{"id":"https://openalex.org/W2202467425","doi":"https://doi.org/10.1016/j.bbrep.2015.12.011","title":"The inhibitors of cyclin-dependent kinases and GSK-3\u03b2 enhance osteoclastogenesis","display_name":"The inhibitors of cyclin-dependent kinases and GSK-3\u03b2 enhance osteoclastogenesis","publication_year":2015,"publication_date":"2015-12-30","ids":{"openalex":"https://openalex.org/W2202467425","doi":"https://doi.org/10.1016/j.bbrep.2015.12.011","mag":"2202467425","pmid":"https://pubmed.ncbi.nlm.nih.gov/28955831","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5600418"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbrep.2015.12.011","doi":"https://doi.org/10.1016/j.bbrep.2015.12.011","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbrep.2015.12.011","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2405580815001569/pdf","source":{"id":"https://openalex.org/S2764640729","display_name":"Biochemistry and Biophysics Reports","issn_l":"2405-5808","issn":["2405-5808"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry and Biophysics Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2405580815001569/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057918467","display_name":"Yosuke Akiba","orcid":"https://orcid.org/0000-0002-7295-8416","observed_orcids":["https://orcid.org/0000-0002-7295-8416"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yosuke Akiba","raw_affiliation_strings":["Division of Bio-Prosthodontics, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkocho-dori, Chuoku, Niigata 951-8514, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Bio-Prosthodontics, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkocho-dori, Chuoku, Niigata 951-8514, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Akiko Mizuta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akiko Mizuta","raw_affiliation_strings":["Department of Pharmacology, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020894596","display_name":"Yoshito Kakihara","orcid":"https://orcid.org/0000-0002-6014-8707","observed_orcids":["https://orcid.org/0000-0002-6014-8707"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yoshito Kakihara","raw_affiliation_strings":["Division of Dental Pharmacology, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkochodori, Chuoku, Niigata 951-8514, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Dental Pharmacology, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkochodori, Chuoku, Niigata 951-8514, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001928499","display_name":"Juri Nakata","orcid":"https://orcid.org/0000-0003-3430-1699","observed_orcids":["https://orcid.org/0000-0003-3430-1699"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Juri Nakata","raw_affiliation_strings":["Division of Dental Pharmacology, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkochodori, Chuoku, Niigata 951-8514, Japan","Division of Orthodontics, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkocho-dori, Chuoku, Niigata 951-8514, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Dental Pharmacology, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkochodori, Chuoku, Niigata 951-8514, Japan","institution_ids":["https://openalex.org/I71395657"]},{"raw_affiliation_string":"Division of Orthodontics, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkocho-dori, Chuoku, Niigata 951-8514, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052042954","display_name":"Jun Nihara","orcid":"https://orcid.org/0000-0002-4811-3077","observed_orcids":["https://orcid.org/0000-0002-4811-3077"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun Nihara","raw_affiliation_strings":["Division of Orthodontics, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkocho-dori, Chuoku, Niigata 951-8514, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Orthodontics, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkocho-dori, Chuoku, Niigata 951-8514, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005023259","display_name":"Isao Saito","orcid":"https://orcid.org/0000-0003-2048-9248","observed_orcids":["https://orcid.org/0000-0003-2048-9248"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Isao Saito","raw_affiliation_strings":["Division of Orthodontics, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkocho-dori, Chuoku, Niigata 951-8514, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Orthodontics, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkocho-dori, Chuoku, Niigata 951-8514, Japan","institution_ids":["https://openalex.org/I71395657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080030836","display_name":"Hiroshi Egusa","orcid":"https://orcid.org/0000-0002-0200-8132","observed_orcids":["https://orcid.org/0000-0002-0200-8132"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Egusa","raw_affiliation_strings":["Division of Molecular and Regenerative Prosthodontics, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular and Regenerative Prosthodontics, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040162933","display_name":"Makio Saeki","orcid":"https://orcid.org/0000-0002-3479-545X","observed_orcids":["https://orcid.org/0000-0002-3479-545X"]},"institutions":[{"id":"https://openalex.org/I71395657","display_name":"Niigata University","ror":"https://ror.org/04ww21r56","country_code":"JP","type":"education","lineage":["https://openalex.org/I71395657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makio Saeki","raw_affiliation_strings":["Division of Dental Pharmacology, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkochodori, Chuoku, Niigata 951-8514, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Dental Pharmacology, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkochodori, Chuoku, Niigata 951-8514, Japan","institution_ids":["https://openalex.org/I71395657"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5020894596"],"corresponding_institution_ids":["https://openalex.org/I71395657"],"apc_list":{"value":2700,"currency":"USD","value_usd":2700},"apc_paid":{"value":2700,"currency":"USD","value_usd":2700},"fwci":0.1153,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.43448203,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"5","issue":null,"first_page":"253","last_page":"258"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13328","display_name":"Osteomyelitis and Bone Disorders Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoclastogenesis","display_name":"osteoclastogenesis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cyclin-dependent-kinases","display_name":"cyclin-dependent kinases","score":0.9559999704360962},{"id":"https://openalex.org/keywords/gsk-3beta","display_name":"GSK3\u03b2","score":0.9049999713897705},{"id":"https://openalex.org/keywords/kenpaullone","display_name":"kenpaullone","score":0.9940000176429749},{"id":"https://openalex.org/keywords/olomoucine","display_name":"olomoucine","score":0.996999979019165},{"id":"https://openalex.org/keywords/roscovitine","display_name":"roscovitine","score":1.0},{"id":"https://openalex.org/keywords/rankl-rank-signaling","display_name":"RANK/RANKL signaling","score":0.9729999899864197},{"id":"https://openalex.org/keywords/nfatc1","display_name":"NFATc1","score":0.996999979019165},{"id":"https://openalex.org/keywords/cathepsin-k","display_name":"cathepsin K","score":0.9129999876022339},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.968999981880188},{"id":"https://openalex.org/keywords/chemical-genetic-screen","display_name":"chemical genetic screen","score":0.7540000081062317},{"id":"https://openalex.org/keywords/raw-264-7-macrophages","display_name":"RAW 264.7 macrophages","score":0.9269999861717224}],"concepts":[{"id":"https://openalex.org/C2779428903","wikidata":"https://www.wikidata.org/wiki/Q418934","display_name":"RANKL","level":4,"score":0.7740232348442078},{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.7492468357086182},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6512216329574585},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.6360255479812622},{"id":"https://openalex.org/C124320809","wikidata":"https://www.wikidata.org/wiki/Q46292","display_name":"Cyclin-dependent kinase","level":4,"score":0.6197877526283264},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6040241718292236},{"id":"https://openalex.org/C101990758","wikidata":"https://www.wikidata.org/wiki/Q14902045","display_name":"Cathepsin K","level":4,"score":0.5793141722679138},{"id":"https://openalex.org/C2909639871","wikidata":"https://www.wikidata.org/wiki/Q418934","display_name":"RANK Ligand","level":5,"score":0.5548396110534668},{"id":"https://openalex.org/C182996813","wikidata":"https://www.wikidata.org/wiki/Q910847","display_name":"GSK-3","level":3,"score":0.5392183065414429},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4878849983215332},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4668691158294678},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.40918785333633423},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3572933077812195},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25172314047813416},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.23502421379089355},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.1528816521167755},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.15015169978141785},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.13358256220817566}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1016/j.bbrep.2015.12.011","doi":"https://doi.org/10.1016/j.bbrep.2015.12.011","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbrep.2015.12.011","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2405580815001569/pdf","source":{"id":"https://openalex.org/S2764640729","display_name":"Biochemistry and Biophysics Reports","issn_l":"2405-5808","issn":["2405-5808"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry and Biophysics Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4536523","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5600418","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:28955831","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28955831","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry and biophysics reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5600418","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5600418/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem Biophys Rep","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:c3af91458502473483704e32fe032292","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c3af91458502473483704e32fe032292","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biochemistry and Biophysics Reports, Vol 5, Iss C, Pp 253-258 (2016)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.bbrep.2015.12.011","doi":"https://doi.org/10.1016/j.bbrep.2015.12.011","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbrep.2015.12.011","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2405580815001569/pdf","source":{"id":"https://openalex.org/S2764640729","display_name":"Biochemistry and Biophysics Reports","issn_l":"2405-5808","issn":["2405-5808"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-40"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry and Biophysics Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G211596075","display_name":"Osteoclast activator: a promising therapeutic target for osteoporosis","funder_award_id":"15K15683","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4872142205","display_name":"\u77ef\u6b63\u5b66\u7684\u6b6f\u306e\u79fb\u52d5\u3092\u4fc3\u9032\u3059\u308bROCK\uff08Rho\u30ad\u30ca\u30fc\u30bc\uff09\u963b\u5bb3\u5264\u306e\u4f5c\u7528\u6a5f\u5e8f\u306e\u89e3\u660e","funder_award_id":"19K19263","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7096508566","display_name":null,"funder_award_id":"15K15683","funder_id":"https://openalex.org/F4320320212","funder_display_name":"Japan Society for the Promotion of Science London"}],"funders":[{"id":"https://openalex.org/F4320320212","display_name":"Japan Society for the Promotion of Science London","ror":"https://ror.org/02m7axw05"},{"id":"https://openalex.org/F4320321041","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2202467425.pdf","grobid_xml":"https://content.openalex.org/works/W2202467425.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W319902876","https://openalex.org/W1919908042","https://openalex.org/W1967502057","https://openalex.org/W1967943295","https://openalex.org/W1970144926","https://openalex.org/W1975505424","https://openalex.org/W1984821835","https://openalex.org/W2009120488","https://openalex.org/W2011588737","https://openalex.org/W2014225480","https://openalex.org/W2039842713","https://openalex.org/W2040502563","https://openalex.org/W2072798629","https://openalex.org/W2077970353","https://openalex.org/W2078419961","https://openalex.org/W2083339409","https://openalex.org/W2089528428","https://openalex.org/W2094321811","https://openalex.org/W2107360846","https://openalex.org/W2135129680","https://openalex.org/W2136274976","https://openalex.org/W2145290432","https://openalex.org/W2167529171","https://openalex.org/W2301131921","https://openalex.org/W4233069694","https://openalex.org/W4254214228"],"related_works":["https://openalex.org/W2077970353","https://openalex.org/W2027392443","https://openalex.org/W7096988656","https://openalex.org/W3033337222","https://openalex.org/W2763676809","https://openalex.org/W2006990379","https://openalex.org/W4395011085","https://openalex.org/W4389341478","https://openalex.org/W2077760373","https://openalex.org/W2811074257"],"abstract_inverted_index":{"Osteoclasts":[0],"are":[1],"multinucleated":[2],"cells":[3,83],"with":[4],"bone":[5,12,112],"resorption":[6,129],"activity":[7,130],"that":[8,99,127,141],"is":[9,135],"crucial":[10],"for":[11,31],"remodeling.":[13],"RANK-RANKL":[14,152],"(receptor":[15],"activator":[16],"of":[17,76,81,89,107,123,131,143],"nuclear":[18],"factor":[19,88],"\u03baB":[20],"ligand)":[21],"signaling":[22,153],"has":[23],"been":[24],"shown":[25],"as":[26],"a":[27,53,59],"main":[28],"signal":[29],"pathway":[30],"osteoclast":[32,108],"differentiation.":[33],"However,":[34],"the":[35,39,100,105,116,128,132,151],"molecular":[36],"mechanism":[37],"and":[38,57,68,73],"factors":[40],"regulating":[41],"osteoclastogenesis":[42,80,148],"remain":[43],"to":[44],"be":[45],"fully":[46],"understood.":[47],"In":[48],"this":[49],"study,":[50],"we":[51],"performed":[52],"chemical":[54],"genetic":[55],"screen,":[56],"identified":[58],"Cdks/GSK-3\u03b2":[60],"(cyclin-dependent":[61],"kinases/glycogen":[62],"synthase":[63],"kinase":[64],"3\u03b2)":[65],"inhibitor,":[66],"kenpaullone,":[67,120],"two":[69],"Cdks":[70,146],"inhibitors,":[71,118],"olomoucine":[72],"roscovitine,":[74],"all":[75,101],"which":[77],"significantly":[78],"enhance":[79,147],"RAW264.7":[82],"by":[84,149],"upregulating":[85],"NFATc1":[86],"(nuclear":[87],"activated":[90],"T":[91],"cells,":[92],"cytoplasmic":[93],"1)":[94],"levels.":[95],"We":[96],"also":[97,136],"determined":[98],"three":[102,117],"compounds":[103],"increase":[104],"number":[106],"differentiated":[109],"from":[110],"murine":[111],"marrow":[113],"cells.":[114],"Furthermore,":[115],"especially":[119],"promoted":[121],"maturation":[122],"cathepsin":[124],"K,":[125],"suggesting":[126],"resultant":[133],"osteoclasts":[134],"activated.":[137],"Our":[138],"findings":[139],"indicate":[140],"inhibition":[142],"GSK-3\u03b2":[144],"and/or":[145],"modulating":[150],"pathway.":[154]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
