{"id":"https://openalex.org/W2211220731","doi":null,"title":"Folate deficiency exacerbates apoptosis by inducing hypomethylation and resultant overexpression of DR4 together with altering DNMTs in Alzheimer's disease.","display_name":"Folate deficiency exacerbates apoptosis by inducing hypomethylation and resultant overexpression of DR4 together with altering DNMTs in Alzheimer's disease.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2211220731","mag":"2211220731","pmid":"https://pubmed.ncbi.nlm.nih.gov/25232375","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4161535"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:3135261","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4161535","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4161535","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100377621","display_name":"Yun Wang","orcid":"https://orcid.org/0000-0002-3644-3466","observed_orcids":["https://orcid.org/0000-0002-3644-3466"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210103957","display_name":"Second Hospital of Shandong University","ror":"https://ror.org/01fd86n56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103957"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yun Wang","raw_affiliation_strings":["Department of Neurology, The Second Hospital of Shandong University, Shandong University Jinan 250033, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Second Hospital of Shandong University, Shandong University Jinan 250033, PR China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210103957"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046436076","display_name":"Shunliang Xu","orcid":"https://orcid.org/0000-0001-6516-723X","observed_orcids":["https://orcid.org/0000-0001-6516-723X"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210103957","display_name":"Second Hospital of Shandong University","ror":"https://ror.org/01fd86n56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103957"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shunliang Xu","raw_affiliation_strings":["Department of Neurology, The Second Hospital of Shandong University, Shandong University Jinan 250033, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Second Hospital of Shandong University, Shandong University Jinan 250033, PR China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210103957"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046852793","display_name":"Yanjun Cao","orcid":"https://orcid.org/0000-0001-9226-1416","observed_orcids":["https://orcid.org/0000-0001-9226-1416"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210103957","display_name":"Second Hospital of Shandong University","ror":"https://ror.org/01fd86n56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103957"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanjun Cao","raw_affiliation_strings":["Department of Neurology, The Second Hospital of Shandong University, Shandong University Jinan 250033, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Second Hospital of Shandong University, Shandong University Jinan 250033, PR China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210103957"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101736154","display_name":"Zhaohong Xie","orcid":"https://orcid.org/0000-0001-6384-5893","observed_orcids":["https://orcid.org/0000-0001-6384-5893"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210103957","display_name":"Second Hospital of Shandong University","ror":"https://ror.org/01fd86n56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103957"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhaohong Xie","raw_affiliation_strings":["Department of Neurology, The Second Hospital of Shandong University, Shandong University Jinan 250033, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Second Hospital of Shandong University, Shandong University Jinan 250033, PR China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210103957"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101735638","display_name":"Chao Lai","orcid":"https://orcid.org/0000-0002-7583-5702","observed_orcids":["https://orcid.org/0000-0002-7583-5702"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210103957","display_name":"Second Hospital of Shandong University","ror":"https://ror.org/01fd86n56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103957"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chao Lai","raw_affiliation_strings":["Department of Neurology, The Second Hospital of Shandong University, Shandong University Jinan 250033, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Second Hospital of Shandong University, Shandong University Jinan 250033, PR China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210103957"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075817604","display_name":"Xiaowei Ji","orcid":"https://orcid.org/0009-0000-7764-6844","observed_orcids":["https://orcid.org/0009-0000-7764-6844"]},"institutions":[{"id":"https://openalex.org/I134738993","display_name":"Shandong University of Traditional Chinese Medicine","ror":"https://ror.org/0523y5c19","country_code":"CN","type":"education","lineage":["https://openalex.org/I134738993"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaowei Ji","raw_affiliation_strings":["Department of Neurology, The Second Hospital of Shandong Traditional Chinese Medicine University Jinan 250001, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Second Hospital of Shandong Traditional Chinese Medicine University Jinan 250001, PR China","institution_ids":["https://openalex.org/I134738993"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015366379","display_name":"Jianzhong Bi","orcid":"https://orcid.org/0000-0003-4129-9865","observed_orcids":["https://orcid.org/0000-0003-4129-9865"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210103957","display_name":"Second Hospital of Shandong University","ror":"https://ror.org/01fd86n56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103957"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianzhong Bi","raw_affiliation_strings":["Department of Neurology, The Second Hospital of Shandong University, Shandong University Jinan 250033, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The Second Hospital of Shandong University, Shandong University Jinan 250033, PR China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210103957"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4318,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.79852543,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"7","issue":"8","first_page":"1945","last_page":"57"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.6265000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.6265000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.3174000084400177,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.020099999383091927,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8870000243186951},{"id":"https://openalex.org/keywords/folate-deficiency","display_name":"folate deficiency","score":1.0},{"id":"https://openalex.org/keywords/dr4","display_name":"DR4","score":0.7950000166893005},{"id":"https://openalex.org/keywords/death-receptor-4","display_name":"death receptor 4","score":0.7850000262260437},{"id":"https://openalex.org/keywords/promoter-hypomethylation","display_name":"promoter hypomethylation","score":0.9139999747276306},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9309999942779541},{"id":"https://openalex.org/keywords/dna-methyltransferases","display_name":"DNA methyltransferases","score":0.8569999933242798},{"id":"https://openalex.org/keywords/dnmt1","display_name":"DNMT1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dnmt3a","display_name":"DNMT3A","score":0.9879999756813049},{"id":"https://openalex.org/keywords/mecp2","display_name":"MeCP2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/serum-folate","display_name":"serum folate","score":0.6909999847412109},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.5960000157356262},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.7041651010513306},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6832756400108337},{"id":"https://openalex.org/C175211621","wikidata":"https://www.wikidata.org/wiki/Q14907998","display_name":"DNMT1","level":5,"score":0.6321280002593994},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.6218954920768738},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.6064240336418152},{"id":"https://openalex.org/C2779979206","wikidata":"https://www.wikidata.org/wiki/Q1154602","display_name":"DNA methyltransferase","level":5,"score":0.5320785045623779},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.5315079092979431},{"id":"https://openalex.org/C2778863441","wikidata":"https://www.wikidata.org/wiki/Q18028997","display_name":"MECP2","level":4,"score":0.5255026817321777},{"id":"https://openalex.org/C189235521","wikidata":"https://www.wikidata.org/wiki/Q4087270","display_name":"Bisulfite sequencing","level":5,"score":0.4683496356010437},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.4210893511772156},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4000087082386017},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39302346110343933},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3451220989227295},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3123294711112976},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16493016481399536},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:3135261","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4161535","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:25232375","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25232375","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4161535","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4161535/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Med","raw_type":"Text"},{"id":"mag:2211220731","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25232375","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3135261","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4161535","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1579578067","https://openalex.org/W1822441228","https://openalex.org/W1895354952","https://openalex.org/W1945836171","https://openalex.org/W1967318479","https://openalex.org/W1971683155","https://openalex.org/W1982354720","https://openalex.org/W1984598610","https://openalex.org/W1990958459","https://openalex.org/W1991327182","https://openalex.org/W1997006242","https://openalex.org/W2003153466","https://openalex.org/W2016664803","https://openalex.org/W2020089910","https://openalex.org/W2029470970","https://openalex.org/W2035744678","https://openalex.org/W2044783100","https://openalex.org/W2052211882","https://openalex.org/W2052659766","https://openalex.org/W2057384340","https://openalex.org/W2066430702","https://openalex.org/W2069217420","https://openalex.org/W2075647382","https://openalex.org/W2078443326","https://openalex.org/W2080487903","https://openalex.org/W2083019740","https://openalex.org/W2089806976","https://openalex.org/W2089883166","https://openalex.org/W2090974028","https://openalex.org/W2093247513","https://openalex.org/W2097319041","https://openalex.org/W2102893853","https://openalex.org/W2106930147","https://openalex.org/W2111638227","https://openalex.org/W2112052880","https://openalex.org/W2113633315","https://openalex.org/W2116030076","https://openalex.org/W2123925888","https://openalex.org/W2130940521","https://openalex.org/W2131989549","https://openalex.org/W2137006779","https://openalex.org/W2140210931","https://openalex.org/W2141835013","https://openalex.org/W2149790281","https://openalex.org/W2157574275","https://openalex.org/W2159677246","https://openalex.org/W2166649920","https://openalex.org/W2170197381"],"related_works":["https://openalex.org/W2096249271","https://openalex.org/W7099581943","https://openalex.org/W937574224","https://openalex.org/W2181347267","https://openalex.org/W1982888850","https://openalex.org/W4313472686","https://openalex.org/W7056413901","https://openalex.org/W2962611808","https://openalex.org/W3203036691","https://openalex.org/W2042729124"],"abstract_inverted_index":{"This":[0],"study":[1],"was":[2,64,80,108,119,133,174],"to":[3,66,82,121],"evaluate":[4],"patterns":[5],"of":[6,12,19,32,39,42,70,87,112,131,172],"gene":[7,72,84],"expression":[8,30,85,170,230],"and":[9,22,28,35,45,47,74,89,99,138,144,151,180,192],"promoter":[10,130,233],"methylation":[11,68],"DR4":[13,71,132,173,229],"from":[14],"peripheral":[15],"circulating":[16],"blood":[17,113],"lymphocytes":[18],"AD":[20,43,136,190],"patients":[21,44,137,191],"folate-deficiency":[23,57,142],"medium":[24,143,195],"cultured":[25,55,140,196],"neuroblast":[26],"cells,":[27],"also":[29,90],"levels":[31,69,86],"DNMT1,":[33],"DNMT3a,":[34],"MECP2.":[36],"Blood":[37],"samples":[38],"25":[40],"pairs":[41],"age-":[46],"sex-matched":[48],"controls":[49,200],"were":[50,54,154,184],"collected.":[51],"SH-SY5Y":[52],"cells":[53,139,197],"with":[56,62,166,199,205,231,238,246],"medium.":[58],"Bisulfite":[59],"cloning":[60],"coupled":[61],"sequencing":[63],"employed":[65],"analyze":[67,122],"promoters,":[73],"quantitative":[75],"real":[76],"time":[77],"PCR":[78],"(qRT-PCR)":[79],"used":[81,120],"detect":[83],"DR4,":[88],"DNA":[91,95,232,249],"methyltransferase":[92,96],"1":[93],"(DNMT1),":[94],"3a":[97],"(DNMT3a)":[98],"methyl":[100],"CpG":[101],"binding":[102,163],"protein":[103],"2":[104],"(MECP2).":[105],"Folate":[106],"concentration":[107,208],"calculated":[109],"in":[110,135,141,189,209,235],"serum":[111],"samples.":[114],"3-(4,5-di-methylthiazol-2-yl)-2,5-diphenyl":[115],"tetrazolium":[116],"(MTT)":[117],"assay":[118,212],"cell":[123,218],"viability.":[124],"The":[125],"results":[126],"showed":[127,213],"that,":[128],"the":[129,167],"hypomethylated":[134],"had":[145],"site-specific":[146],"changes":[147],"(P":[148,176,186,201],"<":[149,177,187,202],"0.05),":[150,203],"these":[152],"sites":[153],"mostly":[155],"at":[156],"or":[157],"nearby":[158],"some":[159],"key":[160],"transcription":[161],"factor":[162],"sites.":[164],"Accordance":[165],"hypomethylation,":[168],"increased":[169],"level":[171,183],"observed":[175],"0.05).":[178],"DNMT1":[179],"DNMT3a":[181],"mRNA":[182],"elevated":[185],"0.05)":[188],"folate":[193,207,215,222,247],"deficient":[194],"compared":[198],"together":[204,237],"lower":[206],"AD.":[210],"MTT":[211],"that":[214],"deficiency":[216,223],"inhibited":[217],"growth.":[219],"In":[220],"summary,":[221],"can":[224],"induce":[225],"apoptosis":[226],"by":[227],"increasing":[228],"hypomethylation":[234],"AD,":[236],"upregulating":[239],"DNMTs":[240],"expression,":[241],"which":[242],"may":[243],"be":[244],"associated":[245],"deficiency-induced":[248],"damage.":[250]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}