{"id":"https://openalex.org/W2216639295","doi":"https://doi.org/10.1189/jlb.4a0115-003rr","title":"Lack of the programmed death-1 receptor renders host susceptible to enteric microbial infection through impairing the production of the mucosal natural killer cell effector molecules","display_name":"Lack of the programmed death-1 receptor renders host susceptible to enteric microbial infection through impairing the production of the mucosal natural killer cell effector molecules","publication_year":2015,"publication_date":"2015-10-14","ids":{"openalex":"https://openalex.org/W2216639295","doi":"https://doi.org/10.1189/jlb.4a0115-003rr","mag":"2216639295","pmid":"https://pubmed.ncbi.nlm.nih.gov/26467188","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6608046"},"language":"en","primary_location":{"id":"doi:10.1189/jlb.4a0115-003rr","doi":"https://doi.org/10.1189/jlb.4a0115-003rr","is_oa":false,"landing_page_url":"https://doi.org/10.1189/jlb.4a0115-003rr","pdf_url":null,"source":{"id":"https://openalex.org/S199011235","display_name":"Journal of Leukocyte Biology","issn_l":"0741-5400","issn":["0741-5400","1938-3673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Leukocyte Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6608046","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036034644","display_name":"Shahram Solaymani-Mohammadi","orcid":"https://orcid.org/0000-0001-9749-3830","observed_orcids":["https://orcid.org/0000-0001-9749-3830"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shahram Solaymani-Mohammadi","raw_affiliation_strings":["Laboratory of Mucosal Immunology , California , USA","Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, Maryland , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Mucosal Immunology , California , USA","institution_ids":[]},{"raw_affiliation_string":"Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, Maryland , USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018345162","display_name":"Omar Lakhdari","orcid":"https://orcid.org/0000-0002-1104-2412","observed_orcids":["https://orcid.org/0000-0002-1104-2412"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Omar Lakhdari","raw_affiliation_strings":["Laboratory of Mucosal Immunology , California , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Mucosal Immunology , California , USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089573357","display_name":"Ivelina Minev","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ivelina Minev","raw_affiliation_strings":["Laboratory of Mucosal Immunology , California , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Mucosal Immunology , California , USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084637483","display_name":"Steve Shenouda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steve Shenouda","raw_affiliation_strings":["Laboratory of Mucosal Immunology , California , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Mucosal Immunology , California , USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009206760","display_name":"Blake F. Frey","orcid":"https://orcid.org/0000-0003-3003-6904","observed_orcids":["https://orcid.org/0000-0003-3003-6904"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Blake F Frey","raw_affiliation_strings":["Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, Maryland , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, Maryland , USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019252419","display_name":"Rolf Billeskov","orcid":"https://orcid.org/0000-0003-4533-7304","observed_orcids":["https://orcid.org/0000-0003-4533-7304"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rolf Billeskov","raw_affiliation_strings":["Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, Maryland , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, Maryland , USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057110585","display_name":"Steven M. Singer","orcid":"https://orcid.org/0000-0001-5719-7535","observed_orcids":["https://orcid.org/0000-0001-5719-7535"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven M Singer","raw_affiliation_strings":["Department of Biology and Center for Infectious Disease, Georgetown University, Washington, District of Columbia , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology and Center for Infectious Disease, Georgetown University, Washington, District of Columbia , USA","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056265030","display_name":"Jay A. Berzofsky","orcid":"https://orcid.org/0000-0002-0342-3194","observed_orcids":["https://orcid.org/0000-0002-0342-3194"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jay A Berzofsky","raw_affiliation_strings":["Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, Maryland , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, Maryland , USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007202760","display_name":"Lars Eckmann","orcid":"https://orcid.org/0000-0002-7987-8742","observed_orcids":["https://orcid.org/0000-0002-7987-8742"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lars Eckmann","raw_affiliation_strings":["Department of Medicine, University of California , San Diego, La Jolla, California , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California , San Diego, La Jolla, California , USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108191565","display_name":"Martin F. Kagnoff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin F Kagnoff","raw_affiliation_strings":["Laboratory of Mucosal Immunology , California , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Mucosal Immunology , California , USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5036034644"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":1.1487,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.77697116,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"99","issue":"3","first_page":"475","last_page":"482"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pdcd1","display_name":"PDCD1","score":0.9520000219345093},{"id":"https://openalex.org/keywords/bacterial-enteric-infections","display_name":"enteric bacterial infection","score":0.7200000286102295},{"id":"https://openalex.org/keywords/citrobacter-rodentium","display_name":"Citrobacter rodentium","score":0.9980000257492065},{"id":"https://openalex.org/keywords/perforin","display_name":"perforin","score":0.7950000166893005},{"id":"https://openalex.org/keywords/granzyme-b","display_name":"granzyme B","score":1.0},{"id":"https://openalex.org/keywords/intestinal-mucosa","display_name":"intestinal mucosa","score":0.7089999914169312},{"id":"https://openalex.org/keywords/host-defense","display_name":"host defense","score":0.515999972820282},{"id":"https://openalex.org/keywords/anti-pd-1-antibody","display_name":"anti-PD-1","score":0.7559999823570251},{"id":"https://openalex.org/keywords/perforin-deficient-mice","display_name":"perforin-deficient mice","score":0.7570000290870667},{"id":"https://openalex.org/keywords/nk-cell-depletion","display_name":"NK cell depletion","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C2910319489","wikidata":"https://www.wikidata.org/wiki/Q16975761","display_name":"Citrobacter rodentium","level":3,"score":0.8914220333099365},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8101479411125183},{"id":"https://openalex.org/C2776062744","wikidata":"https://www.wikidata.org/wiki/Q21103279","display_name":"Perforin","level":4,"score":0.61435467004776},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5992385149002075},{"id":"https://openalex.org/C183193105","wikidata":"https://www.wikidata.org/wiki/Q425068","display_name":"Granzyme","level":5,"score":0.554485559463501},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.5252392292022705},{"id":"https://openalex.org/C139563560","wikidata":"https://www.wikidata.org/wiki/Q224930","display_name":"Natural killer T cell","level":4,"score":0.5194848775863647},{"id":"https://openalex.org/C2778102761","wikidata":"https://www.wikidata.org/wiki/Q332181","display_name":"Natural killer cell","level":4,"score":0.5122184157371521},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5077320337295532},{"id":"https://openalex.org/C2780380082","wikidata":"https://www.wikidata.org/wiki/Q12646460","display_name":"Granzyme B","level":4,"score":0.4946574866771698},{"id":"https://openalex.org/C149532602","wikidata":"https://www.wikidata.org/wiki/Q2409681","display_name":"Interleukin 12","level":4,"score":0.4924388825893402},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.4914644956588745},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.47833916544914246},{"id":"https://openalex.org/C28651165","wikidata":"https://www.wikidata.org/wiki/Q4259786","display_name":"Lymphokine-activated killer cell","level":5,"score":0.4743025302886963},{"id":"https://openalex.org/C2779968557","wikidata":"https://www.wikidata.org/wiki/Q12646459","display_name":"Granzyme A","level":5,"score":0.4503185451030731},{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.39272910356521606},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.3759442865848541},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.34367531538009644},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.337654709815979},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.28813934326171875},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0683542788028717},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004756","descriptor_name":"Enterobacteriaceae Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044082","descriptor_name":"Citrobacter rodentium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053804","descriptor_name":"Granzymes","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D054353","descriptor_name":"Perforin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D061026","descriptor_name":"Programmed Cell Death 1 Receptor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1189/jlb.4a0115-003rr","doi":"https://doi.org/10.1189/jlb.4a0115-003rr","is_oa":false,"landing_page_url":"https://doi.org/10.1189/jlb.4a0115-003rr","pdf_url":null,"source":{"id":"https://openalex.org/S199011235","display_name":"Journal of Leukocyte Biology","issn_l":"0741-5400","issn":["0741-5400","1938-3673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Leukocyte Biology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5590121","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6608046","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6608046","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6608046","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Leukoc Biol","raw_type":"Text"},{"id":"pmid:26467188","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26467188","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of leukocyte biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5590121","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6608046","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1896373246","display_name":null,"funder_award_id":"R15-AI094492","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1954063082","display_name":null,"funder_award_id":"AI 094492","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3071505009","display_name":null,"funder_award_id":"Z01-C04020","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G606857638","display_name":"Immune Control of Giardia Pathogenesis","funder_award_id":"1r15ai094492-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7905461792","display_name":"The Role of Macrophages in Immune Responses to Giardia","funder_award_id":"R15AI109591","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8949402024","display_name":"INTESTINAL IMMUNE SYSTEM IN HOST-ENVIRONMENT INTERACTION","funder_award_id":"P01DK035108","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G981301735","display_name":null,"funder_award_id":"DK 35108","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1522514489","https://openalex.org/W1875845937","https://openalex.org/W1888761419","https://openalex.org/W1984187736","https://openalex.org/W2005879027","https://openalex.org/W2010847298","https://openalex.org/W2012892551","https://openalex.org/W2018449740","https://openalex.org/W2022165351","https://openalex.org/W2022230965","https://openalex.org/W2029724130","https://openalex.org/W2033081825","https://openalex.org/W2042364269","https://openalex.org/W2045323799","https://openalex.org/W2049750787","https://openalex.org/W2058798829","https://openalex.org/W2061429827","https://openalex.org/W2066369312","https://openalex.org/W2073300038","https://openalex.org/W2075257799","https://openalex.org/W2084896925","https://openalex.org/W2095326716","https://openalex.org/W2105510531","https://openalex.org/W2106579717","https://openalex.org/W2107066107","https://openalex.org/W2109604006","https://openalex.org/W2112794401","https://openalex.org/W2113287880","https://openalex.org/W2118498600","https://openalex.org/W2125951290","https://openalex.org/W2127435143","https://openalex.org/W2153476265","https://openalex.org/W2153548762","https://openalex.org/W2156014983","https://openalex.org/W2163807503","https://openalex.org/W2164720040","https://openalex.org/W2170598738"],"related_works":["https://openalex.org/W7098678975","https://openalex.org/W805659434","https://openalex.org/W2109789489","https://openalex.org/W1767233588","https://openalex.org/W1522514489","https://openalex.org/W2281864468","https://openalex.org/W2119842624","https://openalex.org/W2894468473","https://openalex.org/W2922543814","https://openalex.org/W7100881762"],"abstract_inverted_index":{"The":[0],"programmed":[1,37,68,108,131,160,171,208],"death-1":[2,38,69,109,114,172,209],"receptor":[3],"is":[4,42,61,71],"expressed":[5],"on":[6,73,80],"a":[7,46,229],"wide":[8],"range":[9],"of":[10,36,142,166,178,186,239,242],"immune":[11],"effector":[12,148,182],"cells,":[13,16,20,22,87],"including":[14],"T":[15,19,40,86],"natural":[17,25,75,84,156,179,187,215,243],"killer":[18,26,76,85,157,180,188,216,244],"dendritic":[21,94],"macrophages,":[23],"and":[24,30,122,152,190,237],"cells.":[27],"In":[28,154],"malignancies":[29],"chronic":[31],"viral":[32],"infections,":[33],"increased":[34,72,140,194,207],"expression":[35,70,141,165,177,212,236],"by":[39,213,233],"cells":[41,77,95,158,189,217],"generally":[43],"associated":[44],"with":[45,98,112,125,135,170,200,228],"poor":[47],"prognosis.":[48],"However,":[49],"its":[50],"role":[51],"in":[52,107],"early":[53],"host":[54,219],"microbial":[55],"defense":[56],"at":[57,221],"the":[58,99,143,222,235],"intestinal":[59,223],"mucosa":[60,224],"not":[62,79,130],"well":[63],"understood.":[64],"We":[65],"report":[66],"that":[67,206],"conventional":[74,144,214],"but":[78,129],"CD4(+),":[81],"CD8(+)":[82],"or":[83,88,90,93,110],"CD11b(+)":[89],"CD11c(+)":[91],"macrophages":[92],"after":[96],"infection":[97,124,199,227],"mouse":[100],"pathogen":[101,232],"Citrobacter":[102,126,136,201],"rodentium.":[103,127,202],"Mice":[104],"genetically":[105],"deficient":[106],"treated":[111],"anti-programmed":[113],"antibody":[115],"were":[116],"more":[117],"susceptible":[118],"to":[119,196],"acute":[120,197,226],"enteric":[121,198],"systemic":[123],"Wild-type":[128],"death-1-deficient":[132,161],"mice":[133,162,184,192],"infected":[134],"rodentium":[137],"showed":[138],"significantly":[139],"mucosal":[145],"NK":[146],"cell":[147,181,245],"molecules":[149],"granzyme":[150],"B":[151],"perforin.":[153],"contrast,":[155],"from":[159],"had":[163],"impaired":[164],"those":[167],"mediators.":[168],"Consistent":[169],"being":[173],"important":[174,240],"for":[175],"intracellular":[176],"molecules,":[183],"depleted":[185],"perforin-deficient":[191],"manifested":[193],"susceptibility":[195],"Our":[203],"findings":[204],"suggest":[205],"signaling":[210],"pathway":[211],"promotes":[218],"protection":[220],"during":[225],"bacterial":[230],"gut":[231],"enhancing":[234],"production":[238],"effectors":[241],"function.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
