{"id":"https://openalex.org/W2211021037","doi":"https://doi.org/10.1534/genetics.115.181842","title":"An Amino-Terminal Polo Kinase Interaction Motif Acts in the Regulation of Centrosome Formation and Reveals a Novel Function for centrosomin (cnn) in Drosophila","display_name":"An Amino-Terminal Polo Kinase Interaction Motif Acts in the Regulation of Centrosome Formation and Reveals a Novel Function for centrosomin (cnn) in Drosophila","publication_year":2015,"publication_date":"2015-10-01","ids":{"openalex":"https://openalex.org/W2211021037","doi":"https://doi.org/10.1534/genetics.115.181842","mag":"2211021037","pmid":"https://pubmed.ncbi.nlm.nih.gov/26447129","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4596677"},"language":"en","primary_location":{"id":"doi:10.1534/genetics.115.181842","doi":"https://doi.org/10.1534/genetics.115.181842","is_oa":false,"landing_page_url":"https://doi.org/10.1534/genetics.115.181842","pdf_url":null,"source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4596677","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026905564","display_name":"Robert C. Eisman","orcid":"https://orcid.org/0000-0002-4126-9116","observed_orcids":["https://orcid.org/0000-0002-4126-9116"]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert C Eisman","raw_affiliation_strings":["Department of Biology, Indiana University, Bloomington, Indiana 47405"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Indiana University, Bloomington, Indiana 47405","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034293208","display_name":"Melissa Phelps","orcid":"https://orcid.org/0000-0002-4636-4024","observed_orcids":["https://orcid.org/0000-0002-4636-4024"]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa A S Phelps","raw_affiliation_strings":["Department of Biology, Indiana University, Bloomington, Indiana 47405"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Indiana University, Bloomington, Indiana 47405","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037744823","display_name":"Thomas C. Kaufman","orcid":"https://orcid.org/0000-0003-1406-7671","observed_orcids":["https://orcid.org/0000-0003-1406-7671"]},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas Kaufman","raw_affiliation_strings":["Department of Biology, Indiana University, Bloomington, Indiana 47405"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Indiana University, Bloomington, Indiana 47405","institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5037744823"],"corresponding_institution_ids":["https://openalex.org/I4210119109","https://openalex.org/I592451"],"apc_list":{"value":4477,"currency":"USD","value_usd":4477},"apc_paid":null,"fwci":1.0636,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.75047066,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"201","issue":"2","first_page":"685","last_page":"706"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/centrosomin","display_name":"centrosomin","score":0.7910000085830688},{"id":"https://openalex.org/keywords/polo-kinase","display_name":"Polo kinase","score":0.7940000295639038},{"id":"https://openalex.org/keywords/pericentriolar-matrix","display_name":"pericentriolar matrix","score":0.9959999918937683},{"id":"https://openalex.org/keywords/exon-1a","display_name":"exon 1a","score":0.8360000252723694},{"id":"https://openalex.org/keywords/protein-protein-interaction-motifs","display_name":"protein-protein interaction motifs","score":0.7609999775886536},{"id":"https://openalex.org/keywords/centrosome-duplication","display_name":"centrosome duplication","score":0.6850000023841858},{"id":"https://openalex.org/keywords/polar-body-formation","display_name":"polar body formation","score":0.9729999899864197},{"id":"https://openalex.org/keywords/meiosis","display_name":"meiosis","score":0.8799999952316284},{"id":"https://openalex.org/keywords/drosophila-melanogaster-embryo","display_name":"Drosophila melanogaster embryo","score":0.8399999737739563},{"id":"https://openalex.org/keywords/protein-phosphorylation","display_name":"protein phosphorylation","score":0.7250000238418579},{"id":"https://openalex.org/keywords/protein-localization","display_name":"protein localization","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C10447061","wikidata":"https://www.wikidata.org/wiki/Q190769","display_name":"Centrosome","level":4,"score":0.8535925149917603},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8534608483314514},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6276848912239075},{"id":"https://openalex.org/C32276052","wikidata":"https://www.wikidata.org/wiki/Q908349","display_name":"Motif (music)","level":2,"score":0.5122355818748474},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.45090383291244507},{"id":"https://openalex.org/C84815855","wikidata":"https://www.wikidata.org/wiki/Q7225885","display_name":"Polo-like kinase","level":4,"score":0.45009714365005493},{"id":"https://openalex.org/C2776041557","wikidata":"https://www.wikidata.org/wiki/Q3715451","display_name":"Drosophila (subgenus)","level":3,"score":0.4489181339740753},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44164925813674927},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.290566086769104},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.10715329647064209},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D004625","descriptor_name":"Embryo, Nonmammalian","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018385","descriptor_name":"Centrosome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047108","descriptor_name":"Embryonic Development","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1534/genetics.115.181842","doi":"https://doi.org/10.1534/genetics.115.181842","is_oa":false,"landing_page_url":"https://doi.org/10.1534/genetics.115.181842","pdf_url":null,"source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4000203","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4596677","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4596677","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4596677","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"Text"},{"id":"pmid:26447129","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26447129","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:4000203","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4596677","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W310177787","https://openalex.org/W1486381015","https://openalex.org/W1820990168","https://openalex.org/W1856475474","https://openalex.org/W1863636479","https://openalex.org/W1906238116","https://openalex.org/W1967241208","https://openalex.org/W1969412956","https://openalex.org/W1970295089","https://openalex.org/W1971083122","https://openalex.org/W1971667392","https://openalex.org/W1973262048","https://openalex.org/W1989239876","https://openalex.org/W1993860951","https://openalex.org/W1994363752","https://openalex.org/W1994652412","https://openalex.org/W2000055300","https://openalex.org/W2011953977","https://openalex.org/W2018732798","https://openalex.org/W2019114976","https://openalex.org/W2022215247","https://openalex.org/W2026387669","https://openalex.org/W2028174735","https://openalex.org/W2038163496","https://openalex.org/W2039697511","https://openalex.org/W2040400275","https://openalex.org/W2046347502","https://openalex.org/W2048551141","https://openalex.org/W2059843465","https://openalex.org/W2060957469","https://openalex.org/W2073032288","https://openalex.org/W2082968313","https://openalex.org/W2086038715","https://openalex.org/W2086265207","https://openalex.org/W2089996872","https://openalex.org/W2091024669","https://openalex.org/W2092951535","https://openalex.org/W2097401587","https://openalex.org/W2097511273","https://openalex.org/W2105771473","https://openalex.org/W2105909210","https://openalex.org/W2106446195","https://openalex.org/W2107609525","https://openalex.org/W2108882553","https://openalex.org/W2109796319","https://openalex.org/W2110643873","https://openalex.org/W2116282691","https://openalex.org/W2123587496","https://openalex.org/W2127776124","https://openalex.org/W2128879941","https://openalex.org/W2135751988","https://openalex.org/W2137240069","https://openalex.org/W2143720287","https://openalex.org/W2146212019","https://openalex.org/W2146453026","https://openalex.org/W2150704118","https://openalex.org/W2154513960","https://openalex.org/W2157448853","https://openalex.org/W2157810409","https://openalex.org/W2162172965","https://openalex.org/W2163256056","https://openalex.org/W2164799944","https://openalex.org/W2164883807","https://openalex.org/W2166884712","https://openalex.org/W2167364244","https://openalex.org/W2171906885","https://openalex.org/W2283451592","https://openalex.org/W2916483810"],"related_works":["https://openalex.org/W2337239618","https://openalex.org/W7171775297","https://openalex.org/W2123587496","https://openalex.org/W7116316051","https://openalex.org/W4225421620","https://openalex.org/W2171906885","https://openalex.org/W7095199186","https://openalex.org/W6894424011","https://openalex.org/W2046347502","https://openalex.org/W2105909210"],"abstract_inverted_index":{"The":[0],"formation":[1,64,162],"of":[2,21,25,53,85,87,93,114,139,157,163],"the":[3,18,26,45,82,94,106,110,117,137,155,161],"pericentriolar":[4],"matrix":[5],"(PCM)":[6],"and":[7,34,43,144,159],"a":[8,32,51,91,129],"fully":[9],"functional":[10,164],"centrosome":[11,27],"in":[12,90,147],"syncytial":[13],"Drosophila":[14],"melanogaster":[15],"embryos":[16],"requires":[17],"rapid":[19],"transport":[20,80],"Cnn":[22,33,54,79,96,104,115],"during":[23,41,166],"initiation":[24],"replication":[28],"cycle.":[29],"We":[30],"show":[31],"Polo":[35,60,72,77,134,150],"kinase":[36,73,135],"interaction":[37],"is":[38,57,99],"apparently":[39],"required":[40,124,153],"embryogenesis":[42],"involves":[44],"exon":[46,65],"1A-initiating":[47],"coding":[48],"exon,":[49],"suggesting":[50],"subset":[52],"splice":[55],"variants":[56],"regulated":[58],"by":[59,76],"kinase.":[61],"During":[62],"PCM":[63],"1A":[66,142],"Cnn-Long":[67],"Form":[68,121],"proteins":[69,122],"likely":[70],"bind":[71],"before":[74],"phosphorylation":[75],"for":[78,125,160],"to":[81,101,116,132],"centrosome.":[83],"Loss":[84],"either":[86],"these":[88],"interactions":[89],"portion":[92],"total":[95],"protein":[97],"pool":[98],"sufficient":[100],"remove":[102],"native":[103],"from":[105],"pool,":[107],"thereby":[108],"altering":[109],"normal":[111],"localization":[112],"dynamics":[113],"PCM.":[118],"Additionally,":[119],"Cnn-Short":[120],"are":[123,152],"polar":[126],"body":[127],"formation,":[128],"process":[130],"known":[131],"require":[133],"after":[136],"completion":[138,156],"meiosis.":[140],"Exon":[141],"Cnn-LF":[143],"Cnn-SF":[145],"proteins,":[146],"conjunction":[148],"with":[149],"kinase,":[151],"at":[154],"meiosis":[158],"centrosomes":[165],"early":[167],"embryogenesis.":[168]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}