{"id":"https://openalex.org/W2209023325","doi":null,"title":"Pharmacoth\u00e9rapie de la d\u00e9pression chez les a\u00een\u00e9s","display_name":"Pharmacoth\u00e9rapie de la d\u00e9pression chez les a\u00een\u00e9s","publication_year":2014,"publication_date":"2014-02-01","ids":{"openalex":"https://openalex.org/W2209023325","mag":"2209023325"},"language":"fr","primary_location":{"id":"pmh:oai:europepmc.org:2912622","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3922575","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3922575","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053219121","display_name":"Christopher Frank","orcid":"https://orcid.org/0000-0002-1264-4036","observed_orcids":["https://orcid.org/0000-0002-1264-4036"]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Frank, Christopher","raw_affiliation_strings":["Professeur agr\u00e9g\u00e9 au D\u00e9partement de m\u00e9decine de la Queen\u2019s University et directeur clinique de la g\u00e9riatrie sp\u00e9cialis\u00e9e au St Mary\u2019s of the Lake Hospital \u00e0 Kingston, en Ontario"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professeur agr\u00e9g\u00e9 au D\u00e9partement de m\u00e9decine de la Queen\u2019s University et directeur clinique de la g\u00e9riatrie sp\u00e9cialis\u00e9e au St Mary\u2019s of the Lake Hospital \u00e0 Kingston, en Ontario","institution_ids":["https://openalex.org/I204722609"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5053219121"],"corresponding_institution_ids":["https://openalex.org/I204722609"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10272","display_name":"Mental Health Treatment and Access","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/geriatric-depression","display_name":"geriatric depression","score":0.9079999923706055},{"id":"https://openalex.org/keywords/drug-therapy","display_name":"pharmacotherapy","score":0.8209999799728394},{"id":"https://openalex.org/keywords/antidepressants","display_name":"antidepressants","score":0.9639999866485596},{"id":"https://openalex.org/keywords/dose-titration","display_name":"dose titration","score":0.8629999756813049},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.625},{"id":"https://openalex.org/keywords/hyponatremia","display_name":"hyponatremia","score":0.8820000290870667},{"id":"https://openalex.org/keywords/qt-interval-prolongation","display_name":"QT prolongation","score":0.8270000219345093},{"id":"https://openalex.org/keywords/treatment-resistant-depression","display_name":"treatment-resistant depression","score":0.7440000176429749},{"id":"https://openalex.org/keywords/relapse-prevention","display_name":"relapse prevention","score":0.734000027179718},{"id":"https://openalex.org/keywords/maintenance-therapy","display_name":"maintenance therapy","score":0.6710000038146973},{"id":"https://openalex.org/keywords/phq-9","display_name":"PHQ-9","score":0.8220000267028809},{"id":"https://openalex.org/keywords/fall-risk","display_name":"fall risk","score":0.39100000262260437},{"id":"https://openalex.org/keywords/treatment-duration","display_name":"treatment duration","score":0.4869999885559082},{"id":"https://openalex.org/keywords/severe-depression","display_name":"severe depression","score":0.35499998927116394},{"id":"https://openalex.org/keywords/palliative-care","display_name":"palliative care","score":0.414000004529953}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8517459630966187},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.666621208190918}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:europepmc.org:2912622","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3922575","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3922575","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3922575/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Can Fam Physician","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2912622","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3922575","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W52098624","https://openalex.org/W386768877","https://openalex.org/W575855169","https://openalex.org/W1557078286","https://openalex.org/W1856465854","https://openalex.org/W1904816587","https://openalex.org/W1936731931","https://openalex.org/W1971208892","https://openalex.org/W1978933776","https://openalex.org/W2022117805","https://openalex.org/W2022284750","https://openalex.org/W2024099936","https://openalex.org/W2036891177","https://openalex.org/W2055335035","https://openalex.org/W2057144863","https://openalex.org/W2060474514","https://openalex.org/W2066042887","https://openalex.org/W2068293911","https://openalex.org/W2087917352","https://openalex.org/W2095837197","https://openalex.org/W2104518967","https://openalex.org/W2106124216","https://openalex.org/W2108920169","https://openalex.org/W2120590819","https://openalex.org/W2123970441","https://openalex.org/W2133975630","https://openalex.org/W2145846347","https://openalex.org/W2157372020","https://openalex.org/W2158176267","https://openalex.org/W2167068556","https://openalex.org/W2317942085","https://openalex.org/W3021408641","https://openalex.org/W3143499914","https://openalex.org/W3170416365"],"related_works":["https://openalex.org/W7135256488","https://openalex.org/W7204929791","https://openalex.org/W170935311","https://openalex.org/W2529316034","https://openalex.org/W1897982610","https://openalex.org/W7009207109","https://openalex.org/W2032493841","https://openalex.org/W6991026011","https://openalex.org/W2044652949","https://openalex.org/W2516715082"],"abstract_inverted_index":{"OBJECTIF:":[0],"Discuter":[1],"du":[2,105,123,148,378,394],"traitement":[3,34,58,106,143,149,297,379,395],"pharmacologique":[4],"de":[5,20,25,44,46,59,85,159,168,175,180,191,194,278,303,338,341,360,363,373],"la":[6,21,23,26,47,60,109,153,163,169,189,192,214,238,361,364,374,385,391],"d\u00e9pression":[7,61,288,308,312,365],"chez":[8,197],"les":[9,69,73,222,229,236,240,242,260,397,400],"personnes":[10],"\u00e2g\u00e9es,":[11],"y":[12,317],"compris":[13,318],"le":[14,18,33,57,135,142,208,296,319,376,381],"choix":[15,377],"des":[16,29,35,91,111,114,121,155,249,291,383,387],"antid\u00e9presseurs,":[17],"titrage":[19],"dose,":[22],"surveillance":[24,386],"r\u00e9ponse":[27],"et":[28,32,56,99,172,199,248,283,390],"effets":[30,223,230,388],"secondaires":[31,224,231,389],"cas":[36],"r\u00e9fractaires.":[37],"SOURCES":[38],"DES":[39],"DONN\u00c9ES:":[40],"Les":[41,264,325],"lignes":[42,74],"directrices":[43],"2006":[45],"Canadian":[48],"Coalition":[49],"for":[50],"Seniors\u2019":[51],"Mental":[52],"Health":[53,137],"sur":[54],"l\u2019\u00e9valuation":[55],"ont":[62,286],"servi":[63],"comme":[64,134,306],"source":[65],"principale.":[66],"Pour":[67],"recenser":[68],"articles":[70],"publi\u00e9s":[71],"apr\u00e8s":[72],"directrices,":[75],"on":[76,233],"a":[77,126],"proc\u00e9d\u00e9":[78],"\u00e0":[79,87,89,276,321,347,352],"une":[80,157,173,287,307,311,322,329,348],"recherche":[81],"documentaire":[82],"dans":[83,251],"MEDLINE":[84],"2007":[86],"2012":[88],"l\u2019aide":[90],"expressions":[92],"en":[93,119,129,144,225,301,331],"anglais":[94],"depression,":[95],"treatment,":[96],"drug":[97],"therapy":[98],"elderly.":[100],"MESSAGE":[101],"PRINCIPAL:":[102],"Le":[103,184],"but":[104],"devrait":[107,140,187,201],"\u00eatre":[108,117,188,202,269],"r\u00e9mission":[110,154],"sympt\u00f4mes.":[112],"L\u2019am\u00e9lioration":[113],"sympt\u00f4mes":[115,292],"peut":[116,234],"surveill\u00e9e":[118],"fonction":[120],"objectifs":[122],"patient":[124,209],"qu\u2019on":[125],"identifi\u00e9s":[127],"ou":[128,219,258,290,310,351],"se":[130],"servant":[131],"d\u2019outils":[132],"cliniques":[133,355],"Patient":[136],"Questionnaire\u20139.":[138],"On":[139],"envisager":[141],"3":[145],"\u00e9tapes:":[146],"l\u2019\u00e9tape":[147],"aigu":[150],"pour":[151,161,178,256,327,399],"obtenir":[152],"sympt\u00f4mes,":[156],"\u00e9tape":[158,174],"continuation":[160],"pr\u00e9venir":[162,179],"r\u00e9currence":[164],"d\u2019un":[165],"m\u00eame":[166],"\u00e9pisode":[167],"maladie":[170],"(rechute)":[171],"maintien":[176],"(prophylaxie)":[177],"futurs":[181],"\u00e9pisodes":[182],"(r\u00e9currence).":[183],"dosage":[185],"initial":[186],"moiti\u00e9":[190],"dose":[193,215],"d\u00e9part":[195],"habituelle":[196],"l\u2019adulte":[198],"il":[200],"titr\u00e9":[203],"r\u00e9guli\u00e8rement":[204],"jusqu\u2019\u00e0":[205,211],"ce":[206,212],"que":[207,213,221],"r\u00e9ponde,":[210],"maximale":[216],"soit":[217],"atteinte":[218],"encore":[220],"limitent":[226],"l\u2019augmentation.":[227],"Parmi":[228],"fr\u00e9quents,":[232],"mentionner":[235],"chutes,":[237],"naus\u00e9e,":[239],"\u00e9tourdissements,":[241],"c\u00e9phal\u00e9es":[243],"et,":[244],"moins":[245,273],"commun\u00e9ment,":[246],"l\u2019hyponatr\u00e9mie":[247],"changements":[250],"l\u2019intervalle":[252],"QT.":[253],"Des":[254],"strat\u00e9gies":[255,354],"changer":[257],"augmenter":[259],"antid\u00e9presseurs":[261],"sont":[262,334],"pr\u00e9sent\u00e9es.":[263],"patients":[265,401],"plus":[266,402],"\u00e2g\u00e9s":[267],"devraient":[268,294],"trait\u00e9s":[270],"pendant":[271],"au":[272],"un":[274],"an":[275],"compter":[277],"l\u2019observation":[279],"d\u2019une":[280],"am\u00e9lioration":[281],"clinique":[282],"ceux":[284],"qui":[285],"r\u00e9currente":[289],"s\u00e9v\u00e8res":[293],"continuer":[295],"ind\u00e9finiment.":[298],"La":[299],"prise":[300],"charge":[302],"situations":[304],"particuli\u00e8res":[305],"profonde":[309],"avec":[313],"psychose":[314],"est":[315],"discut\u00e9e,":[316],"recours":[320],"th\u00e9rapie":[323],"\u00e9lectroconvulsive.":[324],"crit\u00e8res":[326],"demander":[328],"consultation":[330],"psychiatrie":[332],"g\u00e9riatrique":[333],"indiqu\u00e9s;":[335],"par":[336,370],"ailleurs,":[337],"nombreux":[339],"m\u00e9decins":[340],"famille":[342],"n\u2019ont":[343],"pas":[344,367],"ais\u00e9ment":[345],"acc\u00e8s":[346],"telle":[349],"ressource":[350],"d\u2019autres":[353],"non":[356],"pharmacologiques.":[357],"CONCLUSION:":[358],"L\u2019efficacit\u00e9":[359],"pharmacoth\u00e9rapie":[362],"n\u2019est":[366],"consid\u00e9rablement":[368],"influenc\u00e9e":[369],"l\u2019\u00e2ge.":[371],"L\u2019identification":[372],"d\u00e9pression,":[375],"appropri\u00e9,":[380],"tritrage":[382],"m\u00e9dicaments,":[384],"dur\u00e9e":[392],"suffisante":[393],"am\u00e9lioreront":[396],"r\u00e9sultats":[398],"\u00e2g\u00e9s.":[403]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}