{"id":"https://openalex.org/W2201849221","doi":"https://doi.org/10.1517/14728222.2016.1132702","title":"Epigenetic targets in cancer and aging: dietary and therapeutic interventions","display_name":"Epigenetic targets in cancer and aging: dietary and therapeutic interventions","publication_year":2015,"publication_date":"2015-12-15","ids":{"openalex":"https://openalex.org/W2201849221","doi":"https://doi.org/10.1517/14728222.2016.1132702","mag":"2201849221","pmid":"https://pubmed.ncbi.nlm.nih.gov/26667209"},"language":"en","primary_location":{"id":"doi:10.1517/14728222.2016.1132702","doi":"https://doi.org/10.1517/14728222.2016.1132702","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14728222.2016.1132702","pdf_url":null,"source":{"id":"https://openalex.org/S149756942","display_name":"Expert Opinion on Therapeutic Targets","issn_l":"1472-8222","issn":["1472-8222","1744-7631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Therapeutic Targets","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2201849221"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049748617","display_name":"Sajid Ullah Khan","orcid":"https://orcid.org/0000-0003-1331-8846","observed_orcids":["https://orcid.org/0000-0003-1331-8846","https://orcid.org/0000-0003-1386-3713"]},"institutions":[{"id":"https://openalex.org/I185249246","display_name":"Central Drug Research Institute","ror":"https://ror.org/04t8qjg16","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185249246","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sajid Khan","raw_affiliation_strings":["a Division of Endocrinology , CSIR-Central Drug Research Institute , Lucknow , India","Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Division of Endocrinology , CSIR-Central Drug Research Institute , Lucknow , India","institution_ids":["https://openalex.org/I185249246","https://openalex.org/I66760702"]},{"raw_affiliation_string":"Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India","institution_ids":["https://openalex.org/I185249246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023063853","display_name":"Samriddhi Shukla","orcid":"https://orcid.org/0000-0002-3771-4184","observed_orcids":["https://orcid.org/0000-0002-3771-4184"]},"institutions":[{"id":"https://openalex.org/I185249246","display_name":"Central Drug Research Institute","ror":"https://ror.org/04t8qjg16","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185249246","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Samriddhi Shukla","raw_affiliation_strings":["a Division of Endocrinology , CSIR-Central Drug Research Institute , Lucknow , India","Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Division of Endocrinology , CSIR-Central Drug Research Institute , Lucknow , India","institution_ids":["https://openalex.org/I185249246","https://openalex.org/I66760702"]},{"raw_affiliation_string":"Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India","institution_ids":["https://openalex.org/I185249246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086664985","display_name":"Sonam Sinha","orcid":"https://orcid.org/0000-0002-6996-0611","observed_orcids":["https://orcid.org/0000-0002-6996-0611"]},"institutions":[{"id":"https://openalex.org/I185249246","display_name":"Central Drug Research Institute","ror":"https://ror.org/04t8qjg16","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185249246","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sonam Sinha","raw_affiliation_strings":["a Division of Endocrinology , CSIR-Central Drug Research Institute , Lucknow , India","Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Division of Endocrinology , CSIR-Central Drug Research Institute , Lucknow , India","institution_ids":["https://openalex.org/I185249246","https://openalex.org/I66760702"]},{"raw_affiliation_string":"Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India","institution_ids":["https://openalex.org/I185249246"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004079933","display_name":"Syed Musthapa Meeran","orcid":"https://orcid.org/0000-0003-3859-146X","observed_orcids":["https://orcid.org/0000-0003-3859-146X"]},"institutions":[{"id":"https://openalex.org/I185249246","display_name":"Central Drug Research Institute","ror":"https://ror.org/04t8qjg16","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185249246","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Syed Musthapa Meeran","raw_affiliation_strings":["a Division of Endocrinology , CSIR-Central Drug Research Institute , Lucknow , India","Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Division of Endocrinology , CSIR-Central Drug Research Institute , Lucknow , India","institution_ids":["https://openalex.org/I185249246","https://openalex.org/I66760702"]},{"raw_affiliation_string":"Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India","institution_ids":["https://openalex.org/I185249246"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5004079933"],"corresponding_institution_ids":["https://openalex.org/I185249246","https://openalex.org/I66760702"],"apc_list":null,"apc_paid":null,"fwci":0.1863,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.12326389,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"20","issue":"6","first_page":"689","last_page":"703"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.8840000033378601},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.871999979019165},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":1.0},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.9729999899864197},{"id":"https://openalex.org/keywords/hypomethylating-agents","display_name":"hypomethylating agents","score":0.9990000128746033},{"id":"https://openalex.org/keywords/epigenetic-modifiers","display_name":"epigenetic regulators","score":0.7860000133514404},{"id":"https://openalex.org/keywords/dietary-intervention","display_name":"dietary intervention","score":0.7049999833106995},{"id":"https://openalex.org/keywords/caloric-restriction","display_name":"caloric restriction","score":0.9340000152587891},{"id":"https://openalex.org/keywords/phytochemicals","display_name":"phytochemicals","score":0.8790000081062317},{"id":"https://openalex.org/keywords/cancer-prevention","display_name":"cancer prevention","score":0.9440000057220459},{"id":"https://openalex.org/keywords/epigenetic-therapy","display_name":"epigenetic therapy","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.8962972164154053},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.6504842042922974},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6276770830154419},{"id":"https://openalex.org/C2780737395","wikidata":"https://www.wikidata.org/wiki/Q18353741","display_name":"Epigenetic therapy","level":5,"score":0.5443028211593628},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4919407069683075},{"id":"https://openalex.org/C2780234812","wikidata":"https://www.wikidata.org/wiki/Q1787013","display_name":"Cancer prevention","level":3,"score":0.48051294684410095},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.44577455520629883},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4367283284664154},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.4301239848136902},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.34103256464004517},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1705092191696167},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1501530408859253},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13647615909576416},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.09284988045692444}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004248","descriptor_name":"DNA (Cytosine-5-)-Methyltransferases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008517","descriptor_name":"Phytotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056572","descriptor_name":"Histone Deacetylase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1517/14728222.2016.1132702","doi":"https://doi.org/10.1517/14728222.2016.1132702","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14728222.2016.1132702","pdf_url":null,"source":{"id":"https://openalex.org/S149756942","display_name":"Expert Opinion on Therapeutic Targets","issn_l":"1472-8222","issn":["1472-8222","1744-7631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Therapeutic Targets","raw_type":"journal-article"},{"id":"pmid:26667209","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26667209","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on therapeutic targets","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1561391478","display_name":null,"funder_award_id":"SR/FT/LS-80/2011","funder_id":"https://openalex.org/F4320334771","funder_display_name":"Science and Engineering Research Board"},{"id":"https://openalex.org/G229355000","display_name":null,"funder_award_id":"BCIL/NER-BPMC/2013/722","funder_id":"https://openalex.org/F4320320717","funder_display_name":"Department of Biotechnology, Ministry of Science and Technology, India"},{"id":"https://openalex.org/G6876483475","display_name":null,"funder_award_id":"Network Scheme (BSC0118)","funder_id":"https://openalex.org/F4320320682","funder_display_name":"Council for Scientific and Industrial Research, South Africa"}],"funders":[{"id":"https://openalex.org/F4320320682","display_name":"Council for Scientific and Industrial Research, South Africa","ror":"https://ror.org/05j00sr48"},{"id":"https://openalex.org/F4320320717","display_name":"Department of Biotechnology, Ministry of Science and Technology, India","ror":"https://ror.org/03tjsyq23"},{"id":"https://openalex.org/F4320334771","display_name":"Science and Engineering Research Board","ror":"https://ror.org/03ffdsr55"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":156,"referenced_works":["https://openalex.org/W177649821","https://openalex.org/W1493263872","https://openalex.org/W1504197144","https://openalex.org/W1529595331","https://openalex.org/W1549490493","https://openalex.org/W1561748058","https://openalex.org/W1596075318","https://openalex.org/W1608490912","https://openalex.org/W1658127082","https://openalex.org/W1779082808","https://openalex.org/W1862988248","https://openalex.org/W1920889715","https://openalex.org/W1939667010","https://openalex.org/W1965262464","https://openalex.org/W1965285165","https://openalex.org/W1967108608","https://openalex.org/W1968018974","https://openalex.org/W1969123232","https://openalex.org/W1969227203","https://openalex.org/W1969288350","https://openalex.org/W1972292377","https://openalex.org/W1972462861","https://openalex.org/W1973928348","https://openalex.org/W1975431633","https://openalex.org/W1975705914","https://openalex.org/W1975827192","https://openalex.org/W1976287566","https://openalex.org/W1976882367","https://openalex.org/W1978788671","https://openalex.org/W1983292301","https://openalex.org/W1984004239","https://openalex.org/W1986193321","https://openalex.org/W1990179625","https://openalex.org/W1990916340","https://openalex.org/W1994827921","https://openalex.org/W1996103159","https://openalex.org/W1998111191","https://openalex.org/W2002032609","https://openalex.org/W2002881475","https://openalex.org/W2004078197","https://openalex.org/W2004569410","https://openalex.org/W2006333906","https://openalex.org/W2006600625","https://openalex.org/W2007842741","https://openalex.org/W2009681741","https://openalex.org/W2009826707","https://openalex.org/W2011311685","https://openalex.org/W2013749723","https://openalex.org/W2014037575","https://openalex.org/W2014442719","https://openalex.org/W2017235915","https://openalex.org/W2018600278","https://openalex.org/W2019892867","https://openalex.org/W2021836517","https://openalex.org/W2025041464","https://openalex.org/W2025668535","https://openalex.org/W2026101912","https://openalex.org/W2030029312","https://openalex.org/W2031162955","https://openalex.org/W2034521172","https://openalex.org/W2035478417","https://openalex.org/W2037207156","https://openalex.org/W2038458062","https://openalex.org/W2038796248","https://openalex.org/W2041544048","https://openalex.org/W2041686632","https://openalex.org/W2044769523","https://openalex.org/W2045986053","https://openalex.org/W2046345187","https://openalex.org/W2046414971","https://openalex.org/W2051509673","https://openalex.org/W2051788083","https://openalex.org/W2054974538","https://openalex.org/W2058466726","https://openalex.org/W2059095722","https://openalex.org/W2060814375","https://openalex.org/W2063084036","https://openalex.org/W2063334329","https://openalex.org/W2066186764","https://openalex.org/W2069702490","https://openalex.org/W2070190142","https://openalex.org/W2074717506","https://openalex.org/W2074740541","https://openalex.org/W2077920425","https://openalex.org/W2078003979","https://openalex.org/W2078441617","https://openalex.org/W2080135307","https://openalex.org/W2080821826","https://openalex.org/W2083620394","https://openalex.org/W2085667285","https://openalex.org/W2087102857","https://openalex.org/W2087330696","https://openalex.org/W2089006877","https://openalex.org/W2089889294","https://openalex.org/W2090374150","https://openalex.org/W2092003419","https://openalex.org/W2093172432","https://openalex.org/W2093595618","https://openalex.org/W2095569714","https://openalex.org/W2096158640","https://openalex.org/W2098237331","https://openalex.org/W2100257850","https://openalex.org/W2100680346","https://openalex.org/W2102145994","https://openalex.org/W2108456985","https://openalex.org/W2109560454","https://openalex.org/W2111548270","https://openalex.org/W2111797455","https://openalex.org/W2112702770","https://openalex.org/W2113524127","https://openalex.org/W2114479856","https://openalex.org/W2117247812","https://openalex.org/W2117551340","https://openalex.org/W2117966565","https://openalex.org/W2118540634","https://openalex.org/W2118964113","https://openalex.org/W2119542428","https://openalex.org/W2120595047","https://openalex.org/W2122598808","https://openalex.org/W2126368856","https://openalex.org/W2126401328","https://openalex.org/W2126525177","https://openalex.org/W2130596897","https://openalex.org/W2131072337","https://openalex.org/W2133816851","https://openalex.org/W2133877856","https://openalex.org/W2134555277","https://openalex.org/W2135953007","https://openalex.org/W2136830554","https://openalex.org/W2143716699","https://openalex.org/W2146689062","https://openalex.org/W2148588414","https://openalex.org/W2148693352","https://openalex.org/W2149585679","https://openalex.org/W2149591661","https://openalex.org/W2150265245","https://openalex.org/W2151089679","https://openalex.org/W2151741779","https://openalex.org/W2153106604","https://openalex.org/W2154964951","https://openalex.org/W2157607726","https://openalex.org/W2158876620","https://openalex.org/W2159692046","https://openalex.org/W2162468404","https://openalex.org/W2162672000","https://openalex.org/W2164297850","https://openalex.org/W2164390929","https://openalex.org/W2164411032","https://openalex.org/W2167319166","https://openalex.org/W2167637569","https://openalex.org/W2169082376","https://openalex.org/W2170208753","https://openalex.org/W2172105916","https://openalex.org/W2180937315","https://openalex.org/W2326510287","https://openalex.org/W2915683117"],"related_works":["https://openalex.org/W2167637569","https://openalex.org/W177649821","https://openalex.org/W2919977311","https://openalex.org/W4400154162","https://openalex.org/W2015999693","https://openalex.org/W171420732","https://openalex.org/W4231402699","https://openalex.org/W2036830903","https://openalex.org/W3112245208","https://openalex.org/W2962348202"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Epigenetic":[1],"regulation":[2,32],"plays":[3],"a":[4],"critical":[5],"role":[6],"in":[7,30,37,57,73,139,158],"normal":[8],"growth":[9],"and":[10,39,49,59,75,84,102,124,151,180,184],"embryonic":[11],"development":[12],"by":[13,86],"controlling":[14],"the":[15,31,69,118,153],"transcriptional":[16],"activities":[17,138],"of":[18,24,33,109,155,167],"several":[19,121],"genes.":[20],"A":[21],"growing":[22],"number":[23],"epigenetic":[25,43,71,136,143],"changes":[26],"have":[27,53,98,131,145],"been":[28,132,146],"reported":[29],"key":[34],"genes":[35],"involved":[36],"cancer":[38,60,74,113,156,178],"aging.":[40],"Drugs":[41],"with":[42,77,171,185],"modulatory":[44,137],"activities,":[45],"mainly":[46],"histone":[47],"deacetylase":[48],"DNA":[50],"methyltransferase":[51],"inhibitors,":[52],"received":[54,99],"wider":[55],"attention":[56],"aging":[58,150],"research.":[61],"AREAS":[62],"COVERED:":[63],"In":[64,115],"this":[65],"review,":[66],"we":[67],"summarize":[68],"major":[70],"alterations":[72],"aging,":[76],"special":[78],"emphasis":[79],"on":[80],"possible":[81],"therapeutic":[82],"targets":[83],"interventions":[85,173],"dietary":[87,125,172],"as":[88,90,128,160,162],"well":[89,161],"bioactive":[91,122,168],"phytochemicals.":[92],"EXPERT":[93],"OPINION:":[94],"Some":[95],"epigenetic-targeting":[96],"drugs":[97,187],"FDA":[100],"approval":[101],"many":[103],"others":[104],"are":[105],"undergoing":[106],"different":[107],"phases":[108],"clinical":[110,163],"trials":[111],"for":[112,177],"therapy.":[114],"addition":[116],"to":[117,134,148,188],"synthetic":[119],"compounds,":[120],"phytochemicals":[123,169],"interventions,":[126],"such":[127],"caloric":[129],"restriction,":[130],"shown":[133,147],"possess":[135],"multiple":[140],"cancers.":[141],"These":[142],"modulators":[144],"delay":[149],"minimize":[152],"risk":[154],"both":[157,182],"preclinical":[159],"models.":[164],"Therefore,":[165],"knowledge":[166],"along":[170],"can":[174],"be":[175],"utilized":[176],"prevention":[179],"therapy":[181],"alone":[183],"existing":[186],"achieve":[189],"optimum":[190],"efficacy.":[191]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
