{"id":"https://openalex.org/W2204733539","doi":"https://doi.org/10.1128/iai.00857-15","title":"The Mga Regulon but Not Deoxyribonuclease Sda1 of Invasive M1T1 Group A Streptococcus Contributes to In Vivo Selection of CovRS Mutations and Resistance to Innate Immune Killing Mechanisms","display_name":"The Mga Regulon but Not Deoxyribonuclease Sda1 of Invasive M1T1 Group A Streptococcus Contributes to In Vivo Selection of CovRS Mutations and Resistance to Innate Immune Killing Mechanisms","publication_year":2015,"publication_date":"2015-08-18","ids":{"openalex":"https://openalex.org/W2204733539","doi":"https://doi.org/10.1128/iai.00857-15","mag":"2204733539","pmid":"https://pubmed.ncbi.nlm.nih.gov/26283338","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4598402"},"language":"en","primary_location":{"id":"doi:10.1128/iai.00857-15","doi":"https://doi.org/10.1128/iai.00857-15","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.00857-15","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4598402","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Guanghui Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I23732399","display_name":"Montana State University","ror":"https://ror.org/02w0trx84","country_code":"US","type":"education","lineage":["https://openalex.org/I23732399","https://openalex.org/I4210126032"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guanghui Liu","raw_affiliation_strings":["Department of Microbiology and Immunology, Montana State University, Bozeman, Montana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Montana State University, Bozeman, Montana, USA","institution_ids":["https://openalex.org/I23732399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058130997","display_name":"Wenchao Feng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I23732399","display_name":"Montana State University","ror":"https://ror.org/02w0trx84","country_code":"US","type":"education","lineage":["https://openalex.org/I23732399","https://openalex.org/I4210126032"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenchao Feng","raw_affiliation_strings":["Department of Microbiology and Immunology, Montana State University, Bozeman, Montana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Montana State University, Bozeman, Montana, USA","institution_ids":["https://openalex.org/I23732399"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Dengfeng Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I23732399","display_name":"Montana State University","ror":"https://ror.org/02w0trx84","country_code":"US","type":"education","lineage":["https://openalex.org/I23732399","https://openalex.org/I4210126032"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dengfeng Li","raw_affiliation_strings":["Department of Microbiology and Immunology, Montana State University, Bozeman, Montana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Montana State University, Bozeman, Montana, USA","institution_ids":["https://openalex.org/I23732399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072421280","display_name":"Mengyao Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I23732399","display_name":"Montana State University","ror":"https://ror.org/02w0trx84","country_code":"US","type":"education","lineage":["https://openalex.org/I23732399","https://openalex.org/I4210126032"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mengyao Liu","raw_affiliation_strings":["Department of Microbiology and Immunology, Montana State University, Bozeman, Montana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Montana State University, Bozeman, Montana, USA","institution_ids":["https://openalex.org/I23732399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075146072","display_name":"Daniel C Nelson","orcid":"https://orcid.org/0000-0003-3248-4831","observed_orcids":["https://orcid.org/0000-0003-3248-4831"]},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel C. Nelson","raw_affiliation_strings":["Department of Veterinary Medicine, University of Maryland, College Park, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Medicine, University of Maryland, College Park, Maryland, USA","institution_ids":["https://openalex.org/I66946132"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003712486","display_name":"Benfang Lei","orcid":"https://orcid.org/0000-0001-8133-6021","observed_orcids":["https://orcid.org/0000-0001-8133-6021"]},"institutions":[{"id":"https://openalex.org/I23732399","display_name":"Montana State University","ror":"https://ror.org/02w0trx84","country_code":"US","type":"education","lineage":["https://openalex.org/I23732399","https://openalex.org/I4210126032"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benfang Lei","raw_affiliation_strings":["Department of Microbiology and Immunology, Montana State University, Bozeman, Montana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Montana State University, Bozeman, Montana, USA","institution_ids":["https://openalex.org/I23732399"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.939,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.90713773,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"83","issue":"11","first_page":"4293","last_page":"4303"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11153","display_name":"Streptococcal Infections and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11153","display_name":"Streptococcal Infections and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/invasive-group-a-streptococcus","display_name":"invasive group A Streptococcus","score":0.8569999933242798},{"id":"https://openalex.org/keywords/innate-immune-evasion","display_name":"innate immune evasion","score":0.9150000214576721},{"id":"https://openalex.org/keywords/neutrophil-killing","display_name":"neutrophil killing","score":0.8510000109672546},{"id":"https://openalex.org/keywords/m-protein","display_name":"M protein","score":0.8379999995231628},{"id":"https://openalex.org/keywords/in-vivo-selection","display_name":"in vivo selection","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.873492956161499},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.7627257108688354},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6406402587890625},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.634458601474762},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5268810391426086},{"id":"https://openalex.org/C2779306812","wikidata":"https://www.wikidata.org/wiki/Q131271","display_name":"Streptococcus pyogenes","level":4,"score":0.511363685131073},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.48755091428756714},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4614082872867584},{"id":"https://openalex.org/C62361671","wikidata":"https://www.wikidata.org/wiki/Q1754612","display_name":"Regulon","level":4,"score":0.43466681241989136},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4050506353378296},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3245478868484497},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.07673701643943787},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000071677","descriptor_name":"Histidine Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003850","descriptor_name":"Deoxyribonuclease I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003850","descriptor_name":"Deoxyribonuclease I","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013290","descriptor_name":"Streptococcal Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013290","descriptor_name":"Streptococcal Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D013297","descriptor_name":"Streptococcus pyogenes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D013297","descriptor_name":"Streptococcus pyogenes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013297","descriptor_name":"Streptococcus pyogenes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018085","descriptor_name":"Regulon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057131","descriptor_name":"Immune Evasion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/iai.00857-15","doi":"https://doi.org/10.1128/iai.00857-15","is_oa":false,"landing_page_url":"https://doi.org/10.1128/iai.00857-15","pdf_url":null,"source":{"id":"https://openalex.org/S128227336","display_name":"Infection and Immunity","issn_l":"0019-9567","issn":["0019-9567","1070-6313","1098-5522"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and Immunity","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4598402","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4598402","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Immun","raw_type":"Text"},{"id":"pmid:26283338","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26283338","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection and immunity","raw_type":"Journal Article"},{"id":"mag:2345167898","doi":null,"is_oa":false,"landing_page_url":"https://iai.asm.org/content/early/2015/08/11/IAI.00857-15.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4598402","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4598402","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Immun","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2708906738","display_name":"Evasion of Innate Immunity by Group A Streptococcus","funder_award_id":"R01AI095704","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5020291780","display_name":null,"funder_award_id":"AI095704","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6576428760","display_name":null,"funder_award_id":"AI097703","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G77711611","display_name":null,"funder_award_id":"GM110732","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7838063001","display_name":"Center for Zoonotic and Emerging Infectious Diseases","funder_award_id":"P30GM110732","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G824910568","display_name":"Vaccine and therapeutic antibodies against Group A Streptococcus","funder_award_id":"R21AI097703","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W565221436","https://openalex.org/W1838468050","https://openalex.org/W1890443126","https://openalex.org/W1893024407","https://openalex.org/W1905556451","https://openalex.org/W1987064224","https://openalex.org/W1989769331","https://openalex.org/W1990201591","https://openalex.org/W1993904162","https://openalex.org/W1998384572","https://openalex.org/W2000125928","https://openalex.org/W2001129735","https://openalex.org/W2007843084","https://openalex.org/W2025828314","https://openalex.org/W2040930422","https://openalex.org/W2044905225","https://openalex.org/W2050638908","https://openalex.org/W2059311311","https://openalex.org/W2102732900","https://openalex.org/W2105825563","https://openalex.org/W2105931927","https://openalex.org/W2108166850","https://openalex.org/W2110246931","https://openalex.org/W2111307900","https://openalex.org/W2113737724","https://openalex.org/W2115827828","https://openalex.org/W2116235763","https://openalex.org/W2116757040","https://openalex.org/W2118396872","https://openalex.org/W2118727338","https://openalex.org/W2123321761","https://openalex.org/W2125128437","https://openalex.org/W2129234138","https://openalex.org/W2138202341","https://openalex.org/W2140385029","https://openalex.org/W2144655743","https://openalex.org/W2145584096","https://openalex.org/W2145618406","https://openalex.org/W2149667990","https://openalex.org/W2152262950","https://openalex.org/W2154819732","https://openalex.org/W2158483627","https://openalex.org/W2159439456","https://openalex.org/W2161619131","https://openalex.org/W2163402349","https://openalex.org/W2171780167","https://openalex.org/W2955504961"],"related_works":["https://openalex.org/W2111307900","https://openalex.org/W2161619131","https://openalex.org/W7096636064","https://openalex.org/W4243150962","https://openalex.org/W2093356046","https://openalex.org/W1602833056","https://openalex.org/W2113737724","https://openalex.org/W2066416534","https://openalex.org/W2163402349","https://openalex.org/W2164248975"],"abstract_inverted_index":{"Invasive":[0],"M1T1":[1,38,66,110,214,240,254],"group":[2],"A":[3],"Streptococcus":[4],"(GAS)":[5],"can":[6,18],"have":[7],"a":[8,182],"mutation":[9,17,185],"in":[10,71,78,90,97,109,126,130,152,157,166,186,191,199,209,236],"the":[11,30,45,57,63,86,91,158,161,235,247,250],"regulatory":[12],"system":[13],"CovRS,":[14],"and":[15,74,96,137,154,172,181,189,217,229],"this":[16],"render":[19],"strains":[20],"hypervirulent.":[21],"Interestingly,":[22],"via":[23],"mechanisms":[24],"that":[25,56],"are":[26],"not":[27,114,206],"well":[28],"understood,":[29],"host":[31],"innate":[32,99,221],"immune":[33,50,100,222],"system's":[34],"neutrophils":[35],"select":[36],"spontaneous":[37,183],"GAS":[39,98,218,241,255],"CovRS":[40,82,94,118,150,170,195,215,242],"hypervirulent":[41],"mutants,":[42,196],"thereby":[43],"enhancing":[44],"pathogen's":[46],"ability":[47],"to":[48,69,175,201,220,234],"evade":[49],"killing.":[51,176],"It":[52],"has":[53],"been":[54],"reported":[55],"DNase":[58,107],"Sda1":[59,89,204],"is":[60,205],"critical":[61,207],"for":[62,77,194,208],"resistance":[64,219],"of":[65,81,88,93,103,117,124,169,179,212,239,249,252],"strain":[67,111,127,148,164],"5448":[68,128,146,162],"killing":[70,156,223],"human":[72],"blood":[73],"provides":[75],"pressure":[76],"vivo":[79,153,167,192,210,237],"selection":[80,92,168,193,211,238],"mutations.":[83],"We":[84],"reexamined":[85],"role":[87],"mutations":[95,151,171],"evasion.":[101],"Deletion":[102,123],"sda1":[104,125],"or":[105],"all":[106],"genes":[108],"MGAS2221":[112,187],"did":[113],"alter":[115],"emergence":[116],"mutants":[119,132,216],"during":[120],"murine":[121],"infection.":[122],"resulted":[129],"\u0394sda1":[131],"with":[133],"(5448":[134,139],"\u0394sda1(M+)":[135,147],"strain)":[136,141],"without":[138],"\u0394sda1(M-)":[140,163],"M":[142,227],"protein":[143,228],"production.":[144],"The":[145,177],"accumulated":[149],"resisted":[155],"bloodstream,":[159],"whereas":[160],"lost":[165],"was":[173],"sensitive":[174],"deletion":[178],"emm":[180],"Mga":[184],"reduced":[188],"prevented":[190],"respectively.":[197],"Thus,":[198],"contrast":[200],"previous":[202],"reports,":[203],"invasive":[213,253],"mechanisms.":[224],"In":[225],"contrast,":[226],"other":[230],"Mga-regulated":[231],"proteins":[232],"contribute":[233],"mutants.":[243],"These":[244],"findings":[245],"advance":[246],"understanding":[248],"progression":[251],"infections.":[256]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}