{"id":"https://openalex.org/W2212840997","doi":"https://doi.org/10.1093/oxfordjournals.humrep.a138124","title":"The effects of mifepristone (RU486) on prostaglandin dehydrogenase in decidual and chorionic tissue in early pregnancy","display_name":"The effects of mifepristone (RU486) on prostaglandin dehydrogenase in decidual and chorionic tissue in early pregnancy","publication_year":1993,"publication_date":"1993-05-01","ids":{"openalex":"https://openalex.org/W2212840997","doi":"https://doi.org/10.1093/oxfordjournals.humrep.a138124","mag":"2212840997","pmid":"https://pubmed.ncbi.nlm.nih.gov/8314963"},"language":"en","primary_location":{"id":"doi:10.1093/oxfordjournals.humrep.a138124","doi":"https://doi.org/10.1093/oxfordjournals.humrep.a138124","is_oa":false,"landing_page_url":"https://doi.org/10.1093/oxfordjournals.humrep.a138124","pdf_url":null,"source":{"id":"https://openalex.org/S127900037","display_name":"Human Reproduction","issn_l":"0268-1161","issn":["0268-1161","1460-2350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Reproduction","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Linan Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Linan Cheng","raw_affiliation_strings":["Medical Research Council Reproductive Biology Unit, University of Edinburgh Centre for Reproductive Biology, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Reproductive Biology Unit, University of Edinburgh Centre for Reproductive Biology, UK","institution_ids":["https://openalex.org/I90344618","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109388512","display_name":"RODNEY W. KELLY","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rodney W. Kelly","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109173969","display_name":"Kok Joo Thong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116174","display_name":"MRC Centre for Reproductive Health","ror":"https://ror.org/02f4tsf92","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210116174","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"K.Joo Thong","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, University of Edinburgh Centre for Reproductive Biology 37 Chalmers Street, Edinburgh EH3 9EW"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, University of Edinburgh Centre for Reproductive Biology 37 Chalmers Street, Edinburgh EH3 9EW","institution_ids":["https://openalex.org/I4210116174","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075595875","display_name":"Robert Hume","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Robert Hume","raw_affiliation_strings":["University of Edinburgh Department of Child Life and Health 17 Hatton Place, Edinburgh EH9 1UW, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Edinburgh Department of Child Life and Health 17 Hatton Place, Edinburgh EH9 1UW, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110321498","display_name":"David T. Baird","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116174","display_name":"MRC Centre for Reproductive Health","ror":"https://ror.org/02f4tsf92","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210116174","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David T. Baird","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, University of Edinburgh Centre for Reproductive Biology 37 Chalmers Street, Edinburgh EH3 9EW"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, University of Edinburgh Centre for Reproductive Biology 37 Chalmers Street, Edinburgh EH3 9EW","institution_ids":["https://openalex.org/I4210116174","https://openalex.org/I98677209"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4097,"currency":"EUR","value_usd":4630},"apc_paid":null,"fwci":7.1367,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.97249474,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"8","issue":"5","first_page":"705","last_page":"709"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10600","display_name":"Reproductive Health and Contraception","score":0.8022000193595886,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10600","display_name":"Reproductive Health and Contraception","score":0.8022000193595886,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.16750000417232513,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.01810000091791153,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mifepristone","display_name":"mifepristone","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ru486","display_name":"RU486","score":0.9599999785423279},{"id":"https://openalex.org/keywords/prostaglandin-dehydrogenase","display_name":"prostaglandin dehydrogenase","score":0.9950000047683716},{"id":"https://openalex.org/keywords/decidua","display_name":"decidua","score":0.6819999814033508},{"id":"https://openalex.org/keywords/chorionic-villi","display_name":"chorionic villi","score":0.9980000257492065},{"id":"https://openalex.org/keywords/early-pregnancy","display_name":"early pregnancy","score":0.8569999933242798},{"id":"https://openalex.org/keywords/antiprogestins","display_name":"antiprogestins","score":0.7409999966621399},{"id":"https://openalex.org/keywords/surgical-abortion","display_name":"surgical abortion","score":0.6940000057220459},{"id":"https://openalex.org/keywords/progesterone","display_name":"progesterone","score":0.718999981880188},{"id":"https://openalex.org/keywords/cytotrophoblast","display_name":"cytotrophoblast","score":0.9340000152587891},{"id":"https://openalex.org/keywords/syncytiotrophoblast","display_name":"syncytiotrophoblast","score":0.9950000047683716},{"id":"https://openalex.org/keywords/prostaglandin-metabolism","display_name":"prostaglandin metabolism","score":0.8069999814033508}],"concepts":[{"id":"https://openalex.org/C2778826759","wikidata":"https://www.wikidata.org/wiki/Q411240","display_name":"Mifepristone","level":3,"score":0.9801222085952759},{"id":"https://openalex.org/C2780197806","wikidata":"https://www.wikidata.org/wiki/Q2531387","display_name":"Decidua","level":5,"score":0.6645392179489136},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.5699155330657959},{"id":"https://openalex.org/C2776106523","wikidata":"https://www.wikidata.org/wiki/Q323047","display_name":"Abortifacient","level":4,"score":0.5235040783882141},{"id":"https://openalex.org/C2781107390","wikidata":"https://www.wikidata.org/wiki/Q5249153","display_name":"Decidual cells","level":5,"score":0.519587516784668},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.49219027161598206},{"id":"https://openalex.org/C2781385326","wikidata":"https://www.wikidata.org/wiki/Q2272222","display_name":"Chorionic villi","level":5,"score":0.461327463388443},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.4101920425891876},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34588444232940674},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32676994800567627},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3265576958656311},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.19870370626449585},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.19829663634300232},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000028","descriptor_name":"Abortion, Induced","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002824","descriptor_name":"Chorionic Villi","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002824","descriptor_name":"Chorionic Villi","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D003656","descriptor_name":"Decidua","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003656","descriptor_name":"Decidua","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006911","descriptor_name":"Hydroxyprostaglandin Dehydrogenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015735","descriptor_name":"Mifepristone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/oxfordjournals.humrep.a138124","doi":"https://doi.org/10.1093/oxfordjournals.humrep.a138124","is_oa":false,"landing_page_url":"https://doi.org/10.1093/oxfordjournals.humrep.a138124","pdf_url":null,"source":{"id":"https://openalex.org/S127900037","display_name":"Human Reproduction","issn_l":"0268-1161","issn":["0268-1161","1460-2350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Reproduction","raw_type":"journal-article"},{"id":"pmid:8314963","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8314963","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human reproduction (Oxford, England)","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.897.4181","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.897.4181","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://humrep.oxfordjournals.org/content/8/5/705.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307856","display_name":"World Health Organization","ror":"https://ror.org/01f80g185"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2077479660","https://openalex.org/W7098367036","https://openalex.org/W2102606319","https://openalex.org/W1967038661","https://openalex.org/W2068915467","https://openalex.org/W2108728740","https://openalex.org/W2092853038","https://openalex.org/W1995106464","https://openalex.org/W2130373720","https://openalex.org/W2091315110"],"abstract_inverted_index":{"Prostaglandin":[0],"dehydrogenase":[1,112,125,142,173],"is":[2,18,27,32,41],"the":[3,22,37,44,52,62,75,90,178],"main":[4],"inactivating":[5],"enzyme":[6,26,48,65,113],"for":[7],"prostaglandins":[8],"and":[9,49,69,81,88],"therefore":[10],"controls":[11],"local":[12],"levels":[13],"of":[14,24,36,39,46,55,64,95,110,139,150,180],"prostaglandins.":[15],"Since":[16],"there":[17,166],"some":[19],"evidence":[20],"that":[21,34],"expression":[23],"this":[25,47,137],"under":[28],"progesterone":[29],"control":[30],"it":[31],"reasonable":[33],"one":[35],"effects":[38],"antiprogestin":[40],"to":[42,85],"reduce":[43],"concentration":[45,54,109],"thus":[50],"increase":[51],"effective":[53],"prostaglandin":[56,96,111,124,141,172],"within":[57,67],"tissue.":[58,116],"We":[59],"have":[60],"investigated":[61],"amount":[63],"activity":[66],"decidua":[68],"chorionic":[70,151,159],"villi":[71,152,160],"from":[72,156],"women":[73],"receiving":[74,99],"antigestagen":[76],"mifepristone":[77,100],"(RU486)":[78],"12,":[79],"24":[80],"36":[82],"h":[83],"prior":[84],"surgical":[86],"abortion,":[87],"examined":[89],"effect":[91],"on":[92],"tissue":[93],"concentrations":[94],"dehydrogenase.":[97],"Women":[98],"in":[101,108,114,123,126,145,147,164,171,177],"all":[102],"groups":[103],"had":[104],"a":[105,120],"significant":[106],"reduction":[107,122],"decidual":[115,127],"There":[117],"was":[118,143],"also":[119],"marked":[121],"cells":[128,149],"following":[129],"RU486,":[130],"as":[131],"demonstrated":[132],"by":[133],"immunochemical":[134],"methods.":[135],"At":[136],"stage":[138],"pregnancy,":[140],"present":[144],"abundance":[146],"cytotrophoblast":[148],"but":[153],"virtually":[154],"absent":[155],"syncytiotrophoblast.":[157],"In":[158],"after":[161],"RU486":[162],"administration":[163],"vivo,":[165],"were":[167],"no":[168],"obvious":[169],"differences":[170],"distribution":[174],"or":[175],"reactivity":[176],"majority":[179],"cases.":[181]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}