{"id":"https://openalex.org/W22147650","doi":null,"title":"Stress ulcers are common after aortic surgery. Endoscopic evaluation of prophylactic therapy.","display_name":"Stress ulcers are common after aortic surgery. Endoscopic evaluation of prophylactic therapy.","publication_year":1994,"publication_date":"1994-03-01","ids":{"openalex":"https://openalex.org/W22147650","mag":"22147650","pmid":"https://pubmed.ncbi.nlm.nih.gov/8116975"},"language":"en","primary_location":{"id":"pmid:8116975","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8116975","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American surgeon","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103812616","display_name":"Louis F. Martin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"L F Martin","raw_affiliation_strings":["Department of Surgery, Penn State University College of Medicine, Milton S. Hershey Medical Center, Hershey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Penn State University College of Medicine, Milton S. Hershey Medical Center, Hershey","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5103812616"],"corresponding_institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"],"apc_list":null,"apc_paid":null,"fwci":0.3816,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.59613225,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"60","issue":"3","first_page":"169","last_page":"74"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11378","display_name":"Gastrointestinal Bleeding Diagnosis and Treatment","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11378","display_name":"Gastrointestinal Bleeding Diagnosis and Treatment","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11625","display_name":"Abdominal vascular conditions and treatments","score":0.012900000438094139,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stress-ulcer","display_name":"stress ulcer","score":0.9520000219345093},{"id":"https://openalex.org/keywords/aortic-surgery","display_name":"aortic surgery","score":0.8690000176429749},{"id":"https://openalex.org/keywords/stress-gastritis","display_name":"stress gastritis","score":0.6119999885559082},{"id":"https://openalex.org/keywords/gastrointestinal-bleeding","display_name":"gastrointestinal bleeding","score":0.5640000104904175},{"id":"https://openalex.org/keywords/misoprostol","display_name":"misoprostol","score":0.8330000042915344},{"id":"https://openalex.org/keywords/antacid-therapy","display_name":"antacid therapy","score":0.6949999928474426},{"id":"https://openalex.org/keywords/cimetidine","display_name":"cimetidine","score":0.9670000076293945},{"id":"https://openalex.org/keywords/endoscopy","display_name":"endoscopy","score":0.8299999833106995},{"id":"https://openalex.org/keywords/aortic-aneurysm","display_name":"aortic aneurysm","score":0.828000009059906},{"id":"https://openalex.org/keywords/aortic-occlusive-disease","display_name":"aortic occlusive disease","score":0.9269999861717224},{"id":"https://openalex.org/keywords/ulcer-prevention","display_name":"ulcer prevention","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9902652502059937},{"id":"https://openalex.org/C2779199973","wikidata":"https://www.wikidata.org/wiki/Q416025","display_name":"Misoprostol","level":4,"score":0.7042487263679504},{"id":"https://openalex.org/C2780590083","wikidata":"https://www.wikidata.org/wiki/Q274083","display_name":"Antacid","level":2,"score":0.6295159459114075},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.6294040679931641},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.49722912907600403},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.4920327365398407},{"id":"https://openalex.org/C2776672619","wikidata":"https://www.wikidata.org/wiki/Q7623456","display_name":"Stress ulcer","level":2,"score":0.48219457268714905},{"id":"https://openalex.org/C2780719153","wikidata":"https://www.wikidata.org/wiki/Q409492","display_name":"Cimetidine","level":2,"score":0.45702052116394043},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.34125036001205444},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24034374952316284},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.09959849715232849},{"id":"https://openalex.org/C2778642596","wikidata":"https://www.wikidata.org/wiki/Q8452","display_name":"Abortion","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000536","descriptor_name":"Aluminum Hydroxide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000863","descriptor_name":"Antacids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000897","descriptor_name":"Anti-Ulcer Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001012","descriptor_name":"Aorta, Abdominal","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D002927","descriptor_name":"Cimetidine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005773","descriptor_name":"Gastroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008276","descriptor_name":"Magnesium Hydroxide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010437","descriptor_name":"Peptic Ulcer","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D010437","descriptor_name":"Peptic Ulcer","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D010437","descriptor_name":"Peptic Ulcer","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D016595","descriptor_name":"Misoprostol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8116975","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8116975","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American surgeon","raw_type":"Clinical Trial"},{"id":"mag:22147650","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8116975","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G6512643617","display_name":"CELLULAR ENERGY METABOLISM DURING SHOCK AND REPERFUSION","funder_award_id":"K08HL001502","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W2023553423","https://openalex.org/W2042978244","https://openalex.org/W2129466993","https://openalex.org/W1971302694","https://openalex.org/W1604468403","https://openalex.org/W2053023137","https://openalex.org/W1988325237","https://openalex.org/W2020920713","https://openalex.org/W133663130","https://openalex.org/W2104070754","https://openalex.org/W2164614740","https://openalex.org/W2131695680","https://openalex.org/W2035226186","https://openalex.org/W1967861242","https://openalex.org/W2090640089","https://openalex.org/W2092894835","https://openalex.org/W6667075417","https://openalex.org/W2154362705","https://openalex.org/W4242743062","https://openalex.org/W2066935669","https://openalex.org/W2027663127","https://openalex.org/W2107396458","https://openalex.org/W1998682629","https://openalex.org/W2159029739","https://openalex.org/W2022616207"],"related_works":["https://openalex.org/W2093309382","https://openalex.org/W1991201237","https://openalex.org/W2145799252","https://openalex.org/W2167378024","https://openalex.org/W2371005994","https://openalex.org/W2411049194","https://openalex.org/W2407217519","https://openalex.org/W2391199427","https://openalex.org/W2413542881","https://openalex.org/W2085991347"],"abstract_inverted_index":{"Defining":[0],"who":[1,134,206,219],"is":[2,16,27],"at":[3],"risk":[4],"for":[5,177],"the":[6,47,71,78,106,112,131,152,155,160,167,171,211],"development":[7,153],"of":[8,24,49,55,70,105,130,145,154,162,166],"postoperative":[9,121],"gastric":[10],"mucosal":[11],"ulcers":[12,142,147],"and":[13,67,80,95,123,182,195],"subsequent":[14],"hemorrhage":[15,178],"an":[17],"important":[18],"task":[19],"when":[20],"deciding":[21],"what":[22],"type":[23,161],"prophylactic":[25],"treatment":[26],"appropriate.":[28],"We":[29],"asked":[30],"100":[31,72,168],"consecutive":[32],"patients":[33,73,90,107,119,125,133,169],"requiring":[34],"aortic":[35],"surgery":[36],"to":[37,45,75,84,136,208],"participate":[38,76,209,221],"in":[39,77,201,210],"a":[40,56,186],"randomized,":[41],"double-blind,":[42],"double-dummy":[43],"study":[44,101,212],"compare":[46],"effectiveness":[48],"antacid":[50,196],"titration":[51],"with":[52,93,151,159],"fixed":[53],"doses":[54],"synthetic":[57],"prostaglandin":[58],"E1":[59],"analog":[60],"(misoprostol)":[61],"as":[62,97],"prophylaxis":[63],"against":[64],"stress":[65,141,146,180,203],"gastritis":[66],"bleeding.":[68],"Forty-six":[69],"agreed":[74],"study,":[79],"23":[81],"were":[82,91,100,198],"randomized":[83],"each":[85],"arm.":[86],"The":[87,189],"other":[88,113,156],"54":[89],"treated":[92],"cimetidine":[94,172],"followed":[96],"if":[98],"they":[99],"participants.":[102],"Approximately":[103],"half":[104,114],"had":[108,115,213],"aneurysmal":[109],"disease,":[110],"while":[111],"occlusive":[116],"disease.":[117],"Thirty-one":[118],"developed":[120,140],"complications,":[122],"three":[124],"died.":[126],"Eighty":[127],"per":[128],"cent":[129],"42":[132],"volunteered":[135],"undergo":[137],"endoscopic":[138,190],"evaluation":[139],"postoperatively.":[143],"Development":[144],"did":[148,220],"not":[149],"correlate":[150],"complications":[157,216],"or":[158],"treatment.":[163],"Only":[164],"one":[165],"(in":[170],"group)":[173],"required":[174],"operative":[175],"therapy":[176,197],"from":[179],"ulcers,":[181],"this":[183],"occurred":[184],"after":[185],"protocol":[187],"violation.":[188],"exams":[191],"demonstrated":[192],"that":[193],"misoprostol":[194],"equally":[199],"effective":[200],"preventing":[202],"ulcers.":[204],"Patients":[205],"refused":[207],"significantly":[214],"more":[215],"than":[217],"those":[218],"by":[222],"stepwise":[223],"logistic":[224],"regression":[225],"analysis.(ABSTRACT":[226],"TRUNCATED":[227],"AT":[228],"250":[229],"WORDS)":[230]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}