{"id":"https://openalex.org/W2214517705","doi":null,"title":"Differential regulation of glucocorticoid and progesterone receptor subcellular localization by tetratricopeptide repeat domain proteins","display_name":"Differential regulation of glucocorticoid and progesterone receptor subcellular localization by tetratricopeptide repeat domain proteins","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2214517705","mag":"2214517705"},"language":"en","primary_location":{"id":"pmh:oai:etd.ohiolink.edu:mco1177535048","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=mco1177535048","pdf_url":"https://etd.ohiolink.edu/acprod/odb_etd/ws/send_file/send?accession=mco1177535048&disposition=inline","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=mco1177535048","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://etd.ohiolink.edu/acprod/odb_etd/ws/send_file/send?accession=mco1177535048&disposition=inline","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009979012","display_name":"Ananya Tina Banerjee","orcid":"https://orcid.org/0000-0001-9248-5778","observed_orcids":["https://orcid.org/0000-0001-9248-5778"]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ananya Banerjee","raw_affiliation_strings":["University of Toledo"],"raw_orcid":"https://orcid.org/0000-0001-9248-5778","affiliations":[{"raw_affiliation_string":"University of Toledo","institution_ids":["https://openalex.org/I90871651"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5009979012"],"corresponding_institution_ids":["https://openalex.org/I90871651"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18842659,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.8452000021934509,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.8452000021934509,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.09070000052452087,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"glucocorticoid receptor","score":0.9919999837875366},{"id":"https://openalex.org/keywords/progesterone-receptor","display_name":"progesterone receptor","score":0.9950000047683716},{"id":"https://openalex.org/keywords/fkbp51","display_name":"FKBP51","score":0.968999981880188},{"id":"https://openalex.org/keywords/fkbp52","display_name":"FKBP52","score":1.0},{"id":"https://openalex.org/keywords/immunophilins","display_name":"immunophilins","score":0.9039999842643738},{"id":"https://openalex.org/keywords/cell-type-specific-gene-expression","display_name":"cell type-specific gene expression","score":0.6150000095367432},{"id":"https://openalex.org/keywords/steroid-receptor-signaling","display_name":"steroid receptor signaling","score":0.42899999022483826}],"concepts":[{"id":"https://openalex.org/C59493245","wikidata":"https://www.wikidata.org/wiki/Q14877410","display_name":"Glucocorticoid receptor","level":3,"score":0.7180048227310181},{"id":"https://openalex.org/C2776879804","wikidata":"https://www.wikidata.org/wiki/Q7630919","display_name":"Subcellular localization","level":3,"score":0.6848859190940857},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6623401641845703},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6564984321594238},{"id":"https://openalex.org/C98717036","wikidata":"https://www.wikidata.org/wiki/Q14872994","display_name":"Progesterone receptor","level":5,"score":0.5771543979644775},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49439239501953125},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.46852511167526245},{"id":"https://openalex.org/C27239569","wikidata":"https://www.wikidata.org/wiki/Q189029","display_name":"Cell fractionation","level":3,"score":0.45255813002586365},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25004178285598755},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.12588158249855042},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11406189203262329},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:etd.ohiolink.edu:mco1177535048","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=mco1177535048","pdf_url":"https://etd.ohiolink.edu/acprod/odb_etd/ws/send_file/send?accession=mco1177535048&disposition=inline","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=mco1177535048","raw_type":"text"},{"id":"mag:2214517705","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/theses/ETH/4849","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:etd.ohiolink.edu:mco1177535048","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=mco1177535048","pdf_url":"https://etd.ohiolink.edu/acprod/odb_etd/ws/send_file/send?accession=mco1177535048&disposition=inline","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=mco1177535048","raw_type":"text"},"sustainable_development_goals":[{"score":0.504800021648407,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2214517705.pdf","grobid_xml":"https://content.openalex.org/works/W2214517705.grobid-xml"},"referenced_works_count":192,"referenced_works":["https://openalex.org/W69516432","https://openalex.org/W97536107","https://openalex.org/W129841773","https://openalex.org/W142850513","https://openalex.org/W1213045642","https://openalex.org/W1485044836","https://openalex.org/W1491031366","https://openalex.org/W1494393764","https://openalex.org/W1499226315","https://openalex.org/W1506014073","https://openalex.org/W1508243224","https://openalex.org/W1512688896","https://openalex.org/W1514228149","https://openalex.org/W1517035469","https://openalex.org/W1519370193","https://openalex.org/W1530952467","https://openalex.org/W1538274231","https://openalex.org/W1540101541","https://openalex.org/W1541950600","https://openalex.org/W1552859356","https://openalex.org/W1553142835","https://openalex.org/W1554354855","https://openalex.org/W1555881845","https://openalex.org/W1567400069","https://openalex.org/W1569704074","https://openalex.org/W1604134423","https://openalex.org/W1633015885","https://openalex.org/W1676827704","https://openalex.org/W1915833704","https://openalex.org/W1919133853","https://openalex.org/W1924282271","https://openalex.org/W1941419571","https://openalex.org/W1948123184","https://openalex.org/W1955276614","https://openalex.org/W1963612767","https://openalex.org/W1963761451","https://openalex.org/W1964318436","https://openalex.org/W1965144249","https://openalex.org/W1967169977","https://openalex.org/W1967179182","https://openalex.org/W1969971113","https://openalex.org/W1970078194","https://openalex.org/W1970474015","https://openalex.org/W1971063516","https://openalex.org/W1972783510","https://openalex.org/W1974793156","https://openalex.org/W1975244074","https://openalex.org/W1976261257","https://openalex.org/W1976299410","https://openalex.org/W1976495127","https://openalex.org/W1976582108","https://openalex.org/W1978913374","https://openalex.org/W1980786000","https://openalex.org/W1982688882","https://openalex.org/W1983069964","https://openalex.org/W1983211885","https://openalex.org/W1984182384","https://openalex.org/W1987417875","https://openalex.org/W1990065094","https://openalex.org/W1990567745","https://openalex.org/W1992511009","https://openalex.org/W1992927495","https://openalex.org/W1994489610","https://openalex.org/W1996596163","https://openalex.org/W1998329962","https://openalex.org/W1999465079","https://openalex.org/W2000751880","https://openalex.org/W2000757102","https://openalex.org/W2001036949","https://openalex.org/W2002351432","https://openalex.org/W2005664398","https://openalex.org/W2005769071","https://openalex.org/W2006156792","https://openalex.org/W2006647004","https://openalex.org/W2007093129","https://openalex.org/W2007169317","https://openalex.org/W2008833874","https://openalex.org/W2010142538","https://openalex.org/W2010240180","https://openalex.org/W2012512233","https://openalex.org/W2013085085","https://openalex.org/W2013640714","https://openalex.org/W2015426324","https://openalex.org/W2018157878","https://openalex.org/W2018390282","https://openalex.org/W2021494570","https://openalex.org/W2023166792","https://openalex.org/W2024821272","https://openalex.org/W2025033036","https://openalex.org/W2025485213","https://openalex.org/W2025995094","https://openalex.org/W2026295605","https://openalex.org/W2026911087","https://openalex.org/W2027689592","https://openalex.org/W2028179852","https://openalex.org/W2029451113","https://openalex.org/W2031352187","https://openalex.org/W2033940616","https://openalex.org/W2034060690","https://openalex.org/W2036822027","https://openalex.org/W2037404178","https://openalex.org/W2039187716","https://openalex.org/W2041561339","https://openalex.org/W2042616057","https://openalex.org/W2044768708","https://openalex.org/W2044850116","https://openalex.org/W2045431263","https://openalex.org/W2046699174","https://openalex.org/W2048143680","https://openalex.org/W2048753593","https://openalex.org/W2048800387","https://openalex.org/W2050584068","https://openalex.org/W2050621039","https://openalex.org/W2051208397","https://openalex.org/W2051894528","https://openalex.org/W2052419732","https://openalex.org/W2055654988","https://openalex.org/W2055948779","https://openalex.org/W2056765315","https://openalex.org/W2058229380","https://openalex.org/W2059406989","https://openalex.org/W2059859203","https://openalex.org/W2060037483","https://openalex.org/W2063311617","https://openalex.org/W2064078100","https://openalex.org/W2065295359","https://openalex.org/W2066716403","https://openalex.org/W2067718680","https://openalex.org/W2069699200","https://openalex.org/W2070535450","https://openalex.org/W2070986880","https://openalex.org/W2071307227","https://openalex.org/W2072109709","https://openalex.org/W2072425087","https://openalex.org/W2072931419","https://openalex.org/W2074250505","https://openalex.org/W2075431153","https://openalex.org/W2075796826","https://openalex.org/W2079336387","https://openalex.org/W2079780982","https://openalex.org/W2081091627","https://openalex.org/W2081158713","https://openalex.org/W2082213952","https://openalex.org/W2082559087","https://openalex.org/W2085128427","https://openalex.org/W2085593164","https://openalex.org/W2094984646","https://openalex.org/W2096594220","https://openalex.org/W2096955693","https://openalex.org/W2100837269","https://openalex.org/W2103485019","https://openalex.org/W2103856520","https://openalex.org/W2109243666","https://openalex.org/W2109384319","https://openalex.org/W2111809733","https://openalex.org/W2112133866","https://openalex.org/W2113054579","https://openalex.org/W2114926993","https://openalex.org/W2115799430","https://openalex.org/W2116474322","https://openalex.org/W2121034018","https://openalex.org/W2123164383","https://openalex.org/W2124601841","https://openalex.org/W2125634299","https://openalex.org/W2129618639","https://openalex.org/W2130818619","https://openalex.org/W2131581447","https://openalex.org/W2133208346","https://openalex.org/W2136008463","https://openalex.org/W2139306838","https://openalex.org/W2140682015","https://openalex.org/W2141482826","https://openalex.org/W2145221831","https://openalex.org/W2145752531","https://openalex.org/W2146604249","https://openalex.org/W2148864400","https://openalex.org/W2150658204","https://openalex.org/W2151942052","https://openalex.org/W2153648492","https://openalex.org/W2153682117","https://openalex.org/W2156575042","https://openalex.org/W2158140522","https://openalex.org/W2158289124","https://openalex.org/W2159119513","https://openalex.org/W2159545772","https://openalex.org/W2162886054","https://openalex.org/W2164918994","https://openalex.org/W2165235386","https://openalex.org/W2169457085","https://openalex.org/W2171230661","https://openalex.org/W2172256092","https://openalex.org/W2404397406"],"related_works":["https://openalex.org/W2101440792","https://openalex.org/W2069699200","https://openalex.org/W3133562272","https://openalex.org/W2103485019","https://openalex.org/W2065295359","https://openalex.org/W1583008385","https://openalex.org/W2906661691","https://openalex.org/W1964663826","https://openalex.org/W2167490926","https://openalex.org/W2064078100"],"abstract_inverted_index":{"Steroid-receptor":[0],"associated":[1],"immunophilins":[2],"not":[3,89,120],"only":[4,121],"act":[5],"in":[6,25,33,65,68,83,108,148,169,199,217],"a":[7,22,39,52,123,202],"coordinated":[8],"manner":[9],"to":[10,92,180],"establish":[11],"and":[12,51,73,95,114,118,178,250],"maintain":[13],"receptor":[14,27,35,183],"conformation":[15],"optimal":[16],"for":[17],"signaling":[18],"but":[19,129],"also":[20,130],"play":[21],"critical":[23],"role":[24],"determining":[26],"localization.":[28],"To":[29,228],"demonstrate":[30],"TPR":[31,147,165,246],"preference":[32,243],"steroid":[34,236],"localization,":[36],"we":[37,173],"chose":[38],"mouse":[40,62],"fibroblast":[41],"cell":[42,57,103,171],"line,":[43,58],"which":[44],"expresses":[45],"high":[46],"levels":[47,111,193],"of":[48,112,135,139,167,194,210,215,225,234],"endogenous":[49],"GR,":[50],"Chinese":[53],"hamster":[54],"ovary,":[55],"derived":[56],"WCL2,":[59],"that":[60,77],"over-expresses":[61],"GR":[63,79,157,168,216],"localized":[64],"the":[66,69,84,99,106,109,133,145,164,191,208,223,231],"nucleus":[67],"unliganded":[70],"condition.":[71],"Immunofluorescence":[72],"fractionation":[74],"studies":[75],"showed":[76,201],"although":[78],"is":[80,88,96],"predominantly":[81],"nuclear":[82],"WCL2":[85,119,149,200],"cells,":[86],"it":[87],"tightly":[90],"bound":[91],"this":[93],"compartment":[94],"released":[97],"into":[98,156],"cytosolic":[100],"fraction":[101],"upon":[102],"lysis.":[104],"Comparing":[105],"differences":[107],"equilibrium":[110,192],"FKBP51":[113,152,177],"FKBP52":[115,143,179],"between":[116],"L929":[117,160,218],"revealed":[122],"very":[124],"cell-type":[125],"specific":[126,245],"expression":[127],"pattern":[128],"hinted":[131],"at":[132],"possibility":[134],"differential":[136],"recruitment.":[137],"Analysis":[138],"heterocomplex":[140],"composition":[141],"identified":[142],"as":[144,238],"major":[146],"cells":[150,219],"while":[151,213],"was":[153],"preferentially":[154],"recruited":[155],"complexes":[158],"from":[159,207],"cells.":[161],"Having":[162],"demonstrated":[163],"preferences":[166],"both":[170],"types,":[172],"over-":[174],"expressed":[175],"FLAG-tagged":[176,211],"determine":[181],"if":[182,230],"subcellular":[184,232],"localization":[185,233],"could":[186],"be":[187],"altered":[188],"by":[189,222],"changing":[190],"these":[195],"proteins.":[196],"Receptor":[197],"heterocomplexes":[198],"greater":[203],"cytoplasmic":[204],"distribution":[205,214,224],"resulting":[206],"recruitment":[209],"FKBP51,":[212],"remained":[220],"unaffected":[221],"flag-tagged":[226],"FKBP52.":[227],"assess":[229],"other":[235],"receptors":[237],"well":[239],"hinged":[240],"on":[241],"their":[242],"towards":[244],"proteins,":[247],"GFP":[248],"fluorescence":[249],"co-":[251]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}