{"id":"https://openalex.org/W2202178968","doi":"https://doi.org/10.1021/bi00218a016","title":"Secondary structure of the complement control protein module by two-dimensional proton NMR","display_name":"Secondary structure of the complement control protein module by two-dimensional proton NMR","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W2202178968","doi":"https://doi.org/10.1021/bi00218a016","mag":"2202178968","pmid":"https://pubmed.ncbi.nlm.nih.gov/1824927"},"language":"en","primary_location":{"id":"doi:10.1021/bi00218a016","doi":"https://doi.org/10.1021/bi00218a016","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00218a016","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081507304","display_name":"Paul Nigel Barlow","orcid":"https://orcid.org/0000-0003-4808-6539","observed_orcids":["https://orcid.org/0000-0003-4808-6539","https://orcid.org/0000-0003-4247-6456"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul N. Barlow","raw_affiliation_strings":["Department of Biochemistry, University of Oxford, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Oxford, U.K","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006869242","display_name":"Mart\u00edn Baron","orcid":"https://orcid.org/0000-0002-7375-5784","observed_orcids":["https://orcid.org/0000-0002-7375-5784"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Baron","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"D. G. Norman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. G. Norman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006588214","display_name":"Anthony J. Day","orcid":"https://orcid.org/0000-0002-1415-3134","observed_orcids":["https://orcid.org/0000-0002-1415-3134"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. J. Day","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007285150","display_name":"A.C. Willis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. C. Willis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090308773","display_name":"Robert B. Sim","orcid":"https://orcid.org/0000-0002-2855-7455","observed_orcids":["https://orcid.org/0000-0002-2855-7455"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. B. Sim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108863927","display_name":"Iain Donald Campbell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I. D. Campbell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.0038,"has_fulltext":false,"cited_by_count":94,"citation_normalized_percentile":{"value":0.92530133,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"30","issue":"4","first_page":"997","last_page":"1004"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.6015999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.6015999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.3752000033855438,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/short-consensus-repeats","display_name":"short consensus repeats","score":0.9520000219345093},{"id":"https://openalex.org/keywords/complement-factor-h","display_name":"complement factor H","score":0.9660000205039978},{"id":"https://openalex.org/keywords/protein-secondary-structure","display_name":"protein secondary structure","score":0.9160000085830688},{"id":"https://openalex.org/keywords/antiparallel-beta-sheet","display_name":"antiparallel beta-sheet","score":0.8450000286102295},{"id":"https://openalex.org/keywords/disulfide-bond-formation","display_name":"disulfide bond formation","score":0.7440000176429749},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.5659999847412109},{"id":"https://openalex.org/keywords/conserved-residues","display_name":"conserved residues","score":0.593999981880188},{"id":"https://openalex.org/keywords/sequence-alignment","display_name":"sequence alignment","score":0.46399998664855957}],"concepts":[{"id":"https://openalex.org/C112313634","wikidata":"https://www.wikidata.org/wiki/Q7886648","display_name":"Complement (music)","level":5,"score":0.697522759437561},{"id":"https://openalex.org/C2778805511","wikidata":"https://www.wikidata.org/wiki/Q1713","display_name":"Citation","level":2,"score":0.6564756631851196},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6185792684555054},{"id":"https://openalex.org/C518677369","wikidata":"https://www.wikidata.org/wiki/Q202833","display_name":"Social media","level":2,"score":0.5084768533706665},{"id":"https://openalex.org/C2778447006","wikidata":"https://www.wikidata.org/wiki/Q1156474","display_name":"Icon","level":2,"score":0.5036610960960388},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.4467124938964844},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.43023502826690674},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.33287179470062256},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.32353514432907104},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.26622557640075684},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.13455498218536377},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.0},{"id":"https://openalex.org/C188082640","wikidata":"https://www.wikidata.org/wiki/Q1780899","display_name":"Complementation","level":4,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003180","descriptor_name":"Complement C3b Inactivator Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003180","descriptor_name":"Complement C3b Inactivator Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006859","descriptor_name":"Hydrogen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015003","descriptor_name":"Yeasts","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016384","descriptor_name":"Consensus Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017242","descriptor_name":"Complement Factor H","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/bi00218a016","doi":"https://doi.org/10.1021/bi00218a016","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00218a016","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:1824927","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1824927","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/9c34bfb0-8a0b-449b-94ec-03c45e88469d","doi":null,"is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/publications/9c34bfb0-8a0b-449b-94ec-03c45e88469d","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Barlow, PN, Baron, M, Norman, DG, Day, AJ, Willis, AC, Sim, RB & Campbell, ID 1991, 'Secondary structure of a complement control protein module by two-dimensional 1H NMR.', Biochemistry, vol. 30, no. 4. https://doi.org/10.1021/bi00218a016","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W102276543","https://openalex.org/W1499309587","https://openalex.org/W1966286149","https://openalex.org/W1968343429","https://openalex.org/W1968360065","https://openalex.org/W1969270088","https://openalex.org/W1979756776","https://openalex.org/W1983023359","https://openalex.org/W1984034111","https://openalex.org/W1988394498","https://openalex.org/W1993844842","https://openalex.org/W2001384227","https://openalex.org/W2003802570","https://openalex.org/W2007282272","https://openalex.org/W2016031756","https://openalex.org/W2016706363","https://openalex.org/W2022016707","https://openalex.org/W2024275778","https://openalex.org/W2026070522","https://openalex.org/W2026075546","https://openalex.org/W2031209863","https://openalex.org/W2041349540","https://openalex.org/W2045446885","https://openalex.org/W2049622931","https://openalex.org/W2054049732","https://openalex.org/W2055230647","https://openalex.org/W2055785572","https://openalex.org/W2061186144","https://openalex.org/W2074770586","https://openalex.org/W2086119700","https://openalex.org/W2087777628","https://openalex.org/W2095389787","https://openalex.org/W2121976226","https://openalex.org/W2148740955","https://openalex.org/W2174272589","https://openalex.org/W2222137568","https://openalex.org/W2312537558"],"related_works":["https://openalex.org/W2080178350","https://openalex.org/W200977172","https://openalex.org/W1969211427","https://openalex.org/W2149548016","https://openalex.org/W2110037767","https://openalex.org/W1979756776","https://openalex.org/W2018666295","https://openalex.org/W2059118152","https://openalex.org/W1981559037","https://openalex.org/W1998231198"],"abstract_inverted_index":{"The":[0,112],"complement":[1,46,57],"control":[2],"protein":[3],"(CCP)":[4],"module":[5,93,114],"(also":[6],"known":[7],"as":[8,79],"the":[9,45,52,72,83,177,214,220,237,249],"short":[10,140],"consensus":[11,15],"repeat)":[12],"is":[13,24,80,168],"a":[14,64,139,161,171,245],"sequence":[16],"of":[17,44,75,91,107,125,142,179,183,224,227,239],"about":[18],"60":[19],"amino":[20,229],"acid":[21,230],"residues":[22,231],"which":[23,232],"thought":[25],"to":[26,69,104,159,213,243],"fold":[27,70],"independently.":[28],"It":[29],"occurs":[30],"over":[31],"140":[32],"times":[33],"in":[34,63,82,110,219,247],"more":[35],"than":[36],"20":[37],"extracellular":[38],"mosaic":[39],"proteins":[40,43],"including":[41],"12":[42],"cascade.":[47],"An":[48],"isolated":[49],"CCP":[50,113,187,240],"module,":[51],"16th":[53],"repeat":[54],"from":[55],"human":[56],"factor":[58],"H,":[59],"has":[60],"been":[61,95],"expressed":[62],"yeast":[65],"vector":[66],"and":[67,100,102,121,133,138,147,154,222],"shown":[68],"with":[71,131,136,170],"same":[73],"pattern":[74],"disulfide":[76],"bond":[77],"formation":[78],"seen":[81],"native":[84],"protein.":[85],"Two-dimensional":[86],"600-MHz":[87],"1H":[88],"NMR":[89],"spectra":[90],"this":[92],"have":[94],"recorded":[96],"at":[97,151],"pH":[98],"3.3":[99],"6.0":[101],"analyzed":[103],"permit":[105],"determination":[106],"secondary":[108,172,207],"structure":[109,167,173,208],"solution.":[111],"comprises":[115],"two":[116,123],"predominantly":[117],"extended":[118],"segments":[119,124],"(Glu1-His13":[120],"Ala17-Glu27),":[122],"double-stranded":[126],"antiparallel":[127],"beta-sheet":[128,144],"(Gly14-Val16":[129],"paired":[130,135],"Tyr31-Cys33":[132],"Gly38-Asp40":[134],"Ser57-Ile59),":[137],"piece":[141],"triple-stranded":[143],"(Glu27-Thr30,":[145],"Ile44-Leu48,":[146],"Lys51-Ser53).":[148],"Turns":[149],"occur":[150],"Asp22,":[152],"Gly36,":[153],"Glu50,":[155],"while":[156],"Gly41-Ala43":[157],"appear":[158,242],"form":[160],"looped-out":[162],"segment":[163],"or":[164],"bulge.":[165],"This":[166],"compared":[169],"prediction":[174],"made":[175],"on":[176],"basis":[178],"an":[180,210],"alignment":[181],"scheme":[182],"101":[184],"sequences":[185],"for":[186],"modules":[188,241],"[Perkins,":[189],"S.":[190],"J.,":[191],"Haris,":[192],"P.":[193],"I.,":[194],"Sim,":[195],"R.":[196],"B.,":[197],"&":[198],"Chapman,":[199],"D.":[200],"(1988)":[201],"Biochemistry":[202],"27,":[203],"4004-4012]--the":[204],"experimentally":[205],"determined":[206],"bears":[209],"overall":[211],"resemblance":[212],"predicted":[215],"one":[216],"but":[217],"differs":[218],"number":[221],"position":[223],"turns.":[225],"Some":[226],"those":[228],"are":[233],"highly":[234],"conserved":[235],"throughout":[236],"range":[238],"play":[244],"role":[246],"stabilizing":[248],"global":[250],"fold.":[251]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
