{"id":"https://openalex.org/W2202279480","doi":"https://doi.org/10.1016/b978-0-12-801238-3.05502-1","title":"Gene Therapy From Theoretical Potential to Clinical Implementation","display_name":"Gene Therapy From Theoretical Potential to Clinical Implementation","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2202279480","doi":"https://doi.org/10.1016/b978-0-12-801238-3.05502-1","mag":"2202279480"},"language":"en","primary_location":{"id":"doi:10.1016/b978-0-12-801238-3.05502-1","doi":"https://doi.org/10.1016/b978-0-12-801238-3.05502-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-0-12-801238-3.05502-1","pdf_url":null,"source":{"id":"https://openalex.org/S4306463230","display_name":"Elsevier eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reference Module in Biomedical Sciences","raw_type":"book-chapter"},"volume":null,"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079020508","display_name":"Nicholas S .R. Sauderson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N.S.R Sauderson","raw_affiliation_strings":["The University of Michigan Medical School, Ann Arbor, MI, USA","\u2020University of Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Michigan Medical School, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"\u2020University of Michigan","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082380342","display_name":"Maria Graciela Castro","orcid":"https://orcid.org/0000-0003-2237-2756","observed_orcids":["https://orcid.org/0000-0003-2237-2756"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.G. Castro","raw_affiliation_strings":["The University of Michigan Medical School, Ann Arbor, MI, USA","Cell and Developmental Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Michigan Medical School, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Cell and Developmental Biology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080277287","display_name":"Pedro Ricardo Lowenstein","orcid":"https://orcid.org/0000-0002-8427-4409","observed_orcids":["https://orcid.org/0000-0002-8427-4409"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P.R. Lowenstein","raw_affiliation_strings":["The University of Michigan Medical School, Ann Arbor, MI, USA","Cell and Developmental Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Michigan Medical School, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Cell and Developmental Biology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":null,"apc_paid":null,"fwci":0.659,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.71166448,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":1.0},{"id":"https://openalex.org/keywords/viral-vectors","display_name":"viral vectors","score":0.8370000123977661},{"id":"https://openalex.org/keywords/viral-vector-engineering","display_name":"viral vector engineering","score":0.7870000004768372},{"id":"https://openalex.org/keywords/transgene-expression-regulation","display_name":"transgene expression regulation","score":0.8870000243186951},{"id":"https://openalex.org/keywords/gene-therapy-safety","display_name":"gene therapy safety","score":0.8980000019073486},{"id":"https://openalex.org/keywords/cancer-gene-therapy","display_name":"cancer gene therapy","score":0.902999997138977},{"id":"https://openalex.org/keywords/nucleic-acid-delivery","display_name":"nucleic acid delivery","score":0.8159999847412109},{"id":"https://openalex.org/keywords/clinical-gene-therapy","display_name":"clinical gene therapy","score":0.7229999899864197}],"concepts":[{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.8656337857246399},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.649831235408783},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.6116846203804016},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.5434302687644958},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.5111053586006165},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.49703362584114075},{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.47796890139579773},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.4592357575893402},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4384317994117737},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4106491804122925},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3736640214920044},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.37203964591026306},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3496773838996887},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.33261412382125854},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27430790662765503},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.14157971739768982},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/b978-0-12-801238-3.05502-1","doi":"https://doi.org/10.1016/b978-0-12-801238-3.05502-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-0-12-801238-3.05502-1","pdf_url":null,"source":{"id":"https://openalex.org/S4306463230","display_name":"Elsevier eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reference Module in Biomedical Sciences","raw_type":"book-chapter"},{"id":"mag:2202279480","doi":null,"is_oa":false,"landing_page_url":"https://www.sciencedirect.com/science/article/pii/B9780123838346000379","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:3023659946","doi":null,"is_oa":false,"landing_page_url":"https://www.sciencedirect.com/science/article/pii/B9780123838346000379","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":258,"referenced_works":["https://openalex.org/W58471608","https://openalex.org/W62603772","https://openalex.org/W96036370","https://openalex.org/W168620583","https://openalex.org/W181359990","https://openalex.org/W192711870","https://openalex.org/W203672238","https://openalex.org/W321395463","https://openalex.org/W1481565655","https://openalex.org/W1521887751","https://openalex.org/W1525957882","https://openalex.org/W1532854308","https://openalex.org/W1536266814","https://openalex.org/W1540483167","https://openalex.org/W1544608701","https://openalex.org/W1546694929","https://openalex.org/W1573172871","https://openalex.org/W1582533438","https://openalex.org/W1583992601","https://openalex.org/W1587727277","https://openalex.org/W1606562486","https://openalex.org/W1609471181","https://openalex.org/W1639832183","https://openalex.org/W1651086125","https://openalex.org/W1835972708","https://openalex.org/W1877873625","https://openalex.org/W1913924834","https://openalex.org/W1925251592","https://openalex.org/W1950619641","https://openalex.org/W1963733408","https://openalex.org/W1964598686","https://openalex.org/W1965575378","https://openalex.org/W1967013096","https://openalex.org/W1967983050","https://openalex.org/W1969297400","https://openalex.org/W1970393643","https://openalex.org/W1970586355","https://openalex.org/W1971389338","https://openalex.org/W1972514500","https://openalex.org/W1973391969","https://openalex.org/W1973705988","https://openalex.org/W1973722459","https://openalex.org/W1973773971","https://openalex.org/W1973811358","https://openalex.org/W1974324128","https://openalex.org/W1976161055","https://openalex.org/W1976351579","https://openalex.org/W1977142869","https://openalex.org/W1977376243","https://openalex.org/W1977486219","https://openalex.org/W1981369720","https://openalex.org/W1984030995","https://openalex.org/W1984714304","https://openalex.org/W1987200082","https://openalex.org/W1987286138","https://openalex.org/W1987483457","https://openalex.org/W1987741335","https://openalex.org/W1988078932","https://openalex.org/W1988142389","https://openalex.org/W1988607142","https://openalex.org/W1988791308","https://openalex.org/W1988842802","https://openalex.org/W1989674496","https://openalex.org/W1990561446","https://openalex.org/W1991977041","https://openalex.org/W1993467626","https://openalex.org/W1993935564","https://openalex.org/W1994396884","https://openalex.org/W1994548914","https://openalex.org/W1996065891","https://openalex.org/W1996163490","https://openalex.org/W1996574885","https://openalex.org/W1996916131","https://openalex.org/W1997031405","https://openalex.org/W1997034660","https://openalex.org/W1999893655","https://openalex.org/W1999963160","https://openalex.org/W2000630426","https://openalex.org/W2001176644","https://openalex.org/W2002104055","https://openalex.org/W2002914110","https://openalex.org/W2003950903","https://openalex.org/W2004817863","https://openalex.org/W2005646823","https://openalex.org/W2006231275","https://openalex.org/W2006519535","https://openalex.org/W2007854533","https://openalex.org/W2008260185","https://openalex.org/W2008350281","https://openalex.org/W2008388383","https://openalex.org/W2008759459","https://openalex.org/W2009761723","https://openalex.org/W2009822728","https://openalex.org/W2010050763","https://openalex.org/W2010203554","https://openalex.org/W2011025411","https://openalex.org/W2011486273","https://openalex.org/W2011762615","https://openalex.org/W2013395271","https://openalex.org/W2013868082","https://openalex.org/W2014396854","https://openalex.org/W2014850190","https://openalex.org/W2015372139","https://openalex.org/W2016138321","https://openalex.org/W2016390889","https://openalex.org/W2017304478","https://openalex.org/W2018074747","https://openalex.org/W2019631541","https://openalex.org/W2021904740","https://openalex.org/W2022976505","https://openalex.org/W2023254910","https://openalex.org/W2026155724","https://openalex.org/W2027980197","https://openalex.org/W2028848094","https://openalex.org/W2029571886","https://openalex.org/W2032323486","https://openalex.org/W2033530205","https://openalex.org/W2034462829","https://openalex.org/W2035589234","https://openalex.org/W2037171350","https://openalex.org/W2037455123","https://openalex.org/W2038036971","https://openalex.org/W2040576313","https://openalex.org/W2042018401","https://openalex.org/W2042739691","https://openalex.org/W2042812490","https://openalex.org/W2043741727","https://openalex.org/W2044286471","https://openalex.org/W2044527317","https://openalex.org/W2045140637","https://openalex.org/W2046390966","https://openalex.org/W2047885861","https://openalex.org/W2047945439","https://openalex.org/W2049092411","https://openalex.org/W2049309316","https://openalex.org/W2051159468","https://openalex.org/W2051758487","https://openalex.org/W2053980996","https://openalex.org/W2054810445","https://openalex.org/W2057154598","https://openalex.org/W2057548071","https://openalex.org/W2058315462","https://openalex.org/W2059861908","https://openalex.org/W2060637142","https://openalex.org/W2061680367","https://openalex.org/W2061744249","https://openalex.org/W2061793443","https://openalex.org/W2062679237","https://openalex.org/W2062679571","https://openalex.org/W2063340080","https://openalex.org/W2063695629","https://openalex.org/W2064491673","https://openalex.org/W2064668202","https://openalex.org/W2065547960","https://openalex.org/W2067203342","https://openalex.org/W2067669227","https://openalex.org/W2072543946","https://openalex.org/W2075921029","https://openalex.org/W2079803299","https://openalex.org/W2081633854","https://openalex.org/W2082632242","https://openalex.org/W2082675700","https://openalex.org/W2083120527","https://openalex.org/W2085784105","https://openalex.org/W2089311308","https://openalex.org/W2093424805","https://openalex.org/W2093545276","https://openalex.org/W2093697903","https://openalex.org/W2094949672","https://openalex.org/W2096628715","https://openalex.org/W2096772494","https://openalex.org/W2097068344","https://openalex.org/W2098850271","https://openalex.org/W2098898935","https://openalex.org/W2100898704","https://openalex.org/W2101653431","https://openalex.org/W2104979554","https://openalex.org/W2105784332","https://openalex.org/W2106337012","https://openalex.org/W2106599302","https://openalex.org/W2106636191","https://openalex.org/W2108724455","https://openalex.org/W2111769538","https://openalex.org/W2111837903","https://openalex.org/W2111941303","https://openalex.org/W2112216133","https://openalex.org/W2112802967","https://openalex.org/W2113978517","https://openalex.org/W2117506145","https://openalex.org/W2119143622","https://openalex.org/W2121444412","https://openalex.org/W2121944814","https://openalex.org/W2122304523","https://openalex.org/W2122741223","https://openalex.org/W2123505432","https://openalex.org/W2124026319","https://openalex.org/W2128033750","https://openalex.org/W2128453809","https://openalex.org/W2128780762","https://openalex.org/W2129669946","https://openalex.org/W2130275119","https://openalex.org/W2133753843","https://openalex.org/W2134903479","https://openalex.org/W2137222303","https://openalex.org/W2137969577","https://openalex.org/W2139028184","https://openalex.org/W2139661803","https://openalex.org/W2140440263","https://openalex.org/W2141055671","https://openalex.org/W2141350766","https://openalex.org/W2141570423","https://openalex.org/W2142736780","https://openalex.org/W2142780460","https://openalex.org/W2142781204","https://openalex.org/W2143729842","https://openalex.org/W2143970143","https://openalex.org/W2144450772","https://openalex.org/W2144714494","https://openalex.org/W2145367327","https://openalex.org/W2146261786","https://openalex.org/W2146269275","https://openalex.org/W2146611590","https://openalex.org/W2147319330","https://openalex.org/W2148150092","https://openalex.org/W2148200469","https://openalex.org/W2148223197","https://openalex.org/W2149731696","https://openalex.org/W2150712887","https://openalex.org/W2150857721","https://openalex.org/W2157125891","https://openalex.org/W2157366003","https://openalex.org/W2160690575","https://openalex.org/W2161483044","https://openalex.org/W2166739815","https://openalex.org/W2167523976","https://openalex.org/W2167906381","https://openalex.org/W2168330082","https://openalex.org/W2168806847","https://openalex.org/W2169253011","https://openalex.org/W2170548736","https://openalex.org/W2172477250","https://openalex.org/W2173144205","https://openalex.org/W2177094286","https://openalex.org/W2177449481","https://openalex.org/W2177597220","https://openalex.org/W2178556919","https://openalex.org/W2181006996","https://openalex.org/W2284371762","https://openalex.org/W2302402305","https://openalex.org/W2316736253","https://openalex.org/W2318649714","https://openalex.org/W2330499395","https://openalex.org/W2398946814","https://openalex.org/W2400263007","https://openalex.org/W2403017897","https://openalex.org/W2404092363","https://openalex.org/W2416533262","https://openalex.org/W7097514665"],"related_works":["https://openalex.org/W2037899091","https://openalex.org/W7128813004","https://openalex.org/W4317565902","https://openalex.org/W1580973438","https://openalex.org/W2055800121","https://openalex.org/W2152653642","https://openalex.org/W4300678384","https://openalex.org/W2008026046","https://openalex.org/W2529788512","https://openalex.org/W3016339313"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}