{"id":"https://openalex.org/W2213603003","doi":"https://doi.org/10.1073/pnas.1517930113","title":"In vitro reconstruction and analysis of evolutionary variation of the tomato acylsucrose metabolic network","display_name":"In vitro reconstruction and analysis of evolutionary variation of the tomato acylsucrose metabolic network","publication_year":2015,"publication_date":"2015-12-29","ids":{"openalex":"https://openalex.org/W2213603003","doi":"https://doi.org/10.1073/pnas.1517930113","mag":"2213603003","pmid":"https://pubmed.ncbi.nlm.nih.gov/26715757"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1517930113","doi":"https://doi.org/10.1073/pnas.1517930113","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.1517930113","pdf_url":"https://www.pnas.org/content/pnas/113/2/E239.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.pnas.org/content/pnas/113/2/E239.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030379014","display_name":"Pengxiang Fan","orcid":"https://orcid.org/0000-0002-4560-3783","observed_orcids":["https://orcid.org/0000-0002-4560-3783"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pengxiang Fan","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824;","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110711698","display_name":"Abigail M. Miller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abigail M. Miller","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824;","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070343943","display_name":"Anthony L. Schilmiller","orcid":"https://orcid.org/0000-0001-7069-7120","observed_orcids":["https://orcid.org/0000-0001-7069-7120"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony L. Schilmiller","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824;","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100338985","display_name":"Xiaoxiao Liu","orcid":"https://orcid.org/0000-0002-6333-3772","observed_orcids":["https://orcid.org/0000-0002-6333-3772"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoxiao Liu","raw_affiliation_strings":["Department of Chemistry, Michigan State University, East Lansing, MI 48824;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Michigan State University, East Lansing, MI 48824;","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001529285","display_name":"Itai Ofner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Itai Ofner","raw_affiliation_strings":["The Institute of Plant Sciences and Genetics in Agriculture, Faculty of Agriculture, The Hebrew University of Jerusalem, Rehovot 76100, Israel;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Plant Sciences and Genetics in Agriculture, Faculty of Agriculture, The Hebrew University of Jerusalem, Rehovot 76100, Israel;","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006267438","display_name":"A. Daniel Jones","orcid":"https://orcid.org/0000-0002-7408-6690","observed_orcids":["https://orcid.org/0000-0002-7408-6690"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Daniel Jones","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824;","Department of Chemistry, Michigan State University, East Lansing, MI 48824;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824;","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Department of Chemistry, Michigan State University, East Lansing, MI 48824;","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001930617","display_name":"Dani Zamir","orcid":"https://orcid.org/0000-0003-4867-7806","observed_orcids":["https://orcid.org/0000-0003-4867-7806"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Dani Zamir","raw_affiliation_strings":["The Institute of Plant Sciences and Genetics in Agriculture, Faculty of Agriculture, The Hebrew University of Jerusalem, Rehovot 76100, Israel;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Plant Sciences and Genetics in Agriculture, Faculty of Agriculture, The Hebrew University of Jerusalem, Rehovot 76100, Israel;","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024993299","display_name":"Robert L. Last","orcid":"https://orcid.org/0000-0001-6974-9587","observed_orcids":["https://orcid.org/0000-0001-6974-9587"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert L. Last","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824;","Department of Plant Biology, Michigan State University, East Lansing, MI 48824"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824;","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Department of Plant Biology, Michigan State University, East Lansing, MI 48824","institution_ids":["https://openalex.org/I87216513"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5024993299"],"corresponding_institution_ids":["https://openalex.org/I87216513"],"apc_list":null,"apc_paid":null,"fwci":5.0193,"has_fulltext":true,"cited_by_count":117,"citation_normalized_percentile":{"value":0.96416501,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"113","issue":"2","first_page":"E239","last_page":"48"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10135","display_name":"Insect-Plant Interactions and Control","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tomato","display_name":"tomato","score":0.7710000276565552},{"id":"https://openalex.org/keywords/glandular-trichomes","display_name":"glandular trichomes","score":0.8700000047683716},{"id":"https://openalex.org/keywords/bahd-acyltransferase","display_name":"BAHD acyltransferase","score":0.9210000038146973},{"id":"https://openalex.org/keywords/insecticidal-metabolites","display_name":"insecticidal metabolites","score":0.8140000104904175},{"id":"https://openalex.org/keywords/metabolic-pathway-reconstruction","display_name":"metabolic pathway reconstruction","score":0.5260000228881836},{"id":"https://openalex.org/keywords/metabolic-engineering","display_name":"metabolic engineering","score":0.781000018119812},{"id":"https://openalex.org/keywords/plant-defense-compounds","display_name":"plant defense compounds","score":0.35199999809265137}],"concepts":[{"id":"https://openalex.org/C56221022","wikidata":"https://www.wikidata.org/wiki/Q1125215","display_name":"Trichome","level":2,"score":0.7333065867424011},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7207751274108887},{"id":"https://openalex.org/C6350086","wikidata":"https://www.wikidata.org/wiki/Q6822347","display_name":"Metabolic engineering","level":3,"score":0.5694603323936462},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5095241665840149},{"id":"https://openalex.org/C2778761015","wikidata":"https://www.wikidata.org/wiki/Q134172","display_name":"Solanaceae","level":3,"score":0.48427027463912964},{"id":"https://openalex.org/C22508944","wikidata":"https://www.wikidata.org/wiki/Q568174","display_name":"PEST analysis","level":2,"score":0.4377969801425934},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.4250490665435791},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4100317060947418},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.39551740884780884},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3753593862056732},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2853052318096161},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18362507224082947}],"mesh":[{"descriptor_ui":"D000214","descriptor_name":"Acyl Coenzyme A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000214","descriptor_name":"Acyl Coenzyme A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000214","descriptor_name":"Acyl Coenzyme A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000215","descriptor_name":"Acylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000215","descriptor_name":"Acylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000215","descriptor_name":"Acylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000217","descriptor_name":"Acyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000217","descriptor_name":"Acyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000217","descriptor_name":"Acyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000217","descriptor_name":"Acyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000217","descriptor_name":"Acyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000217","descriptor_name":"Acyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010940","descriptor_name":"Plant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010940","descriptor_name":"Plant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010940","descriptor_name":"Plant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013395","descriptor_name":"Sucrose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013395","descriptor_name":"Sucrose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013395","descriptor_name":"Sucrose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013395","descriptor_name":"Sucrose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013395","descriptor_name":"Sucrose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013395","descriptor_name":"Sucrose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018551","descriptor_name":"Solanum lycopersicum","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D018551","descriptor_name":"Solanum lycopersicum","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D018551","descriptor_name":"Solanum lycopersicum","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D018551","descriptor_name":"Solanum lycopersicum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018551","descriptor_name":"Solanum lycopersicum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018551","descriptor_name":"Solanum lycopersicum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064201","descriptor_name":"Trichomes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D064201","descriptor_name":"Trichomes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D064201","descriptor_name":"Trichomes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.1517930113","doi":"https://doi.org/10.1073/pnas.1517930113","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.1517930113","pdf_url":"https://www.pnas.org/content/pnas/113/2/E239.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:26715757","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26715757","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4720351","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4720351","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1073/pnas.1517930113","doi":"https://doi.org/10.1073/pnas.1517930113","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.1517930113","pdf_url":"https://www.pnas.org/content/pnas/113/2/E239.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Zero hunger","score":0.9208999872207642,"id":"https://metadata.un.org/sdg/2"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1952366054","display_name":null,"funder_award_id":"MICL-02143","funder_id":"https://openalex.org/F4320312587","funder_display_name":"AgBioResearch, Michigan State University"},{"id":"https://openalex.org/G8759565682","display_name":"Building and Operating Chemical Factories: Comparative Studies of Biochemical Pathways for Specialized Metabolites in the Solanum","funder_award_id":"1025636","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320308456","display_name":"American Society of Plant Biologists","ror":"https://ror.org/04f49a463"},{"id":"https://openalex.org/F4320310016","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993"},{"id":"https://openalex.org/F4320312587","display_name":"AgBioResearch, Michigan State University","ror":"https://ror.org/05hs6h993"},{"id":"https://openalex.org/F4320332431","display_name":"College of Engineering, Michigan State University","ror":"https://ror.org/05hs6h993"},{"id":"https://openalex.org/F4320332564","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69"},{"id":"https://openalex.org/F4320334678","display_name":"European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2213603003.pdf","grobid_xml":"https://content.openalex.org/works/W2213603003.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1817067","https://openalex.org/W59020042","https://openalex.org/W1501210939","https://openalex.org/W1602846680","https://openalex.org/W1602977284","https://openalex.org/W1608287400","https://openalex.org/W1913722666","https://openalex.org/W1971375261","https://openalex.org/W1972300657","https://openalex.org/W1991512161","https://openalex.org/W1992581858","https://openalex.org/W2004587545","https://openalex.org/W2019880401","https://openalex.org/W2021565547","https://openalex.org/W2026910666","https://openalex.org/W2037391176","https://openalex.org/W2040874089","https://openalex.org/W2044384855","https://openalex.org/W2052792021","https://openalex.org/W2060259273","https://openalex.org/W2060687391","https://openalex.org/W2061275245","https://openalex.org/W2066214058","https://openalex.org/W2068585747","https://openalex.org/W2077640503","https://openalex.org/W2077866928","https://openalex.org/W2082283774","https://openalex.org/W2085472819","https://openalex.org/W2085767669","https://openalex.org/W2108440119","https://openalex.org/W2108853918","https://openalex.org/W2112169196","https://openalex.org/W2112727163","https://openalex.org/W2121557860","https://openalex.org/W2123695536","https://openalex.org/W2126658049","https://openalex.org/W2130111617","https://openalex.org/W2134062490","https://openalex.org/W2147818769","https://openalex.org/W2150264480","https://openalex.org/W2150371887","https://openalex.org/W2156532005","https://openalex.org/W2157202448","https://openalex.org/W2159848960","https://openalex.org/W2159980121","https://openalex.org/W2161305024","https://openalex.org/W2163522799","https://openalex.org/W2167902483","https://openalex.org/W2171991204","https://openalex.org/W2179635788","https://openalex.org/W2330823806","https://openalex.org/W2331463834","https://openalex.org/W2753202227","https://openalex.org/W4210251535"],"related_works":["https://openalex.org/W2356988972","https://openalex.org/W2104032652","https://openalex.org/W2405374521","https://openalex.org/W2795816667","https://openalex.org/W2385117758","https://openalex.org/W2888556706","https://openalex.org/W2359579671","https://openalex.org/W2184540180","https://openalex.org/W4297682621","https://openalex.org/W2141716034"],"abstract_inverted_index":{"Plant":[0],"glandular":[1],"secreting":[2],"trichomes":[3],"are":[4,35,71],"epidermal":[5],"protuberances":[6],"that":[7,132,146],"produce":[8,26],"structurally":[9],"diverse":[10],"specialized":[11],"metabolites,":[12],"including":[13],"medically":[14],"important":[15],"compounds.":[16],"Trichomes":[17],"of":[18,37,40,44,61,119,144,159,163],"many":[19],"plants":[20,168],"in":[21,29,64,107,125,142,148,167],"the":[22,57,65,100,157,160],"nightshade":[23],"family":[24],"(Solanaceae)":[25],"O-acylsugars,":[27],"and":[28,31,42,47,111,116,138,150,169],"cultivated":[30,66,102,149],"wild":[32,151],"tomatoes":[33],"these":[34,164],"mixtures":[36],"aliphatic":[38],"esters":[39],"sucrose":[41,110],"glucose":[43],"varying":[45],"structures":[46],"quantities":[48],"documented":[49],"to":[50,52,128,140],"contribute":[51,139],"insect":[53],"defense.":[54],"We":[55],"characterized":[56],"first":[58],"two":[59,94],"enzymes":[60,89,121],"acylsucrose":[62,82,104],"biosynthesis":[63],"tomato":[67,103,152],"Solanum":[68],"lycopersicum.":[69],"These":[70,88],"type":[72],"I/IV":[73],"trichome-expressed":[74],"BAHD":[75,97],"acyltransferases":[76],"encoded":[77],"by":[78],"Solyc12g006330--or":[79],"S.":[80],"lycopersicum":[81],"acyltransferase":[83],"1":[84],"(Sl-ASAT1)--and":[85],"Solyc04g012020":[86],"(Sl-ASAT2).":[87],"were":[90,122],"used--in":[91],"concert":[92],"with":[93,124],"previously":[95],"identified":[96],"acyltransferases--to":[98],"reconstruct":[99],"entire":[101],"biosynthetic":[105],"pathway":[106],"vitro":[108,126],"using":[109],"acyl-CoA":[112],"substrates.":[113],"Comparative":[114],"genomics":[115],"biochemical":[117],"analysis":[118],"ASAT":[120],"combined":[123],"mutagenesis":[127],"identify":[129],"amino":[130],"acids":[131],"influence":[133],"CoA":[134],"ester":[135],"substrate":[136],"specificity":[137],"differences":[141],"types":[143],"acylsucroses":[145],"accumulate":[147],"species.":[153],"This":[154],"work":[155],"demonstrates":[156],"feasibility":[158],"metabolic":[161],"engineering":[162],"insecticidal":[165],"metabolites":[166],"microbes.":[170]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":19},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":9}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
