{"id":"https://openalex.org/W2218152255","doi":null,"title":"Inhibition of drug efflux by pluronics in S. cerevisiae","display_name":"Inhibition of drug efflux by pluronics in S. cerevisiae","publication_year":2007,"publication_date":"2007-05-31","ids":{"openalex":"https://openalex.org/W2218152255","mag":"2218152255"},"language":"en","primary_location":{"id":"pmh:oai:escholarshare.drake.edu:2092/566","doi":null,"is_oa":false,"landing_page_url":"https://escholarshare.drake.edu/bitstream/2092/566/1/duk06_21.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306400646","display_name":"BIA (Drake University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I87213936","host_organization_name":"Drake University","host_organization_lineage":["https://openalex.org/I87213936"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Presentation"},"volume":null,"type":"other","is_traditional":false,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068145842","display_name":"Thomas A. Diezi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas A. Diezi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051782416","display_name":"Brian Ruggle","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian Ruggle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111725595","display_name":"Nivedita K. Pandit","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nivedita K. Pandit","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5061319538","display_name":"Heidi Major Sleister","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heidi Sleister","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pluronic-p85","display_name":"Pluronic P85","score":0.9570000171661377},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.7829999923706055},{"id":"https://openalex.org/keywords/efflux-pump-inhibition","display_name":"efflux pump inhibition","score":0.7820000052452087},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.8450000286102295},{"id":"https://openalex.org/keywords/cycloheximide","display_name":"cycloheximide","score":0.9810000061988831},{"id":"https://openalex.org/keywords/itraconazole","display_name":"itraconazole","score":0.8119999766349792},{"id":"https://openalex.org/keywords/micelles","display_name":"micelles","score":0.7080000042915344},{"id":"https://openalex.org/keywords/minimum-inhibitory-concentration","display_name":"minimum inhibitory concentration","score":0.8040000200271606},{"id":"https://openalex.org/keywords/nonionic-surfactants","display_name":"nonionic surfactants","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.5546676516532898},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5327214002609253},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4399498999118805},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4393399953842163},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3295718729496002},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17044246196746826}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:escholarshare.drake.edu:2092/566","doi":null,"is_oa":false,"landing_page_url":"https://escholarshare.drake.edu/bitstream/2092/566/1/duk06_21.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306400646","display_name":"BIA (Drake University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I87213936","host_organization_name":"Drake University","host_organization_lineage":["https://openalex.org/I87213936"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Presentation"},{"id":"mag:2218152255","doi":null,"is_oa":false,"landing_page_url":"https://escholarshare.drake.edu/handle/2092/566","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2067850619","https://openalex.org/W2093768915","https://openalex.org/W1602351898","https://openalex.org/W4301035043","https://openalex.org/W2035299701","https://openalex.org/W2146560076","https://openalex.org/W2066484040","https://openalex.org/W7027935231","https://openalex.org/W376969648","https://openalex.org/W7135930377"],"abstract_inverted_index":{"Overexpression":[0],"of":[1,13,18,31,71,87,92,127,130,146,158,178,206,258],"P-gp":[2,45],"efflux":[3,46,57,151],"pumps":[4,20],"is":[5,21,40],"believed":[6],"to":[7,23,42,49,148,231],"be":[8],"responsible":[9],"for":[10,140],"multidrug":[11],"resistance":[12],"mammalian":[14,44,224],"cancer":[15],"cells.":[16,225],"Inhibition":[17],"these":[19],"expected":[22],"increase":[24,203],"the":[25,29,64,69,84,104,109,125,144,174,182,194,210],"efficacy":[26],"and":[27,103,134,185,238,246,253],"decrease":[28],"toxicity":[30],"chemotherapeutic":[32],"agents.":[33],"The":[34],"non-ionic":[35],"triblock":[36],"copolymer":[37],"Pluronic":[38,72],"P85":[39,88,135,147,172,201,261],"reported":[41,221],"inhibit":[43,149,241],"pumps,":[47],"leading":[48],"higher":[50],"intracellular":[51,204],"drug":[52],"concentrations.":[53],"An":[54],"analogous,":[55],"well-characterized":[56],"transporter,":[58],"Pdr5p,":[59],"has":[60,77],"been":[61,79],"identified":[62],"in":[63,124,180,215,223,260],"yeast":[65],"Saccharomyces":[66],"cerevisiae,":[67],"but":[68],"effect":[70,192],"copolymers":[73],"on":[74,89,193],"this":[75],"transporter":[76],"not":[78],"studied.":[80],"We":[81],"have":[82],"examined":[83,154],"inhibitory":[85,176],"effects":[86],"three":[90],"strains":[91],"S.":[93,216],"cerevisiae:":[94],"a":[95,99,116,128,156,249],"pdr5":[96,195],"deletion":[97,196],"strain,":[98,102],"PDR5":[100,105,183,186],"over-expressing":[101,187],"wild-type":[106,184],"strain":[107],"using":[108,243],"hydrophilic":[110],"Pdr5p":[111],"substrate":[112],"cycloheximide":[113,179],"(CHX)":[114],"as":[115,155],"model":[117],"antifungal":[118,251,265],"\u201cdrug\u201d.":[119],"Yeast":[120],"cells":[121],"were":[122],"grown":[123],"presence":[126],"range":[129],"CHX":[131,207,245],"(0-0.3":[132],"mcg/ml)":[133],"(0-10":[136],"mg/ml).":[137],"After":[138],"incubation":[139],"24hrs":[141],"at":[142,165],"30\u00b0C,":[143],"ability":[145],"Pdr5":[150,211,242],"activity":[152],"was":[153],"function":[157],"cellular":[159],"growth":[160],"(as":[161],"determined":[162],"by":[163,208],"absorbance":[164],"600":[166],"nm).":[167],"Our":[168,213],"results":[169,214],"indicate":[170],"that":[171,200],"lowers":[173],"minimal":[175],"concentration":[177],"both":[181],"strains,":[188],"while":[189],"having":[190],"no":[191],"strain.":[197],"This":[198],"shows":[199],"can":[202],"concentrations":[205],"inhibiting":[209],"transporter.":[212],"cerevisiae":[217],"are":[218,228],"consistent":[219],"with":[220],"observations":[222],"Further":[226],"investigations":[227],"being":[229],"performed":[230],"(1)":[232],"see":[233],"if":[234],"pluronics":[235],"F127,":[236],"L64,":[237],"L81":[239],"also":[240],"substrates":[244],"itraconazole":[247],"(ITZ),":[248],"hydrophobic":[250],"drug,":[252],"(2)":[254],"determine":[255],"whether":[256],"solubilization":[257],"ITZ":[259],"micelles":[262],"influences":[263],"its":[264],"activity.":[266]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
