{"id":"https://openalex.org/W2211397752","doi":"https://doi.org/10.1111/imr.12379","title":"Mechanisms involved in triggering rheumatoid arthritis","display_name":"Mechanisms involved in triggering rheumatoid arthritis","publication_year":2015,"publication_date":"2015-12-19","ids":{"openalex":"https://openalex.org/W2211397752","doi":"https://doi.org/10.1111/imr.12379","mag":"2211397752","pmid":"https://pubmed.ncbi.nlm.nih.gov/26683152"},"language":"en","primary_location":{"id":"doi:10.1111/imr.12379","doi":"https://doi.org/10.1111/imr.12379","is_oa":false,"landing_page_url":"https://doi.org/10.1111/imr.12379","pdf_url":null,"source":{"id":"https://openalex.org/S133112385","display_name":"Immunological Reviews","issn_l":"0105-2896","issn":["0105-2896","1600-065X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological Reviews","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046583167","display_name":"Anca I. Catrina","orcid":"https://orcid.org/0000-0002-1292-1152","observed_orcids":["https://orcid.org/0000-0002-1292-1152"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Anca I. Catrina","raw_affiliation_strings":["Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018585450","display_name":"Vijay Joshua","orcid":"https://orcid.org/0000-0002-2606-8180","observed_orcids":["https://orcid.org/0000-0002-2606-8180"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Vijay Joshua","raw_affiliation_strings":["Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071491614","display_name":"Lars Klareskog","orcid":"https://orcid.org/0000-0001-9601-6186","observed_orcids":["https://orcid.org/0000-0001-9601-6186"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Lars Klareskog","raw_affiliation_strings":["Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088539282","display_name":"Vivianne Malmstr\u00f6m","orcid":"https://orcid.org/0000-0001-9251-8082","observed_orcids":["https://orcid.org/0000-0001-9251-8082"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Vivianne Malmstr\u00f6m","raw_affiliation_strings":["Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5088539282"],"corresponding_institution_ids":["https://openalex.org/I28166907"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":2.6486,"has_fulltext":false,"cited_by_count":164,"citation_normalized_percentile":{"value":0.92927757,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"269","issue":"1","first_page":"162","last_page":"174"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.996999979019165},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.7089999914169312},{"id":"https://openalex.org/keywords/citrullinated-proteins","display_name":"citrullinated proteins","score":0.9520000219345093},{"id":"https://openalex.org/keywords/post-translational-protein-modification","display_name":"post-translational protein modification","score":0.7680000066757202},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.9490000009536743},{"id":"https://openalex.org/keywords/adaptive-immunity","display_name":"adaptive immunity","score":0.9819999933242798},{"id":"https://openalex.org/keywords/autoantigens","display_name":"autoantigens","score":0.75},{"id":"https://openalex.org/keywords/joint-inflammation","display_name":"joint inflammation","score":0.722000002861023},{"id":"https://openalex.org/keywords/disease-onset","display_name":"disease onset","score":0.6700000166893005},{"id":"https://openalex.org/keywords/early-diagnosis","display_name":"early diagnosis","score":0.7089999914169312},{"id":"https://openalex.org/keywords/disease-prevention","display_name":"disease prevention","score":0.8500000238418579},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.8149999976158142}],"concepts":[{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.7386754751205444},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5501514077186584},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.48209765553474426},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45474717020988464},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3674788475036621},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3561903238296509}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001324","descriptor_name":"Autoantigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002956","descriptor_name":"Citrulline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056704","descriptor_name":"Adaptive Immunity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/imr.12379","doi":"https://doi.org/10.1111/imr.12379","is_oa":false,"landing_page_url":"https://doi.org/10.1111/imr.12379","pdf_url":null,"source":{"id":"https://openalex.org/S133112385","display_name":"Immunological Reviews","issn_l":"0105-2896","issn":["0105-2896","1600-065X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological Reviews","raw_type":"journal-article"},{"id":"pmid:26683152","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26683152","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunological reviews","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320317958","display_name":"Margareta af Ugglas Foundation","ror":null},{"id":"https://openalex.org/F4320321491","display_name":"Cancerfonden","ror":"https://ror.org/0527jb766"},{"id":"https://openalex.org/F4320322327","display_name":"Knut och Alice Wallenbergs Stiftelse","ror":"https://ror.org/004hzzk67"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":122,"referenced_works":["https://openalex.org/W16948095","https://openalex.org/W1523144803","https://openalex.org/W1533294137","https://openalex.org/W1549470277","https://openalex.org/W1589308530","https://openalex.org/W1591773945","https://openalex.org/W1604890903","https://openalex.org/W1832022780","https://openalex.org/W1856651500","https://openalex.org/W1906434119","https://openalex.org/W1913865297","https://openalex.org/W1936939552","https://openalex.org/W1966061020","https://openalex.org/W1967211753","https://openalex.org/W1974718865","https://openalex.org/W1974774736","https://openalex.org/W1975069505","https://openalex.org/W1980379994","https://openalex.org/W1983798402","https://openalex.org/W1985133443","https://openalex.org/W1985281288","https://openalex.org/W1986572176","https://openalex.org/W1987772124","https://openalex.org/W1988468169","https://openalex.org/W1991472750","https://openalex.org/W1999129356","https://openalex.org/W1999888795","https://openalex.org/W2002401357","https://openalex.org/W2004476106","https://openalex.org/W2009103286","https://openalex.org/W2013375004","https://openalex.org/W2015865604","https://openalex.org/W2016370312","https://openalex.org/W2018337150","https://openalex.org/W2021296708","https://openalex.org/W2023715743","https://openalex.org/W2024988150","https://openalex.org/W2025408360","https://openalex.org/W2025412364","https://openalex.org/W2029106619","https://openalex.org/W2031170496","https://openalex.org/W2031184234","https://openalex.org/W2031294882","https://openalex.org/W2031823694","https://openalex.org/W2032349776","https://openalex.org/W2035483456","https://openalex.org/W2037706885","https://openalex.org/W2041654486","https://openalex.org/W2049448291","https://openalex.org/W2053236795","https://openalex.org/W2054802348","https://openalex.org/W2060098353","https://openalex.org/W2060930483","https://openalex.org/W2061067592","https://openalex.org/W2062566352","https://openalex.org/W2064349379","https://openalex.org/W2064990609","https://openalex.org/W2065734531","https://openalex.org/W2067645583","https://openalex.org/W2072660904","https://openalex.org/W2078599166","https://openalex.org/W2099911518","https://openalex.org/W2100025622","https://openalex.org/W2101061213","https://openalex.org/W2101290319","https://openalex.org/W2103445654","https://openalex.org/W2106360870","https://openalex.org/W2107005433","https://openalex.org/W2107300453","https://openalex.org/W2107398008","https://openalex.org/W2110085609","https://openalex.org/W2110508835","https://openalex.org/W2110835305","https://openalex.org/W2111608476","https://openalex.org/W2113468396","https://openalex.org/W2113748628","https://openalex.org/W2115421086","https://openalex.org/W2117839723","https://openalex.org/W2118474453","https://openalex.org/W2119832209","https://openalex.org/W2119900188","https://openalex.org/W2126226937","https://openalex.org/W2128952811","https://openalex.org/W2130426567","https://openalex.org/W2132402446","https://openalex.org/W2133538370","https://openalex.org/W2133964489","https://openalex.org/W2134871263","https://openalex.org/W2136131602","https://openalex.org/W2137027434","https://openalex.org/W2137333865","https://openalex.org/W2139011163","https://openalex.org/W2139379942","https://openalex.org/W2141522272","https://openalex.org/W2142802169","https://openalex.org/W2142845896","https://openalex.org/W2143603194","https://openalex.org/W2145227714","https://openalex.org/W2146707828","https://openalex.org/W2147780684","https://openalex.org/W2149953008","https://openalex.org/W2150663819","https://openalex.org/W2152348310","https://openalex.org/W2154447283","https://openalex.org/W2155099477","https://openalex.org/W2156070134","https://openalex.org/W2156518945","https://openalex.org/W2158236406","https://openalex.org/W2159497758","https://openalex.org/W2160340969","https://openalex.org/W2163363738","https://openalex.org/W2164744416","https://openalex.org/W2167213128","https://openalex.org/W2167539659","https://openalex.org/W2169364567","https://openalex.org/W2169532722","https://openalex.org/W2170270098","https://openalex.org/W2171871586","https://openalex.org/W2177851274","https://openalex.org/W2188147812","https://openalex.org/W2231410460","https://openalex.org/W2249934287"],"related_works":["https://openalex.org/W2164903899","https://openalex.org/W2909117008","https://openalex.org/W1987772124","https://openalex.org/W4390353677","https://openalex.org/W16948095","https://openalex.org/W4391980970","https://openalex.org/W2735602290","https://openalex.org/W4403214160","https://openalex.org/W4292332807","https://openalex.org/W2995734501"],"abstract_inverted_index":{"Rheumatoid":[0],"arthritis":[1],"(RA)":[2],"is":[3,92],"a":[4,9,24,53],"chronic":[5,80],"inflammatory":[6],"syndrome":[7],"with":[8,94],"strong":[10],"autoimmune":[11,57,96],"component.":[12],"The":[13],"autoantigens":[14],"in":[15,83],"RA":[16,120],"are":[17,37,103,128],"neither":[18],"tissue":[19],"nor":[20],"organ-specific,":[21],"but":[22],"comprise":[23],"broad":[25],"collection":[26],"of":[27,67,87,111,119,123,131,147,157,166],"post-translational":[28],"modified":[29],"proteins,":[30],"such":[31],"as":[32],"citrullinated":[33],"proteins.":[34],"These":[35],"modifications":[36],"likely":[38],"to":[39,52,78,163],"be":[40],"triggered":[41],"by":[42],"innate":[43,70,148],"stimuli.":[44],"In":[45,139],"genetically":[46],"susceptible":[47],"hosts,":[48],"they":[49],"can":[50],"lead":[51],"more":[54],"substantiated":[55],"secondary":[56],"reaction":[58],"targeting":[59],"the":[60,64,84,144,154,164],"joints":[61],"and":[62,71,121,149],"precipitating":[63],"clinical":[65],"onset":[66],"RA.":[68,167],"Both":[69],"adaptive":[72,150],"mechanisms":[73],"will":[74,114],"then":[75],"closely":[76],"interplay":[77],"promote":[79],"joint":[81],"inflammation":[82],"several":[85],"absence":[86],"appropriate":[88],"treatment.":[89],"This":[90],"scenario,":[91],"shared":[93],"other":[95],"diseases":[97],"where":[98],"potentially":[99],"pathogenic":[100],"immune":[101,158],"responses":[102],"present":[104],"already":[105],"before":[106],"disease":[107,137],"onset.":[108],"Better":[109],"understanding":[110],"these":[112],"processes":[113,146],"allow":[115],"both":[116],"earlier":[117],"diagnosis":[118],"identification":[122],"those":[124],"healthy":[125],"individuals":[126],"that":[127,160],"at":[129],"risk":[130],"developing":[132],"disease,":[133],"opening":[134],"possibilities":[135],"for":[136,153],"prevention.":[138],"this":[140],"review,":[141],"we":[142],"discuss":[143],"iterative":[145],"immunity":[151],"responsible":[152],"(longitudinal)":[155],"development":[156,165],"reactions":[159],"may":[161],"contribute":[162]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":21},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":24},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}