{"id":"https://openalex.org/W2216182014","doi":"https://doi.org/10.3171/2015.4.jns1582","title":"MRI-guided stereotactic radiofrequency thermocoagulation for 100 hypothalamic hamartomas","display_name":"MRI-guided stereotactic radiofrequency thermocoagulation for 100 hypothalamic hamartomas","publication_year":2015,"publication_date":"2015-11-20","ids":{"openalex":"https://openalex.org/W2216182014","doi":"https://doi.org/10.3171/2015.4.jns1582","mag":"2216182014","pmid":"https://pubmed.ncbi.nlm.nih.gov/26587652"},"language":"en","primary_location":{"id":"doi:10.3171/2015.4.jns1582","doi":"https://doi.org/10.3171/2015.4.jns1582","is_oa":false,"landing_page_url":"https://doi.org/10.3171/2015.4.jns1582","pdf_url":null,"source":{"id":"https://openalex.org/S1995308","display_name":"Journal of neurosurgery","issn_l":"0022-3085","issn":["0022-3085","1933-0693"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316861","host_organization_name":"American Association of Neurological Surgeons","host_organization_lineage":["https://openalex.org/P4310316861"],"host_organization_lineage_names":["American Association of Neurological Surgeons"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurosurgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112699583","display_name":"Shigeki Kameyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157408","display_name":"Nishi Niigata Chuo National Hospital","ror":"https://ror.org/059wef195","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4210157408"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeki Kameyama","raw_affiliation_strings":["Hypothalamic Hamartoma Center, Department of Functional Neurosurgery, Nishi-Niigata Chuo National Hospital; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hypothalamic Hamartoma Center, Department of Functional Neurosurgery, Nishi-Niigata Chuo National Hospital; and","institution_ids":["https://openalex.org/I4210157408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058915957","display_name":"Hiroshi Shirozu","orcid":"https://orcid.org/0000-0003-3506-1471","observed_orcids":["https://orcid.org/0000-0003-3506-1471"]},"institutions":[{"id":"https://openalex.org/I4210157408","display_name":"Nishi Niigata Chuo National Hospital","ror":"https://ror.org/059wef195","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4210157408"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Shirozu","raw_affiliation_strings":["Hypothalamic Hamartoma Center, Department of Functional Neurosurgery, Nishi-Niigata Chuo National Hospital; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hypothalamic Hamartoma Center, Department of Functional Neurosurgery, Nishi-Niigata Chuo National Hospital; and","institution_ids":["https://openalex.org/I4210157408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102010874","display_name":"Hiroshi Masuda","orcid":"https://orcid.org/0000-0001-5890-6647","observed_orcids":["https://orcid.org/0000-0001-5890-6647"]},"institutions":[{"id":"https://openalex.org/I4210157408","display_name":"Nishi Niigata Chuo National Hospital","ror":"https://ror.org/059wef195","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4210157408"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Masuda","raw_affiliation_strings":["Hypothalamic Hamartoma Center, Department of Functional Neurosurgery, Nishi-Niigata Chuo National Hospital; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hypothalamic Hamartoma Center, Department of Functional Neurosurgery, Nishi-Niigata Chuo National Hospital; and","institution_ids":["https://openalex.org/I4210157408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063918575","display_name":"Yosuke Ito","orcid":"https://orcid.org/0000-0003-3245-3840","observed_orcids":["https://orcid.org/0000-0003-3245-3840"]},"institutions":[{"id":"https://openalex.org/I4210157408","display_name":"Nishi Niigata Chuo National Hospital","ror":"https://ror.org/059wef195","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4210157408"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yosuke Ito","raw_affiliation_strings":["Hypothalamic Hamartoma Center, Department of Functional Neurosurgery, Nishi-Niigata Chuo National Hospital; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hypothalamic Hamartoma Center, Department of Functional Neurosurgery, Nishi-Niigata Chuo National Hospital; and","institution_ids":["https://openalex.org/I4210157408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037977979","display_name":"Masaki Sonoda","orcid":"https://orcid.org/0000-0002-4612-5728","observed_orcids":["https://orcid.org/0000-0002-4612-5728"]},"institutions":[{"id":"https://openalex.org/I4210157408","display_name":"Nishi Niigata Chuo National Hospital","ror":"https://ror.org/059wef195","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4210157408"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaki Sonoda","raw_affiliation_strings":["Hypothalamic Hamartoma Center, Department of Functional Neurosurgery, Nishi-Niigata Chuo National Hospital; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hypothalamic Hamartoma Center, Department of Functional Neurosurgery, Nishi-Niigata Chuo National Hospital; and","institution_ids":["https://openalex.org/I4210157408"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039094816","display_name":"Kohei Akazawa","orcid":"https://orcid.org/0000-0002-8434-1376","observed_orcids":["https://orcid.org/0000-0002-8434-1376"]},"institutions":[{"id":"https://openalex.org/I4210124653","display_name":"Niigata University Medical and Dental Hospital","ror":"https://ror.org/03b0x6j22","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210124653"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kohei Akazawa","raw_affiliation_strings":["Department of Medical Informatics, Niigata University Medical and Dental Hospital, Niigata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Informatics, Niigata University Medical and Dental Hospital, Niigata, Japan","institution_ids":["https://openalex.org/I4210124653"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.5125,"has_fulltext":false,"cited_by_count":113,"citation_normalized_percentile":{"value":0.96544264,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"124","issue":"5","first_page":"1503","last_page":"1512"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.5776000022888184,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.5776000022888184,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.18770000338554382,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.052299998700618744,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypothalamic-hamartoma","display_name":"hypothalamic hamartoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mri-guided-surgery","display_name":"MRI-guided surgery","score":0.6359999775886536},{"id":"https://openalex.org/keywords/gelastic-seizures","display_name":"gelastic seizures","score":0.9150000214576721},{"id":"https://openalex.org/keywords/drug-resistant-epilepsy","display_name":"drug-resistant epilepsy","score":0.8730000257492065},{"id":"https://openalex.org/keywords/seizure-freedom","display_name":"seizure freedom","score":0.6589999794960022},{"id":"https://openalex.org/keywords/precocious-puberty","display_name":"precocious puberty","score":0.8199999928474426},{"id":"https://openalex.org/keywords/behavioral-disorders","display_name":"behavioral disorders","score":0.7689999938011169},{"id":"https://openalex.org/keywords/minimally-invasive-surgery","display_name":"minimally invasive surgery","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9275096654891968},{"id":"https://openalex.org/C2779088118","wikidata":"https://www.wikidata.org/wiki/Q16963628","display_name":"Radiofrequency thermocoagulation","level":3,"score":0.8956937789916992},{"id":"https://openalex.org/C2779449703","wikidata":"https://www.wikidata.org/wiki/Q5530367","display_name":"Gelastic seizure","level":5,"score":0.8757349848747253},{"id":"https://openalex.org/C2908900992","wikidata":"https://www.wikidata.org/wiki/Q7850809","display_name":"Hypothalamic hamartoma","level":4,"score":0.76658695936203},{"id":"https://openalex.org/C2778367240","wikidata":"https://www.wikidata.org/wiki/Q224513","display_name":"Precocious puberty","level":3,"score":0.46588224172592163},{"id":"https://openalex.org/C2775932916","wikidata":"https://www.wikidata.org/wiki/Q525075","display_name":"Hamartoma","level":2,"score":0.4439561367034912},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.43615174293518066},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.4200395941734314},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2177959680557251},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18779072165489197},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10468587279319763},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.0},{"id":"https://openalex.org/C2780355897","wikidata":"https://www.wikidata.org/wiki/Q1132120","display_name":"Trigeminal neuralgia","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004828","descriptor_name":"Epilepsies, Partial","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D005240","descriptor_name":"Feasibility Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006222","descriptor_name":"Hamartoma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007027","descriptor_name":"Hypothalamic Diseases","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013238","descriptor_name":"Stereotaxic Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016634","descriptor_name":"Radiosurgery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025321","descriptor_name":"Surgery, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053783","descriptor_name":"Magnetic Resonance Imaging, Interventional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3171/2015.4.jns1582","doi":"https://doi.org/10.3171/2015.4.jns1582","is_oa":false,"landing_page_url":"https://doi.org/10.3171/2015.4.jns1582","pdf_url":null,"source":{"id":"https://openalex.org/S1995308","display_name":"Journal of neurosurgery","issn_l":"0022-3085","issn":["0022-3085","1933-0693"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316861","host_organization_name":"American Association of Neurological Surgeons","host_organization_lineage":["https://openalex.org/P4310316861"],"host_organization_lineage_names":["American Association of Neurological Surgeons"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurosurgery","raw_type":"journal-article"},{"id":"pmid:26587652","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26587652","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurosurgery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306684","display_name":"Epilepsy Foundation","ror":"https://ror.org/01pxre019"},{"id":"https://openalex.org/F4320321945","display_name":"Ministry of Health, Labour and Welfare","ror":"https://ror.org/03mwa7s65"},{"id":"https://openalex.org/F4320327691","display_name":"Japan Epilepsy Research Foundation","ror":"https://ror.org/053ee9k66"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W106441133","https://openalex.org/W1488532404","https://openalex.org/W1499583897","https://openalex.org/W1737808969","https://openalex.org/W1826370134","https://openalex.org/W1965502237","https://openalex.org/W1967920644","https://openalex.org/W1978343926","https://openalex.org/W2011829233","https://openalex.org/W2015604341","https://openalex.org/W2027480428","https://openalex.org/W2032146895","https://openalex.org/W2034948511","https://openalex.org/W2048908268","https://openalex.org/W2051523366","https://openalex.org/W2052569134","https://openalex.org/W2058363675","https://openalex.org/W2069727923","https://openalex.org/W2081564004","https://openalex.org/W2088708160","https://openalex.org/W2103922992","https://openalex.org/W2116317791","https://openalex.org/W2121333309","https://openalex.org/W2124930446","https://openalex.org/W2145074684","https://openalex.org/W2171428275","https://openalex.org/W2325932780"],"related_works":["https://openalex.org/W2199985865","https://openalex.org/W1967920644","https://openalex.org/W3016820774","https://openalex.org/W4414747944","https://openalex.org/W2999318414","https://openalex.org/W3201270905","https://openalex.org/W6927313055","https://openalex.org/W6908680204","https://openalex.org/W2392814802","https://openalex.org/W3128761529"],"abstract_inverted_index":{"OBJECT":[0],"The":[1,25,60,87,230],"aim":[2],"of":[3,14,31,63,78,84,90,104,113,133,150,153,157,193,199,222,257,270],"this":[4,164],"study":[5],"was":[6,65,140,189],"to":[7,96,220,226],"elucidate":[8],"the":[9,28,91,105,145,148,180],"invasiveness,":[10],"effectiveness,":[11],"and":[12,37,58,102,126,175,203,225,238,260],"feasibility":[13],"MRI-guided":[15],"stereotactic":[16],"radiofrequency":[17],"thermocoagulation":[18],"(SRT)":[19],"for":[20,144,215,254],"hypothalamic":[21,182],"hamartoma":[22],"(HH).":[23],"METHODS":[24],"authors":[26],"examined":[27],"clinical":[29],"records":[30],"100":[32],"consecutive":[33],"patients":[34,79,265],"(66":[35],"male":[36],"34":[38],"female)":[39],"with":[40,110,266],"intractable":[41],"gelastic":[42],"seizures":[43,85,200,207],"(GS)":[44],"caused":[45],"by":[46],"HH,":[47,151],"who":[48],"underwent":[49],"SRT":[50,135,232,246],"as":[51],"a":[52,111,235,249],"sole":[53],"surgical":[54,158,241,251],"treatment":[55,159],"between":[56],"1997":[57],"2013.":[59],"median":[61],"duration":[62],"follow-up":[64],"3":[66],"years":[67],"(range":[68],"1-17":[69],"years).":[70],"Seventy":[71],"cases":[72],"involved":[73],"pediatric":[74],"patients.":[75],"Ninety":[76],"percent":[77],"also":[80],"had":[81],"other":[82,197],"types":[83,198],"(non-GS).":[86],"maximum":[88],"diameter":[89,112],"HHs":[92,109],"ranged":[93],"from":[94,187,196,205],"5":[95],"80":[97],"mm":[98,115],"(median":[99],"15":[100,103],"mm),":[101],"tumors":[106],"were":[107,137,212],"giant":[108,146],"30":[114],"or":[116,147,160],"more.":[117],"Comorbidities":[118],"included":[119],"precocious":[120,169],"puberty":[121,170],"(33.0%),":[122],"behavioral":[123,223],"disorder":[124],"(49.0%),":[125],"mental":[127],"retardation":[128],"(50.0%).":[129],"RESULTS":[130],"A":[131],"total":[132],"140":[134],"procedures":[136],"performed.":[138],"There":[139],"no":[141],"adaptive":[142,244],"restriction":[143],"subtype":[149],"regardless":[152],"any":[154],"prior":[155],"history":[156,269],"comorbidities.":[161],"Patients":[162],"in":[163,191,201,208,264],"case":[165],"series":[166],"exhibited":[167],"delayed":[168],"(9.0%),":[171],"pituitary":[172],"dysfunction":[173],"(2.0%),":[174],"weight":[176],"gain":[177],"(7.0%),":[178],"besides":[179],"transient":[181],"symptoms":[183],"after":[184],"SRT.":[185],"Freedom":[186],"GS":[188],"achieved":[190],"86.0%":[192],"patients,":[194],"freedom":[195,204,218],"78.9%,":[202],"all":[206,255],"71.0%.":[209],"Repeat":[210],"surgeries":[211],"not":[213],"effective":[214,240],"non-GS.":[216],"Seizure":[217],"led":[219],"disappearance":[221],"disorders":[224],"intellectual":[227],"improvement.":[228],"CONCLUSIONS":[229],"present":[231],"procedure":[233,242,252],"is":[234],"minimally":[236],"invasive":[237],"highly":[239],"without":[243],"limitations.":[245],"involves":[247],"only":[248],"single":[250],"appropriate":[253],"forms":[256],"epileptogenic":[258],"HH":[259],"should":[261],"be":[262],"considered":[263],"an":[267],"early":[268],"GS.":[271]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}