{"id":"https://openalex.org/W2213530256","doi":null,"title":"Mechanism and Function of Dendritic Self-Avoidance and Self/non-Self Discrimination in the Mammalian Nervous System","display_name":"Mechanism and Function of Dendritic Self-Avoidance and Self/non-Self Discrimination in the Mammalian Nervous System","publication_year":2015,"publication_date":"2015-06-29","ids":{"openalex":"https://openalex.org/W2213530256","mag":"2213530256"},"language":"en","primary_location":{"id":"pmh:oai:dash.harvard.edu:1/23845402","doi":null,"is_oa":false,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:23845402","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis or Dissertation"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032550493","display_name":"Dimitar Kostadinov","orcid":"https://orcid.org/0000-0001-7548-2209","observed_orcids":["https://orcid.org/0000-0001-7548-2209"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Dimitar Kostadinov","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7548-2209","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5032550493"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/self-nonself-discrimination","display_name":"self/non-self discrimination","score":0.9860000014305115},{"id":"https://openalex.org/keywords/clustered-protocadherins","display_name":"clustered protocadherins","score":0.8569999933242798},{"id":"https://openalex.org/keywords/starburst-amacrine-cells","display_name":"starburst amacrine cells","score":0.875},{"id":"https://openalex.org/keywords/purkinje-cells","display_name":"Purkinje cells","score":0.9700000286102295},{"id":"https://openalex.org/keywords/retinal-ganglion-cells","display_name":"retinal ganglion cells","score":0.9539999961853027},{"id":"https://openalex.org/keywords/dendritic-branching","display_name":"dendritic branching","score":0.593999981880188},{"id":"https://openalex.org/keywords/synaptogenesis","display_name":"synaptogenesis","score":0.6029999852180481}],"concepts":[{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.644742488861084},{"id":"https://openalex.org/C2909320318","wikidata":"https://www.wikidata.org/wiki/Q1356761","display_name":"Self Tolerance","level":4,"score":0.5416013598442078},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5026350021362305},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4457387626171112},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3412700891494751},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2646741569042206},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.15599212050437927},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.12086367607116699},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.11336132884025574},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10246306657791138},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dash.harvard.edu:1/23845402","doi":null,"is_oa":false,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:23845402","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis or Dissertation"},{"id":"mag:2213530256","doi":null,"is_oa":false,"landing_page_url":"https://dash.harvard.edu/handle/1/23845402","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/10","score":0.800000011920929,"display_name":"Reduced inequalities"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2132637814","https://openalex.org/W7099400290","https://openalex.org/W2168153190","https://openalex.org/W4401992585","https://openalex.org/W4312892048","https://openalex.org/W2748141341","https://openalex.org/W1973450666","https://openalex.org/W2035089302","https://openalex.org/W2516982540","https://openalex.org/W7132957228"],"abstract_inverted_index":{"Dendritic":[0],"and":[1,75,81,103,112,118,132,179,200,238,310,314],"axonal":[2],"arbors":[3],"of":[4,27,38,64,78,84,106,120,177,185,195,203,244,252,265,277,286,299,338],"many":[5],"neuronal":[6],"types":[7],"exhibit":[8],"self-avoidance,":[9,253],"a":[10,54,88,147,186],"phenomenon":[11,55],"in":[12,72,87,182,223,241],"which":[13,305],"branches":[14],"repel":[15],"each":[16,50,227,273],"other.":[17],"This":[18],"process":[19],"ensures":[20],"that":[21,33,43,96,125,190,233,330],"individual":[22],"neurons":[23,32,46],"cover":[24],"all":[25,300],"parts":[26],"their":[28,151,162,168,258,331],"territory":[29],"uniformly.":[30],"Some":[31],"self-avoid":[34],"overlap":[35],"with":[36,167,207,257,272],"neighbors":[37,169],"the":[39,62,65,82,175,183,235,242,250,263,296],"same":[40],"type,":[41],"suggesting":[42,344],"nominally":[44],"identical":[45],"are":[47,98,333],"immune":[48],"to":[49,138,145,160,225,294,322],"other\u2019s":[51,228],"repellent":[52],"forces,":[53],"called":[56],"self/non-self":[57,76,104,180,239,266,281],"discrimination.":[58],"Here,":[59],"I":[60,92,173,230,290],"describe":[61,174,291],"roles":[63,83,176,236,298],"22":[66,311],"clustered":[67,301],"gamma-Protocadherin":[68],"(Pcdhg)":[69],"recognition":[70],"molecules":[71],"dendritic":[73,101],"self-avoidance":[74,102,178,237,279],"discrimination":[77,105,181,240,282],"mammalian":[79],"neurons,":[80],"these":[85,347],"phenomena":[86],"retinal":[89,107,187,204],"circuit.":[90],"First,":[91],"present":[93,231],"studies":[94],"showing":[95],"Pcdhgs":[97],"necessary":[99,131,157],"for":[100,158],"starburst":[108],"amacrine":[109],"cells":[110,206],"(SACs)":[111],"cerebellar":[113],"Purkinje":[114],"cells.":[115,288],"Using":[116],"loss":[117],"gain":[119],"function":[121,184,243],"experiments,":[122],"we":[123],"showed":[124],"no":[126],"single":[127,148],"Pcdhg":[128,134,149,154,342],"isoform":[129,135],"is":[130,136,156],"any":[133],"sufficient":[137],"mediate":[139],"self-avoidance.":[140],"However,":[141],"forcing":[142],"neighboring":[143],"SACs":[144,159,196,219,254,268],"express":[146],"decreases":[150],"overlap.":[152],"Thus,":[153],"diversity":[155],"avoid":[161],"own":[163,259],"dendrites,":[164],"but":[165],"interact":[166],"(self/non-self":[170],"discrimination).":[171],"Second,":[172],"direction-selective":[188,246],"circuit":[189],"depends":[191],"on":[192],"SACs.":[193],"Dendrites":[194],"compute":[197],"directional":[198,284],"motion":[199],"endow":[201],"classes":[202],"ganglion":[205,287],"this":[208,245],"property":[209],"by":[210],"inhibiting":[211],"them":[212],"asymmetrically":[213],"during":[214],"visual":[215],"motion.":[216],"In":[217,249,262],"addition,":[218],"form":[220,255,269],"inhibitory":[221],"synapses":[222,256,271],"order":[224],"sharpen":[226],"direction-selectivity.":[229],"findings":[232],"elucidate":[234],"circuit:":[247],"(1)":[248],"absence":[251,264],"dendrites.":[260],"(2)":[261],"discrimination,":[267],"few":[270],"other,":[274],"(3)":[275],"Loss":[276],"either":[278,339],"or":[280,341],"degrades":[283],"responses":[285],"Lastly,":[289],"initial":[292],"efforts":[293],"understand":[295],"combinatorial":[297],"Pcdh":[302],"family":[303],"members,":[304],"also":[306],"include":[307],"14":[308],"alpha-":[309],"beta-Protocadherins":[312],"(Pcdhas":[313],"Pcdhbs,":[315],"respectively).":[316],"We":[317],"used":[318],"CRISPR-mediated":[319],"genome":[320],"engineering":[321],"generate":[323],"Pcdha/Pcdhg":[324],"double":[325],"mutants.":[326],"Initial":[327],"analysis":[328],"shows":[329],"defects":[332],"more":[334],"striking":[335],"than":[336],"those":[337],"Pcdha":[340],"mutants,":[343],"redundancy":[345],"between":[346],"two":[348],"subclusters.":[349]},"counts_by_year":[],"updated_date":"2026-08-18T07:49:30.821534","created_date":"2016-06-24T00:00:00"}