{"id":"https://openalex.org/W2206410233","doi":"https://doi.org/10.1152/ajpcell.2000.279.3.c587","title":"Acute glucose-induced downregulation of PKC-\u03b2II accelerates cultured VSMC proliferation","display_name":"Acute glucose-induced downregulation of PKC-\u03b2II accelerates cultured VSMC proliferation","publication_year":2000,"publication_date":"2000-09-01","ids":{"openalex":"https://openalex.org/W2206410233","doi":"https://doi.org/10.1152/ajpcell.2000.279.3.c587","mag":"2206410233","pmid":"https://pubmed.ncbi.nlm.nih.gov/10942708"},"language":"en","primary_location":{"id":"doi:10.1152/ajpcell.2000.279.3.c587","doi":"https://doi.org/10.1152/ajpcell.2000.279.3.c587","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpcell.2000.279.3.c587","pdf_url":null,"source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014053586","display_name":"Mayumi Yamamoto","orcid":"https://orcid.org/0000-0002-5603-6825","observed_orcids":["https://orcid.org/0000-0002-5603-6825"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mayumi Yamamoto","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002044383","display_name":"Mildred E. Acevedo-Duncan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088910","display_name":"James A. Haley Veterans' Hospital","ror":"https://ror.org/006xyf785","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210088910","https://openalex.org/I4210119004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mildred Acevedo-Duncan","raw_affiliation_strings":["Research Service, J. A. Haley Veterans Hospital, Tampa, Florida 33612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Service, J. A. Haley Veterans Hospital, Tampa, Florida 33612","institution_ids":["https://openalex.org/I4210088910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009408265","display_name":"Charles Edward Chalfant","orcid":"https://orcid.org/0000-0002-5844-5235","observed_orcids":["https://orcid.org/0000-0002-5844-5235"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles E. Chalfant","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002759908","display_name":"Niketa A. Patel","orcid":"https://orcid.org/0000-0003-4811-8596","observed_orcids":["https://orcid.org/0000-0003-4811-8596"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Niketa A. Patel","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"James E. Watson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088910","display_name":"James A. Haley Veterans' Hospital","ror":"https://ror.org/006xyf785","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210088910","https://openalex.org/I4210119004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James E. Watson","raw_affiliation_strings":["Research Service, J. A. Haley Veterans Hospital, Tampa, Florida 33612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Service, J. A. Haley Veterans Hospital, Tampa, Florida 33612","institution_ids":["https://openalex.org/I4210088910"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022601205","display_name":"Denise R. Cooper","orcid":"https://orcid.org/0000-0001-5220-0192","observed_orcids":["https://orcid.org/0000-0001-5220-0192"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I4210088910","display_name":"James A. Haley Veterans' Hospital","ror":"https://ror.org/006xyf785","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210088910","https://openalex.org/I4210119004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denise R. Cooper","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology and","Department of Internal Medicine, University of South Florida, College of Medicine, and","Research Service, J. A. Haley Veterans Hospital, Tampa, Florida 33612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology and","institution_ids":[]},{"raw_affiliation_string":"Department of Internal Medicine, University of South Florida, College of Medicine, and","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"Research Service, J. A. Haley Veterans Hospital, Tampa, Florida 33612","institution_ids":["https://openalex.org/I4210088910"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.095,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.75225158,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"279","issue":"3","first_page":"C587","last_page":"C595"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cell-proliferation","display_name":"vascular smooth muscle cell proliferation","score":0.8199999928474426},{"id":"https://openalex.org/keywords/high-glucose","display_name":"high glucose","score":0.9369999766349792},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.7450000047683716},{"id":"https://openalex.org/keywords/cell-cycle-progression","display_name":"cell cycle progression","score":0.9010000228881836},{"id":"https://openalex.org/keywords/dna-synthesis","display_name":"DNA synthesis","score":0.8849999904632568},{"id":"https://openalex.org/keywords/aorta","display_name":"aorta","score":0.4059999883174896}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.8776376247406006},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.5615898370742798},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43136170506477356},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4162462055683136},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38687339425086975},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24243834614753723},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.21672123670578003},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12157440185546875},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07070446014404297}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010797","descriptor_name":"Phthalimides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013936","descriptor_name":"Thymidine","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D013936","descriptor_name":"Thymidine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016196","descriptor_name":"S Phase","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064546","descriptor_name":"Protein Kinase C beta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1152/ajpcell.2000.279.3.c587","doi":"https://doi.org/10.1152/ajpcell.2000.279.3.c587","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpcell.2000.279.3.c587","pdf_url":null,"source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},{"id":"pmid:10942708","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10942708","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Cell physiology","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.usf.edu:intmed_facpub-1205","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.usf.edu/intmed_facpub/217","pdf_url":null,"source":{"id":"https://openalex.org/S4377196272","display_name":"Digital Commons - University of South Florida (University of South Florida)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2613432","host_organization_name":"University of South Florida","host_organization_lineage":["https://openalex.org/I2613432"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Internal Medicine Faculty Publications","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1488755326","https://openalex.org/W1572814792","https://openalex.org/W1573000660","https://openalex.org/W1905490886","https://openalex.org/W1973331210","https://openalex.org/W1975499537","https://openalex.org/W1976005877","https://openalex.org/W1983330637","https://openalex.org/W1985395951","https://openalex.org/W1986947117","https://openalex.org/W1991959541","https://openalex.org/W1993282564","https://openalex.org/W2006012802","https://openalex.org/W2007319015","https://openalex.org/W2013660721","https://openalex.org/W2016756597","https://openalex.org/W2018028495","https://openalex.org/W2022643576","https://openalex.org/W2034156463","https://openalex.org/W2040816657","https://openalex.org/W2046028018","https://openalex.org/W2046694960","https://openalex.org/W2047691371","https://openalex.org/W2053332583","https://openalex.org/W2055168506","https://openalex.org/W2057960696","https://openalex.org/W2065086918","https://openalex.org/W2069863621","https://openalex.org/W2082110343","https://openalex.org/W2088695660","https://openalex.org/W2091508965","https://openalex.org/W2091851800","https://openalex.org/W2092717619","https://openalex.org/W2093071923","https://openalex.org/W2100837269","https://openalex.org/W2113452187","https://openalex.org/W2128300830","https://openalex.org/W2128635872","https://openalex.org/W2137570167","https://openalex.org/W2138899231","https://openalex.org/W2143480749","https://openalex.org/W2164627733","https://openalex.org/W2434541077"],"related_works":["https://openalex.org/W2253422667","https://openalex.org/W2019484475","https://openalex.org/W2120567861","https://openalex.org/W1488755326","https://openalex.org/W2171729741","https://openalex.org/W2434541077","https://openalex.org/W2099756365","https://openalex.org/W2921884957","https://openalex.org/W2088695660","https://openalex.org/W2095941907"],"abstract_inverted_index":{"Accelerated":[0],"vascular":[1],"smooth":[2],"muscle":[3],"cell":[4,74,101,127,188,202],"(VSMC)":[5],"proliferation":[6,75,102,197],"contributes":[7],"to":[8,23,57],"the":[9,52,118,134,149,181,193,201],"formation":[10],"of":[11,36,54,120,136,151,185,195,200],"atherosclerotic":[12],"lesions.":[13],"To":[14],"investigate":[15],"protein":[16,145,162],"kinase":[17],"C":[18],"(PKC)-betaII":[19],"functions":[20],"with":[21,51,77],"regard":[22],"glucose-induced":[24,100],"VSMC":[25,28,34,196],"proliferation,":[26],"human":[27],"from":[29],"aorta":[30,38],"(AoSMC),":[31],"a":[32],"clonal":[33],"line":[35],"rat":[37],"(A10),":[39],"and":[40,46,72,84,91,103,108,154,161,166],"A10":[41,85,109,121,167],"cells":[42,122,140],"overexpressing":[43],"PKC-betaI":[44],"(betaI-A10)":[45],"PKC-betaII":[47,95,144,159,186],"(betaII-A10)":[48],"were":[49],"studied":[50],"use":[53],"three":[55],"techniques":[56],"evaluate":[58],"glucose":[59,66,79,116,156,174],"effects":[60],"on":[61],"aspects":[62],"affecting":[63],"proliferation.":[64],"High":[65],"(25":[67],"mM)":[68,81],"increased":[69,117],"DNA":[70,104,152],"synthesis":[71,105],"accelerated":[73],"compared":[76],"normal":[78,182],"(5.5":[80],"in":[82,89,106,164,187,192],"AoSMC":[83,107,165],"cells,":[86],"but":[87,130],"not":[88,132],"betaI-A10":[90,137],"betaII-A10":[92,139],"cells.":[93,110,168],"The":[94],"specific":[96],"inhibitor":[97],"CGP-53353":[98],"inhibited":[99],"In":[111],"flow":[112],"cytometry":[113],"analysis,":[114],"high":[115,155,173],"percentage":[119,135],"at":[123],"12":[124],"h":[125],"after":[126],"cycle":[128,189],"initiation":[129],"did":[131],"increase":[133],"or":[138],"entering":[141],"S":[142],"phase.":[143],"levels":[146,163],"decreased":[147,158],"before":[148],"peak":[150],"synthesis,":[153],"further":[157],"mRNA":[160],"These":[169],"results":[170],"suggest":[171],"that":[172],"downregulates":[175],"endogenous":[176],"PKC-betaII,":[177],"which":[178],"then":[179],"alters":[180],"inhibitory":[183],"role":[184],"progression,":[190],"resulting":[191],"stimulation":[194],"through":[198],"acceleration":[199],"cycle.":[203]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
