{"id":"https://openalex.org/W2216485355","doi":"https://doi.org/10.1007/s00018-015-2119-4","title":"Exploring NAD+ metabolism in host\u2013pathogen interactions","display_name":"Exploring NAD+ metabolism in host\u2013pathogen interactions","publication_year":2015,"publication_date":"2015-12-30","ids":{"openalex":"https://openalex.org/W2216485355","doi":"https://doi.org/10.1007/s00018-015-2119-4","mag":"2216485355","pmid":"https://pubmed.ncbi.nlm.nih.gov/26718485","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11108276"},"language":"en","primary_location":{"id":"doi:10.1007/s00018-015-2119-4","doi":"https://doi.org/10.1007/s00018-015-2119-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00018-015-2119-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00018-015-2119-4.pdf","source":{"id":"https://openalex.org/S60362788","display_name":"Cellular and Molecular Life Sciences","issn_l":"1420-682X","issn":["1420-682X","1420-9071"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Life Sciences","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://link.springer.com/content/pdf/10.1007/s00018-015-2119-4.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103133345","display_name":"In\u00eas Mesquita","orcid":"https://orcid.org/0000-0002-3538-9867","observed_orcids":["https://orcid.org/0000-0002-3538-9867"]},"institutions":[{"id":"https://openalex.org/I99682543","display_name":"University of Minho","ror":"https://ror.org/037wpkx04","country_code":"PT","type":"education","lineage":["https://openalex.org/I99682543"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"In\u00eas Mesquita","raw_affiliation_strings":["ICVS/3B's-PT Government Associate Laboratory, Braga/Guimar\u00e3es, Portugal","Microbiology and Infection Research Domain, Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICVS/3B's-PT Government Associate Laboratory, Braga/Guimar\u00e3es, Portugal","institution_ids":[]},{"raw_affiliation_string":"Microbiology and Infection Research Domain, Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal","institution_ids":["https://openalex.org/I99682543"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Patr\u00edcia Varela","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99682543","display_name":"University of Minho","ror":"https://ror.org/037wpkx04","country_code":"PT","type":"education","lineage":["https://openalex.org/I99682543"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Patr\u00edcia Varela","raw_affiliation_strings":["ICVS/3B's-PT Government Associate Laboratory, Braga/Guimar\u00e3es, Portugal","Microbiology and Infection Research Domain, Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICVS/3B's-PT Government Associate Laboratory, Braga/Guimar\u00e3es, Portugal","institution_ids":[]},{"raw_affiliation_string":"Microbiology and Infection Research Domain, Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal","institution_ids":["https://openalex.org/I99682543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025715234","display_name":"Ana Belinha","orcid":"https://orcid.org/0000-0003-4275-7821","observed_orcids":["https://orcid.org/0000-0003-4275-7821"]},"institutions":[{"id":"https://openalex.org/I99682543","display_name":"University of Minho","ror":"https://ror.org/037wpkx04","country_code":"PT","type":"education","lineage":["https://openalex.org/I99682543"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Ana Belinha","raw_affiliation_strings":["ICVS/3B's-PT Government Associate Laboratory, Braga/Guimar\u00e3es, Portugal","Microbiology and Infection Research Domain, Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICVS/3B's-PT Government Associate Laboratory, Braga/Guimar\u00e3es, Portugal","institution_ids":[]},{"raw_affiliation_string":"Microbiology and Infection Research Domain, Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal","institution_ids":["https://openalex.org/I99682543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081758055","display_name":"Joana Gaifem","orcid":"https://orcid.org/0000-0001-7306-7378","observed_orcids":["https://orcid.org/0000-0001-7306-7378"]},"institutions":[{"id":"https://openalex.org/I99682543","display_name":"University of Minho","ror":"https://ror.org/037wpkx04","country_code":"PT","type":"education","lineage":["https://openalex.org/I99682543"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Joana Gaifem","raw_affiliation_strings":["ICVS/3B's-PT Government Associate Laboratory, Braga/Guimar\u00e3es, Portugal","Microbiology and Infection Research Domain, Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICVS/3B's-PT Government Associate Laboratory, Braga/Guimar\u00e3es, Portugal","institution_ids":[]},{"raw_affiliation_string":"Microbiology and Infection Research Domain, Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal","institution_ids":["https://openalex.org/I99682543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019057263","display_name":"Mireille Laforge","orcid":"https://orcid.org/0000-0002-1892-5250","observed_orcids":["https://orcid.org/0000-0002-1892-5250"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4387156284","display_name":"Universit\u00e9 Paris Descartes","ror":"https://ror.org/0220k9r37","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387156284"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mireille Laforge","raw_affiliation_strings":["CNRS FR 3636, Universit\u00e9 Paris Descartes, 75006, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS FR 3636, Universit\u00e9 Paris Descartes, 75006, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4387156284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013936064","display_name":"Baptiste Vergnes","orcid":"https://orcid.org/0000-0002-9640-2009","observed_orcids":["https://orcid.org/0000-0002-9640-2009"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210087127","display_name":"Maladies Infectieuses et Vecteurs: \u00c9cologie, G\u00e9n\u00e9tique, \u00c9volution et Contr\u00f4le","ror":"https://ror.org/00357kh21","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I2802818602","https://openalex.org/I4210087127","https://openalex.org/I4210088668","https://openalex.org/I4210090127","https://openalex.org/I4210107625","https://openalex.org/I4210131494","https://openalex.org/I4210166444"]},{"id":"https://openalex.org/I4210166444","display_name":"Institut de Recherche pour le D\u00e9veloppement","ror":"https://ror.org/05q3vnk25","country_code":"FR","type":"government","lineage":["https://openalex.org/I2802818602","https://openalex.org/I4210090127","https://openalex.org/I4210131494","https://openalex.org/I4210166444"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Baptiste Vergnes","raw_affiliation_strings":["MIVEGEC (IRD 224-CNRS 5290-Universit\u00e9 Montpellier), Institut de Recherche pour le D\u00e9veloppement (IRD), Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MIVEGEC (IRD 224-CNRS 5290-Universit\u00e9 Montpellier), Institut de Recherche pour le D\u00e9veloppement (IRD), Montpellier, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210087127","https://openalex.org/I4210166444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013917588","display_name":"J\u00e9r\u00f4me Estaquier","orcid":"https://orcid.org/0000-0002-9432-8044","observed_orcids":["https://orcid.org/0000-0002-9432-8044"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4387156284","display_name":"Universit\u00e9 Paris Descartes","ror":"https://ror.org/0220k9r37","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387156284"]},{"id":"https://openalex.org/I4405256986","display_name":"Centre de recherche du CHU de Qu\u00e9bec-Universit\u00e9 Laval","ror":"https://ror.org/04rgqcd02","country_code":"CA","type":"facility","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256986","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405260198","display_name":"F\u00e9d\u00e9ration de Recherche en Neurosciences des Saints-P\u00e8res","ror":"https://ror.org/03d3nc825","country_code":"FR","type":"facility","lineage":["https://openalex.org/I204730241","https://openalex.org/I4405260198"]}],"countries":["CA","FR"],"is_corresponding":true,"raw_author_name":"J\u00e9r\u00f4me Estaquier","raw_affiliation_strings":["CNRS FR 3636, Universit\u00e9 Paris Descartes, 75006, Paris, France. estaquier@yahoo.fr","Centre de Recherche du CHU de Qu\u00e9bec, Universit\u00e9 Laval, Quebec, G1V 4G2, Canada. estaquier@yahoo.fr","CNRS FR 3636, Universit\u00e9 Paris Descartes, 75006, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS FR 3636, Universit\u00e9 Paris Descartes, 75006, Paris, France. estaquier@yahoo.fr","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4387156284","https://openalex.org/I4405260198"]},{"raw_affiliation_string":"Centre de Recherche du CHU de Qu\u00e9bec, Universit\u00e9 Laval, Quebec, G1V 4G2, Canada. estaquier@yahoo.fr","institution_ids":["https://openalex.org/I4405256986"]},{"raw_affiliation_string":"CNRS FR 3636, Universit\u00e9 Paris Descartes, 75006, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4387156284"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018751446","display_name":"Ricardo Silvestre","orcid":"https://orcid.org/0000-0002-9270-2717","observed_orcids":["https://orcid.org/0000-0002-9270-2717"]},"institutions":[{"id":"https://openalex.org/I99682543","display_name":"University of Minho","ror":"https://ror.org/037wpkx04","country_code":"PT","type":"education","lineage":["https://openalex.org/I99682543"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Ricardo Silvestre","raw_affiliation_strings":["ICVS/3B's-PT Government Associate Laboratory, Braga/Guimar\u00e3es, Portugal. ricardosilvestre@ecsaude.uminho.pt","Microbiology and Infection Research Domain, Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal. ricardosilvestre@ecsaude.uminho.pt","ICVS/3B's-PT Government Associate Laboratory, Braga/Guimar\u00e3es, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICVS/3B's-PT Government Associate Laboratory, Braga/Guimar\u00e3es, Portugal. ricardosilvestre@ecsaude.uminho.pt","institution_ids":[]},{"raw_affiliation_string":"Microbiology and Infection Research Domain, Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal. ricardosilvestre@ecsaude.uminho.pt","institution_ids":["https://openalex.org/I99682543"]},{"raw_affiliation_string":"ICVS/3B's-PT Government Associate Laboratory, Braga/Guimar\u00e3es, Portugal","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5013917588","https://openalex.org/A5018751446"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4387156284","https://openalex.org/I4405256986","https://openalex.org/I4405260198","https://openalex.org/I99682543"],"apc_list":{"value":4290,"currency":"USD","value_usd":4290},"apc_paid":null,"fwci":0.5538,"has_fulltext":true,"cited_by_count":52,"citation_normalized_percentile":{"value":0.48502994,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"73","issue":"6","first_page":"1225","last_page":"1236"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.01860000006854534,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nad-metabolism","display_name":"NAD+ metabolism","score":0.9990000128746033},{"id":"https://openalex.org/keywords/host-pathogen-interaction","display_name":"host-pathogen interaction","score":0.9940000176429749},{"id":"https://openalex.org/keywords/nad-biosynthesis","display_name":"NAD biosynthesis","score":0.8069999814033508},{"id":"https://openalex.org/keywords/de-novo-pathway","display_name":"de novo pathway","score":0.7310000061988831},{"id":"https://openalex.org/keywords/salvage-pathway","display_name":"salvage pathway","score":0.9959999918937683},{"id":"https://openalex.org/keywords/immune-response","display_name":"immune response","score":0.5600000023841858},{"id":"https://openalex.org/keywords/pathogen-persistence","display_name":"pathogen persistence","score":0.7279999852180481},{"id":"https://openalex.org/keywords/infection-treatment","display_name":"infection treatment","score":0.7609999775886536},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.9515963792800903},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.7146177291870117},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.610993504524231},{"id":"https://openalex.org/C2776901170","wikidata":"https://www.wikidata.org/wiki/Q12499775","display_name":"Nicotinamide adenine dinucleotide","level":4,"score":0.5999445915222168},{"id":"https://openalex.org/C96942376","wikidata":"https://www.wikidata.org/wiki/Q21130714","display_name":"Catabolism","level":3,"score":0.5958859920501709},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5876699686050415},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5519202351570129},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4778701663017273},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4707803428173065},{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.469709575176239},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38582995533943176},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.27149704098701477}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004747","descriptor_name":"Entamoeba","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004749","descriptor_name":"Entamoebiasis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007891","descriptor_name":"Leishmania","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007896","descriptor_name":"Leishmaniasis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009243","descriptor_name":"NAD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010961","descriptor_name":"Plasmodium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018406","descriptor_name":"Virus Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018407","descriptor_name":"Bacterial Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053898","descriptor_name":"Biosynthetic Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1007/s00018-015-2119-4","doi":"https://doi.org/10.1007/s00018-015-2119-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00018-015-2119-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00018-015-2119-4.pdf","source":{"id":"https://openalex.org/S60362788","display_name":"Cellular and Molecular Life Sciences","issn_l":"1420-682X","issn":["1420-682X","1420-9071"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Life Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11108276","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11108276","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Mol Life Sci","raw_type":"Text"},{"id":"pmid:26718485","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26718485","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and molecular life sciences : CMLS","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-02002338v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-02002338v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cellular and Molecular Life Sciences, 2016, 73 (6), pp.1225-1236","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-03090290v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-03090290","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cellular and Molecular Life Sciences, 2016, 73 (6), pp.1225-1236. ⟨10.1007/s00018-015-2119-4⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repositorium.sdum.uminho.pt:1822/46276","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1822/46276","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journal article"},{"id":"pmh:oai:repositorium.uminho.pt:1822/46276","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1822/46276","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1007/s00018-015-2119-4","doi":"https://doi.org/10.1007/s00018-015-2119-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00018-015-2119-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00018-015-2119-4.pdf","source":{"id":"https://openalex.org/S60362788","display_name":"Cellular and Molecular Life Sciences","issn_l":"1420-682X","issn":["1420-682X","1420-9071"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Life Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2711672494","display_name":null,"funder_award_id":"MA/11/262)","funder_id":"https://openalex.org/F4320313549","funder_display_name":"Providence Health Care"},{"id":"https://openalex.org/G2967624632","display_name":null,"funder_award_id":"602773 (Project KINDRED)","funder_id":"https://openalex.org/F4320334960","funder_display_name":"Seventh Framework Programme"},{"id":"https://openalex.org/G660878546","display_name":null,"funder_award_id":"IF/00021/2014","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G7114427391","display_name":null,"funder_award_id":"602773","funder_id":"https://openalex.org/F2094871694","funder_display_name":"Business Events Perth"},{"id":"https://openalex.org/G7392906655","display_name":"A designar","funder_award_id":"PD/BD/106053/2015","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"}],"funders":[{"id":"https://openalex.org/F2094871694","display_name":"Business Events Perth","ror":null},{"id":"https://openalex.org/F4320313549","display_name":"Providence Health Care","ror":"https://ror.org/03qqdf793"},{"id":"https://openalex.org/F4320313932","display_name":"Institut de Recherche pour le D\u00e9veloppement","ror":"https://ror.org/05q3vnk25"},{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320320994","display_name":"Canada Research Chairs","ror":"https://ror.org/0517h6h17"},{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"},{"id":"https://openalex.org/F4320334960","display_name":"Seventh Framework Programme","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2216485355.pdf","grobid_xml":"https://content.openalex.org/works/W2216485355.grobid-xml"},"referenced_works_count":112,"referenced_works":["https://openalex.org/W30283994","https://openalex.org/W857540058","https://openalex.org/W1491167991","https://openalex.org/W1502236509","https://openalex.org/W1544387209","https://openalex.org/W1553473844","https://openalex.org/W1560040722","https://openalex.org/W1563715672","https://openalex.org/W1597207963","https://openalex.org/W1640068223","https://openalex.org/W1648872901","https://openalex.org/W1799014439","https://openalex.org/W1801184284","https://openalex.org/W1823199340","https://openalex.org/W1876790360","https://openalex.org/W1958764225","https://openalex.org/W1966928113","https://openalex.org/W1967359688","https://openalex.org/W1969876005","https://openalex.org/W1970598701","https://openalex.org/W1971033371","https://openalex.org/W1977082621","https://openalex.org/W1977919654","https://openalex.org/W1979648475","https://openalex.org/W1980751665","https://openalex.org/W1981280554","https://openalex.org/W1981575339","https://openalex.org/W1982534097","https://openalex.org/W1983275536","https://openalex.org/W1983609229","https://openalex.org/W1985075679","https://openalex.org/W1987526188","https://openalex.org/W1988125999","https://openalex.org/W1990273064","https://openalex.org/W1990704025","https://openalex.org/W1992913613","https://openalex.org/W1995717418","https://openalex.org/W1998865995","https://openalex.org/W2002811789","https://openalex.org/W2005789183","https://openalex.org/W2013485183","https://openalex.org/W2017163181","https://openalex.org/W2017322181","https://openalex.org/W2018932226","https://openalex.org/W2022643490","https://openalex.org/W2025926061","https://openalex.org/W2028178274","https://openalex.org/W2031590006","https://openalex.org/W2033872291","https://openalex.org/W2039159718","https://openalex.org/W2039449039","https://openalex.org/W2043417840","https://openalex.org/W2045402305","https://openalex.org/W2045738978","https://openalex.org/W2052729921","https://openalex.org/W2054812913","https://openalex.org/W2055333406","https://openalex.org/W2066105662","https://openalex.org/W2067443877","https://openalex.org/W2068487474","https://openalex.org/W2069623008","https://openalex.org/W2072528578","https://openalex.org/W2073436727","https://openalex.org/W2073673719","https://openalex.org/W2074161856","https://openalex.org/W2075094265","https://openalex.org/W2076955223","https://openalex.org/W2077411059","https://openalex.org/W2077490715","https://openalex.org/W2078752695","https://openalex.org/W2079639127","https://openalex.org/W2085100495","https://openalex.org/W2086274343","https://openalex.org/W2086613620","https://openalex.org/W2088888368","https://openalex.org/W2091273641","https://openalex.org/W2091281735","https://openalex.org/W2097613160","https://openalex.org/W2098666944","https://openalex.org/W2099536121","https://openalex.org/W2099580944","https://openalex.org/W2105383486","https://openalex.org/W2106077763","https://openalex.org/W2107226705","https://openalex.org/W2107491018","https://openalex.org/W2108979163","https://openalex.org/W2112336352","https://openalex.org/W2113549156","https://openalex.org/W2114809075","https://openalex.org/W2115963743","https://openalex.org/W2116856707","https://openalex.org/W2126674505","https://openalex.org/W2131850213","https://openalex.org/W2138985573","https://openalex.org/W2139656848","https://openalex.org/W2144188747","https://openalex.org/W2145230779","https://openalex.org/W2145779143","https://openalex.org/W2147722794","https://openalex.org/W2151999854","https://openalex.org/W2155956789","https://openalex.org/W2158936599","https://openalex.org/W2160455928","https://openalex.org/W2161995590","https://openalex.org/W2167872299","https://openalex.org/W2170733875","https://openalex.org/W2319886547","https://openalex.org/W2326208956","https://openalex.org/W2346149398","https://openalex.org/W2393553660","https://openalex.org/W2504389868","https://openalex.org/W4296241157"],"related_works":["https://openalex.org/W2896833522","https://openalex.org/W4412707576","https://openalex.org/W3162068124","https://openalex.org/W4309447698","https://openalex.org/W2795506427","https://openalex.org/W4376133136","https://openalex.org/W7165542177","https://openalex.org/W3120618864","https://openalex.org/W3010636379","https://openalex.org/W4408649311"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}