{"id":"https://openalex.org/W221024378","doi":null,"title":"\u8d8b\u5316\u56e0\u5b50\u53d7\u4f53CCR5\u80de\u5916\u6bb5\u91cd\u7ec4\u86cb\u767d\u7684\u514b\u9686\u3001\u8868\u8fbe\u3001\u7eaf\u5316\u53ca\u9274\u5b9a","display_name":"\u8d8b\u5316\u56e0\u5b50\u53d7\u4f53CCR5\u80de\u5916\u6bb5\u91cd\u7ec4\u86cb\u767d\u7684\u514b\u9686\u3001\u8868\u8fbe\u3001\u7eaf\u5316\u53ca\u9274\u5b9a","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W221024378","mag":"221024378"},"language":"zh","primary_location":{"id":"mag:221024378","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/qk/93577X/200605/21352212.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306556491","display_name":"\u7b2c\u56db\u519b\u533b\u5927\u5b66\u5b66\u62a5","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u7b2c\u56db\u519b\u533b\u5927\u5b66\u5b66\u62a5","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024432508","display_name":"\u5434\u5b54\u7530","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u5434\u5b54\u7530","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035284174","display_name":"\u5f20\u82f1\u8d77","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u5f20\u82f1\u8d77","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5023177864","display_name":"\u989c\u771f","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u989c\u771f","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02425433,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"5","first_page":"412","last_page":"415"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.8715999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.8715999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.05950000137090683,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.040300000458955765,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ccr5","display_name":"CCR5","score":0.8939999938011169},{"id":"https://openalex.org/keywords/chemokine-receptors","display_name":"chemokine receptors","score":0.9700000286102295},{"id":"https://openalex.org/keywords/extracellular-domain","display_name":"extracellular domain","score":0.8420000076293945},{"id":"https://openalex.org/keywords/recombinant-protein","display_name":"recombinant protein","score":0.968999981880188},{"id":"https://openalex.org/keywords/prokaryotic-expression","display_name":"prokaryotic expression","score":0.8429999947547913},{"id":"https://openalex.org/keywords/inclusion-bodies","display_name":"inclusion bodies","score":0.675000011920929},{"id":"https://openalex.org/keywords/protein-refolding","display_name":"protein refolding","score":0.859000027179718},{"id":"https://openalex.org/keywords/hiv-1-infection","display_name":"HIV-1 infection","score":0.4970000088214874},{"id":"https://openalex.org/keywords/vaccine-antigens","display_name":"vaccine antigens","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.36848825216293335}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:221024378","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/qk/93577X/200605/21352212.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306556491","display_name":"\u7b2c\u56db\u519b\u533b\u5927\u5b66\u5b66\u62a5","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u7b2c\u56db\u519b\u533b\u5927\u5b66\u5b66\u62a5","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6998052386","https://openalex.org/W7064680565","https://openalex.org/W985959535","https://openalex.org/W3030674519","https://openalex.org/W2380379426","https://openalex.org/W2351691589","https://openalex.org/W2389337112","https://openalex.org/W1526625946","https://openalex.org/W3032008784","https://openalex.org/W2259740703"],"abstract_inverted_index":{"\u76ee\u7684\uff1a\u6784\u5efa\u8d8b\u5316\u56e0\u5b50\u53d7\u4f535\uff08CCR5\uff09\u80de\u5916\u6bb5\u91cd\u7ec4\u86cb\u767d\uff08\u547d\u540d\u4e3a\uff1arCCR5\uff09\u539f\u6838\u8868\u8fbe\u8f7d\u4f53\uff0c\u5e76\u8fdb\u884c\u8bf1\u5bfc\u8868\u8fbe\uff0e\u5bf9\u8868\u8fbe\u4ea7\u7269\u8fdb\u884c\u7eaf\u5316\u548c\u9274\u5b9a\uff0e\u65b9\u6cd5\uff1a\u622a\u53d6CCR5\u80de\u5916\u7ed3\u67844\u4e2a\u7247\u6bb5N-Term\uff0cECL1\uff0cECL2\u548cECL3\u7684\u6c28\u57fa\u9178\u5e8f\u5217\uff0c\u5e94\u7528\u67d4\u6027linker\u5206\u522b\u4e32\u8054\uff0c\u6a21\u62dfCCR5\u80de\u5916\u7ed3\u6784\uff0c\u4f9d\u636e\u5927\u80a0\u6746\u83cc\u504f\u7231\u5bc6\u7801\u5b50\u4eba\u5de5\u5408\u6210\u57fa\u56e0\uff0e\u8fd0\u7528\u57fa\u56e0\u91cd\u7ec4\u65b9\u6cd5\u5728\u5927\u80a0\u6746\u83cc\u4e2d\u8fdb\u884c\u8868\u8fbe\u3002\u8868\u8fbe\u4ea7\u7269\u7ecf\u7eaf\u5316\u3001\u590d\u6027\u540e\u8fdb\u884cWesternblot\u9274\u5b9a\uff0e\u7ed3\u679c\uff1a\u76ee\u7684\u86cb\u767d\u4ee5\u5305\u6db5\u4f53\u5f62\u5f0f\u5b58\u5728\uff0c\u7ecf\u5305\u6db5\u4f53\u6d17\u6da4\u3001\u53d8\u6027\u6eb6\u89e3\uff0cSephacrylS-300\u51dd\u80f6\u8fc7\u6ee4\u5c42\u6790\u53caSephacrylS-100\u51dd\u80f6\u67f1\u590d\u6027\u83b7\u5f97\u4e86\u7eaf\u5316\u7684\u86cb\u767d\u8d28\uff0c\u76ee\u7684\u86cb\u767d\u80fd\u4e0eCCR5":[0],"mAb\u7279\u5f02\u6027\u7ed3\u5408\uff0e\u7ed3\u8bba\uff1a\u83b7\u5f97\u4e86\u5927\u91cf\u7eaf\u5316\u7684rCCR5\u91cd\u7ec4\u86cb\u767d\uff0c\u53ef\u4f5c\u4e3a\u7814\u5236CCR5\u81ea\u4f53\u86cb\u767d\u75ab\u82d7\u4ee5\u963b\u65adHIV-1\u611f\u67d3\u7684\u5019\u9009\u6297\u539f\u86cb\u767d\u3002":[1]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}