{"id":"https://openalex.org/W2212870523","doi":"https://doi.org/10.1152/ajpheart.1998.275.3.h1084","title":"Increased levels of myocardial I\u03baB-\u03b1 protein promote tolerance to endotoxin","display_name":"Increased levels of myocardial I\u03baB-\u03b1 protein promote tolerance to endotoxin","publication_year":1998,"publication_date":"1998-09-01","ids":{"openalex":"https://openalex.org/W2212870523","doi":"https://doi.org/10.1152/ajpheart.1998.275.3.h1084","mag":"2212870523","pmid":"https://pubmed.ncbi.nlm.nih.gov/9724317"},"language":"en","primary_location":{"id":"doi:10.1152/ajpheart.1998.275.3.h1084","doi":"https://doi.org/10.1152/ajpheart.1998.275.3.h1084","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.1998.275.3.h1084","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043499587","display_name":"Brian D. Shames","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian D. Shames","raw_affiliation_strings":["Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado 80262"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado 80262","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013438877","display_name":"Daniel R. Meldrum","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel R. Meldrum","raw_affiliation_strings":["Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado 80262"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado 80262","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031493840","display_name":"Craig H. Selzman","orcid":"https://orcid.org/0000-0001-9218-4764","observed_orcids":["https://orcid.org/0000-0001-9218-4764"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Craig H. Selzman","raw_affiliation_strings":["Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado 80262"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado 80262","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080430742","display_name":"Edward J. Pulido","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Edward J. Pulido","raw_affiliation_strings":["Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado 80262"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado 80262","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108488198","display_name":"Brian S. Cain","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian S. Cain","raw_affiliation_strings":["Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado 80262"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado 80262","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102733596","display_name":"Anirban M. Banerjee","orcid":"https://orcid.org/0000-0003-1690-2618","observed_orcids":["https://orcid.org/0000-0003-1690-2618"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anirban Banerjee","raw_affiliation_strings":["Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado 80262"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado 80262","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087253902","display_name":"Alden H. Harken","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alden H. Harken","raw_affiliation_strings":["Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado 80262"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado 80262","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069922286","display_name":"Xianzhong Meng","orcid":"https://orcid.org/0000-0002-0201-1008","observed_orcids":["https://orcid.org/0000-0002-0201-1008","https://orcid.org/0000-0002-3463-690X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xianzhong Meng","raw_affiliation_strings":["Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado 80262"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado 80262","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2375,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.89353921,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"275","issue":"3","first_page":"H1084","last_page":"H1091"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.45410001277923584,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.45410001277923584,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.4180000126361847,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.03700000047683716,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ikappabalpha","display_name":"I\u03baB\u03b1","score":0.7900000214576721},{"id":"https://openalex.org/keywords/endotoxin-tolerance","display_name":"endotoxin tolerance","score":0.8040000200271606},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.796999990940094},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9549999833106995},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.968999981880188},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.9039999842643738},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.7149999737739563},{"id":"https://openalex.org/keywords/nf-kappab-nuclear-translocation","display_name":"NF-\u03baB nuclear translocation","score":0.6819999814033508}],"concepts":[{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.690172553062439},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6606172323226929},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.6404239535331726},{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.6379616856575012},{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.614427924156189},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5906853675842285},{"id":"https://openalex.org/C2779730028","wikidata":"https://www.wikidata.org/wiki/Q15325101","display_name":"I\u03baB\u03b1","level":4,"score":0.5372149348258972},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5146371126174927},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.4390562176704407},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3947467803955078},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37656670808792114},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.21891340613365173},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09176993370056152},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05545797944068909}],"mesh":[{"descriptor_ui":"D000072000","descriptor_name":"NF-KappaB Inhibitor alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004361","descriptor_name":"Drug Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020672","descriptor_name":"I-kappa B Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpheart.1998.275.3.h1084","doi":"https://doi.org/10.1152/ajpheart.1998.275.3.h1084","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.1998.275.3.h1084","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},{"id":"pmid:9724317","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9724317","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G568948654","display_name":null,"funder_award_id":"GM 08315","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000913843","display_name":"Mechanisms of Trauma-Induced Coagulopathy","funder_award_id":"T32GM008315","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1481788230","https://openalex.org/W1509979785","https://openalex.org/W1522773084","https://openalex.org/W1717444875","https://openalex.org/W1750368568","https://openalex.org/W1769448430","https://openalex.org/W1775749144","https://openalex.org/W1776880984","https://openalex.org/W1868478050","https://openalex.org/W1877432882","https://openalex.org/W1892154908","https://openalex.org/W1897496706","https://openalex.org/W1973170858","https://openalex.org/W1976591684","https://openalex.org/W1987190501","https://openalex.org/W1989920052","https://openalex.org/W1997564374","https://openalex.org/W2009286881","https://openalex.org/W2016383542","https://openalex.org/W2016730049","https://openalex.org/W2017487826","https://openalex.org/W2019951936","https://openalex.org/W2025899545","https://openalex.org/W2031202929","https://openalex.org/W2045356063","https://openalex.org/W2051831012","https://openalex.org/W2101439763","https://openalex.org/W2105415988","https://openalex.org/W2122339994","https://openalex.org/W2142541950","https://openalex.org/W2151892297","https://openalex.org/W2161089523","https://openalex.org/W2165523226","https://openalex.org/W2166781237","https://openalex.org/W2182141197","https://openalex.org/W2186453757","https://openalex.org/W2192309718","https://openalex.org/W2270586006","https://openalex.org/W2338117247","https://openalex.org/W2419291948"],"related_works":["https://openalex.org/W2113488772","https://openalex.org/W2106467650","https://openalex.org/W2102801331","https://openalex.org/W2002170574","https://openalex.org/W2002880283","https://openalex.org/W2105070354","https://openalex.org/W2068587303","https://openalex.org/W2099586170","https://openalex.org/W2182730598","https://openalex.org/W1967110581"],"abstract_inverted_index":{"Endotoxin":[0],"[lipopolysaccharide":[1],"(LPS)]":[2],"causes":[3,45],"tumor":[4],"necrosis":[5],"factor-alpha":[6],"(TNF-alpha)-mediated":[7],"myocardial":[8,70,103,119,127,147,159,175,185,199,209,225],"contractile":[9,120],"depression.":[10,121],"Tolerance":[11],"to":[12,25,40,57,79,133,165,216],"the":[13,36,76,123],"cardiac":[14,190,214],"toxicity":[15],"of":[16,49,69,108,174,208,220],"LPS":[17,26,41,44,65,86,97,156,169,195,217],"can":[18],"be":[19],"induced":[20],"by":[21,28,34,118,140,218],"a":[22,99,134],"prior":[23],"exposure":[24],"or":[27,92,157],"pretreatment":[29,88,144],"with":[30,85,89,154,180],"glucocorticoids.":[31],"The":[32,171],"mechanisms":[33],"which":[35],"myocardium":[37,77],"acquires":[38],"tolerance":[39,215],"remain":[42],"unknown.":[43],"phosphorylation":[46],"and":[47,73,110,188,196,203,224],"degradation":[48],"inhibitory":[50],"kappaB-alpha":[51],"(IkappaB-alpha),":[52],"releasing":[53],"nuclear":[54],"factor-kappaB":[55],"(NF-kappaB)":[56],"activate":[58],"TNF-alpha":[59,112,186,226],"gene":[60],"transcription.":[61],"We":[62,192],"hypothesized":[63],"that":[64,194,204],"induces":[66],"supranormal":[67],"synthesis":[68],"IkappaB-alpha":[71,104,129,148,160,176,200,210],"protein":[72,105,130,149,161,177,201,211],"thus":[74],"renders":[75],"tolerant":[78],"subsequent":[80],"LPS.":[81],"Rats":[82],"were":[83,116],"challenged":[84],"after":[87,168],"LPS,":[90],"dexamethasone,":[91,158],"saline.":[93],"In":[94,151],"saline-pretreated":[95],"rats,":[96],"caused":[98],"rapid":[100],"decrease":[101,125],"in":[102,126],"levels,":[106],"activation":[107],"NF-kappaB,":[109],"increased":[111,146,206],"production.":[113,227],"These":[114],"events":[115],"followed":[117],"After":[122],"initial":[124],"IkappaB-alpha,":[128],"levels":[131,139,162,167],"rebounded":[132],"level":[135,173,207],"greater":[136],"than":[137],"control":[138,166],"24":[141],"h.":[142],"Dexamethasone":[143],"similarly":[145],"levels.":[150],"rats":[152],"pretreated":[153],"either":[155],"remained":[163],"similar":[164],"challenge.":[170],"preserved":[172],"was":[178],"associated":[179],"diminished":[181],"NF-kappaB":[182,221],"activation,":[183],"attenuated":[184],"production,":[187],"improved":[189],"contractility.":[191],"conclude":[193],"dexamethasone":[197],"upregulate":[198],"expression":[202],"an":[205],"may":[212],"promote":[213],"inhibition":[219],"intranuclear":[222],"translocation":[223]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
