{"id":"https://openalex.org/W2203979020","doi":null,"title":"RNA recognition: Controlling RNA-protein complexes with small molecules","display_name":"RNA recognition: Controlling RNA-protein complexes with small molecules","publication_year":2010,"publication_date":"2010-05-14","ids":{"openalex":"https://openalex.org/W2203979020","mag":"2203979020"},"language":"en","primary_location":{"id":"pmh:oai:www.ideals.illinois.edu:2142/15581","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2142/15581","pdf_url":"https://www.ideals.illinois.edu/items/15638/bitstreams/55289/data.pdf","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ideals.illinois.edu/items/15638/bitstreams/55289/data.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015736332","display_name":"Sreenivasa Rao Ramisetty","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sreenivasa Rao Ramisetty","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5015736332"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.5062999725341797,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.5062999725341797,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.3711000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.051100000739097595,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-rna-interactions","display_name":"RNA-protein interactions","score":0.6650000214576721},{"id":"https://openalex.org/keywords/rna-hairpin-loops","display_name":"RNA hairpin loops","score":0.6790000200271606},{"id":"https://openalex.org/keywords/quinoline-derivatives","display_name":"quinoline derivatives","score":0.734000027179718},{"id":"https://openalex.org/keywords/trinucleotide-repeat-expansion","display_name":"trinucleotide repeat expansion","score":0.8349999785423279},{"id":"https://openalex.org/keywords/myotonic-dystrophy-type-1","display_name":"myotonic dystrophy type 1","score":0.9649999737739563},{"id":"https://openalex.org/keywords/zinc-finger","display_name":"zinc finger","score":0.6639999747276306}],"concepts":[{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.7041941285133362},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4203639626502991},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3870887756347656},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32902127504348755},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3250883221626282},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2756757438182831},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24663114547729492}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:www.ideals.illinois.edu:2142/15581","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2142/15581","pdf_url":"https://www.ideals.illinois.edu/items/15638/bitstreams/55289/data.pdf","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:2203979020","doi":null,"is_oa":false,"landing_page_url":"https://www.ideals.illinois.edu/handle/2142/15581","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:www.ideals.illinois.edu:2142/15581","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2142/15581","pdf_url":"https://www.ideals.illinois.edu/items/15638/bitstreams/55289/data.pdf","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2203979020.pdf","grobid_xml":"https://content.openalex.org/works/W2203979020.grobid-xml"},"referenced_works_count":164,"referenced_works":["https://openalex.org/W1489623410","https://openalex.org/W1492012195","https://openalex.org/W1555409852","https://openalex.org/W1611419331","https://openalex.org/W1800711983","https://openalex.org/W1869970222","https://openalex.org/W1922238526","https://openalex.org/W1955360692","https://openalex.org/W1963589494","https://openalex.org/W1965327108","https://openalex.org/W1967083311","https://openalex.org/W1967243325","https://openalex.org/W1967483799","https://openalex.org/W1968688959","https://openalex.org/W1971135346","https://openalex.org/W1971507786","https://openalex.org/W1974277212","https://openalex.org/W1981578291","https://openalex.org/W1986503748","https://openalex.org/W1988283896","https://openalex.org/W1988380385","https://openalex.org/W1989187665","https://openalex.org/W1989958289","https://openalex.org/W1990630139","https://openalex.org/W1994674028","https://openalex.org/W1996827828","https://openalex.org/W1997405837","https://openalex.org/W1997953216","https://openalex.org/W1998775526","https://openalex.org/W2000213161","https://openalex.org/W2000750967","https://openalex.org/W2002718082","https://openalex.org/W2005081154","https://openalex.org/W2006640104","https://openalex.org/W2009370969","https://openalex.org/W2009818318","https://openalex.org/W2010120270","https://openalex.org/W2010245041","https://openalex.org/W2012195419","https://openalex.org/W2012813328","https://openalex.org/W2013317908","https://openalex.org/W2014473124","https://openalex.org/W2014599804","https://openalex.org/W2016557841","https://openalex.org/W2016866962","https://openalex.org/W2016928156","https://openalex.org/W2019848417","https://openalex.org/W2020334159","https://openalex.org/W2020357919","https://openalex.org/W2023387311","https://openalex.org/W2023416588","https://openalex.org/W2024059257","https://openalex.org/W2026995402","https://openalex.org/W2027013607","https://openalex.org/W2029327369","https://openalex.org/W2032930812","https://openalex.org/W2036743084","https://openalex.org/W2039383512","https://openalex.org/W2041948784","https://openalex.org/W2042750467","https://openalex.org/W2042829272","https://openalex.org/W2043548965","https://openalex.org/W2044247083","https://openalex.org/W2045131720","https://openalex.org/W2046127685","https://openalex.org/W2048359227","https://openalex.org/W2050774163","https://openalex.org/W2050939941","https://openalex.org/W2052279614","https://openalex.org/W2052630418","https://openalex.org/W2054184368","https://openalex.org/W2055039476","https://openalex.org/W2056518115","https://openalex.org/W2056911242","https://openalex.org/W2057130873","https://openalex.org/W2057957131","https://openalex.org/W2063936397","https://openalex.org/W2064654376","https://openalex.org/W2066906496","https://openalex.org/W2067260382","https://openalex.org/W2067306139","https://openalex.org/W2069727672","https://openalex.org/W2069966411","https://openalex.org/W2070669937","https://openalex.org/W2071444881","https://openalex.org/W2072527146","https://openalex.org/W2073699723","https://openalex.org/W2074202320","https://openalex.org/W2074631079","https://openalex.org/W2074716800","https://openalex.org/W2076611050","https://openalex.org/W2078217107","https://openalex.org/W2081280332","https://openalex.org/W2081470277","https://openalex.org/W2082068785","https://openalex.org/W2082192988","https://openalex.org/W2084091637","https://openalex.org/W2084548137","https://openalex.org/W2087966415","https://openalex.org/W2088481301","https://openalex.org/W2091419711","https://openalex.org/W2091756240","https://openalex.org/W2092831145","https://openalex.org/W2094757867","https://openalex.org/W2097000233","https://openalex.org/W2098775968","https://openalex.org/W2099399810","https://openalex.org/W2099643329","https://openalex.org/W2099897940","https://openalex.org/W2100793313","https://openalex.org/W2102791251","https://openalex.org/W2102914911","https://openalex.org/W2106096530","https://openalex.org/W2109436341","https://openalex.org/W2109936378","https://openalex.org/W2113333419","https://openalex.org/W2119966574","https://openalex.org/W2120235717","https://openalex.org/W2120610548","https://openalex.org/W2122377457","https://openalex.org/W2123560621","https://openalex.org/W2125598283","https://openalex.org/W2125777370","https://openalex.org/W2126935614","https://openalex.org/W2128066844","https://openalex.org/W2129286776","https://openalex.org/W2133296358","https://openalex.org/W2133350967","https://openalex.org/W2134664665","https://openalex.org/W2135732933","https://openalex.org/W2138438888","https://openalex.org/W2138679397","https://openalex.org/W2140074138","https://openalex.org/W2140188816","https://openalex.org/W2141124826","https://openalex.org/W2142393243","https://openalex.org/W2144496362","https://openalex.org/W2146506312","https://openalex.org/W2149845308","https://openalex.org/W2151612484","https://openalex.org/W2154183412","https://openalex.org/W2154550174","https://openalex.org/W2154856213","https://openalex.org/W2158534713","https://openalex.org/W2159985046","https://openalex.org/W2160286042","https://openalex.org/W2166393079","https://openalex.org/W2166507757","https://openalex.org/W2167119720","https://openalex.org/W2167120376","https://openalex.org/W2167616277","https://openalex.org/W2171643158","https://openalex.org/W2176277664","https://openalex.org/W2505157809","https://openalex.org/W2949059453","https://openalex.org/W2949803422","https://openalex.org/W2949983130","https://openalex.org/W2950782346","https://openalex.org/W2951268479","https://openalex.org/W3005428319","https://openalex.org/W3014765040","https://openalex.org/W3121278448","https://openalex.org/W3128276863","https://openalex.org/W7033783247"],"related_works":["https://openalex.org/W1984907324","https://openalex.org/W2522180404","https://openalex.org/W7161042228","https://openalex.org/W4400618374","https://openalex.org/W1993237785","https://openalex.org/W2103235053","https://openalex.org/W2038306358","https://openalex.org/W2014599804","https://openalex.org/W7113513062","https://openalex.org/W2076655665"],"abstract_inverted_index":{"ABSTRACT":[0],"PART":[1,17,35,182],"I.":[2,36],"Investigation":[3],"of":[4,22,73,78,87,115,119,151,170,175,191,229,244,276,281,287,297,305,326,347,366],"Small":[5,33],"Molecule":[6],"Binding":[7],"to":[8,54,62,64,93,137,259,329],"an":[9,213],"RNA":[10,37,65,96,144,176,375],"Hairpin":[11],"Loop":[12],"Containing":[13],"a":[14,88,94,99,112,220,242,380],"Dangling":[15],"End":[16],"II.":[18,183],"Unraveling":[19],"the":[20,26,51,82,116,124,152,173,179,188,226,230,245,285,288,303,306,348,361,364,370,411],"Interaction":[21],"Pathogenic":[23],"RNAs":[24],"with":[25,219,284,309,354,376,406],"MBNL1":[27,266,377],"Protein":[28],"and":[29,40,49,66,85,122,129,163,177,202,210,222,251,256,260,343,350,395,403,414,424],"Complex":[30],"Inhibition":[31],"by":[32,46,110,241,357,379,386],"Molecules":[34],"plays":[38],"important":[39,316],"versatile":[41],"roles":[42],"in":[43,225,291,314,324],"gene":[44],"expression":[45],"both":[47],"carrying":[48],"regulating":[50,273],"information":[52],"used":[53],"direct":[55],"protein":[56,233,268,308,328,349,356,378],"synthesis.":[57],"Therefore,":[58],"small":[59,381,391],"molecules":[60,382,392],"able":[61],"bind":[63],"alter":[67],"these":[68],"biological":[69],"processes":[70],"would":[71],"be":[72],"great":[74],"utility.":[75],"This":[76],"part":[77,296],"my":[79],"thesis":[80],"describes":[81],"virtual":[83],"screening":[84],"identification":[86],"quinoline":[89],"derivative":[90],"binding":[91,140,148,155,169],"cooperatively":[92,136],"GCAA":[95],"tetraloop":[97],"containing":[98,393],"3\u2019":[100],"dangling":[101],"end":[102],"(tGCAA).":[103],"The":[104,146,237,253,279,294],"compound":[105],"NSC5485":[106],"(QD2)":[107],"was":[108],"identified":[109,390],"performing":[111],"similarity":[113],"search":[114],"NCI":[117],"database":[118],"250,000":[120],"compounds":[121,412,420],"using":[123],"program":[125],"AutoDock":[126],"3.":[127],"Fluorescence":[128],"ITC":[130],"experiments":[131,166],"revealed":[132],"that":[133,168],"QD2":[134,171,180],"binds":[135,258],"four":[138,153],"identical":[139,154],"sites":[141,156],"on":[142],"tGCAA":[143],"hairpin.":[145],"equilibrium":[147],"dissociation":[149],"constant":[150],"is":[157,212,239,300],"8.2":[158],"(\u00b10.4)":[159],"\u00b5M.":[160],"CD":[161],"spectroscopy":[162],"UV":[164],"titration":[165],"suggested":[167],"changes":[172],"conformation":[174],"perturbs":[178],"chromophore.":[181],"Trinucleotide":[184],"repeat":[185,289],"expansions":[186],"are":[187,312,417],"genetic":[189],"cause":[190],"numerous":[192],"human":[193],"diseases,":[194],"including":[195],"Huntington\u2019s":[196],"disease,":[197],"Fragile":[198],"X":[199],"mental":[200],"retardation,":[201],"myotonic":[203],"dystrophy":[204,208],"type":[205],"1.":[206],"Myotonic":[207],"(DM1":[209],"DM2)":[211],"autosomal":[214],"dominant":[215],"neuromuscular":[216],"disorder":[217],"associated":[218],"(CTG)n":[221],"(CCTG)n":[223],"expansion":[224],"3\u2019-untranslated":[227],"region":[228],"Dystrophia":[231],"Myotonica":[232],"kinase":[234],"(DMPK)":[235],"gene.":[236],"disease":[238,282],"characterized":[240],"waning":[243],"muscles":[246],"(muscular":[247],"dystrophy),":[248],"eye-lens":[249],"opacity":[250],"myotonia.":[252],"pathogenic":[254],"poly(CUG)RNA":[255,372],"poly(CCUG)RNA":[257],"sequesters":[261],"key":[262],"proteins,":[263],"such":[264],"as":[265],"(muscleblind-like":[267],"1),":[269],"preventing":[270],"them":[271],"from":[272],"proper":[274],"splicing":[275],"different":[277],"pre-mRNAs.":[278],"severity":[280],"correlates":[283],"length":[286],"tract":[290],"peripheral":[292],"blood.":[293],"first":[295],"this":[298,333],"project":[299],"about":[301],"investigating":[302],"interaction":[304,353],"MBNL1N":[307,327,355],"poly(CUG)RNA.":[310,330],"We":[311,389],"interested":[313],"identifying":[315],"amino":[317,341],"acids":[318,342],"or":[319,373],"zinc":[320],"finger":[321],"domains":[322],"involved":[323],"recognition":[325],"To":[331],"address":[332],"question":[334],"we":[335],"did":[336],"alanine":[337],"scanning":[338],"for":[339,421],"six":[340],"expressed":[344],"truncated":[345],"versions":[346],"studied":[351],"their":[352],"gel-shift":[358,387],"assays.":[359,388],"In":[360],"second":[362],"part,":[363],"inhibition":[365],"complexes":[367,405],"formed":[368],"between":[369],"toxic":[371],"poly(CCUG)":[374],"has":[383],"been":[384],"shown":[385],"triaminotriazine-acridine":[394,413],"triaminopyrimidine-acridine":[396,415],"conjugates":[397,416],"which":[398],"can":[399],"specifically":[400],"inhibit":[401],"(CUG)12":[402],"(CCUG)6":[404],"MBN1N":[407],"protein,":[408],"respectively.":[409,426],"Thus":[410],"potential":[418],"lead":[419],"targeting":[422],"DM1":[423],"DM2,":[425]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
