{"id":"https://openalex.org/W2210090508","doi":"https://doi.org/10.1182/blood.v90.2.535","title":"All patients with the T(11;16)(q23;p13.3) that involves MLL and CBP have treatment-related hematologic disorders.","display_name":"All patients with the T(11;16)(q23;p13.3) that involves MLL and CBP have treatment-related hematologic disorders.","publication_year":1997,"publication_date":"1997-07-15","ids":{"openalex":"https://openalex.org/W2210090508","doi":"https://doi.org/10.1182/blood.v90.2.535","mag":"2210090508","pmid":"https://pubmed.ncbi.nlm.nih.gov/9226152"},"language":"en","primary_location":{"id":"pmid:9226152","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9226152","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004347976","display_name":"Janet D. Rowley","orcid":"https://orcid.org/0000-0001-7218-6578","observed_orcids":["https://orcid.org/0000-0001-7218-6578"]},"institutions":[{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J D Rowley","raw_affiliation_strings":["Department of Medicine, University of Chicago Medical Center, IL 60637-1470, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Chicago Medical Center, IL 60637-1470, USA","institution_ids":["https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066343875","display_name":"Shalini C. Reshmi","orcid":"https://orcid.org/0000-0003-1491-077X","observed_orcids":["https://orcid.org/0000-0003-1491-077X"]},"institutions":[{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Reshmi","raw_affiliation_strings":["From the Department of Medicine, Section of Hematology/Oncology, and the Department of Pathology, University of Chicago Medical Center, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine, Section of Hematology/Oncology, and the Department of Pathology, University of Chicago Medical Center, Chicago, IL","institution_ids":["https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036847818","display_name":"Olatoyosi M. Sobulo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"O Sobulo","raw_affiliation_strings":["From the Department of Medicine, Section of Hematology/Oncology, and the Department of Pathology, University of Chicago Medical Center, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine, Section of Hematology/Oncology, and the Department of Pathology, University of Chicago Medical Center, Chicago, IL","institution_ids":["https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011850604","display_name":"Tarannum Musvee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T Musvee","raw_affiliation_strings":["From the Department of Medicine, Section of Hematology/Oncology, and the Department of Pathology, University of Chicago Medical Center, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine, Section of Hematology/Oncology, and the Department of Pathology, University of Chicago Medical Center, Chicago, IL","institution_ids":["https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089125878","display_name":"John Anastasi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Anastasi","raw_affiliation_strings":["From the Department of Medicine, Section of Hematology/Oncology, and the Department of Pathology, University of Chicago Medical Center, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine, Section of Hematology/Oncology, and the Department of Pathology, University of Chicago Medical Center, Chicago, IL","institution_ids":["https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012776569","display_name":"Susana Catalina Raimondi","orcid":"https://orcid.org/0000-0001-8155-3018","observed_orcids":["https://orcid.org/0000-0001-8155-3018"]},"institutions":[{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Raimondi","raw_affiliation_strings":["From the Department of Medicine, Section of Hematology/Oncology, and the Department of Pathology, University of Chicago Medical Center, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine, Section of Hematology/Oncology, and the Department of Pathology, University of Chicago Medical Center, Chicago, IL","institution_ids":["https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113669750","display_name":"Nancy R. Schneider","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N R Schneider","raw_affiliation_strings":["From the Department of Medicine, Section of Hematology/Oncology, and the Department of Pathology, University of Chicago Medical Center, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine, Section of Hematology/Oncology, and the Department of Pathology, University of Chicago Medical Center, Chicago, IL","institution_ids":["https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010703149","display_name":"Julio C. Barredo","orcid":"https://orcid.org/0000-0003-4654-4145","observed_orcids":["https://orcid.org/0000-0003-4654-4145"]},"institutions":[{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J C Barredo","raw_affiliation_strings":["From the Department of Medicine, Section of Hematology/Oncology, and the Department of Pathology, University of Chicago Medical Center, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine, Section of Hematology/Oncology, and the Department of Pathology, University of Chicago Medical Center, Chicago, IL","institution_ids":["https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109101058","display_name":"Eduardo S. Cant\u00fa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E S Cantu","raw_affiliation_strings":["From the Department of Medicine, Section of Hematology/Oncology, and the Department of Pathology, University of Chicago Medical Center, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine, Section of Hematology/Oncology, and the Department of Pathology, University of Chicago Medical Center, Chicago, IL","institution_ids":["https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031540176","display_name":"Brigitte Schlegelberger","orcid":"https://orcid.org/0000-0001-5256-1270","observed_orcids":["https://orcid.org/0000-0001-5256-1270"]},"institutions":[{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B Schlegelberger","raw_affiliation_strings":["From the Department of Medicine, Section of Hematology/Oncology, and the Department of Pathology, University of Chicago Medical Center, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine, Section of Hematology/Oncology, and the Department of Pathology, University of Chicago Medical Center, Chicago, IL","institution_ids":["https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108357016","display_name":"Frederick G. Behm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F Behm","raw_affiliation_strings":["From the Department of Medicine, Section of Hematology/Oncology, and the Department of Pathology, University of Chicago Medical Center, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine, Section of Hematology/Oncology, and the Department of Pathology, University of Chicago Medical Center, Chicago, IL","institution_ids":["https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010297697","display_name":"Norman A. Doggett","orcid":"https://orcid.org/0000-0001-8254-2126","observed_orcids":["https://orcid.org/0000-0001-8254-2126"]},"institutions":[{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N A Doggett","raw_affiliation_strings":["From the Department of Medicine, Section of Hematology/Oncology, and the Department of Pathology, University of Chicago Medical Center, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine, Section of Hematology/Oncology, and the Department of Pathology, University of Chicago Medical Center, Chicago, IL","institution_ids":["https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054785349","display_name":"Julian Borrow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Borrow","raw_affiliation_strings":["From the Department of Medicine, Section of Hematology/Oncology, and the Department of Pathology, University of Chicago Medical Center, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine, Section of Hematology/Oncology, and the Department of Pathology, University of Chicago Medical Center, Chicago, IL","institution_ids":["https://openalex.org/I4210087865"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111695395","display_name":"Nancy J. Zeleznik\u2010Le","orcid":"https://orcid.org/0009-0005-2432-9892","observed_orcids":["https://orcid.org/0009-0005-2432-9892"]},"institutions":[{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N Zeleznik-Le","raw_affiliation_strings":["From the Department of Medicine, Section of Hematology/Oncology, and the Department of Pathology, University of Chicago Medical Center, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medicine, Section of Hematology/Oncology, and the Department of Pathology, University of Chicago Medical Center, Chicago, IL","institution_ids":["https://openalex.org/I4210087865"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210087865"],"apc_list":null,"apc_paid":null,"fwci":10.3307,"has_fulltext":false,"cited_by_count":213,"citation_normalized_percentile":{"value":0.98947516,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"90","issue":"2","first_page":"535","last_page":"41"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.638700008392334,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.638700008392334,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.2433999925851822,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.05079999938607216,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mll","display_name":"MLL","score":0.7630000114440918},{"id":"https://openalex.org/keywords/cbp","display_name":"CBP","score":0.8830000162124634},{"id":"https://openalex.org/keywords/11q23-translocation","display_name":"11q23 translocation","score":0.8130000233650208},{"id":"https://openalex.org/keywords/treatment-related-leukemia","display_name":"treatment-related leukemia","score":0.8460000157356262},{"id":"https://openalex.org/keywords/topoisomerase-ii-inhibitors","display_name":"topoisomerase II inhibitors","score":0.8769999742507935},{"id":"https://openalex.org/keywords/myelodysplastic-syndrome","display_name":"myelodysplastic syndrome","score":0.843999981880188},{"id":"https://openalex.org/keywords/chronic-myelomonocytic-leukemia","display_name":"chronic myelomonocytic leukemia","score":0.9950000047683716},{"id":"https://openalex.org/keywords/dyserythropoiesis","display_name":"dyserythropoiesis","score":0.8339999914169312},{"id":"https://openalex.org/keywords/fusion-genes","display_name":"fusion genes","score":0.4519999921321869},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.7595604658126831},{"id":"https://openalex.org/C206936463","wikidata":"https://www.wikidata.org/wiki/Q634179","display_name":"Breakpoint","level":4,"score":0.685328483581543},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.6387082934379578},{"id":"https://openalex.org/C35101798","wikidata":"https://www.wikidata.org/wiki/Q414491","display_name":"Cosmid","level":3,"score":0.5800224542617798},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.567914605140686},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.5434231758117676},{"id":"https://openalex.org/C2777542201","wikidata":"https://www.wikidata.org/wiki/Q1336182","display_name":"Fluorescence in situ hybridization","level":4,"score":0.5396212935447693},{"id":"https://openalex.org/C2778608605","wikidata":"https://www.wikidata.org/wiki/Q4677943","display_name":"Acute myelomonocytic leukemia","level":3,"score":0.4753698706626892},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.46436187624931335},{"id":"https://openalex.org/C2776863199","wikidata":"https://www.wikidata.org/wiki/Q976388","display_name":"Acute leukemia","level":3,"score":0.43963950872421265},{"id":"https://openalex.org/C43907098","wikidata":"https://www.wikidata.org/wiki/Q903924","display_name":"breakpoint cluster region","level":3,"score":0.41137897968292236},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39419665932655334},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34415560960769653},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28943783044815063},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.2697327136993408}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002880","descriptor_name":"Chromosomes, Human, Pair 11","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002885","descriptor_name":"Chromosomes, Human, Pair 16","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009190","descriptor_name":"Myelodysplastic Syndromes","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D009190","descriptor_name":"Myelodysplastic Syndromes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009190","descriptor_name":"Myelodysplastic Syndromes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011495","descriptor_name":"Histone-Lysine N-Methyltransferase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011519","descriptor_name":"Proto-Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014178","descriptor_name":"Translocation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016335","descriptor_name":"Zinc Fingers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016609","descriptor_name":"Neoplasms, Second Primary","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D016609","descriptor_name":"Neoplasms, Second Primary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017404","descriptor_name":"In Situ Hybridization, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050882","descriptor_name":"CREB-Binding Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051788","descriptor_name":"Myeloid-Lymphoid Leukemia Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059005","descriptor_name":"Topoisomerase II Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9226152","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9226152","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"},{"id":"mag:2210090508","doi":"https://doi.org/10.1182/blood.v90.2.535","is_oa":false,"landing_page_url":"https://www.bloodjournal.org/content/bloodjournal/90/2/535.full.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Blood","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[{"id":"https://openalex.org/G440993082","display_name":"CLINICAL PHENOTYPE TARGETED ANTIFOLATE CHEMOTHERAPY","funder_award_id":"R29CA072734","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4832054694","display_name":"CHROMOSOME ABNORMALITIES AND HUMAN LEUKEMIA AND LYMPHOMA","funder_award_id":"R35CA042557","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W2287952","https://openalex.org/W4908868","https://openalex.org/W215965135","https://openalex.org/W1432929478","https://openalex.org/W1635992089","https://openalex.org/W1899521092","https://openalex.org/W1976631985","https://openalex.org/W2013348417","https://openalex.org/W2013570099","https://openalex.org/W2056369410","https://openalex.org/W2069428560","https://openalex.org/W2072924157","https://openalex.org/W2083912192","https://openalex.org/W2096450527","https://openalex.org/W2104681334","https://openalex.org/W2242925189","https://openalex.org/W2333611917","https://openalex.org/W2339788226","https://openalex.org/W2405944022","https://openalex.org/W2409952447","https://openalex.org/W2415919798","https://openalex.org/W2416812816","https://openalex.org/W2438479965"],"related_works":["https://openalex.org/W2562587210","https://openalex.org/W2015919288","https://openalex.org/W1786259862","https://openalex.org/W2008799566","https://openalex.org/W2166907165","https://openalex.org/W2262294716","https://openalex.org/W190101321","https://openalex.org/W1432929478","https://openalex.org/W2312753950","https://openalex.org/W2053340754"],"abstract_inverted_index":{"The":[0,111,333,383],"involvement":[1],"of":[2,16,43,89,147,197,206,248,254,297,320,326,335,380,404],"11q23-balanced":[3],"translocations":[4,58,280],"in":[5,41,59,68,121,126,135,159,180,215,224,230,234,278,361,368],"acute":[6,127,137],"leukemia":[7,71,129,267],"after":[8],"treatment":[9],"with":[10,25,77,152,157,193,257,285,304],"drugs":[11,153],"that":[12,33,38,102,124,239,308,358,392],"inhibit":[13],"the":[14,34,57,63,78,97,122,173,185,204,216,222,228,240,295,310,314,321,327,330,346,388,401],"function":[15,334],"DNA":[17],"topoisomerase":[18],"II":[19,156],"(topo":[20],"II)":[21],"is":[22,39,47,244,250,275,337,354,359,365,372,394],"being":[23],"recognized":[24],"increasing":[26],"frequency.":[27],"We":[28,94,140,237],"and":[29,53,75,99,106,133,168,184,232,269,289,323],"others":[30],"have":[31,95,100,141],"shown":[32,101],"gene":[35,113,120,243,381,385],"at":[36,203],"11q23":[37,279],"involved":[40,360,367],"all":[42,146,181,309],"these":[44,60,290],"treatment-related":[45,79,136],"leukemias":[46,61,80],"MLL":[48,105,167,336,347],"(also":[49],"called":[50],"ALL1,":[51],"Htrx,":[52],"HRX).":[54],"In":[55],"general,":[56],"are":[62],"same":[64,291],"as":[65,117,317],"those":[66],"occurring":[67],"de":[69,131,282],"novo":[70,132,283],"[eg,":[72],"t(9;11),":[73],"t(11;19),":[74],"t(4;11)],":[76],"accounting":[81],"for":[82,166],"no":[83],"more":[84],"than":[85],"5%":[86],"to":[87,264,293,349,374,376],"10%":[88],"any":[90],"particular":[91,350],"translocation":[92],"type.":[93],"cloned":[96],"t(11;16)(q23;p13.3)":[98],"it":[103,219,393,398],"involves":[104],"CBP":[107,112,174,353,389],"(CREB":[108],"binding":[109],"protein).":[110],"was":[114,220],"recently":[115],"identified":[116],"a":[118,164,169,258],"partner":[119],"t(8;16)":[123],"occurs":[125],"myelomonocytic":[128,266],"(AML-M4)":[130],"rarely":[134,276],"myeloid":[138],"leukemia.":[139],"studied":[142],"eight":[143,182],"t(11;16)":[144],"patients,":[145,226],"whom":[148],"had":[149,272],"prior":[150],"therapy":[151],"targetting":[154],"topo":[155],"fluorescence":[158],"situ":[160],"hybridization":[161],"(FISH)":[162],"using":[163],"probe":[165],"cosmid":[170],"contig":[171],"covering":[172],"gene.":[175,332],"Both":[176],"probes":[177,292],"were":[178,190],"split":[179,233],"patients":[183,249],"two":[186],"derivative":[187],"(der)":[188],"chromosomes":[189],"each":[191],"labeled":[192],"both":[194],"probes.":[195],"Use":[196],"an":[198,355,377],"approximately":[199],"100-kb":[200],"PAC":[201],"located":[202],"breakpoint":[205,217],"chromosome":[207],"16":[208],"from":[209,301],"one":[210,270,302],"patient":[211,303],"revealed":[212],"some":[213,319],"variability":[214],"because":[218,252],"on":[221,227],"der(16)":[223],"three":[225,253],"der(11)":[229],"another,":[231],"four":[235],"others.":[236],"assume":[238],"critical":[241],"fusion":[242,315,331,384],"5'MLL/3'CBP.":[245],"Our":[246],"series":[247],"unusual":[251],"them":[255],"presented":[256],"myelodysplastic":[259],"syndrome":[260],"(MDS)":[261],"most":[262],"similar":[263],"chronic":[265],"(CMMoL)":[268],"other":[271],"dyserythropoiesis;":[273],"MDS":[274],"seen":[277],"either":[281],"or":[284],"t-AML.":[286],"Using":[287],"FISH":[288],"analyze":[294],"lineage":[296],"bone":[298],"marrow":[299],"cells":[300],"CMMoL,":[305],"we":[306],"showed":[307],"mature":[311],"monocytes":[312],"contained":[313,329],"genes":[316],"did":[318],"granulocytes":[322],"erythroblasts;":[324],"none":[325],"lymphocytes":[328],"not":[338],"well":[339],"understood,":[340],"but":[341],"many":[342],"domains":[343],"could":[344,386,399],"target":[345],"protein":[348,357,390],"chromatin":[351],"complexes.":[352],"adapter":[356],"regulating":[362],"transcription.":[363],"It":[364],"also":[366],"histone":[369],"acetylation,":[370],"which":[371],"thought":[373],"contribute":[375],"increased":[378],"level":[379],"expression.":[382],"alter":[387],"such":[391],"constitutively":[395],"active;":[396],"alternatively,":[397],"modify":[400],"chromatin-association":[402],"functions":[403],"MLL.":[405]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}