{"id":"https://openalex.org/W2218220126","doi":null,"title":"Organelle specific mechanisms of neuronal cell death","display_name":"Organelle specific mechanisms of neuronal cell death","publication_year":2012,"publication_date":"2012-10-26","ids":{"openalex":"https://openalex.org/W2218220126","mag":"2218220126"},"language":"en","primary_location":{"id":"pmh:oai:helda.helsinki.fi:10138/37065","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/37065","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10138/37065","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091769250","display_name":"Noora Putkonen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Noora Putkonen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5091769250"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9560999870300293,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9560999870300293,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.03849999979138374,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuronal-death","display_name":"neuronal cell death","score":0.8640000224113464},{"id":"https://openalex.org/keywords/excitotoxicity","display_name":"excitotoxicity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/kainic-acid","display_name":"kainic acid","score":0.8349999785423279},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.8629999756813049},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":0.9980000257492065},{"id":"https://openalex.org/keywords/salubrinal","display_name":"salubrinal","score":0.9700000286102295},{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":0.9739999771118164},{"id":"https://openalex.org/keywords/cdk5","display_name":"cyclin-dependent kinase 5","score":0.8659999966621399},{"id":"https://openalex.org/keywords/glur6","display_name":"GluR6","score":0.9419999718666077},{"id":"https://openalex.org/keywords/ampa-receptors","display_name":"AMPA receptors","score":0.7170000076293945},{"id":"https://openalex.org/keywords/ionotropic-glutamate-receptors","display_name":"ionotropic glutamate receptors","score":0.8050000071525574},{"id":"https://openalex.org/keywords/mitochondria","display_name":"mitochondria","score":0.597000002861023},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6359999775886536},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.6140000224113464},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.5419999957084656},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.7829999923706055},{"id":"https://openalex.org/keywords/mutant-huntingtin-aggregation","display_name":"mutant huntingtin aggregation","score":0.7620000243186951},{"id":"https://openalex.org/keywords/hippocampal-neurons","display_name":"hippocampal neurons","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C168240541","wikidata":"https://www.wikidata.org/wiki/Q45948","display_name":"Organelle","level":2,"score":0.6509568691253662},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5496196150779724},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46016475558280945},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4209347665309906},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4183926582336426},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3825376033782959},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3667263984680176},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2518550157546997},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2233201563358307}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:helda.helsinki.fi:10138/37065","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/37065","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},{"id":"mag:2218220126","doi":null,"is_oa":false,"landing_page_url":"https://helda.helsinki.fi/bitstream/10138/37065/2/organell.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:helda.helsinki.fi:10138/37065","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/37065","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":244,"referenced_works":["https://openalex.org/W19003993","https://openalex.org/W1535874622","https://openalex.org/W1546139069","https://openalex.org/W1547075145","https://openalex.org/W1548089209","https://openalex.org/W1571689838","https://openalex.org/W1576577565","https://openalex.org/W1583498507","https://openalex.org/W1606672690","https://openalex.org/W1608535600","https://openalex.org/W1612819372","https://openalex.org/W1615546978","https://openalex.org/W1618299283","https://openalex.org/W1648092162","https://openalex.org/W1673170827","https://openalex.org/W1713405122","https://openalex.org/W1781119783","https://openalex.org/W1825468095","https://openalex.org/W1832527043","https://openalex.org/W1847469566","https://openalex.org/W1901072277","https://openalex.org/W1903414318","https://openalex.org/W1914313496","https://openalex.org/W1948270772","https://openalex.org/W1963552002","https://openalex.org/W1963888791","https://openalex.org/W1964706050","https://openalex.org/W1966611928","https://openalex.org/W1966928113","https://openalex.org/W1967659527","https://openalex.org/W1967912613","https://openalex.org/W1969331809","https://openalex.org/W1970090817","https://openalex.org/W1971125884","https://openalex.org/W1972336737","https://openalex.org/W1972771185","https://openalex.org/W1972876997","https://openalex.org/W1975153732","https://openalex.org/W1975417521","https://openalex.org/W1975449325","https://openalex.org/W1976881265","https://openalex.org/W1977499961","https://openalex.org/W1979733074","https://openalex.org/W1980336239","https://openalex.org/W1983097317","https://openalex.org/W1984073321","https://openalex.org/W1984547206","https://openalex.org/W1984873106","https://openalex.org/W1985058202","https://openalex.org/W1985474993","https://openalex.org/W1986048086","https://openalex.org/W1986308149","https://openalex.org/W1986737010","https://openalex.org/W1986817930","https://openalex.org/W1987700551","https://openalex.org/W1989566057","https://openalex.org/W1993068285","https://openalex.org/W1993385893","https://openalex.org/W1993470377","https://openalex.org/W1994056283","https://openalex.org/W1994637483","https://openalex.org/W1995185770","https://openalex.org/W1996789718","https://openalex.org/W1997996318","https://openalex.org/W1999818832","https://openalex.org/W1999968276","https://openalex.org/W2000894919","https://openalex.org/W2002360326","https://openalex.org/W2002478276","https://openalex.org/W2002763309","https://openalex.org/W2002915599","https://openalex.org/W2004496381","https://openalex.org/W2006690805","https://openalex.org/W2007279797","https://openalex.org/W2008261126","https://openalex.org/W2008597649","https://openalex.org/W2009204794","https://openalex.org/W2010270082","https://openalex.org/W2010298858","https://openalex.org/W2011573205","https://openalex.org/W2012166934","https://openalex.org/W2012173926","https://openalex.org/W2012333728","https://openalex.org/W2014486882","https://openalex.org/W2015290558","https://openalex.org/W2015913538","https://openalex.org/W2016758992","https://openalex.org/W2018667542","https://openalex.org/W2019019017","https://openalex.org/W2021958350","https://openalex.org/W2025364264","https://openalex.org/W2025818427","https://openalex.org/W2025896287","https://openalex.org/W2026873116","https://openalex.org/W2028279477","https://openalex.org/W2028592029","https://openalex.org/W2029568863","https://openalex.org/W2030410903","https://openalex.org/W2030864103","https://openalex.org/W2031367365","https://openalex.org/W2033678540","https://openalex.org/W2034213169","https://openalex.org/W2034823585","https://openalex.org/W2034857163","https://openalex.org/W2035336615","https://openalex.org/W2035636256","https://openalex.org/W2036191765","https://openalex.org/W2036274324","https://openalex.org/W2036298036","https://openalex.org/W2037653131","https://openalex.org/W2037658687","https://openalex.org/W2038407368","https://openalex.org/W2039321926","https://openalex.org/W2041456356","https://openalex.org/W2041867459","https://openalex.org/W2042409437","https://openalex.org/W2042716629","https://openalex.org/W2043769210","https://openalex.org/W2046205790","https://openalex.org/W2047512647","https://openalex.org/W2047887493","https://openalex.org/W2048399408","https://openalex.org/W2048661219","https://openalex.org/W2049354825","https://openalex.org/W2051658957","https://openalex.org/W2052687799","https://openalex.org/W2053846841","https://openalex.org/W2054314612","https://openalex.org/W2057257609","https://openalex.org/W2057823004","https://openalex.org/W2058570072","https://openalex.org/W2058826061","https://openalex.org/W2059223526","https://openalex.org/W2059428912","https://openalex.org/W2060153749","https://openalex.org/W2060240421","https://openalex.org/W2060426018","https://openalex.org/W2061468529","https://openalex.org/W2061803285","https://openalex.org/W2062469344","https://openalex.org/W2062682951","https://openalex.org/W2062853648","https://openalex.org/W2063535351","https://openalex.org/W2063540863","https://openalex.org/W2063869707","https://openalex.org/W2067201874","https://openalex.org/W2067780683","https://openalex.org/W2069924169","https://openalex.org/W2070114283","https://openalex.org/W2071318481","https://openalex.org/W2072554501","https://openalex.org/W2072729793","https://openalex.org/W2073865059","https://openalex.org/W2076700300","https://openalex.org/W2076762827","https://openalex.org/W2077353205","https://openalex.org/W2077869213","https://openalex.org/W2078914325","https://openalex.org/W2078935283","https://openalex.org/W2079177754","https://openalex.org/W2080744747","https://openalex.org/W2080901528","https://openalex.org/W2081678712","https://openalex.org/W2082259697","https://openalex.org/W2082443574","https://openalex.org/W2082624222","https://openalex.org/W2084609653","https://openalex.org/W2086754177","https://openalex.org/W2087654725","https://openalex.org/W2088380513","https://openalex.org/W2089865526","https://openalex.org/W2090061589","https://openalex.org/W2090839493","https://openalex.org/W2092700031","https://openalex.org/W2093076184","https://openalex.org/W2095099413","https://openalex.org/W2095123707","https://openalex.org/W2105628355","https://openalex.org/W2105629775","https://openalex.org/W2106042714","https://openalex.org/W2106258762","https://openalex.org/W2107601804","https://openalex.org/W2108626763","https://openalex.org/W2109679459","https://openalex.org/W2110483280","https://openalex.org/W2110855516","https://openalex.org/W2111335165","https://openalex.org/W2111567059","https://openalex.org/W2112497627","https://openalex.org/W2114366341","https://openalex.org/W2115205812","https://openalex.org/W2116449089","https://openalex.org/W2119683782","https://openalex.org/W2120633856","https://openalex.org/W2122857482","https://openalex.org/W2124173184","https://openalex.org/W2125054419","https://openalex.org/W2126998553","https://openalex.org/W2127848114","https://openalex.org/W2131695915","https://openalex.org/W2131994406","https://openalex.org/W2134808298","https://openalex.org/W2134831330","https://openalex.org/W2135178483","https://openalex.org/W2135619279","https://openalex.org/W2136706395","https://openalex.org/W2137022580","https://openalex.org/W2137513442","https://openalex.org/W2137662702","https://openalex.org/W2137809055","https://openalex.org/W2139568257","https://openalex.org/W2140487984","https://openalex.org/W2143022663","https://openalex.org/W2143772496","https://openalex.org/W2144139389","https://openalex.org/W2144701362","https://openalex.org/W2144841919","https://openalex.org/W2146267270","https://openalex.org/W2148401770","https://openalex.org/W2148894303","https://openalex.org/W2149313534","https://openalex.org/W2149967205","https://openalex.org/W2151501496","https://openalex.org/W2152783554","https://openalex.org/W2153043611","https://openalex.org/W2154359531","https://openalex.org/W2157544393","https://openalex.org/W2157999078","https://openalex.org/W2159650080","https://openalex.org/W2159663149","https://openalex.org/W2160690724","https://openalex.org/W2161483534","https://openalex.org/W2165721689","https://openalex.org/W2166601968","https://openalex.org/W2167036095","https://openalex.org/W2168019526","https://openalex.org/W2168084429","https://openalex.org/W2168415166","https://openalex.org/W2168681133","https://openalex.org/W2169105392","https://openalex.org/W2169635583","https://openalex.org/W2169927110","https://openalex.org/W2338173205","https://openalex.org/W4300457050"],"related_works":["https://openalex.org/W2003723352","https://openalex.org/W2071955212","https://openalex.org/W69960442","https://openalex.org/W3016458212","https://openalex.org/W2041287954","https://openalex.org/W1613986623","https://openalex.org/W2372685009","https://openalex.org/W2100727635","https://openalex.org/W2034734237","https://openalex.org/W2050279035"],"abstract_inverted_index":{"Neuronal":[0],"cell":[1,50,98,113,126,156,171,186,229,246,255,274,293,306,339,350,374],"death":[2,51,99,127,172,230,256,275,294,307,351,375],"caused":[3,173,277,376],"by":[4,90,174,278,361,369,377],"excitotoxicity":[5,388],"accompanies":[6],"neurodegenerative":[7,87],"disorders,":[8],"such":[9,145],"as":[10,146,181,183,371,373],"Alzheimer":[11],"s":[12,17],"disease":[13,18,88],"(AD)":[14],"and":[15,21,31,67,76,96,123,137,152,178,236,250,257,280,297,338,389],"Huntington":[16],"(HD),":[19],"epilepsy":[20],"ischaemia.":[22],"Glutamate":[23],"is":[24,56],"the":[25,29,101,147,161,205,214,265,268,271,353,403],"major":[26],"excitotoxin":[27],"in":[28,74,100,120,155,176,179,184,231,234,237,244,273,295,318,321,331,352,379,386,397],"CNS":[30],"causes":[32,77],"activation":[33,48,192,203],"of":[34,49,92,103,163,188,193,204,248,270,283,304,333,364],"glutamate":[35,38,63],"receptors.":[36,69],"Ionotropic":[37],"receptors":[39],"can":[40],"directly":[41],"cause":[42],"calcium":[43],"influx":[44],"that":[45,197,281,313,406],"further":[46],"enables":[47],"pathways.":[52,218],"Kainic":[53],"acid":[54],"(KA)":[55],"a":[57,86,185,245,288,344,393],"specific":[58],"agonist":[59],"for":[60,264,329,348],"ionotropic":[61],"non-NMDA":[62],"receptors,":[64],"namely":[65],"KA":[66,70,175,190,345,370,378,387,413],"AMPA":[68],"induces":[71],"epiletic":[72],"activity":[73],"rodents":[75],"hippocampal":[78,170,232],"sclerosis,":[79],"similar":[80],"to":[81,110,125,134,168,199,358,410,412],"human":[82],"temporal":[83],"epilepsy.":[84],"HD,":[85],"characterized":[89],"accumulation":[91],"mutant":[93,258],"huntingtin":[94],"protein,":[95],"causing":[97],"striatum":[102],"affected":[104],"individuals,":[105],"has":[106,140,314,326],"also":[107,141,242,391],"been":[108,118,131,315,327],"shown":[109,167,357,409],"involve":[111],"excitotoxic":[112],"death.":[114,157,340],"Intracellular":[115],"organelles":[116],"have":[117,130],"implicated":[119,142,316],"stress":[121,165,195,223,240,285,337],"sensing":[122],"contribute":[124,411],"signaling.":[128],"Mitochondria":[129],"closely":[132],"linked":[133],"apoptotic":[135,217],"pathways":[136,276],"recent":[138],"research":[139],"other":[143,298,305],"organelles,":[144],"endoplasmic":[148],"reticulum":[149],"(ER),":[150],"lysosomes":[151],"Golgi":[153],"apparatus":[154],"In":[158,210,302,341],"this":[159,342,401],"thesis,":[160,343],"involvement":[162,269,385],"ER":[164,194,222,239,272,284,336],"was":[166,241,356,402,408],"accompany":[169],"vivo":[177,235],"vitro":[180],"well":[182,372],"model":[187,247],"HD.":[189],"induced":[191],"sensors":[196],"aim":[198],"restore":[200],"homeostasis":[201],"via":[202],"unfolded":[206],"protein":[207],"response":[208],"(UPR).":[209],"prolonged":[211],"stressful":[212],"conditions,":[213],"UPR":[215],"activates":[216],"Treatment":[219],"with":[220,252],"an":[221],"inhibitor,":[224],"Salubrinal":[225],"(Sal),":[226],"significantly":[227],"attenuated":[228],"neurons":[233],"vitro.":[238,380],"activated":[243],"HD":[249,296],"treatment":[251,290],"Sal":[253],"reduced":[254,366],"hungtingtin":[259],"aggregation.":[260],"These":[261,381],"data":[262,382],"indicated":[263,383],"first":[266,404],"time":[267,405],"excitotoxicity,":[279],"inhibition":[282],"could":[286,390],"be":[287,359],"potential":[289,394],"against":[291],"neuronal":[292],"disorders":[299],"involving":[300],"excitotoxicity.":[301,319],"search":[303],"mediators":[308],"we":[309],"focused":[310],"on":[311],"Cdk5":[312,365,384,407],"deregulated":[317],"Involved":[320],"multiple":[322],"signaling":[323],"pathways,":[324],"Cdk5,":[325],"implicated,":[328],"instance,":[330],"regulation":[332],"synaptic":[334],"proteins,":[335],"receptor":[346,414],"important":[347],"mediating":[349],"hippocampus,":[354],"GluR6,":[355],"regulated":[360],"Cdk5.":[362],"Inhibition":[363],"GluR6":[367],"downregulation":[368],"present":[392],"drug":[395],"target":[396],"neurological":[398],"disorders.":[399],"Moreover,":[400],"regulation.":[415]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}