{"id":"https://openalex.org/W2215827658","doi":"https://doi.org/10.3109/17435390.2015.1133861","title":"Nano zerovalent iron particles induce pulmonary and cardiovascular toxicity in anin vitrohuman co-culture model","display_name":"Nano zerovalent iron particles induce pulmonary and cardiovascular toxicity in anin vitrohuman co-culture model","publication_year":2015,"publication_date":"2015-12-23","ids":{"openalex":"https://openalex.org/W2215827658","doi":"https://doi.org/10.3109/17435390.2015.1133861","mag":"2215827658","pmid":"https://pubmed.ncbi.nlm.nih.gov/26694701"},"language":"en","primary_location":{"id":"doi:10.3109/17435390.2015.1133861","doi":"https://doi.org/10.3109/17435390.2015.1133861","is_oa":false,"landing_page_url":"https://doi.org/10.3109/17435390.2015.1133861","pdf_url":null,"source":{"id":"https://openalex.org/S193535841","display_name":"Nanotoxicology","issn_l":"1743-5390","issn":["1743-5390","1743-5404"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanotoxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011353195","display_name":"Zhelin Sun","orcid":"https://orcid.org/0000-0002-4286-6684","observed_orcids":["https://orcid.org/0000-0002-4286-6684"]},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210092495","display_name":"Suzhou Institute of Nano-tech and Nano-bionics","ror":"https://ror.org/0027d9x02","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210092495"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhelin Sun","raw_affiliation_strings":["Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, China,","School of Life Sciences, Shanghai University, Shanghai, China,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, China,","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210092495"]},{"raw_affiliation_string":"School of Life Sciences, Shanghai University, Shanghai, China,","institution_ids":["https://openalex.org/I113940042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010822210","display_name":"Lingyan Yang","orcid":"https://orcid.org/0000-0002-7307-4030","observed_orcids":["https://orcid.org/0000-0002-7307-4030"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210092495","display_name":"Suzhou Institute of Nano-tech and Nano-bionics","ror":"https://ror.org/0027d9x02","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210092495"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingyan Yang","raw_affiliation_strings":["Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, China,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, China,","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210092495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057274224","display_name":"Ku\u2010Fan Chen","orcid":"https://orcid.org/0000-0002-9572-3134","observed_orcids":["https://orcid.org/0000-0002-9572-3134"]},"institutions":[{"id":"https://openalex.org/I193365169","display_name":"National Chi Nan University","ror":"https://ror.org/03ha6v181","country_code":"TW","type":"education","lineage":["https://openalex.org/I193365169"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ku-Fan Chen","raw_affiliation_strings":["Department of Civil Engineering, National Chi Nan University, Nantou, Taiwan,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Civil Engineering, National Chi Nan University, Nantou, Taiwan,","institution_ids":["https://openalex.org/I193365169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021531173","display_name":"Guanwen Chen","orcid":"https://orcid.org/0000-0002-3435-0725","observed_orcids":["https://orcid.org/0000-0002-3435-0725"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guan-Wen Chen","raw_affiliation_strings":["Department of Food and Beverage Management, Taipei College of Maritime Technology, Taipei, Taiwan,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food and Beverage Management, Taipei College of Maritime Technology, Taipei, Taiwan,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085141357","display_name":"Yen-Ping Peng","orcid":"https://orcid.org/0000-0001-9513-2054","observed_orcids":["https://orcid.org/0000-0001-9513-2054"]},"institutions":[{"id":"https://openalex.org/I169090423","display_name":"Tunghai University","ror":"https://ror.org/00zhvdn11","country_code":"TW","type":"education","lineage":["https://openalex.org/I169090423"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yen-Ping Peng","raw_affiliation_strings":["Department of Environmental Science and Engineering, Tunghai University, Taichung, Taiwan,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Science and Engineering, Tunghai University, Taichung, Taiwan,","institution_ids":["https://openalex.org/I169090423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035666454","display_name":"Jen\u2010Kun Chen","orcid":"https://orcid.org/0000-0002-3433-5971","observed_orcids":["https://orcid.org/0000-0002-3433-5971"]},"institutions":[{"id":"https://openalex.org/I165441096","display_name":"National Health Research Institutes","ror":"https://ror.org/02r6fpx29","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I165441096"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jen-Kun Chen","raw_affiliation_strings":["Institute of Biomedical Engineering & Nanomedicine, National Health Research Institutes, Miaoli, Taiwan,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Engineering & Nanomedicine, National Health Research Institutes, Miaoli, Taiwan,","institution_ids":["https://openalex.org/I165441096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019698374","display_name":"Guangli Suo","orcid":"https://orcid.org/0000-0003-4381-3864","observed_orcids":["https://orcid.org/0000-0003-4381-3864"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210092495","display_name":"Suzhou Institute of Nano-tech and Nano-bionics","ror":"https://ror.org/0027d9x02","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210092495"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guangli Suo","raw_affiliation_strings":["Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, China,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, China,","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210092495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083594493","display_name":"Jiantao Yu","orcid":"https://orcid.org/0009-0002-7722-8233","observed_orcids":["https://orcid.org/0009-0002-7722-8233"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210092495","display_name":"Suzhou Institute of Nano-tech and Nano-bionics","ror":"https://ror.org/0027d9x02","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210092495"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiantao Yu","raw_affiliation_strings":["Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, China,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, China,","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210092495"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wen-Cheng Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145996","display_name":"Research Center for Environmental Changes, Academia Sinica","ror":"https://ror.org/050qpg053","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210145996","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Wen-Cheng Wang","raw_affiliation_strings":["Research Center for Environmental Changes, Academia Sinica, Taipei, Taiwan, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Environmental Changes, Academia Sinica, Taipei, Taiwan, and","institution_ids":["https://openalex.org/I4210145996","https://openalex.org/I84653119"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047259190","display_name":"Chia\u2010Hua Lin","orcid":"https://orcid.org/0000-0003-4103-9617","observed_orcids":["https://orcid.org/0000-0003-4103-9617"]},"institutions":[{"id":"https://openalex.org/I40689657","display_name":"National Formosa University","ror":"https://ror.org/00q523p52","country_code":"TW","type":"education","lineage":["https://openalex.org/I40689657"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Chia-Hua Lin","raw_affiliation_strings":["Department of Biotechnology, National Formosa University, Yunlin, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, National Formosa University, Yunlin, Taiwan","institution_ids":["https://openalex.org/I40689657"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5047259190"],"corresponding_institution_ids":["https://openalex.org/I40689657","https://openalex.org/I4210145996","https://openalex.org/I84653119"],"apc_list":null,"apc_paid":null,"fwci":1.7588,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.81398561,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"10","issue":"7","first_page":"881","last_page":"890"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12078","display_name":"Environmental remediation with nanomaterials","score":0.7035999894142151,"subfield":{"id":"https://openalex.org/subfields/2305","display_name":"Environmental Engineering"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12078","display_name":"Environmental remediation with nanomaterials","score":0.7035999894142151,"subfield":{"id":"https://openalex.org/subfields/2305","display_name":"Environmental Engineering"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.2759000062942505,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nanoscale-zero-valent-iron","display_name":"nanoscale zero-valent iron","score":0.9890000224113464},{"id":"https://openalex.org/keywords/pulmonary-toxicity","display_name":"pulmonary toxicity","score":0.8809999823570251},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.996999979019165},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.8769999742507935},{"id":"https://openalex.org/keywords/ea-hy926-cells","display_name":"EA.hy926 cells","score":0.9200000166893005},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7879999876022339},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9200000166893005},{"id":"https://openalex.org/keywords/epithelial-barrier-integrity","display_name":"epithelial barrier integrity","score":0.9350000023841858},{"id":"https://openalex.org/keywords/transepithelial-electrical-resistance","display_name":"transepithelial electrical resistance","score":0.8669999837875366},{"id":"https://openalex.org/keywords/oxidized-ldl","display_name":"oxidized LDL","score":0.9679999947547913},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.972000002861023},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.6349999904632568},{"id":"https://openalex.org/keywords/inhalation-exposure","display_name":"inhalation exposure","score":0.7860000133514404}],"concepts":[{"id":"https://openalex.org/C40472508","wikidata":"https://www.wikidata.org/wiki/Q8069649","display_name":"Zerovalent iron","level":3,"score":0.6802149415016174},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5865746736526489},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5855460166931152},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5808157920837402},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.5759811997413635},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5726833343505859},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.529421865940094},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.4679053723812103},{"id":"https://openalex.org/C81729549","wikidata":"https://www.wikidata.org/wiki/Q4649475","display_name":"A549 cell","level":3,"score":0.4572768211364746},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43016231060028076},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.41576775908470154},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3989357352256775},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3662879467010498},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30079835653305054},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2743636965751648},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.23451533913612366},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13877812027931213},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13022750616073608},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.07211306691169739},{"id":"https://openalex.org/C150394285","wikidata":"https://www.wikidata.org/wiki/Q180254","display_name":"Adsorption","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072283","descriptor_name":"A549 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000515","descriptor_name":"alpha 1-Antitrypsin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002319","descriptor_name":"Cardiovascular System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013499","descriptor_name":"Surface Properties","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3109/17435390.2015.1133861","doi":"https://doi.org/10.3109/17435390.2015.1133861","is_oa":false,"landing_page_url":"https://doi.org/10.3109/17435390.2015.1133861","pdf_url":null,"source":{"id":"https://openalex.org/S193535841","display_name":"Nanotoxicology","issn_l":"1743-5390","issn":["1743-5390","1743-5404"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanotoxicology","raw_type":"journal-article"},{"id":"pmid:26694701","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26694701","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanotoxicology","raw_type":"Journal Article"},{"id":"pmh:oai:ir.sinano.ac.cn:332007/4707","doi":null,"is_oa":false,"landing_page_url":"http://ir.sinano.ac.cn/handle/332007/4707","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"\u671f\u520a\u8bba\u6587"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W168858771","https://openalex.org/W1714859825","https://openalex.org/W1963723016","https://openalex.org/W1968171440","https://openalex.org/W1968289848","https://openalex.org/W1970232637","https://openalex.org/W1972492067","https://openalex.org/W1975354138","https://openalex.org/W1975480898","https://openalex.org/W1976616659","https://openalex.org/W1978589242","https://openalex.org/W1979003194","https://openalex.org/W1981564755","https://openalex.org/W1989953524","https://openalex.org/W1995618558","https://openalex.org/W1996413859","https://openalex.org/W1998763977","https://openalex.org/W2011254969","https://openalex.org/W2015929094","https://openalex.org/W2018873398","https://openalex.org/W2022966459","https://openalex.org/W2024602981","https://openalex.org/W2027779256","https://openalex.org/W2036772185","https://openalex.org/W2041742565","https://openalex.org/W2044531112","https://openalex.org/W2052015694","https://openalex.org/W2052689139","https://openalex.org/W2055023391","https://openalex.org/W2056765371","https://openalex.org/W2059582758","https://openalex.org/W2060227609","https://openalex.org/W2061139669","https://openalex.org/W2068067174","https://openalex.org/W2072194367","https://openalex.org/W2079330967","https://openalex.org/W2080534792","https://openalex.org/W2081763037","https://openalex.org/W2083559318","https://openalex.org/W2084912727","https://openalex.org/W2087010189","https://openalex.org/W2091889781","https://openalex.org/W2093218391","https://openalex.org/W2094432813","https://openalex.org/W2095681885","https://openalex.org/W2097395419","https://openalex.org/W2101182707","https://openalex.org/W2107811195","https://openalex.org/W2111671872","https://openalex.org/W2117163161","https://openalex.org/W2120523053","https://openalex.org/W2122901018","https://openalex.org/W2127316279","https://openalex.org/W2127823826","https://openalex.org/W2129656867","https://openalex.org/W2130212885","https://openalex.org/W2135300998","https://openalex.org/W2155987457","https://openalex.org/W2161350787","https://openalex.org/W2166255156","https://openalex.org/W2171757971","https://openalex.org/W2313706612","https://openalex.org/W2315539895","https://openalex.org/W2332115519"],"related_works":["https://openalex.org/W2735568001","https://openalex.org/W3140910926","https://openalex.org/W3096533079","https://openalex.org/W4224999478","https://openalex.org/W1969029151","https://openalex.org/W2966156903","https://openalex.org/W2990899601","https://openalex.org/W2347440088","https://openalex.org/W7168889304","https://openalex.org/W2164448407"],"abstract_inverted_index":{"Despite":[0],"promising":[1],"environmental":[2],"applications":[3],"for":[4,98],"nano":[5],"zerovalent":[6],"iron":[7],"(nZVI),":[8],"concerns":[9],"remain":[10],"about":[11],"the":[12,51,55,88,131,139,153,166],"potential":[13,154],"accumulation":[14],"and":[15,39,41,62,68,93,109,126,146,161],"toxic":[16,72,102],"effects":[17,73],"of":[18,100,141,150],"nZVI":[19,38,45,57,76,117,136,151],"particles.":[20],"Here,":[21],"we":[22],"use":[23],"an":[24],"alveolar-capillary":[25],"co-culture":[26,132],"model":[27,133],"to":[28,37,48,80,116,155],"investigate":[29],"a":[30],"possible":[31],"link":[32],"between":[33,91],"low-level":[34],"epithelial":[35,52,67,81,114,119],"exposure":[36,58,115,137],"pulmonary":[40,144],"cardiovascular":[42,157],"toxicity.":[43],"While":[44],"was":[46],"unable":[47],"pass":[49],"through":[50,159],"barrier":[53,120],"into":[54,87],"endothelium,":[56],"did":[59],"cause":[60],"oxidative":[61,160],"inflammatory":[63,162],"responses":[64],"in":[65,105,123,130,170],"both":[66],"endothelial":[69],"cells.":[70],"Therefore,":[71,148],"induced":[74],"by":[75],"are":[77],"not":[78],"restricted":[79],"cells":[82,95],"but":[83],"can":[84],"be":[85],"transferred":[86],"endothelium.":[89],"Communication":[90],"A549":[92],"EA.hy926":[94],"is":[96],"responsible":[97],"amplification":[99],"nZVI-induced":[101],"responses.":[103],"Decreases":[104],"transepithelial":[106],"electrical":[107],"resistance":[108],"zonula":[110],"occludens":[111],"proteins":[112],"after":[113],"impaired":[118],"integrity.":[121],"Increases":[122],"oxidized":[124,127],"\u03b11-antitrypsin":[125],"low-density":[128],"lipoprotein":[129],"suggest":[134],"that":[135],"increases":[138],"risk":[140],"chronic":[142,171],"obstructive":[143],"disease":[145,158],"atherosclerosis.":[147],"inhalation":[149],"has":[152],"induce":[156],"mediators":[163],"produced":[164],"from":[165],"damaged":[167],"lung":[168,172],"epithelium":[169],"diseases.":[173]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}