{"id":"https://openalex.org/W22085891","doi":null,"title":"Linear quadratic model--estimation of alpha/beta ratio for mucosal reaction.","display_name":"Linear quadratic model--estimation of alpha/beta ratio for mucosal reaction.","publication_year":1993,"publication_date":"1993-07-01","ids":{"openalex":"https://openalex.org/W22085891","mag":"22085891","pmid":"https://pubmed.ncbi.nlm.nih.gov/8342116"},"language":"en","primary_location":{"id":"pmid:8342116","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8342116","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089917090","display_name":"Arun Chougule","orcid":"https://orcid.org/0000-0002-0277-1832","observed_orcids":["https://orcid.org/0000-0002-0277-1832"]},"institutions":[{"id":"https://openalex.org/I2803033815","display_name":"Rabindranath Tagore Medical College","ror":"https://ror.org/007r42p71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2803033815"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"A Chougule","raw_affiliation_strings":["Department of Radiotherapy, R.N.T. Medical College and Hospital, Udaipur, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiotherapy, R.N.T. Medical College and Hospital, Udaipur, India","institution_ids":["https://openalex.org/I2803033815"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055862672","display_name":"Sudhakar J. Supe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S J Supe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0098,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.70866729,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"169","issue":"7","first_page":"427","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.5942000150680542,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.5942000150680542,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.3052000105381012,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12198","display_name":"Oral health in cancer treatment","score":0.04490000009536743,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/linear-quadratic-model","display_name":"linear-quadratic model","score":0.8820000290870667},{"id":"https://openalex.org/keywords/alpha-beta-ratio","display_name":"alpha/beta ratio","score":0.9829999804496765},{"id":"https://openalex.org/keywords/mucositis","display_name":"mucositis","score":0.8650000095367432},{"id":"https://openalex.org/keywords/head-and-neck-radiotherapy","display_name":"head and neck radiotherapy","score":0.9139999747276306},{"id":"https://openalex.org/keywords/mucosal-reactions","display_name":"mucosal reactions","score":0.5789999961853027},{"id":"https://openalex.org/keywords/normal-tissue-tolerance","display_name":"normal tissue tolerance","score":0.5600000023841858},{"id":"https://openalex.org/keywords/twice-daily-fractionation","display_name":"twice-daily fractionation","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C2778496288","wikidata":"https://www.wikidata.org/wiki/Q6931269","display_name":"Mucositis","level":3,"score":0.898638129234314},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.729041576385498},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7122147679328918},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.6662253737449646},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.6624642610549927},{"id":"https://openalex.org/C2780918802","wikidata":"https://www.wikidata.org/wiki/Q25091543","display_name":"Repopulation","level":4,"score":0.5944070816040039},{"id":"https://openalex.org/C3018411727","wikidata":"https://www.wikidata.org/wiki/Q3867488","display_name":"Head and neck","level":2,"score":0.5410290360450745},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.5313554406166077},{"id":"https://openalex.org/C129844170","wikidata":"https://www.wikidata.org/wiki/Q41299","display_name":"Quadratic equation","level":2,"score":0.4572474956512451},{"id":"https://openalex.org/C155806632","wikidata":"https://www.wikidata.org/wiki/Q5299253","display_name":"Dose fractionation","level":3,"score":0.4153828024864197},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2191089689731598},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1406974196434021},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.0929945707321167},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0844988226890564},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08055582642555237},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D004307","descriptor_name":"Dose-Response Relationship, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009061","descriptor_name":"Mouth Mucosa","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D012062","descriptor_name":"Relative Biological Effectiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8342116","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8342116","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]","raw_type":"Comparative Study"},{"id":"mag:22085891","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8342116","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2587898840","https://openalex.org/W2806116757","https://openalex.org/W2022495760","https://openalex.org/W2609311130","https://openalex.org/W6939750497","https://openalex.org/W4404349955","https://openalex.org/W2051513584","https://openalex.org/W2090514969","https://openalex.org/W2222161254","https://openalex.org/W1999639264"],"abstract_inverted_index":{"In":[0],"radiotherapy":[1],"to":[2,28,55,58,145],"ensure":[3],"that":[4,94],"appropriate":[5],"tumor":[6],"lethal":[7],"dose":[8],"is":[9,45,53,154],"delivered":[10],"without":[11],"exceeding":[12],"normal":[13,68,108,128],"tissue":[14,129],"tolerance,":[15],"concepts":[16,33],"like":[17],"NSD":[18],"and":[19,91,107,142,156,161],"its":[20],"derivatives":[21],"were":[22],"used":[23],"in":[24,97,132],"the":[25,48,60,73,79,98,105,112],"past.":[26],"Due":[27],"their":[29],"short":[30],"coming":[31],"these":[32],"are":[34,95,114],"now":[35],"replaced":[36],"by":[37],"a":[38],"linear":[39,99],"quadratic":[40,100],"model.":[41,101],"As":[42],"this":[43],"model":[44],"based":[46],"on":[47,78],"recent":[49],"radiobiological":[50],"data,":[51],"it":[52,144,153],"claimed":[54],"be":[56,146],"able":[57],"predict":[59],"biological":[61],"responses":[62],"of":[63,75,82,104,111],"tumors":[64,106],"as":[65,67,86],"well":[66],"tissues":[69],"more":[70],"accurately.":[71],"However,":[72],"accuracy":[74],"prediction":[76],"depends":[77],"precise":[80],"values":[81,110],"various":[83],"parameters":[84,113],"such":[85],"alpha/beta,":[87],"repair":[88],"constant":[89],"mu":[90],"repopulation":[92],"factor":[93],"involved":[96],"For":[102],"most":[103],"tissues,":[109],"not":[115],"yet":[116],"accurately":[117],"known.":[118],"We":[119],"have":[120],"estimated":[121],"alpha/beta":[122],"value":[123],"for":[124,149,159],"mucosal":[125],"reactions,":[126],"i.e.":[127],"early":[130],"reactions":[131],"head":[133],"neck":[134],"cases":[135],"treated":[136],"with":[137],"twice":[138],"daily":[139],"fractionation":[140],"schedules":[141],"observed":[143],"7.90":[147],"Gy":[148,158],"slight":[150],"mucositis":[151],"whereas":[152],"7.68":[155],"8.11":[157],"patchy":[160],"confluent":[162],"mucositis,":[163],"respectively.":[164]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}