{"id":"https://openalex.org/W2204756702","doi":null,"title":"The role of HLA-A*02 and biomarkers in solid malignant tumours","display_name":"The role of HLA-A*02 and biomarkers in solid malignant tumours","publication_year":2015,"publication_date":"2015-10-19","ids":{"openalex":"https://openalex.org/W2204756702","mag":"2204756702"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/26914162","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/The_role_of_HLA-A_02_and_biomarkers_in_solid_malignant_tumours/26914162","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10616/44823","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073774276","display_name":"Emilia K. Andersson","orcid":"https://orcid.org/0000-0002-5772-112X","observed_orcids":["https://orcid.org/0000-0002-5772-112X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Emilia Andersson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5073774276"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.6371999979019165,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.6371999979019165,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.07810000330209732,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.038600001484155655,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hla-a-02","display_name":"HLA-A*02","score":0.9200000166893005},{"id":"https://openalex.org/keywords/hla-a-02-06","display_name":"HLA-A*02:06","score":0.6890000104904175},{"id":"https://openalex.org/keywords/serous-ovarian-cancer","display_name":"serous ovarian cancer","score":0.7919999957084656},{"id":"https://openalex.org/keywords/cutaneous-melanoma","display_name":"cutaneous melanoma","score":0.8769999742507935},{"id":"https://openalex.org/keywords/hla-b15","display_name":"HLA-B15","score":0.6620000004768372},{"id":"https://openalex.org/keywords/hla-drb1-04","display_name":"HLA-DRB1*04","score":0.8399999737739563},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7020000219345093},{"id":"https://openalex.org/keywords/mhc-class-i-expression","display_name":"MHC class I expression","score":0.7329999804496765},{"id":"https://openalex.org/keywords/beta2-microglobulin","display_name":"beta2-microglobulin","score":0.8730000257492065},{"id":"https://openalex.org/keywords/hla-g","display_name":"HLA-G","score":0.6859999895095825},{"id":"https://openalex.org/keywords/hla-e","display_name":"HLA-E","score":0.9819999933242798},{"id":"https://openalex.org/keywords/tumor-immune-evasion","display_name":"tumor immune evasion","score":0.7870000004768372},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.3799999952316284}],"concepts":[{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.4962306618690491},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4262917637825012},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4137091636657715},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3679251968860626},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.30393171310424805},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2814466953277588},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.08953550457954407}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/26914162","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/The_role_of_HLA-A_02_and_biomarkers_in_solid_malignant_tumours/26914162","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:openarchive.ki.se:10616/44823","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/44823","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2204756702","doi":null,"is_oa":false,"landing_page_url":"https://openarchive.ki.se/xmlui/bitstream/handle/10616/44823/Thesis_Emilia_Andersson.pdf;sequence=3","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:openarchive.ki.se:10616/44823","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/44823","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":89,"referenced_works":["https://openalex.org/W74857381","https://openalex.org/W430085733","https://openalex.org/W1429913920","https://openalex.org/W1561153455","https://openalex.org/W1571612306","https://openalex.org/W1572743872","https://openalex.org/W1832375081","https://openalex.org/W1958095124","https://openalex.org/W1964653209","https://openalex.org/W1967041353","https://openalex.org/W1967954493","https://openalex.org/W1968550069","https://openalex.org/W1970096724","https://openalex.org/W1972708834","https://openalex.org/W1974756790","https://openalex.org/W1976681938","https://openalex.org/W1981505729","https://openalex.org/W1982086114","https://openalex.org/W1984162437","https://openalex.org/W1985774274","https://openalex.org/W1988219173","https://openalex.org/W1992248540","https://openalex.org/W1994993231","https://openalex.org/W1998240361","https://openalex.org/W1999924804","https://openalex.org/W2000939924","https://openalex.org/W2005062591","https://openalex.org/W2011639909","https://openalex.org/W2015866509","https://openalex.org/W2029175700","https://openalex.org/W2032181922","https://openalex.org/W2032233271","https://openalex.org/W2032492606","https://openalex.org/W2034804331","https://openalex.org/W2035619667","https://openalex.org/W2038781914","https://openalex.org/W2039266996","https://openalex.org/W2039339794","https://openalex.org/W2043904711","https://openalex.org/W2044835625","https://openalex.org/W2047418972","https://openalex.org/W2047627836","https://openalex.org/W2052313621","https://openalex.org/W2055375399","https://openalex.org/W2056828169","https://openalex.org/W2056872894","https://openalex.org/W2056967793","https://openalex.org/W2057024445","https://openalex.org/W2057619131","https://openalex.org/W2064882706","https://openalex.org/W2065465102","https://openalex.org/W2067777120","https://openalex.org/W2070855360","https://openalex.org/W2072912490","https://openalex.org/W2075800386","https://openalex.org/W2088779353","https://openalex.org/W2088899370","https://openalex.org/W2090317322","https://openalex.org/W2090887099","https://openalex.org/W2095529707","https://openalex.org/W2098677755","https://openalex.org/W2099657841","https://openalex.org/W2099794762","https://openalex.org/W2100279258","https://openalex.org/W2102537478","https://openalex.org/W2103333248","https://openalex.org/W2103558694","https://openalex.org/W2112525546","https://openalex.org/W2115521843","https://openalex.org/W2135086805","https://openalex.org/W2136388877","https://openalex.org/W2138497734","https://openalex.org/W2139898172","https://openalex.org/W2142168740","https://openalex.org/W2142300779","https://openalex.org/W2142940604","https://openalex.org/W2150633526","https://openalex.org/W2152014155","https://openalex.org/W2153659006","https://openalex.org/W2159803625","https://openalex.org/W2168234885","https://openalex.org/W2170137783","https://openalex.org/W2172076789","https://openalex.org/W2187216524","https://openalex.org/W2188167204","https://openalex.org/W2259178548","https://openalex.org/W2402614542","https://openalex.org/W2415190756","https://openalex.org/W2766751225"],"related_works":["https://openalex.org/W2288481234","https://openalex.org/W1988656658","https://openalex.org/W2214918248","https://openalex.org/W2079739619","https://openalex.org/W2167698933","https://openalex.org/W2255055969","https://openalex.org/W2255550817","https://openalex.org/W1980094840","https://openalex.org/W1967041353","https://openalex.org/W2412337571"],"abstract_inverted_index":{"HLA-A*02":[0,16,64,120,197,223,356,366,549],"genotype":[1,121,357,550],"generates":[2],"significantly":[3,202,277,286],"worse":[4],"outcome":[5],"in":[6,19,30,36,105,124,205,224,249,304,341,348,353,360,455,513,596],"patients":[7,106,156,206,225,253,290,354,459,514],"with":[8,41,107,200,207,226,254,291,355,460,515,557,602],"metastatic":[9,208],"serous":[10,69,211,597],"ovarian":[11,66,108,212,228,463,562,598],"cancer":[12,67,148,269],"and":[13,45,71,99,110,122,137,143,152,184,271,336,358,392,442,453,497,543,551,588,609],"malignant":[14,112,167,215,255,517],"melanoma.":[15,113,216,256,518],"is":[17,54,173,179,198,218,276,285],"common":[18,502],"the":[20,37,43,46,57,92,97,117,161,170,182,185,234,250,272,282,298,361,368,397,558,603],"Swedish":[21],"population":[22],"(about":[23],"60":[24],"%),":[25],"but":[26,351],"has":[27,75,163,329],"decreasing":[28],"frequency":[29,98,452],"European":[31],"countries":[32],"further":[33],"south.":[34],"Mortality":[35],"aforementioned":[38],"tumours":[39,209],"correlates":[40],"both":[42],"latitude":[44],"corresponding":[47],"HLA-A":[48],"*":[49],"02":[50],"frequency.":[51],"This":[52,80,244,405],"thesis":[53,93],"based":[55],"on":[56,169,181],"original":[58],"findings":[59,345],"that":[60,196,297,385],"a":[61,201,219,231,309,378,386,456],"combination":[62,81],"of":[63,68,82,91,101,132,155,210,222,233,252,318,322,327,403,415,447,458,548,560],"genotype,":[65],"histology":[70],"advanced":[72,227,461,516],"surgical":[73,375],"stage":[74,376,462],"an":[76,264],"extremely":[77],"dismal":[78],"prognosis.":[79,610],"factors":[83],"was":[84,94,242,246,367],"named":[85],"\u201cworst":[86],"prognosis":[87,123,340,559],"group\u201d.":[88],"The":[89,191,257,294,501],"aim":[90],"to":[95,262,274,289,338,410],"elucidate":[96],"distribution":[100],"different":[102],"HLA":[103,448,552],"genotypes":[104],"carcinoma":[109,213,599],"cutaneous":[111],"We":[114],"then":[115],"investigated":[116],"correlation":[118,601],"between":[119],"these":[125],"tumour":[126,162,333,390,605],"diseases":[127],"as":[128,130,332,394,396,510],"well":[129,395],"expression":[131,326,595],"immunological":[133,311],"biomarkers":[134,393],"for":[135],"classical":[136],"non-classical":[138],"MHC":[139,319],"class":[140,449,553],"I,":[141],"\u03b22-mikroglobulin":[142],"infiltrating":[144,606],"immune":[145,305,607],"cells.":[146],"Ovarian":[147],"symptoms":[149],"are":[150,157],"discrete":[151],"about":[153],"75%":[154],"detected":[158],"late,":[159],"when":[160],"already":[164],"spread.":[165],"Cutaneous":[166],"melanoma":[168],"other":[171,292,342],"hand,":[172],"often":[174],"discovered":[175],"early":[176],"since":[177],"it":[178],"visible":[180],"skin":[183],"disease":[186,283],"progression":[187,284],"more":[188],"easily":[189],"recorded.":[190],"studies":[192],"confirmed":[193,347],"previous":[194],"finding":[195],"associated":[199],"shortened":[203],"survival":[204],"or":[214,320,324],"There":[217],"high":[220],"over-representation":[221],"carcinoma.":[229],"Especially":[230],"segregation":[232,454],"ancestral":[235,258,507],"haplotype":[236,245,259,451,508],"62.1":[237,260,300,509],"(HLAA*02,":[238],"-B*15,":[239],"-Cw*3,":[240],"-DRB1*04)":[241],"identified.":[243],"also":[247],"present":[248],"group":[251],"seems":[261],"give":[263],"initial":[265],"enhanced":[266],"protection":[267],"against":[268],"cells":[270,608],"time":[273],"recurrence":[275],"extended.":[278],"After":[279],"metastases,":[280],"however,":[281],"shorter":[287],"compared":[288],"haplotypes.":[293],"results":[295,383],"indicate":[296],"AHH":[299],"might":[301],"be":[302],"involved":[303],"selection,":[306],"possibly":[307],"through":[308],"specific":[310],"mechanism":[312],"called":[313],"\"eliminationequilibrium-escape\"":[314],"mechanism.":[315],"Down-":[316],"regulation":[317],"up-regulation":[321],"HLA-G":[323],"aberrant":[325],"HLA\u2013E":[328],"been":[330],"described":[331],"escape":[334],"mechanisms":[335],"linked":[337],"poor":[339],"studies.":[343],"These":[344],"were":[346],"our":[349],"cohorts,":[350],"only":[352,374],"not":[359],"others.":[362],"In":[363],"multivariate":[364],"analysis":[365],"second":[369],"most":[370],"important":[371],"prognostic":[372,511],"factor,":[373],"had":[377],"higher":[379],"hazard":[380],"ratio.":[381],"Our":[382],"demonstrate":[384],"multifactorial":[387],"approach,":[388],"considering":[389],"characteristics":[391],"patient's":[398],"genetics,":[399],"can":[400],"outline":[401],"subgroups":[402],"patients.":[404],"may":[406],"provide":[407],"improved":[408],"opportunities":[409],"tailor":[411],"targeted":[412],"therapies.":[413],"List":[414],"scientific":[416],"papers":[417],"I.":[418,576],"Gamzatova,":[419],"Z.":[420],"Villabona,":[421,476,530,577],"L.":[422,437,477,479,531,578],"van":[423,480],"der":[424,481],"Zanden,":[425,482],"H.":[426,473,483],"Haasnoot,":[427,484],"G":[428,444,485,499,545,590],"W.":[429,486,536,581],"Andersson,":[430,474,528,573],"E.":[431,475,529],"Kiessling,":[432,495,539,584],"R.":[433,540,585],"Seliger,":[434,487,541,586],"B.":[435,488,494],"Kanter,":[436,478],"Dalianis,":[438],"T.":[439],"Bergfeldt,":[440,489,532],"K":[441],"Masucci,":[443,498,544,589],"V.":[445,500,546,591],"Analysis":[446],"I-II":[450],"cohort":[457],"cancer.":[464,563],"Tissue":[465],"Antigens.":[466],"2007":[467],"Sep;70(3):":[468],"205-13.":[469],"https://doi.org/10.1111/j.1399-0039.2007.00875.x":[470],"II.":[471],"Helgadottir,":[472],"K.":[490,533],"Hansson,":[491],"J.":[492],"Ragnarsson-Olding,":[493],"R":[496],"Scandinavian":[503],"human":[504],"leucocyte":[505],"antigen":[506,555],"factor":[512],"Cancer":[519,564],"Immunol":[520,565],"Immunother":[521],"2009":[522],"Oct;":[523],"58(10):":[524],"1599-608.":[525],"https://doi.org/10.1007/s00262-009-0669-8":[526],"III.":[527],"Carlson,":[534,579],"J":[535,580],"Ferrone,":[537],"S.":[538],"B":[542,587],"Correlation":[547],"I":[554,594],"downregulation":[556],"epithelial":[561],"Immunother.":[566],"2012":[567],"Aug;":[568],"61(8):":[569],"1243-53.":[570],"https://doi.org/10.1007/s00262-012-1201-0":[571],"IV.":[572],"E,":[574],"Poschke,":[575],"Lundqvist,":[582],"A.":[583],"Non-classical":[592],"HLA-class":[593],":":[600],"HLA-genotype,":[604],"Oncoimmunology":[611],"2015":[612],"sept.":[613],"https://doi.org/10.1080/2162402X.2015.1052213":[614]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2016-06-24T00:00:00"}
