{"id":"https://openalex.org/W2202809274","doi":"https://doi.org/10.4414/smw.2015.14230","title":"The CRISPR revolution and its impact on cancer research","display_name":"The CRISPR revolution and its impact on cancer research","publication_year":2015,"publication_date":"2015-11-29","ids":{"openalex":"https://openalex.org/W2202809274","doi":"https://doi.org/10.4414/smw.2015.14230","mag":"2202809274","pmid":"https://pubmed.ncbi.nlm.nih.gov/26661454","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5512432"},"language":"en","primary_location":{"id":"doi:10.4414/smw.2015.14230","doi":"https://doi.org/10.4414/smw.2015.14230","is_oa":true,"landing_page_url":"https://doi.org/10.4414/smw.2015.14230","pdf_url":"https://smw.ch/index.php/smw/article/download/2113/3104","source":{"id":"https://openalex.org/S4394736658","display_name":"Swiss Medical Weekly","issn_l":"0036-7672","issn":["0036-7672","1424-3997","1424-7860"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["ddh","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Swiss Medical Weekly","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://smw.ch/index.php/smw/article/download/2113/3104","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112010187","display_name":"Ram Kannan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ram Kannan","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, Cancer Biology and Genetics Program, New York","Memorial Sloan Kettering Cancer Center, Cancer Biology and Genetics Program, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, Cancer Biology and Genetics Program, New York","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, Cancer Biology and Genetics Program, New York, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033666678","display_name":"Andrea Ventura","orcid":"https://orcid.org/0000-0003-4320-9907","observed_orcids":["https://orcid.org/0000-0003-4320-9907"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea Ventura","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, Cancer Biology and Genetics Program, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, Cancer Biology and Genetics Program, New York, USA","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1334819555"],"apc_list":null,"apc_paid":null,"fwci":0.2909,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.24782453,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"145","issue":"4950","first_page":"w14230","last_page":"w14230"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crispr-cas9","display_name":"CRISPR/Cas9","score":0.9990000128746033},{"id":"https://openalex.org/keywords/genome-editing","display_name":"genome editing","score":0.9750000238418579},{"id":"https://openalex.org/keywords/cancer-research","display_name":"cancer research","score":0.6970000267028809},{"id":"https://openalex.org/keywords/in-vivo-tumor-model","display_name":"in vivo tumor model","score":0.7310000061988831},{"id":"https://openalex.org/keywords/somatic-cells","display_name":"somatic cells","score":0.8640000224113464},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.746999979019165}],"concepts":[{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.905318021774292},{"id":"https://openalex.org/C168725872","wikidata":"https://www.wikidata.org/wiki/Q991663","display_name":"Sophistication","level":2,"score":0.8439569473266602},{"id":"https://openalex.org/C144501496","wikidata":"https://www.wikidata.org/wiki/Q5533489","display_name":"Genome editing","level":4,"score":0.6053555011749268},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5870914459228516},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5503012537956238},{"id":"https://openalex.org/C132455925","wikidata":"https://www.wikidata.org/wiki/Q16965677","display_name":"Cas9","level":4,"score":0.5361229181289673},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.5019595623016357},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4764012396335602},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.42569032311439514},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3833116590976715},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24192532896995544},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2343050241470337},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.17699754238128662},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14019456505775452},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.08620229363441467},{"id":"https://openalex.org/C36289849","wikidata":"https://www.wikidata.org/wiki/Q34749","display_name":"Social science","level":1,"score":0.08032983541488647},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.4414/smw.2015.14230","doi":"https://doi.org/10.4414/smw.2015.14230","is_oa":true,"landing_page_url":"https://doi.org/10.4414/smw.2015.14230","pdf_url":"https://smw.ch/index.php/smw/article/download/2113/3104","source":{"id":"https://openalex.org/S4394736658","display_name":"Swiss Medical Weekly","issn_l":"0036-7672","issn":["0036-7672","1424-3997","1424-7860"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["ddh","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Swiss Medical Weekly","raw_type":"journal-article"},{"id":"pmid:26661454","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26661454","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Swiss medical weekly","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4358084","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5512432","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5512432","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5512432","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Swiss Med Wkly","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:10addd8cfb634d1bab5a5935c7b6a121","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/10addd8cfb634d1bab5a5935c7b6a121","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Swiss Medical Weekly, Vol 145, Iss 4950 (2015)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.4414/smw.2015.14230","doi":"https://doi.org/10.4414/smw.2015.14230","is_oa":true,"landing_page_url":"https://doi.org/10.4414/smw.2015.14230","pdf_url":"https://smw.ch/index.php/smw/article/download/2113/3104","source":{"id":"https://openalex.org/S4394736658","display_name":"Swiss Medical Weekly","issn_l":"0036-7672","issn":["0036-7672","1424-3997","1424-7860"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["ddh","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Swiss Medical Weekly","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1407169771","display_name":"Translational Research in Oncology Training Program","funder_award_id":"T32CA160001","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000856728","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA008748","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2202809274.pdf","grobid_xml":"https://content.openalex.org/works/W2202809274.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W616296877","https://openalex.org/W1435110089","https://openalex.org/W1504222414","https://openalex.org/W1575193685","https://openalex.org/W1608084731","https://openalex.org/W1635615463","https://openalex.org/W1859117663","https://openalex.org/W1939365747","https://openalex.org/W1966737051","https://openalex.org/W1971191097","https://openalex.org/W1972476556","https://openalex.org/W1972759536","https://openalex.org/W1973260880","https://openalex.org/W1982831423","https://openalex.org/W1982969769","https://openalex.org/W2000774201","https://openalex.org/W2003171404","https://openalex.org/W2005622066","https://openalex.org/W2008147758","https://openalex.org/W2014639769","https://openalex.org/W2026592619","https://openalex.org/W2031984687","https://openalex.org/W2035420256","https://openalex.org/W2036176224","https://openalex.org/W2041217592","https://openalex.org/W2043972484","https://openalex.org/W2045435533","https://openalex.org/W2050169742","https://openalex.org/W2051549807","https://openalex.org/W2055402151","https://openalex.org/W2055790209","https://openalex.org/W2057224174","https://openalex.org/W2061650108","https://openalex.org/W2062521268","https://openalex.org/W2064815984","https://openalex.org/W2066783444","https://openalex.org/W2070614858","https://openalex.org/W2072299899","https://openalex.org/W2073217307","https://openalex.org/W2087517352","https://openalex.org/W2089142941","https://openalex.org/W2091772801","https://openalex.org/W2098669942","https://openalex.org/W2101749257","https://openalex.org/W2104091091","https://openalex.org/W2104830962","https://openalex.org/W2105841770","https://openalex.org/W2115192209","https://openalex.org/W2119771879","https://openalex.org/W2122563582","https://openalex.org/W2127749855","https://openalex.org/W2127862779","https://openalex.org/W2140754284","https://openalex.org/W2150856504","https://openalex.org/W2153268494","https://openalex.org/W2153344788","https://openalex.org/W2153552126","https://openalex.org/W2154283358","https://openalex.org/W2161488472","https://openalex.org/W2165869860","https://openalex.org/W2167778259","https://openalex.org/W2169373177","https://openalex.org/W3020907828","https://openalex.org/W4235992666","https://openalex.org/W4245053291","https://openalex.org/W6651296210","https://openalex.org/W6659440081","https://openalex.org/W6673557639","https://openalex.org/W6682369470","https://openalex.org/W7073528042"],"related_works":["https://openalex.org/W2612339358","https://openalex.org/W2563770935","https://openalex.org/W2659099693","https://openalex.org/W2116553552","https://openalex.org/W2419237405","https://openalex.org/W3135365442","https://openalex.org/W4400155451","https://openalex.org/W2556732566","https://openalex.org/W4385185749","https://openalex.org/W7096906583"],"abstract_inverted_index":{"A":[0],"revolution":[1],"in":[2,54],"cancer":[3,52],"research":[4],"is":[5],"underway.":[6],"Spurred":[7],"by":[8],"the":[9,12,19,36,48],"advent":[10],"of":[11,38,41,60,68],"CRISPR-Cas9":[13],"technology,":[14],"new":[15,45],"methods":[16,46],"to":[17,32,50],"probe":[18],"mammalian":[20],"genomes":[21],"are":[22],"being":[23],"developed.":[24],"By":[25],"providing":[26],"simple,":[27],"flexible,":[28],"and":[29,34,71],"cost-effective":[30],"ways":[31],"edit":[33],"manipulate":[35],"genome":[37],"somatic":[39],"cells":[40],"adult":[42],"animals,":[43],"these":[44],"present":[47],"opportunity":[49],"model":[51],"progression":[53],"vivo":[55],"with":[56],"an":[57],"unprecedented":[58],"degree":[59],"sophistication.":[61],"Here":[62],"we":[63],"provide":[64],"a":[65],"brief":[66],"overview":[67],"this":[69],"exciting":[70],"fast-moving":[72],"field.":[73]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}