{"id":"https://openalex.org/W2204707461","doi":"https://doi.org/10.1161/hyp.66.suppl_1.001","title":"Abstract 001: Mutation in the PPAR\u03b3 Ligand Binding Domain Impairs the Anti-inflammatory Action of PPAR\u03b3","display_name":"Abstract 001: Mutation in the PPAR\u03b3 Ligand Binding Domain Impairs the Anti-inflammatory Action of PPAR\u03b3","publication_year":2015,"publication_date":"2015-09-01","ids":{"openalex":"https://openalex.org/W2204707461","doi":"https://doi.org/10.1161/hyp.66.suppl_1.001","mag":"2204707461"},"language":"en","primary_location":{"id":"doi:10.1161/hyp.66.suppl_1.001","doi":"https://doi.org/10.1161/hyp.66.suppl_1.001","is_oa":false,"landing_page_url":"https://doi.org/10.1161/hyp.66.suppl_1.001","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026836502","display_name":"Masashi Mukohda","orcid":"https://orcid.org/0000-0003-1774-4156","observed_orcids":["https://orcid.org/0000-0003-1774-4156"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masashi Mukohda","raw_affiliation_strings":["Univ of Iowa Carver College of Medicine, Iowa City, IA","Masashi Mukohda"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Iowa Carver College of Medicine, Iowa City, IA","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Masashi Mukohda","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055284798","display_name":"Pimonrat Ketsawatsomkron","orcid":"https://orcid.org/0000-0002-3332-1615","observed_orcids":["https://orcid.org/0000-0002-3332-1615"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pimonrat Ketsawatsomkron","raw_affiliation_strings":["Univ of Iowa Carver College of Medicine, Iowa City, IA","Pimonrat Ketsawatsomkron"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Iowa Carver College of Medicine, Iowa City, IA","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Pimonrat Ketsawatsomkron","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038236518","display_name":"Madeliene Stump","orcid":"https://orcid.org/0000-0002-2505-5994","observed_orcids":["https://orcid.org/0000-0002-2505-5994"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Madeliene Stump","raw_affiliation_strings":["Univ of Iowa Carver College of Medicine, Iowa City, IA","Madeliene Stump"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Iowa Carver College of Medicine, Iowa City, IA","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Madeliene Stump","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085327021","display_name":"Frederick W. Quelle","orcid":"https://orcid.org/0000-0002-1184-6170","observed_orcids":["https://orcid.org/0000-0002-1184-6170"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederick W Quelle","raw_affiliation_strings":["Univ of Iowa Carver College of Medicine, Iowa City, IA","Frederick W Quelle"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Iowa Carver College of Medicine, Iowa City, IA","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Frederick W Quelle","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022804707","display_name":"Curt D. Sigmund","orcid":"https://orcid.org/0000-0002-1453-0921","observed_orcids":["https://orcid.org/0000-0002-1453-0921"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Curt D Sigmund","raw_affiliation_strings":["Univ of Iowa Carver College of Medicine, Iowa City, IA","Curt D Sigmund"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ of Iowa Carver College of Medicine, Iowa City, IA","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Curt D Sigmund","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I126307644"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"66","issue":"suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12975","display_name":"Paraoxonase enzyme and polymorphisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":0.9710000157356262},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.7860000133514404},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.9309999942779541},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.8709999918937683},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7710000276565552},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9589999914169312},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.8849999904632568},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.9589999914169312},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9459999799728394},{"id":"https://openalex.org/keywords/ap2","display_name":"AP-2","score":0.6510000228881836},{"id":"https://openalex.org/keywords/anti-inflammatory-signaling","display_name":"anti-inflammatory signaling","score":0.5339999794960022},{"id":"https://openalex.org/keywords/aorta","display_name":"aorta","score":0.5540000200271606},{"id":"https://openalex.org/keywords/carotid-artery","display_name":"carotid artery","score":0.9940000176429749}],"concepts":[{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.705524742603302},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5757536292076111},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5662907361984253},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5464760065078735},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5163208842277527},{"id":"https://openalex.org/C125929170","wikidata":"https://www.wikidata.org/wiki/Q908966","display_name":"Cre recombinase","level":5,"score":0.5132672786712646},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.49063220620155334},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4717227816581726},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4413449764251709},{"id":"https://openalex.org/C123298856","wikidata":"https://www.wikidata.org/wiki/Q15317427","display_name":"NFKB1","level":4,"score":0.44097819924354553},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.43881526589393616},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.43820640444755554},{"id":"https://openalex.org/C2775997469","wikidata":"https://www.wikidata.org/wiki/Q18029196","display_name":"MMP9","level":4,"score":0.4323166310787201},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.42903757095336914},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.26603764295578003},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.20917737483978271},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18785125017166138},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16990229487419128},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14665919542312622},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07331269979476929}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/hyp.66.suppl_1.001","doi":"https://doi.org/10.1161/hyp.66.suppl_1.001","is_oa":false,"landing_page_url":"https://doi.org/10.1161/hyp.66.suppl_1.001","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4389027485","https://openalex.org/W2607794899","https://openalex.org/W2616846388","https://openalex.org/W1549534253","https://openalex.org/W2349804144","https://openalex.org/W2274265577","https://openalex.org/W2093087068","https://openalex.org/W2091917316","https://openalex.org/W3175809597","https://openalex.org/W3089417505"],"abstract_inverted_index":{"Peroxisome":[0],"proliferator-activated":[1],"receptor":[2],"gamma":[3],"(PPAR\u03b3)":[4],"has":[5,317],"been":[6],"proposed":[7],"to":[8,18,75,104,111,165,188,239,255,300,310],"antagonize":[9],"the":[10,39,144,257,283,306],"activities":[11],"of":[12,143,163,217,305,323],"nuclear":[13],"factor":[14],"kappa":[15],"B":[16],"(NF\u03baB)":[17],"regulate":[19],"inflammation.":[20],"Transgenic":[21],"mice":[22,62,203,212,237,241],"expressing":[23,77,204,213],"dominant":[24],"negative":[25],"(DN)":[26],"PPAR\u03b3":[27,47,71,80,145,206,278,289],"specifically":[28,207],"in":[29,51,73,84,108,120,124,136,148,155,175,184,198,208,230,274],"vascular":[30],"smooth":[31],"muscle":[32],"cells":[33],"(SMC)":[34],"exhibited":[35],"exacerbated":[36],"atherosclerosis":[37],"but":[38,150,282],"mechanism":[40,258],"remains":[41],"unknown.":[42],"We":[43,313],"hypothesized":[44],"that":[45,63,303,315],"DN":[46,70,263],"promotes":[48],"NF\u03baB-induced":[49],"inflammation":[50],"SMC.":[52],"To":[53,195],"test":[54],"this,":[55],"we":[56,200,265],"cultured":[57],"mesenteric":[58],"SMCs":[59],"from":[60,235],"transgenic":[61,202],"would":[64],"conditionally":[65],"express":[66],"wild-type":[67],"(WT)":[68],"or":[69,173],"(P467L)":[72],"response":[74],"adenovirus":[76],"Cre-recombinase":[78],"(AdCRE).":[79],"expression":[81,103,116,170,180],"remained":[82],"silent":[83],"control":[85,216,240],"SMC":[86,209],"infected":[87,157],"with":[88,158,211,269,280],"AdGFP.":[89],"TNF-\u03b1":[90,164,221],"(0.05":[91],"ng/ml,":[92,223],"6":[93],"hr)":[94],"induced":[95,118,153],"NF\u03baB":[96,128,167,226,324],"target":[97,146,168],"gene":[98,169],"(MCP-1,":[99],"iNOS":[100],"and":[101,178,232,287],"MMP9)":[102],"a":[105,218],"greater":[106],"extent":[107],"P467L-Cre":[109,121],"compared":[110,187,238],"P467L-GFP.":[112],"For":[113],"example,":[114],"MMP9":[115],"was":[117,133,140,152,171,181,228,290],"6.3\u00b10.2-fold":[119],"vs":[122,192,251],"3.2\u00b10.5-fold":[123],"P467L-GFP":[125],"(p<0.01).":[126],"The":[127,161],"subunit,":[129],"p65,":[130,281,301],"mRNA":[131],"level":[132],"not":[134],"altered":[135],"these":[137],"cells.":[138,276],"There":[139],"no":[141],"induction":[142],"aP2":[147],"P467L-Cre,":[149],"it":[151],"6.5\u00b11.7-fold":[154],"WT-SMC":[156],"AdCRE":[159],"(WT-Cre).":[160],"ability":[162,307],"induce":[166],"blunted":[172],"abrogated":[174],"WT-Cre":[176,186],"cells,":[177],"their":[179],"significantly":[182],"reduced":[183],"TNF-\u03b1-treated":[185],"WT-GFP":[189],"(MMP9:":[190],"0.7\u00b11.2":[191],"6.0\u00b10.3,":[193],"p<0.01).":[194,253],"examine":[196],"mechanisms":[197],"vivo,":[199],"crossbred":[201],"WT":[205,277],"(S-WT)":[210],"luciferase":[214],"under":[215],"NF\u03baB-responsive":[219],"promoter.":[220],"(500":[222],"24":[224],"hr)-induced":[225],"activity":[227,261],"decreased":[229],"aorta":[231],"carotid":[233,248],"artery":[234],"S-WT":[236],"(aorta:":[242],"4.7\u00b11.1":[243],"v":[244],"s":[245],"6.7\u00b10.7,":[246],"p<0.05,":[247],"artery:":[249],"4.0\u00b10.6":[250],"8.7\u00b11.2,":[252],"Finally,":[254],"assess":[256],"preventing":[259],"anti-inflammatory":[260,318],"by":[262,329],"PPAR\u03b3,":[264],"assessed":[266],"its":[267],"interaction":[268,284],"p65":[270,286],"protein":[271],"when":[272],"co-expressed":[273],"HEK293T":[275],"co-precipitated":[279],"between":[285],"P467L":[288,311,330],"severely":[291],"impaired":[292],"(n=6).":[293],"Other":[294],"mutants":[295],"(R165T,":[296],"V290M)":[297],"could":[298],"bind":[299],"suggesting":[302],"loss":[304],"is":[308,327],"specific":[309],"PPAR\u03b3.":[312],"conclude":[314],"SMC-PPAR\u03b3":[316],"effects":[319],"mediated":[320],"through":[321],"inhibition":[322],"activity,":[325],"which":[326],"abolished":[328],"mutation.":[331]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}
