{"id":"https://openalex.org/W2213823677","doi":null,"title":"Nischarin inhibits LIMK to regulate cofilin phosphorylation and tumor cell invasion","display_name":"Nischarin inhibits LIMK to regulate cofilin phosphorylation and tumor cell invasion","publication_year":2007,"publication_date":"2007-05-01","ids":{"openalex":"https://openalex.org/W2213823677","mag":"2213823677"},"language":"en","primary_location":{"id":"mag:2213823677","doi":null,"is_oa":false,"landing_page_url":"https://cancerres.aacrjournals.org/content/67/9_Supplement/2182","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075895520","display_name":"Yuemin Ding","orcid":"https://orcid.org/0000-0003-0547-5358","observed_orcids":["https://orcid.org/0000-0003-0547-5358"]},"institutions":[{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuemin Ding","raw_affiliation_strings":["LSU Health Science Center, New Orleans, LA"],"raw_orcid":"https://orcid.org/0000-0003-0547-5358","affiliations":[{"raw_affiliation_string":"LSU Health Science Center, New Orleans, LA","institution_ids":["https://openalex.org/I75420490"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049332865","display_name":"Suresh K. Alahari","orcid":"https://orcid.org/0000-0002-9651-6727","observed_orcids":["https://orcid.org/0000-0002-9651-6727"]},"institutions":[{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suresh K. Alahari","raw_affiliation_strings":["LSU Health Science Center, New Orleans, LA"],"raw_orcid":"https://orcid.org/0000-0002-9651-6727","affiliations":[{"raw_affiliation_string":"LSU Health Science Center, New Orleans, LA","institution_ids":["https://openalex.org/I75420490"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I75420490"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.16445442,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"67","issue":null,"first_page":"2182","last_page":"2182"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.8901000022888184,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.8901000022888184,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.0714000016450882,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.031599998474121094,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nischarin","display_name":"Nischarin","score":0.984000027179718},{"id":"https://openalex.org/keywords/lim-kinase","display_name":"LIM kinase","score":0.9350000023841858},{"id":"https://openalex.org/keywords/cofilin-phosphorylation","display_name":"cofilin phosphorylation","score":0.9639999866485596},{"id":"https://openalex.org/keywords/p21-activated-kinase","display_name":"p21-activated kinase","score":0.8939999938011169},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.7260000109672546},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9639999866485596},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7910000085830688},{"id":"https://openalex.org/keywords/pdz-domain","display_name":"PDZ domain","score":0.9089999794960022},{"id":"https://openalex.org/keywords/rac-activation","display_name":"Rac activation","score":0.8569999933242798},{"id":"https://openalex.org/keywords/limk1","display_name":"LIMK1","score":0.5839999914169312},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.4880000054836273},{"id":"https://openalex.org/keywords/rna-interference","display_name":"RNA interference","score":0.38499999046325684}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5048719048500061},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4281327724456787}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2213823677","doi":null,"is_oa":false,"landing_page_url":"https://cancerres.aacrjournals.org/content/67/9_Supplement/2182","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2003024744","https://openalex.org/W2079053718","https://openalex.org/W2156867189","https://openalex.org/W7097920275","https://openalex.org/W2087683624","https://openalex.org/W2320634624","https://openalex.org/W2077482758","https://openalex.org/W2382262399","https://openalex.org/W2162426917","https://openalex.org/W2012960245"],"abstract_inverted_index":{"AACR":[0],"Annual":[1],"Meeting--":[2],"Apr":[3],"14-18,":[4],"2007;":[5],"Los":[6],"Angeles,":[7],"CA\n\n2182":[8],"\n\nNischarin":[9],"is":[10,155],"a":[11,144,193],"novel":[12,194],"protein":[13],"that":[14,28,49,55,160,181],"regulates":[15,30,183],"cell":[16,31,40,81,117,133,184],"migration":[17],"by":[18,42,127,169],"inhibiting":[19],"p21":[20],"activated":[21],"kinase":[22,66],"(PAK).":[23],"Previously":[24],"we":[25,44,158],"have":[26,45],"shown":[27],"Nischarin":[29,56,76,103,106,125,137,148,163,182,197],"invasion.":[32,134],"To":[33],"understand":[34],"the":[35,65,70,173,199],"mechanism":[36],"of":[37,39,73,83,96,102,119,124,176,196,201],"regulation":[38],"invasion":[41,118,185],"Nischarin,":[43],"searched":[46],"for":[47,165],"proteins":[48],"associate":[50],"with":[51,58,104,167],"Nischarin.":[52,99],"We":[53],"show":[54],"interacts":[57],"LIM":[59],"Kinase":[60],"(LIMK),":[61],"more":[62],"specifically":[63],"to":[64,209],"as":[67,69,86,88,112,114],"well":[68,87,113],"PDZ":[71],"domains":[72],"LIMK.":[74],"Both":[75],"and":[77,98,138,149,162,205,207],"LIMK":[78,97,108,139,150,168,204,213],"co-precipitated":[79],"from":[80,89],"lysates":[82],"overexpressed":[84],"cells":[85],"endogenous":[90],"proteins.":[91],"Activated":[92],"Rac":[93],"enhances":[94],"association":[95,101],"By":[100],"LIMK,":[105],"inhibits":[107],"activation,":[109],"Cofilin":[110],"phosphorylation":[111],"PAK-LIMK":[115],"mediated":[116],"breast":[120,131],"cancer":[121,132],"cells.":[122],"Inhibition":[123],"expression":[126],"RNA":[128],"interference":[129],"stimulates":[130],"Although":[135],"PAK,":[136,206],"exist":[140,151],"in":[141],"tripartite":[142],"complex,":[143],"strong":[145],"interaction":[146,166],"between":[147,203],"only":[152],"when":[153],"PAK":[154,161],"inactive.":[156],"Also":[157],"confirmed":[159],"compete":[164],"using":[170],"PAK1":[171],"inhibitor,":[172],"autoinhibitory":[174],"domain":[175],"PAK.":[177],"These":[178],"data":[179],"suggest":[180],"through":[186],"LIMK1-Cofilin":[187],"signaling":[188],"cascade.":[189],"This":[190],"study":[191],"identifies":[192],"function":[195],"demonstrating":[198],"disruption":[200],"complexes":[202],"leading":[208],"inhibitory":[210],"effects":[211],"on":[212],"signaling.":[214]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2016-06-24T00:00:00"}
