex.org/W2158251453","https://openalex.org/W2161356999","https://openalex.org/W2169175461","https://openalex.org/W2582743722"],"related_works":["https://openalex.org/W3200326624","https://openalex.org/W2953583576","https://openalex.org/W1975968907","https://openalex.org/W2983865156","https://openalex.org/W4280646784","https://openalex.org/W2576933161","https://openalex.org/W4409658266","https://openalex.org/W4411777712","https://openalex.org/W4382181847","https://openalex.org/W4309410980"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}