{"id":"https://openalex.org/W2203348730","doi":"https://doi.org/10.1128/aac.02121-15","title":"Alkyl Amine Bevirimat Derivatives Are Potent and Broadly Active HIV-1 Maturation Inhibitors","display_name":"Alkyl Amine Bevirimat Derivatives Are Potent and Broadly Active HIV-1 Maturation Inhibitors","publication_year":2015,"publication_date":"2015-10-20","ids":{"openalex":"https://openalex.org/W2203348730","doi":"https://doi.org/10.1128/aac.02121-15","mag":"2203348730","pmid":"https://pubmed.ncbi.nlm.nih.gov/26482309","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4704169"},"language":"en","primary_location":{"id":"doi:10.1128/aac.02121-15","doi":"https://doi.org/10.1128/aac.02121-15","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.02121-15","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4704169","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038735632","display_name":"Emiko Urano","orcid":"https://orcid.org/0000-0001-5586-9377","observed_orcids":["https://orcid.org/0000-0001-5586-9377"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emiko Urano","raw_affiliation_strings":["Virus-Cell Interaction Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virus-Cell Interaction Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053248401","display_name":"Sherimay D. Ablan","orcid":"https://orcid.org/0000-0001-9466-8332","observed_orcids":["https://orcid.org/0000-0001-9466-8332"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sherimay D. Ablan","raw_affiliation_strings":["Virus-Cell Interaction Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virus-Cell Interaction Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038120209","display_name":"Rebecca E. K. Mandt","orcid":"https://orcid.org/0000-0001-7165-7876","observed_orcids":["https://orcid.org/0000-0001-7165-7876"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca Mandt","raw_affiliation_strings":["Virus-Cell Interaction Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virus-Cell Interaction Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013480909","display_name":"Gary T. Pauly","orcid":"https://orcid.org/0000-0002-3481-7129","observed_orcids":["https://orcid.org/0000-0002-3481-7129"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary T. Pauly","raw_affiliation_strings":["Chemical Synthesis Group, Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Synthesis Group, Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011029797","display_name":"Dina M. Sigano","orcid":"https://orcid.org/0000-0001-7489-9555","observed_orcids":["https://orcid.org/0000-0001-7489-9555"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dina M. Sigano","raw_affiliation_strings":["Chemical Synthesis Group, Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Synthesis Group, Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082962021","display_name":"Joel P. Schneider","orcid":"https://orcid.org/0000-0002-4403-7900","observed_orcids":["https://orcid.org/0000-0002-4403-7900"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel P. Schneider","raw_affiliation_strings":["Chemical Synthesis Group, Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Synthesis Group, Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088174722","display_name":"David E. Martin","orcid":"https://orcid.org/0000-0003-2820-5983","observed_orcids":["https://orcid.org/0000-0003-2820-5983"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David E. Martin","raw_affiliation_strings":["DFH Pharma, Gaithersburg, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DFH Pharma, Gaithersburg, Maryland, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021524482","display_name":"Theodore J. Nitz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Theodore J. Nitz","raw_affiliation_strings":["DFH Pharma, Gaithersburg, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DFH Pharma, Gaithersburg, Maryland, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076898142","display_name":"Carl T. Wild","orcid":"https://orcid.org/0009-0009-1195-1497","observed_orcids":["https://orcid.org/0009-0009-1195-1497"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carl T. Wild","raw_affiliation_strings":["DFH Pharma, Gaithersburg, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DFH Pharma, Gaithersburg, Maryland, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054660762","display_name":"Eric O. Freed","orcid":"https://orcid.org/0000-0003-3345-022X","observed_orcids":["https://orcid.org/0000-0003-3345-022X"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric O. Freed","raw_affiliation_strings":["Virus-Cell Interaction Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virus-Cell Interaction Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.1798,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.96078583,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"60","issue":"1","first_page":"190","last_page":"197"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bevirimat","display_name":"bevirimat","score":0.9350000023841858},{"id":"https://openalex.org/keywords/hiv-1-maturation-inhibitors","display_name":"HIV-1 maturation inhibitors","score":0.9860000014305115},{"id":"https://openalex.org/keywords/gag-processing","display_name":"Gag processing","score":0.7820000052452087},{"id":"https://openalex.org/keywords/hiv-1-protease","display_name":"HIV-1 protease","score":0.8550000190734863},{"id":"https://openalex.org/keywords/antiviral-resistance","display_name":"antiviral resistance","score":0.703000009059906},{"id":"https://openalex.org/keywords/nl4-3","display_name":"NL4-3","score":0.871999979019165}],"concepts":[{"id":"https://openalex.org/C131779359","wikidata":"https://www.wikidata.org/wiki/Q471875","display_name":"Amine gas treating","level":2,"score":0.559295654296875},{"id":"https://openalex.org/C2780263894","wikidata":"https://www.wikidata.org/wiki/Q335268","display_name":"Alkyl","level":2,"score":0.5418340563774109},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.494975745677948},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.4808976650238037},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4663754105567932},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.40151798725128174},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3421083986759186},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3331349492073059},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3321576714515686},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.24143698811531067},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1879059374332428}],"mesh":[{"descriptor_ui":"D000478","descriptor_name":"Alkylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000586","descriptor_name":"Amination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002213","descriptor_name":"Capsid","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013386","descriptor_name":"Succinates","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D013386","descriptor_name":"Succinates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013386","descriptor_name":"Succinates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D014315","descriptor_name":"Triterpenes","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D014315","descriptor_name":"Triterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014315","descriptor_name":"Triterpenes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014771","descriptor_name":"Virion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014771","descriptor_name":"Virion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014771","descriptor_name":"Virion","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D036022","descriptor_name":"Capsid Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D036022","descriptor_name":"Capsid Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D036022","descriptor_name":"Capsid Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053978","descriptor_name":"Pentacyclic Triterpenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054301","descriptor_name":"gag Gene Products, Human Immunodeficiency Virus","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D054301","descriptor_name":"gag Gene Products, Human Immunodeficiency Virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054301","descriptor_name":"gag Gene Products, Human Immunodeficiency Virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/aac.02121-15","doi":"https://doi.org/10.1128/aac.02121-15","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.02121-15","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4704169","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4704169","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},{"id":"pmid:26482309","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26482309","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4704169","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4704169","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4759710072","display_name":"Preparation and Characterization of 2nd Generation HIV-1 Maturation Inhibitor Dru","funder_award_id":"R41AI108457","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5787704048","display_name":null,"funder_award_id":"HHSN272200700041C","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G695647867","display_name":null,"funder_award_id":"N01-AI-70041","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7308000536","display_name":null,"funder_award_id":"BC 011515","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8029156463","display_name":null,"funder_award_id":"BC010778","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8108636825","display_name":"Inhibition of HIV-1 Maturation","funder_award_id":"Z01BC010778","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000873887","display_name":"Chemical Synthesis Group","funder_award_id":"ZICBC011515","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1507261754","https://openalex.org/W1585440676","https://openalex.org/W1595806441","https://openalex.org/W1599995235","https://openalex.org/W1753916721","https://openalex.org/W1816747902","https://openalex.org/W1823429634","https://openalex.org/W1964146897","https://openalex.org/W1967760407","https://openalex.org/W1970930966","https://openalex.org/W1973282984","https://openalex.org/W1977136326","https://openalex.org/W1977218442","https://openalex.org/W1999148331","https://openalex.org/W1999429374","https://openalex.org/W2002445611","https://openalex.org/W2010599757","https://openalex.org/W2016353171","https://openalex.org/W2018697541","https://openalex.org/W2024131050","https://openalex.org/W2028985917","https://openalex.org/W2029944114","https://openalex.org/W2048107562","https://openalex.org/W2052622203","https://openalex.org/W2058140034","https://openalex.org/W2077795431","https://openalex.org/W2078205352","https://openalex.org/W2087978946","https://openalex.org/W2102953571","https://openalex.org/W2110977476","https://openalex.org/W2113606450","https://openalex.org/W2116262094","https://openalex.org/W2118798209","https://openalex.org/W2122102984","https://openalex.org/W2123634339","https://openalex.org/W2127153680","https://openalex.org/W2128580131","https://openalex.org/W2132762790","https://openalex.org/W2142892346","https://openalex.org/W2145482724","https://openalex.org/W2145652748","https://openalex.org/W2151116772","https://openalex.org/W2160176988","https://openalex.org/W2162004774","https://openalex.org/W2166678307","https://openalex.org/W2169408873","https://openalex.org/W2401346588"],"related_works":["https://openalex.org/W7096367501","https://openalex.org/W2415920471","https://openalex.org/W2155380502","https://openalex.org/W1964146897","https://openalex.org/W2028985917","https://openalex.org/W7112058573","https://openalex.org/W2045584504","https://openalex.org/W3149958601","https://openalex.org/W2029944114","https://openalex.org/W1457137500"],"abstract_inverted_index":{"Concomitant":[0],"with":[1],"the":[2,13,16,20,55,58,91,117,125,159,163,197,204,236],"release":[3],"of":[4,27,57,94,110,119,127,162,170,194,203,207,216,228,238],"human":[5],"immunodeficiency":[6],"virus":[7,31],"type":[8],"1":[9,61],"(HIV-1)":[10],"particles":[11],"from":[12],"infected":[14],"cell,":[15],"viral":[17,81],"protease":[18],"cleaves":[19],"Gag":[21,53,95],"polyprotein":[22],"precursor":[23],"at":[24,158],"a":[25,37,48,100,168,192,213,232],"number":[26],"sites":[28],"to":[29,64,74,99,113,143,231],"trigger":[30],"maturation.":[32],"We":[33,166],"previously":[34],"reported":[35],"that":[36,172,223],"betulinic":[38],"acid-derived":[39],"compound,":[40],"bevirimat":[41],"(BVM),":[42],"blocks":[43],"HIV-1":[44,112,181,218],"maturation":[45,146],"by":[46,131,241],"disrupting":[47],"late":[49],"step":[50],"in":[51,70,79,83,90,103,116,133,200,243],"protease-mediated":[52],"processing:":[54],"cleavage":[56],"capsid-spacer":[59],"peptide":[60],"(CA-SP1)":[62],"intermediate":[63],"mature":[65],"CA.":[66],"BVM":[67,114,128,164,178,229],"was":[68],"shown":[69],"multiple":[71],"clinical":[72,121],"trials":[73],"be":[75],"safe":[76],"and":[77,186],"effective":[78],"reducing":[80],"loads":[82],"HIV-1-infected":[84],"patients.":[85,106],"However,":[86],"naturally":[87],"occurring":[88],"polymorphisms":[89,132,242],"SP1":[92],"region":[93],"(e.g.,":[96],"SP1-V7A)":[97],"led":[98],"variable":[101],"response":[102],"some":[104],"BVM-treated":[105],"The":[107],"reduced":[108],"susceptibility":[109,239],"SP1-polymorphic":[111],"resulted":[115],"discontinuation":[118],"its":[120],"development.":[122],"To":[123],"overcome":[124,235],"loss":[126,237],"activity":[129,190],"induced":[130],"SP1,":[134],"we":[135,151],"carried":[136],"out":[137],"an":[138,180],"extensive":[139],"medicinal":[140],"chemistry":[141],"campaign":[142],"develop":[144],"novel":[145],"inhibitors.":[147],"In":[148],"this":[149],"study,":[150],"focused":[152],"on":[153],"alkyl":[154,225],"amine":[155,226],"derivatives":[156,171,227],"modified":[157],"C-28":[160,224],"position":[161],"scaffold.":[165],"identified":[167],"set":[169],"are":[173],"markedly":[174],"more":[175],"potent":[176,206],"than":[177],"against":[179,191],"clade":[182],"B":[183],"clone":[184],"(NL4-3)":[185],"show":[187],"robust":[188],"antiviral":[189],"variant":[193],"NL4-3":[195],"containing":[196],"V7A":[198],"polymorphism":[199],"SP1.":[201,244],"One":[202],"most":[205],"these":[208],"compounds":[209],"also":[210],"strongly":[211],"inhibited":[212],"multiclade":[214],"panel":[215],"primary":[217],"isolates.":[219],"These":[220],"data":[221],"demonstrate":[222],"can,":[230],"large":[233],"extent,":[234],"imposed":[240]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":11}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
