{"id":"https://openalex.org/W2206139976","doi":"https://doi.org/10.1007/978-94-015-8070-0_80","title":"Macrophage activation by recombinant cytokines","display_name":"Macrophage activation by recombinant cytokines","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W2206139976","doi":"https://doi.org/10.1007/978-94-015-8070-0_80","mag":"2206139976"},"language":"en","primary_location":{"id":"doi:10.1007/978-94-015-8070-0_80","doi":"https://doi.org/10.1007/978-94-015-8070-0_80","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-94-015-8070-0_80","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mononuclear Phagocytes","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4245105474","display_name":"Mononuclear Phagocytes"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061911871","display_name":"Jan A. M. Langermans","orcid":"https://orcid.org/0000-0002-4806-4412","observed_orcids":["https://orcid.org/0000-0002-4806-4412"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J. A. M. Langermans","raw_affiliation_strings":["Department of Infectious Diseases, University Hospital Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, University Hospital Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062066729","display_name":"Peter H. Nibbering","orcid":"https://orcid.org/0000-0002-0432-8340","observed_orcids":["https://orcid.org/0000-0002-0432-8340"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"P. H. Nibbering","raw_affiliation_strings":["Department of Infectious Diseases, University Hospital Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, University Hospital Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063453092","display_name":"Mari\u00eblle E.B. van der Hulst","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"M. E. B. Van Der Hulst","raw_affiliation_strings":["Department of Infectious Diseases, University Hospital Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, University Hospital Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026846238","display_name":"Ralph van Furth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"R. Van Furth","raw_affiliation_strings":["Department of Infectious Diseases, University Hospital Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, University Hospital Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5026846238","https://openalex.org/A5062066729"],"corresponding_institution_ids":["https://openalex.org/I2800006345"],"apc_list":null,"apc_paid":null,"fwci":0.8551,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.79972184,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"602","last_page":"617"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.7074999809265137,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.7074999809265137,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.15880000591278076,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.02280000038444996,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macrophage-activation","display_name":"macrophage activation","score":1.0},{"id":"https://openalex.org/keywords/recombinant-cytokines","display_name":"recombinant cytokines","score":0.9929999709129333},{"id":"https://openalex.org/keywords/facultative-intracellular-pathogen","display_name":"facultative intracellular pathogen","score":0.9139999747276306},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8500000238418579},{"id":"https://openalex.org/keywords/reactive-nitrogen-intermediates","display_name":"reactive nitrogen intermediates","score":0.9929999709129333},{"id":"https://openalex.org/keywords/microbicidal-activity","display_name":"microbicidal activity","score":0.7979999780654907},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.7559999823570251},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.7429999709129333},{"id":"https://openalex.org/keywords/interleukins","display_name":"interleukins","score":0.6290000081062317},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.7559999823570251},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9520000219345093}],"concepts":[{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.7279632091522217},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.6695473790168762},{"id":"https://openalex.org/C7244527","wikidata":"https://www.wikidata.org/wiki/Q6725501","display_name":"Macrophage-activating factor","level":4,"score":0.6462720632553101},{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.6406200528144836},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.5288622975349426},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5081686973571777},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.500154972076416},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.49606022238731384},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4770297706127167},{"id":"https://openalex.org/C153726182","wikidata":"https://www.wikidata.org/wiki/Q3720909","display_name":"Intracellular parasite","level":3,"score":0.4484979808330536},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.43303972482681274},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.42717570066452026},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3851120173931122},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35368824005126953},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2245824635028839},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1391821801662445}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-94-015-8070-0_80","doi":"https://doi.org/10.1007/978-94-015-8070-0_80","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-94-015-8070-0_80","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mononuclear Phagocytes","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":83,"referenced_works":["https://openalex.org/W19572556","https://openalex.org/W174236543","https://openalex.org/W1488731849","https://openalex.org/W1492433545","https://openalex.org/W1505649902","https://openalex.org/W1508470956","https://openalex.org/W1510294526","https://openalex.org/W1516830966","https://openalex.org/W1530923508","https://openalex.org/W1537582746","https://openalex.org/W1540820582","https://openalex.org/W1558104450","https://openalex.org/W1566128266","https://openalex.org/W1574821943","https://openalex.org/W1584602588","https://openalex.org/W1587195158","https://openalex.org/W1591899727","https://openalex.org/W1592104297","https://openalex.org/W1606617874","https://openalex.org/W1777738472","https://openalex.org/W1879039980","https://openalex.org/W1903933791","https://openalex.org/W1921414939","https://openalex.org/W1929330671","https://openalex.org/W1934337364","https://openalex.org/W1946603093","https://openalex.org/W1957404430","https://openalex.org/W1968713831","https://openalex.org/W1968850794","https://openalex.org/W1985235031","https://openalex.org/W1986992784","https://openalex.org/W1990230871","https://openalex.org/W1994389040","https://openalex.org/W1997752389","https://openalex.org/W1998680279","https://openalex.org/W2003281598","https://openalex.org/W2003484888","https://openalex.org/W2015295078","https://openalex.org/W2017347652","https://openalex.org/W2018233688","https://openalex.org/W2018972324","https://openalex.org/W2022775599","https://openalex.org/W2024256058","https://openalex.org/W2033546635","https://openalex.org/W2040462750","https://openalex.org/W2046779553","https://openalex.org/W2054941139","https://openalex.org/W2057123987","https://openalex.org/W2057516079","https://openalex.org/W2061830662","https://openalex.org/W2067201373","https://openalex.org/W2073132923","https://openalex.org/W2077104885","https://openalex.org/W2080452611","https://openalex.org/W2081798138","https://openalex.org/W2086592423","https://openalex.org/W2100843497","https://openalex.org/W2101771134","https://openalex.org/W2111382822","https://openalex.org/W2112171196","https://openalex.org/W2113497740","https://openalex.org/W2115358950","https://openalex.org/W2116797822","https://openalex.org/W2117411464","https://openalex.org/W2117793283","https://openalex.org/W2118446850","https://openalex.org/W2130282385","https://openalex.org/W2140917849","https://openalex.org/W2148088522","https://openalex.org/W2151218951","https://openalex.org/W2153741820","https://openalex.org/W2155524302","https://openalex.org/W2165003244","https://openalex.org/W2171302182","https://openalex.org/W2171822696","https://openalex.org/W2191654227","https://openalex.org/W2235619063","https://openalex.org/W2321305299","https://openalex.org/W2399925067","https://openalex.org/W2411016700","https://openalex.org/W2418973482","https://openalex.org/W4285719527","https://openalex.org/W6605596141"],"related_works":["https://openalex.org/W1516622687","https://openalex.org/W1991414321","https://openalex.org/W4296370848","https://openalex.org/W2338222515","https://openalex.org/W763231270","https://openalex.org/W4237136827","https://openalex.org/W2415504776","https://openalex.org/W173450995","https://openalex.org/W2439117707","https://openalex.org/W7101009271"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2016-06-24T00:00:00"}