{"id":"https://openalex.org/W2216762807","doi":"https://doi.org/10.7554/elife.09436","title":"Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma","display_name":"Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma","publication_year":2015,"publication_date":"2015-10-24","ids":{"openalex":"https://openalex.org/W2216762807","doi":"https://doi.org/10.7554/elife.09436","mag":"2216762807","pmid":"https://pubmed.ncbi.nlm.nih.gov/26499495","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4695385"},"language":"en","primary_location":{"id":"doi:10.7554/elife.09436","doi":"https://doi.org/10.7554/elife.09436","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.09436","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.09436","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037943971","display_name":"Simone Hettmer","orcid":"https://orcid.org/0000-0003-1709-4448","observed_orcids":["https://orcid.org/0000-0003-1709-4448"]},"institutions":[{"id":"https://openalex.org/I1293231726","display_name":"Joslin Diabetes Center","ror":"https://ror.org/0280a3n32","country_code":"US","type":"facility","lineage":["https://openalex.org/I1293231726"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210157861","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Simone Hettmer","raw_affiliation_strings":["Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, United States","Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, United States","Division of Pediatric Hematology and Oncology, Department of Pediatric and Adolescent Medicine, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany","Joslin Diabetes Center, Harvard Medical School, Boston, United States","Pediatric Hematology/Oncology, Charit\u00e9, University Hospital Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, United States","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, United States","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]},{"raw_affiliation_string":"Division of Pediatric Hematology and Oncology, Department of Pediatric and Adolescent Medicine, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]},{"raw_affiliation_string":"Joslin Diabetes Center, Harvard Medical School, Boston, United States","institution_ids":["https://openalex.org/I1293231726","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Pediatric Hematology/Oncology, Charit\u00e9, University Hospital Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113794564","display_name":"Anna C. Schinzel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna C Schinzel","raw_affiliation_strings":["Broad Institute of Harvard and MIT, Cambridge, United States","Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Institute of Harvard and MIT, Cambridge, United States","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034683398","display_name":"Daria Tchessalova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1293231726","display_name":"Joslin Diabetes Center","ror":"https://ror.org/0280a3n32","country_code":"US","type":"facility","lineage":["https://openalex.org/I1293231726"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210157861","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daria Tchessalova","raw_affiliation_strings":["Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, United States","Joslin Diabetes Center, Harvard Medical School, Boston, United States","Harvard University, Cambridge, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, United States","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]},{"raw_affiliation_string":"Joslin Diabetes Center, Harvard Medical School, Boston, United States","institution_ids":["https://openalex.org/I1293231726","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard University, Cambridge, United States;","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076673394","display_name":"Michaela Schneider","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michaela Schneider","raw_affiliation_strings":["Division of Pediatric Hematology and Oncology, Department of Pediatric and Adolescent Medicine, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Hematology and Oncology, Department of Pediatric and Adolescent Medicine, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087952756","display_name":"Christina L. Parker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I79272384","display_name":"University of Maryland, Baltimore County","ror":"https://ror.org/02qskvh78","country_code":"US","type":"education","lineage":["https://openalex.org/I79272384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina L Parker","raw_affiliation_strings":["Summer Honors Undergraduate Program, Harvard Medical School, Boston, United States","University of Maryland, Baltimore County, Baltimore, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Summer Honors Undergraduate Program, Harvard Medical School, Boston, United States","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"University of Maryland, Baltimore County, Baltimore, United States","institution_ids":["https://openalex.org/I79272384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054412365","display_name":"Roderick Terry Bronson","orcid":"https://orcid.org/0000-0003-3725-2511","observed_orcids":["https://orcid.org/0000-0003-3725-2511"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roderick T Bronson","raw_affiliation_strings":["Department of Biomedical Sciences, Tufts University Veterinary School, North Grafton, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Tufts University Veterinary School, North Grafton, United States","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033047262","display_name":"Nigel G. J. Richards","orcid":"https://orcid.org/0000-0002-0375-0881","observed_orcids":["https://orcid.org/0000-0002-0375-0881"]},"institutions":[{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nigel GJ Richards","raw_affiliation_strings":["Department of Chemistry and Chemical Biology, Indiana University - Purdue University Indianapolis, Indianapolis, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Indiana University - Purdue University Indianapolis, Indianapolis, United States","institution_ids":["https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063875415","display_name":"William C. Hahn","orcid":"https://orcid.org/0000-0003-2840-9791","observed_orcids":["https://orcid.org/0000-0003-2840-9791"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William C Hahn","raw_affiliation_strings":["Broad Institute of Harvard and MIT, Cambridge, United States","Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Institute of Harvard and MIT, Cambridge, United States","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, United States","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030798882","display_name":"Amy J. Wagers","orcid":"https://orcid.org/0000-0002-0066-0485","observed_orcids":["https://orcid.org/0000-0002-0066-0485"]},"institutions":[{"id":"https://openalex.org/I1293231726","display_name":"Joslin Diabetes Center","ror":"https://ror.org/0280a3n32","country_code":"US","type":"facility","lineage":["https://openalex.org/I1293231726"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210157861","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Amy J Wagers","raw_affiliation_strings":["Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, United States","Joslin Diabetes Center, Harvard Medical School, Boston, United States","Harvard University, Cambridge, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, United States","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]},{"raw_affiliation_string":"Joslin Diabetes Center, Harvard Medical School, Boston, United States","institution_ids":["https://openalex.org/I1293231726","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard University, Cambridge, United States;","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5030798882"],"corresponding_institution_ids":["https://openalex.org/I1293231726","https://openalex.org/I136199984","https://openalex.org/I4210157861"],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":2.5001,"has_fulltext":true,"cited_by_count":58,"citation_normalized_percentile":{"value":0.8870674,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"4","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.5185999870300293,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.5185999870300293,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.21570000052452087,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.11349999904632568,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sarcoma","display_name":"sarcoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/asparagine-synthetase","display_name":"asparagine synthetase","score":0.9750000238418579},{"id":"https://openalex.org/keywords/metabolic-vulnerability","display_name":"metabolic vulnerability","score":0.7839999794960022},{"id":"https://openalex.org/keywords/amino-acid-metabolism","display_name":"amino acid metabolism","score":0.6570000052452087},{"id":"https://openalex.org/keywords/l-asparaginase","display_name":"L-asparaginase","score":0.8230000138282776},{"id":"https://openalex.org/keywords/cdkn2a-deletion","display_name":"CDKN2A deletion","score":0.859000027179718},{"id":"https://openalex.org/keywords/s-phase-arrest","display_name":"S phase arrest","score":0.6150000095367432},{"id":"https://openalex.org/keywords/polypeptide-synthesis","display_name":"polypeptide synthesis","score":0.7279999852180481},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.6159999966621399},{"id":"https://openalex.org/keywords/functional-genomic-screens","display_name":"functional genomic screens","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C2780240386","wikidata":"https://www.wikidata.org/wiki/Q21131459","display_name":"Asparagine synthetase","level":4,"score":0.8091879487037659},{"id":"https://openalex.org/C2775895851","wikidata":"https://www.wikidata.org/wiki/Q185906","display_name":"Asparagine","level":3,"score":0.7064282298088074},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.6750878095626831},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6207408308982849},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6101810336112976},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.4721681475639343},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26320916414260864},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.18142104148864746},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14621827006340027},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13316115736961365},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10664239525794983}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001216","descriptor_name":"Asparagine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.7554/elife.09436","doi":"https://doi.org/10.7554/elife.09436","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.09436","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4695385","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4695385","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Text"},{"id":"pmid:26499495","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26499495","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Journal Article"},{"id":"pmh:oai:http://orca.cardiff.ac.uk:98704","doi":null,"is_oa":false,"landing_page_url":"https://orca.cardiff.ac.uk/id/eprint/98704/1/e09436-download.pdf","pdf_url":"https://orca.cardiff.ac.uk/id/eprint/98704/1/e09436-download.pdf","source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:https://orca.cardiff.ac.uk:98704","doi":null,"is_oa":true,"landing_page_url":"https://orca.cardiff.ac.uk/id/eprint/98704/1/e09436-download.pdf","pdf_url":"https://orca.cardiff.ac.uk/id/eprint/98704/1/e09436-download.pdf","source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:dash.harvard.edu:1/23993621","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:23993621","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:02c860c99dd149119671592902b66edd","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/02c860c99dd149119671592902b66edd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife, Vol 4 (2015)","raw_type":"article"},{"id":"pmh:oai:freidok.uni-freiburg.de:129731","doi":null,"is_oa":false,"landing_page_url":"https://freidok.uni-freiburg.de/data/129731","pdf_url":null,"source":{"id":"https://openalex.org/S4306401057","display_name":"FreiDok plus (Universit\u00e4tsbibliothek Freiburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I161046081","host_organization_name":"University of Freiburg","host_organization_lineage":["https://openalex.org/I161046081"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife. - 4 (2015) , e09436, ISSN: 2050-084X","raw_type":"article"}],"best_oa_location":{"id":"doi:10.7554/elife.09436","doi":"https://doi.org/10.7554/elife.09436","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.09436","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1393590083","display_name":"Therapeutic Opportunities for Pediatric Astrocytoma","funder_award_id":"P01CA142536","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3057836367","display_name":null,"funder_award_id":"P30DK036836","funder_id":"https://openalex.org/F4320310143","funder_display_name":"Joslin Diabetes Center"},{"id":"https://openalex.org/G3835540860","display_name":null,"funder_award_id":"SU2C-AACR-IRG1111","funder_id":"https://openalex.org/F4320306091","funder_display_name":"American Association for Cancer Research"},{"id":"https://openalex.org/G5782343497","display_name":null,"funder_award_id":"U01 CA176058","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G6018147714","display_name":"Papova Virus Transforming Mechanisms","funder_award_id":"P01CA050661","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6022809732","display_name":null,"funder_award_id":"P01 CA050661","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G6620512095","display_name":null,"funder_award_id":"P01 CA142536","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G6875816607","display_name":"The Dana-Farber Cancer Institute Cancer Target Discovery and Development Center","funder_award_id":"U01CA176058","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000868266","display_name":"Diabetes Research Center","funder_award_id":"P30DK036836","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306091","display_name":"American Association for Cancer Research","ror":"https://ror.org/02fnpv153"},{"id":"https://openalex.org/F4320307446","display_name":"Sarcoma Foundation of America","ror":"https://ror.org/022tv3h63"},{"id":"https://openalex.org/F4320308906","display_name":"St. Baldrick's Foundation","ror":"https://ror.org/03h1gea69"},{"id":"https://openalex.org/F4320310143","display_name":"Joslin Diabetes Center","ror":"https://ror.org/0280a3n32"},{"id":"https://openalex.org/F4320310151","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332616","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59"},{"id":"https://openalex.org/F4320332898","display_name":"Stand Up To Cancer","ror":"https://ror.org/01dmpb598"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2216762807.pdf","grobid_xml":"https://content.openalex.org/works/W2216762807.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W90249845","https://openalex.org/W1867192423","https://openalex.org/W1937206487","https://openalex.org/W1948547675","https://openalex.org/W1966435120","https://openalex.org/W2000144783","https://openalex.org/W2000246857","https://openalex.org/W2007725129","https://openalex.org/W2014988241","https://openalex.org/W2018310400","https://openalex.org/W2020589011","https://openalex.org/W2021156741","https://openalex.org/W2022899908","https://openalex.org/W2028640227","https://openalex.org/W2054272344","https://openalex.org/W2062972691","https://openalex.org/W2076090859","https://openalex.org/W2108195113","https://openalex.org/W2114079476","https://openalex.org/W2125390368","https://openalex.org/W2125877121","https://openalex.org/W2126524529","https://openalex.org/W2127736279","https://openalex.org/W2132051882","https://openalex.org/W2136346901","https://openalex.org/W2149414729","https://openalex.org/W2157760261","https://openalex.org/W2162438404","https://openalex.org/W2162953952","https://openalex.org/W2168980975"],"related_works":["https://openalex.org/W2562598891","https://openalex.org/W4306736928","https://openalex.org/W7100937522","https://openalex.org/W3118711948","https://openalex.org/W2010695000","https://openalex.org/W3181727368","https://openalex.org/W4399699600","https://openalex.org/W4406035207","https://openalex.org/W4402048454","https://openalex.org/W4412075409"],"abstract_inverted_index":{"Current":[0],"therapies":[1],"for":[2],"sarcomas":[3,54],"are":[4],"often":[5],"inadequate.":[6],"This":[7],"study":[8],"sought":[9],"to":[10],"identify":[11],"actionable":[12],"gene":[13],"targets":[14],"by":[15,56,91],"selective":[16],"targeting":[17],"of":[18,28,52,61,75,86,120,129,139],"the":[19,40,73,100],"molecular":[20],"networks":[21],"that":[22,34],"support":[23],"sarcoma":[24,45,69,113,124,140],"cell":[25,70],"proliferation.":[26],"Silencing":[27],"asparagine":[29,97,131],"synthetase":[30],"(ASNS),":[31],"an":[32],"amidotransferase":[33],"converts":[35],"aspartate":[36],"into":[37],"asparagine,":[38],"produced":[39],"strongest":[41],"inhibitory":[42],"effect":[43],"on":[44],"growth":[46,114,134],"in":[47,65,115,122,135],"a":[48,144],"functional":[49],"genomic":[50],"screen":[51],"mouse":[53,66,110,123],"generated":[55],"oncogenic":[57],"Kras":[58],"and":[59,67,79,111,117],"disruption":[60],"Cdkn2a.":[62],"ASNS":[63,87,101,121],"silencing":[64,88,119],"human":[68,112],"lines":[71],"reduced":[72],"percentage":[74],"S":[76],"phase":[77],"cells":[78,125,141],"impeded":[80],"new":[81],"polypeptide":[82],"synthesis.":[83],"These":[84],"effects":[85],"were":[89],"reversed":[90],"exogenous":[92],"supplementation":[93],"with":[94,127,147],"asparagine.":[95],"Also,":[96],"depletion":[98,128],"via":[99],"inhibitor":[102],"amino":[103],"sulfoximine":[104],"5":[105],"(AS5)":[106],"or":[107],"asparaginase":[108],"inhibited":[109,132],"vitro,":[116],"genetic":[118],"combined":[126],"plasma":[130],"tumor":[133],"vivo.":[136],"Asparagine":[137],"reliance":[138],"may":[142],"represent":[143],"metabolic":[145],"vulnerability":[146],"potential":[148],"anti-sarcoma":[149],"therapeutic":[150],"value.":[151]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
