{"id":"https://openalex.org/W2210489647","doi":"https://doi.org/10.1007/978-1-4899-1739-3_12","title":"Cloning and Expression of Large Mammalian cDNAs: Lessons from ATM","display_name":"Cloning and Expression of Large Mammalian cDNAs: Lessons from ATM","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W2210489647","doi":"https://doi.org/10.1007/978-1-4899-1739-3_12","mag":"2210489647","pmid":"https://pubmed.ncbi.nlm.nih.gov/9666562"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-4899-1739-3_12","doi":"https://doi.org/10.1007/978-1-4899-1739-3_12","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4899-1739-3_12","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetic Engineering","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4205731425","display_name":"Genetic Engineering"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086398854","display_name":"Yosef Shiloh","orcid":"https://orcid.org/0000-0002-1538-6060","observed_orcids":["https://orcid.org/0000-0002-1538-6060"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Yosef Shiloh","raw_affiliation_strings":["Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Israel","Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, 69978, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, 69978, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080088757","display_name":"Anat Bar\u2010Shira","orcid":"https://orcid.org/0009-0005-8772-0303","observed_orcids":["https://orcid.org/0009-0005-8772-0303"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Anat Bar-Shira","raw_affiliation_strings":["Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, 69978, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, 69978, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082694913","display_name":"Yaron Galanty","orcid":"https://orcid.org/0000-0001-7167-9004","observed_orcids":["https://orcid.org/0000-0001-7167-9004"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Yaron Galanty","raw_affiliation_strings":["Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, 69978, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, 69978, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069098638","display_name":"Yael Ziv","orcid":"https://orcid.org/0000-0002-2131-5648","observed_orcids":["https://orcid.org/0000-0002-2131-5648"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Yael Ziv","raw_affiliation_strings":["Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, 69978, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, 69978, Israel","institution_ids":["https://openalex.org/I16391192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I16391192"],"apc_list":null,"apc_paid":null,"fwci":0.4541,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.67799151,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":null,"first_page":"239","last_page":"248"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atm-gene","display_name":"ATM gene","score":0.9890000224113464},{"id":"https://openalex.org/keywords/ataxia-telangiectasia","display_name":"ataxia telangiectasia","score":0.8920000195503235},{"id":"https://openalex.org/keywords/cdna-cloning","display_name":"cDNA cloning","score":0.8370000123977661},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.8519999980926514},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.6980000138282776},{"id":"https://openalex.org/keywords/cell-cycle-checkpoints","display_name":"cell cycle checkpoints","score":0.9240000247955322},{"id":"https://openalex.org/keywords/chromosomal-instability","display_name":"chromosomal instability","score":0.7850000262260437},{"id":"https://openalex.org/keywords/radiosensitivity","display_name":"radiosensitivity","score":0.7210000157356262},{"id":"https://openalex.org/keywords/cancer-susceptibility","display_name":"cancer susceptibility","score":0.781000018119812},{"id":"https://openalex.org/keywords/genotoxic-stress","display_name":"genotoxic stress","score":0.6769999861717224},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.4350000023841858}],"concepts":[{"id":"https://openalex.org/C2779486608","wikidata":"https://www.wikidata.org/wiki/Q387082","display_name":"Ataxia-telangiectasia","level":4,"score":0.762223482131958},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6213367581367493},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5781225562095642},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5760902166366577},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.531220555305481},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.465166836977005},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4363764524459839},{"id":"https://openalex.org/C15152581","wikidata":"https://www.wikidata.org/wiki/Q7833966","display_name":"Transduction (biophysics)","level":2,"score":0.4281505048274994},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3418596684932709},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33991044759750366},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33160361647605896},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.25450554490089417},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08088719844818115}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016350","descriptor_name":"Leucine Zippers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016366","descriptor_name":"Open Reading Frames","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064007","descriptor_name":"Ataxia Telangiectasia Mutated Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/978-1-4899-1739-3_12","doi":"https://doi.org/10.1007/978-1-4899-1739-3_12","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4899-1739-3_12","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetic Engineering","raw_type":"book-chapter"},{"id":"pmid:9666562","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9666562","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetic engineering","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7746514025","display_name":"ATAXIA-TELANGIECTASIS: FROM GENE BACK TO PHENOTYPE","funder_award_id":"R01NS031763","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1487477578","https://openalex.org/W1640093800","https://openalex.org/W1967264277","https://openalex.org/W1969393623","https://openalex.org/W1973969831","https://openalex.org/W1974010399","https://openalex.org/W1983254392","https://openalex.org/W2003090737","https://openalex.org/W2008684482","https://openalex.org/W2012430176","https://openalex.org/W2015221134","https://openalex.org/W2024696996","https://openalex.org/W2030720512","https://openalex.org/W2035498459","https://openalex.org/W2048458949","https://openalex.org/W2052598236","https://openalex.org/W2062232773","https://openalex.org/W2067191626","https://openalex.org/W2073469664","https://openalex.org/W2092129193","https://openalex.org/W2097316296","https://openalex.org/W2105071129","https://openalex.org/W2123304039","https://openalex.org/W2143287752","https://openalex.org/W2153923420","https://openalex.org/W2158728679","https://openalex.org/W2159168998","https://openalex.org/W2165449806","https://openalex.org/W2169830490","https://openalex.org/W2171439103","https://openalex.org/W2172192445","https://openalex.org/W6600002382","https://openalex.org/W6732277591"],"related_works":["https://openalex.org/W53650051","https://openalex.org/W1979800136","https://openalex.org/W1971850308","https://openalex.org/W2397363571","https://openalex.org/W1983254392","https://openalex.org/W1969424937","https://openalex.org/W2071564289","https://openalex.org/W7096018049","https://openalex.org/W2172192445","https://openalex.org/W2158505124"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}