{"id":"https://openalex.org/W2217670202","doi":"https://doi.org/10.1152/jappl.1994.77.1.127","title":"An ATP-sensitive potassium channel blocker decreases diaphragmatic circulation in anesthetized dogs","display_name":"An ATP-sensitive potassium channel blocker decreases diaphragmatic circulation in anesthetized dogs","publication_year":1994,"publication_date":"1994-07-01","ids":{"openalex":"https://openalex.org/W2217670202","doi":"https://doi.org/10.1152/jappl.1994.77.1.127","mag":"2217670202","pmid":"https://pubmed.ncbi.nlm.nih.gov/7961224"},"language":"en","primary_location":{"id":"doi:10.1152/jappl.1994.77.1.127","doi":"https://doi.org/10.1152/jappl.1994.77.1.127","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jappl.1994.77.1.127","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054859471","display_name":"Alain Steve Comtois","orcid":"https://orcid.org/0000-0002-6159-3220","observed_orcids":["https://orcid.org/0000-0002-6159-3220"]},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"A. Comtois","raw_affiliation_strings":["University of Ottawa, Department of Physiology, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Ottawa, Department of Physiology, Ontario, Canada","institution_ids":["https://openalex.org/I153718931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048969739","display_name":"Christer A. Sinderby","orcid":"https://orcid.org/0000-0003-4049-1564","observed_orcids":["https://orcid.org/0000-0003-4049-1564"]},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"C. Sinderby","raw_affiliation_strings":["University of Ottawa, Department of Physiology, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Ottawa, Department of Physiology, Ontario, Canada","institution_ids":["https://openalex.org/I153718931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112507496","display_name":"Norman Comtois","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"N. Comtois","raw_affiliation_strings":["University of Ottawa, Department of Physiology, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Ottawa, Department of Physiology, Ontario, Canada","institution_ids":["https://openalex.org/I153718931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108572591","display_name":"Alejandro E. Grassino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"A. Grassino","raw_affiliation_strings":["University of Ottawa, Department of Physiology, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Ottawa, Department of Physiology, Ontario, Canada","institution_ids":["https://openalex.org/I153718931"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008505811","display_name":"Jean\u2010Marc Renaud","orcid":"https://orcid.org/0000-0002-5902-0677","observed_orcids":["https://orcid.org/0000-0002-5902-0677"]},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J. M. Renaud","raw_affiliation_strings":["University of Ottawa, Department of Physiology, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Ottawa, Department of Physiology, Ontario, Canada","institution_ids":["https://openalex.org/I153718931"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I153718931"],"apc_list":null,"apc_paid":null,"fwci":0.6326,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.65909244,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"77","issue":"1","first_page":"127","last_page":"134"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.6445000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.6445000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.11869999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.1185000017285347,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atp-sensitive-potassium-channels","display_name":"ATP-sensitive potassium channels","score":0.9940000176429749},{"id":"https://openalex.org/keywords/glibenclamide","display_name":"glibenclamide","score":0.9940000176429749},{"id":"https://openalex.org/keywords/diaphragm-blood-flow","display_name":"diaphragm blood flow","score":0.8859999775886536},{"id":"https://openalex.org/keywords/diaphragm-pacing","display_name":"diaphragm pacing","score":0.8379999995231628},{"id":"https://openalex.org/keywords/phrenic-nerve","display_name":"phrenic nerve","score":0.6690000295639038},{"id":"https://openalex.org/keywords/vascular-resistance","display_name":"vascular resistance","score":0.6460000276565552},{"id":"https://openalex.org/keywords/potassium-content","display_name":"potassium content","score":0.6499999761581421},{"id":"https://openalex.org/keywords/respiratory-muscle-blood-flow","display_name":"respiratory muscle blood flow","score":0.5899999737739563}],"concepts":[{"id":"https://openalex.org/C2779768347","wikidata":"https://www.wikidata.org/wiki/Q420626","display_name":"Glibenclamide","level":3,"score":0.9358570575714111},{"id":"https://openalex.org/C20463939","wikidata":"https://www.wikidata.org/wiki/Q811123","display_name":"Diaphragmatic breathing","level":3,"score":0.7950681447982788},{"id":"https://openalex.org/C2777099253","wikidata":"https://www.wikidata.org/wiki/Q737313","display_name":"Phrenic nerve","level":3,"score":0.6547244191169739},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.609075129032135},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.5268786549568176},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5061842799186707},{"id":"https://openalex.org/C2776894844","wikidata":"https://www.wikidata.org/wiki/Q1197437","display_name":"Fissipedia","level":2,"score":0.45368707180023193},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.4487610161304474},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4166058897972107},{"id":"https://openalex.org/C2776309818","wikidata":"https://www.wikidata.org/wiki/Q4654794","display_name":"ATP-sensitive potassium channel","level":4,"score":0.41136395931243896},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.3472065329551697},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3284400403499603},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2964245080947876},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.08147507905960083},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000758","descriptor_name":"Anesthesia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003964","descriptor_name":"Diaphragm","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D003964","descriptor_name":"Diaphragm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005905","descriptor_name":"Glyburide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010791","descriptor_name":"Phrenic Nerve","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D010791","descriptor_name":"Phrenic Nerve","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014655","descriptor_name":"Vascular Resistance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014939","descriptor_name":"Work of Breathing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1152/jappl.1994.77.1.127","doi":"https://doi.org/10.1152/jappl.1994.77.1.127","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jappl.1994.77.1.127","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},{"id":"pmid:7961224","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7961224","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied physiology (Bethesda, Md. : 1985)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2221699438","https://openalex.org/W2256230238","https://openalex.org/W2275777884","https://openalex.org/W2411141327","https://openalex.org/W2009120973","https://openalex.org/W2076748620","https://openalex.org/W2412006883","https://openalex.org/W3018149811","https://openalex.org/W2068672251","https://openalex.org/W2020733727"],"abstract_inverted_index":{"The":[0],"goal":[1],"of":[2,51,77,94,159,215],"this":[3],"study":[4],"was":[5,64,105,154,200],"to":[6],"determine":[7],"whether":[8],"in":[9,74,96,102,110,118,128,134,144,172,179,187,193,212],"the":[10,75,111,119,129,135,145,157,173,180,194,213],"dog":[11],"ATP-sensitive":[12,205],"K+":[13,150,190,206],"channels":[14,207],"blocked":[15],"with":[16,115,167],"glibenclamide":[17],"affect":[18],"diaphragmatic":[19,35,91],"blood":[20,24],"flow":[21,25],"[phrenic":[22],"arterial":[23],"(Qpa)]":[26],"during":[27],"both":[28,97],"spontaneous":[29,59],"breathing":[30,60],"at":[31,61,107,152],"rest":[32,153],"and":[33,45,70,132],"increased":[34,124],"activity.":[36],"A":[37,99],"control":[38,120,136,174,181],"group":[39,48,113,131,182,196],"(no":[40],"glibenclamide;":[41,52],"n":[42,53],"=":[43,54],"4)":[44],"an":[46,89,209],"experimental":[47,112,130,146,195],"(50":[49],"mg/kg":[50],"5)":[55],"were":[56],"studied.":[57],"During":[58],"rest,":[62],"Qpa":[63,125],"15.0":[65],"ml.min-1":[66],"x":[67],"100":[68],"g-1":[69],"decreased":[71],"by":[72,84,126,156],"5%":[73],"presence":[76,158],"glibenclamide.":[78],"Diaphragmatic":[79,122],"pacing":[80,87,123,178],"(30":[81],"min-1)":[82],"generated":[83],"phrenic":[85,188],"nerve":[86,177],"produced":[88,183],"initial":[90],"tension-time":[92],"index":[93],"0.25":[95],"groups.":[98],"50%":[100],"decay":[101],"transdiaphragmatic":[103],"pressure":[104],"reached":[106],"165":[108],"s":[109,117],"compared":[114,166],"421":[116],"group.":[121,147,175],"46%":[127],"65%":[133],"group,":[137],"yielding":[138],"a":[139,184,197],"63%":[140],"greater":[141],"vascular":[142],"resistance":[143],"Phrenic":[148,176],"vein":[149,189],"content":[151],"unchanged":[155],"glibenclamide,":[160],"being":[161],"3.6":[162],"+/-":[163,169],"0.16":[164],"mmol/l":[165,171],"3.5":[168],"0.19":[170],"13%":[185],"increase":[186],"content,":[191],"whereas":[192],"16%":[198],"decrease":[199],"observed.":[201],"We":[202],"suggest":[203],"that":[204],"play":[208],"important":[210],"role":[211],"modulation":[214],"Qpa.":[216]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
