{"id":"https://openalex.org/W2207302007","doi":"https://doi.org/10.1016/j.jconrel.2015.12.023","title":"The structure-dependent toxicity, pharmacokinetics and anti-tumour activity of HPMA copolymer conjugates in the treatment of solid tumours and leukaemia","display_name":"The structure-dependent toxicity, pharmacokinetics and anti-tumour activity of HPMA copolymer conjugates in the treatment of solid tumours and leukaemia","publication_year":2015,"publication_date":"2015-12-19","ids":{"openalex":"https://openalex.org/W2207302007","doi":"https://doi.org/10.1016/j.jconrel.2015.12.023","mag":"2207302007","pmid":"https://pubmed.ncbi.nlm.nih.gov/26708020"},"language":"en","primary_location":{"id":"doi:10.1016/j.jconrel.2015.12.023","doi":"https://doi.org/10.1016/j.jconrel.2015.12.023","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jconrel.2015.12.023","pdf_url":null,"source":{"id":"https://openalex.org/S161954266","display_name":"Journal of Controlled Release","issn_l":"0168-3659","issn":["0168-3659","1873-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Controlled Release","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042579010","display_name":"Barbora Tomalov\u00e1","orcid":"https://orcid.org/0000-0002-9080-6168","observed_orcids":["https://orcid.org/0000-0002-9080-6168"]},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I4210122847","display_name":"Czech Academy of Sciences, Institute of Microbiology","ror":"https://ror.org/02p1jz666","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210122847"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Barbora Tomalova","raw_affiliation_strings":["Institute of Microbiology, Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic. Electronic address: barbora.tomalova@biomed.cas.cz","Institute of Microbiology, Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microbiology, Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic. Electronic address: barbora.tomalova@biomed.cas.cz","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210122847"]},{"raw_affiliation_string":"Institute of Microbiology, Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210122847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017762135","display_name":"Milada \u0160\u00edrov\u00e1","orcid":"https://orcid.org/0000-0002-7645-1495","observed_orcids":["https://orcid.org/0000-0002-7645-1495"]},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I4210122847","display_name":"Czech Academy of Sciences, Institute of Microbiology","ror":"https://ror.org/02p1jz666","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210122847"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Milada Sirova","raw_affiliation_strings":["Institute of Microbiology, Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic. Electronic address: sirova@biomed.cas.cz","Institute of Microbiology, Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microbiology, Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic. Electronic address: sirova@biomed.cas.cz","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210122847"]},{"raw_affiliation_string":"Institute of Microbiology, Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210122847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078047610","display_name":"Pavel Rossmann","orcid":"https://orcid.org/0000-0001-5410-3150","observed_orcids":["https://orcid.org/0000-0001-5410-3150"]},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I4210122847","display_name":"Czech Academy of Sciences, Institute of Microbiology","ror":"https://ror.org/02p1jz666","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210122847"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Pavel Rossmann","raw_affiliation_strings":["Institute of Microbiology, Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic. Electronic address: rossmannp@seznam.cz","Institute of Microbiology, Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microbiology, Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic. Electronic address: rossmannp@seznam.cz","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210122847"]},{"raw_affiliation_string":"Institute of Microbiology, Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210122847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057164265","display_name":"Robert Pola","orcid":"https://orcid.org/0000-0003-0025-2016","observed_orcids":["https://orcid.org/0000-0003-0025-2016"]},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I4210101964","display_name":"Czech Academy of Sciences, Institute of Macromolecular Chemistry","ror":"https://ror.org/0143w7709","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210101964"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Robert Pola","raw_affiliation_strings":["Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovskeho nam. 2, 16206 Prague, Czech Republic. Electronic address: pola@imc.cas.cz","Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovskeho nam. 2, 16206 Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovskeho nam. 2, 16206 Prague, Czech Republic. Electronic address: pola@imc.cas.cz","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210101964"]},{"raw_affiliation_string":"Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovskeho nam. 2, 16206 Prague, Czech Republic","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210101964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111815289","display_name":"Ji\u0159\u00ed Strohalm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I4210101964","display_name":"Czech Academy of Sciences, Institute of Macromolecular Chemistry","ror":"https://ror.org/0143w7709","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210101964"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Jiri Strohalm","raw_affiliation_strings":["Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovskeho nam. 2, 16206 Prague, Czech Republic. Electronic address: strohalm@imc.cas.cz","Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovskeho nam. 2, 16206 Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovskeho nam. 2, 16206 Prague, Czech Republic. Electronic address: strohalm@imc.cas.cz","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210101964"]},{"raw_affiliation_string":"Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovskeho nam. 2, 16206 Prague, Czech Republic","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210101964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050968087","display_name":"Petr Chytil","orcid":"https://orcid.org/0000-0002-7135-9796","observed_orcids":["https://orcid.org/0000-0002-7135-9796"]},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I4210101964","display_name":"Czech Academy of Sciences, Institute of Macromolecular Chemistry","ror":"https://ror.org/0143w7709","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210101964"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Petr Chytil","raw_affiliation_strings":["Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovskeho nam. 2, 16206 Prague, Czech Republic. Electronic address: chytil@imc.cas.cz","Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovskeho nam. 2, 16206 Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovskeho nam. 2, 16206 Prague, Czech Republic. Electronic address: chytil@imc.cas.cz","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210101964"]},{"raw_affiliation_string":"Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovskeho nam. 2, 16206 Prague, Czech Republic","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210101964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090888852","display_name":"Viktor \u010cern\u00fd","orcid":"https://orcid.org/0000-0002-8319-7827","observed_orcids":["https://orcid.org/0000-0002-8319-7827"]},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I4210122847","display_name":"Czech Academy of Sciences, Institute of Microbiology","ror":"https://ror.org/02p1jz666","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210122847"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Viktor Cerny","raw_affiliation_strings":["Institute of Microbiology, Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic. Electronic address: viktor.cerny@biomed.cas.cz","Institute of Microbiology, Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microbiology, Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic. Electronic address: viktor.cerny@biomed.cas.cz","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210122847"]},{"raw_affiliation_string":"Institute of Microbiology, Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210122847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001240494","display_name":"Jakub Tomala","orcid":"https://orcid.org/0000-0002-6315-2832","observed_orcids":["https://orcid.org/0000-0002-6315-2832"]},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I4210122847","display_name":"Czech Academy of Sciences, Institute of Microbiology","ror":"https://ror.org/02p1jz666","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210122847"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Jakub Tomala","raw_affiliation_strings":["Institute of Microbiology, Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic. Electronic address: tomala@biomed.cas.cz","Institute of Microbiology, Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microbiology, Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic. Electronic address: tomala@biomed.cas.cz","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210122847"]},{"raw_affiliation_string":"Institute of Microbiology, Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210122847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049664995","display_name":"Martina Kabe\u0161ov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I4210122847","display_name":"Czech Academy of Sciences, Institute of Microbiology","ror":"https://ror.org/02p1jz666","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210122847"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Martina Kabesova","raw_affiliation_strings":["Institute of Microbiology, Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic. Electronic address: kabesova@biomed.cas.cz","Institute of Microbiology, Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microbiology, Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic. Electronic address: kabesova@biomed.cas.cz","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210122847"]},{"raw_affiliation_string":"Institute of Microbiology, Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210122847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088745217","display_name":"Blanka \u0158\u0131\u0301hov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I4210122847","display_name":"Czech Academy of Sciences, Institute of Microbiology","ror":"https://ror.org/02p1jz666","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210122847"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Blanka Rihova","raw_affiliation_strings":["Institute of Microbiology, Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic. Electronic address: rihova@biomed.cas.cz","Institute of Microbiology, Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microbiology, Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic. Electronic address: rihova@biomed.cas.cz","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210122847"]},{"raw_affiliation_string":"Institute of Microbiology, Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210122847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040270800","display_name":"Karel Ulbrich","orcid":"https://orcid.org/0000-0003-2174-9654","observed_orcids":["https://orcid.org/0000-0003-2174-9654"]},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I4210101964","display_name":"Czech Academy of Sciences, Institute of Macromolecular Chemistry","ror":"https://ror.org/0143w7709","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210101964"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Karel Ulbrich","raw_affiliation_strings":["Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovskeho nam. 2, 16206 Prague, Czech Republic. Electronic address: ulbrich@imc.cas.cz","Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovskeho nam. 2, 16206 Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovskeho nam. 2, 16206 Prague, Czech Republic. Electronic address: ulbrich@imc.cas.cz","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210101964"]},{"raw_affiliation_string":"Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovskeho nam. 2, 16206 Prague, Czech Republic","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210101964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066624795","display_name":"Tom\u00e1\u0161 Etrych","orcid":"https://orcid.org/0000-0001-5908-5182","observed_orcids":["https://orcid.org/0000-0001-5908-5182"]},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I4210101964","display_name":"Czech Academy of Sciences, Institute of Macromolecular Chemistry","ror":"https://ror.org/0143w7709","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210101964"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Tomas Etrych","raw_affiliation_strings":["Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovskeho nam. 2, 16206 Prague, Czech Republic. Electronic address: etrych@imc.cas.cz","Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovskeho nam. 2, 16206 Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovskeho nam. 2, 16206 Prague, Czech Republic. Electronic address: etrych@imc.cas.cz","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210101964"]},{"raw_affiliation_string":"Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovskeho nam. 2, 16206 Prague, Czech Republic","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210101964"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060179690","display_name":"Marek Kov\u00e1\u0159","orcid":"https://orcid.org/0000-0002-6602-1678","observed_orcids":["https://orcid.org/0000-0002-6602-1678"]},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I4210122847","display_name":"Czech Academy of Sciences, Institute of Microbiology","ror":"https://ror.org/02p1jz666","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210122847"]}],"countries":["CZ"],"is_corresponding":true,"raw_author_name":"Marek Kovar","raw_affiliation_strings":["Institute of Microbiology, Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic. Electronic address: makovar@biomed.cas.cz","Institute of Microbiology, Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microbiology, Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic. Electronic address: makovar@biomed.cas.cz","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210122847"]},{"raw_affiliation_string":"Institute of Microbiology, Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210122847"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5060179690"],"corresponding_institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210122847"],"apc_list":{"value":4440,"currency":"USD","value_usd":4440},"apc_paid":null,"fwci":2.4128,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.890903,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"223","issue":null,"first_page":"1","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11686","display_name":"Dendrimers and Hyperbranched Polymers","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hpma-copolymer","display_name":"HPMA copolymer","score":0.9390000104904175},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.7609999775886536},{"id":"https://openalex.org/keywords/star-polymers","display_name":"star polymers","score":0.7039999961853027},{"id":"https://openalex.org/keywords/linear-polymers","display_name":"linear polymers","score":0.7789999842643738},{"id":"https://openalex.org/keywords/polymer-drug-conjugates","display_name":"polymer-drug conjugates","score":0.8529999852180481},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.7699999809265137},{"id":"https://openalex.org/keywords/toxicity","display_name":"toxicity","score":0.8159999847412109},{"id":"https://openalex.org/keywords/intestinal-barrier-integrity","display_name":"intestinal barrier integrity","score":0.7110000252723694},{"id":"https://openalex.org/keywords/b-cell-leukemia","display_name":"B-cell leukemia","score":0.8669999837875366},{"id":"https://openalex.org/keywords/t-cell-lymphoma","display_name":"T-cell lymphoma","score":0.972000002861023},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.8080000281333923},{"id":"https://openalex.org/keywords/antitumour-activity","display_name":"antitumour activity","score":0.7490000128746033},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7599999904632568},{"id":"https://openalex.org/keywords/drug-delivery-systems","display_name":"drug delivery systems","score":0.3880000114440918}],"concepts":[{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.8850694894790649},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6065523624420166},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.5215156674385071},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5117475986480713},{"id":"https://openalex.org/C2781021840","wikidata":"https://www.wikidata.org/wiki/Q411659","display_name":"Daunorubicin","level":3,"score":0.49967432022094727},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.4643326997756958},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4548918902873993},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4536452293395996},{"id":"https://openalex.org/C2776802502","wikidata":"https://www.wikidata.org/wiki/Q417589","display_name":"Anthracycline","level":4,"score":0.4280424118041992},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.42264309525489807},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.41345149278640747},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2523239552974701},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23040226101875305},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20736545324325562},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.17321184277534485},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14507800340652466},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0936356782913208},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08592697978019714},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000178","descriptor_name":"Acrylamides","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000178","descriptor_name":"Acrylamides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000178","descriptor_name":"Acrylamides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D000178","descriptor_name":"Acrylamides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020714","descriptor_name":"Maximum Tolerated Dose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050091","descriptor_name":"Dendrimers","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D050091","descriptor_name":"Dendrimers","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D050091","descriptor_name":"Dendrimers","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D050091","descriptor_name":"Dendrimers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.jconrel.2015.12.023","doi":"https://doi.org/10.1016/j.jconrel.2015.12.023","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jconrel.2015.12.023","pdf_url":null,"source":{"id":"https://openalex.org/S161954266","display_name":"Journal of Controlled Release","issn_l":"0168-3659","issn":["0168-3659","1873-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Controlled Release","raw_type":"journal-article"},{"id":"pmid:26708020","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26708020","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of controlled release : official journal of the Controlled Release Society","raw_type":"Journal Article"},{"id":"pmh:oai:asep.lib.cas.cz:CavUnEpca/0463915","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11104/0263061","pdf_url":null,"source":{"id":"https://openalex.org/S7407055266","display_name":"ASEP","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G321106277","display_name":null,"funder_award_id":"CZ.1.05/1.100/02.0109","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G5249547472","display_name":null,"funder_award_id":"P-301/11/0325","funder_id":"https://openalex.org/F4320321006","funder_display_name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky"},{"id":"https://openalex.org/G8016214587","display_name":null,"funder_award_id":"RVO61388971","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"}],"funders":[{"id":"https://openalex.org/F4320321006","display_name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","ror":"https://ror.org/01pv73b02"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W88713093","https://openalex.org/W1543790510","https://openalex.org/W1871308790","https://openalex.org/W1946671908","https://openalex.org/W1970499331","https://openalex.org/W1986960592","https://openalex.org/W1996275708","https://openalex.org/W2011008013","https://openalex.org/W2021642581","https://openalex.org/W2024315050","https://openalex.org/W2025036947","https://openalex.org/W2029364244","https://openalex.org/W2030094610","https://openalex.org/W2044885178","https://openalex.org/W2059128083","https://openalex.org/W2060868916","https://openalex.org/W2064844509","https://openalex.org/W2080099034","https://openalex.org/W2087414776","https://openalex.org/W2088501009","https://openalex.org/W2093359612","https://openalex.org/W2095412415","https://openalex.org/W2097857976","https://openalex.org/W2113410381","https://openalex.org/W2116118767","https://openalex.org/W2121762276","https://openalex.org/W2126044151","https://openalex.org/W2128383701","https://openalex.org/W2140814172","https://openalex.org/W2141518860","https://openalex.org/W2171227711"],"related_works":["https://openalex.org/W2942564096","https://openalex.org/W2068175198","https://openalex.org/W2560658828","https://openalex.org/W1496075563","https://openalex.org/W2157166246","https://openalex.org/W2077405964","https://openalex.org/W1971820715","https://openalex.org/W1970499331","https://openalex.org/W2386525858","https://openalex.org/W1986960592"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}