{"id":"https://openalex.org/W2201825518","doi":"https://doi.org/10.3109/10641968309048844","title":"The tissue Renin-Angiotensin Systems: Focus on Brain Angiotensin, Adrenal Gland and Arterial Wall","display_name":"The tissue Renin-Angiotensin Systems: Focus on Brain Angiotensin, Adrenal Gland and Arterial Wall","publication_year":1983,"publication_date":"1983-01-01","ids":{"openalex":"https://openalex.org/W2201825518","doi":"https://doi.org/10.3109/10641968309048844","mag":"2201825518","pmid":"https://pubmed.ncbi.nlm.nih.gov/6640963"},"language":"en","primary_location":{"id":"doi:10.3109/10641968309048844","doi":"https://doi.org/10.3109/10641968309048844","is_oa":false,"landing_page_url":"https://doi.org/10.3109/10641968309048844","pdf_url":null,"source":{"id":"https://openalex.org/S203233286","display_name":"Clinical and Experimental Hypertension","issn_l":"0148-3927","issn":["0148-3927","0730-0077","1064-1963","1525-6006"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Hypertension. Part A: Theory and Practice","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092173916","display_name":"Detlev Ganten","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"D. Ganten","raw_affiliation_strings":["German Institute for High Blood Pressure Research, Department of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, D-6900, Heidelberg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Institute for High Blood Pressure Research, Department of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, D-6900, Heidelberg","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110141001","display_name":"Klaus Hermann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K. Hermann","raw_affiliation_strings":["German Institute for High Blood Pressure Research, Department of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, D-6900, Heidelberg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Institute for High Blood Pressure Research, Department of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, D-6900, Heidelberg","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109833771","display_name":"Th. Unger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Th. Unger","raw_affiliation_strings":["German Institute for High Blood Pressure Research, Department of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, D-6900, Heidelberg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Institute for High Blood Pressure Research, Department of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, D-6900, Heidelberg","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109127716","display_name":"Rudolf Ernst Lang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R. E. Lang","raw_affiliation_strings":["German Institute for High Blood Pressure Research, Department of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, D-6900, Heidelberg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Institute for High Blood Pressure Research, Department of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, D-6900, Heidelberg","institution_ids":["https://openalex.org/I223822909"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I223822909"],"apc_list":null,"apc_paid":null,"fwci":4.3857,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.9418708,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"5","issue":"7-8","first_page":"1099","last_page":"1118"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/renin-angiotensin-system","display_name":"renin-angiotensin system","score":0.9309999942779541},{"id":"https://openalex.org/keywords/angiotensin","display_name":"angiotensin","score":0.8100000023841858},{"id":"https://openalex.org/keywords/adrenal-gland","display_name":"adrenal gland","score":0.8259999752044678},{"id":"https://openalex.org/keywords/arterial-wall","display_name":"arterial wall","score":0.9399999976158142},{"id":"https://openalex.org/keywords/neurohormones","display_name":"neurohormones","score":0.8859999775886536},{"id":"https://openalex.org/keywords/renin","display_name":"renin","score":0.4699999988079071}],"concepts":[{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.8748812079429626},{"id":"https://openalex.org/C2780694816","wikidata":"https://www.wikidata.org/wiki/Q712294","display_name":"Adrenal gland","level":2,"score":0.7574688196182251},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7369678020477295},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7166846990585327},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.6553642153739929},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.608025074005127},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4314384460449219},{"id":"https://openalex.org/C27016395","wikidata":"https://www.wikidata.org/wiki/Q128861","display_name":"Angiotensin-converting enzyme","level":3,"score":0.4172550439834595},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39899882674217224},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2725052833557129},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.2006664276123047}],"mesh":[{"descriptor_ui":"D000311","descriptor_name":"Adrenal Glands","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000450","descriptor_name":"Aldosterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001158","descriptor_name":"Arteries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003345","descriptor_name":"Corticosterone","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012084","descriptor_name":"Renin-Angiotensin System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/10641968309048844","doi":"https://doi.org/10.3109/10641968309048844","is_oa":false,"landing_page_url":"https://doi.org/10.3109/10641968309048844","pdf_url":null,"source":{"id":"https://openalex.org/S203233286","display_name":"Clinical and Experimental Hypertension","issn_l":"0148-3927","issn":["0148-3927","0730-0077","1064-1963","1525-6006"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Hypertension. Part A: Theory and Practice","raw_type":"journal-article"},{"id":"pmid:6640963","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6640963","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental hypertension. Part A, Theory and practice","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W153898574","https://openalex.org/W253995053","https://openalex.org/W610129849","https://openalex.org/W1506645419","https://openalex.org/W1517578770","https://openalex.org/W1534407529","https://openalex.org/W1975005022","https://openalex.org/W1991841545","https://openalex.org/W2002110655","https://openalex.org/W2002160197","https://openalex.org/W2009711601","https://openalex.org/W2014246630","https://openalex.org/W2024912244","https://openalex.org/W2034223419","https://openalex.org/W2040970156","https://openalex.org/W2046452564","https://openalex.org/W2054359587","https://openalex.org/W2064258032","https://openalex.org/W2070534059","https://openalex.org/W2078092107","https://openalex.org/W2084150614","https://openalex.org/W2085993274","https://openalex.org/W2089657765","https://openalex.org/W2107921277","https://openalex.org/W2113014059","https://openalex.org/W2162259151","https://openalex.org/W2164282833","https://openalex.org/W2171251866","https://openalex.org/W2181173018","https://openalex.org/W2289983993","https://openalex.org/W2318193935","https://openalex.org/W2322249047","https://openalex.org/W2340504042","https://openalex.org/W2411715689","https://openalex.org/W2472485166","https://openalex.org/W2489239373"],"related_works":["https://openalex.org/W2157466080","https://openalex.org/W2086516161","https://openalex.org/W2079190193","https://openalex.org/W7034185227","https://openalex.org/W3000669598","https://openalex.org/W308831378","https://openalex.org/W2042953335","https://openalex.org/W2111214782","https://openalex.org/W2029772347","https://openalex.org/W2089904626"],"abstract_inverted_index":{"The":[0,74],"enzyme":[1,10],"renin":[2,32],"has":[3,33,87],"long":[4],"been":[5,34],"considered":[6,23],"an":[7],"exclusively":[8],"renal":[9],"responsible":[11],"for":[12],"the":[13,18,41,54,57,59,62,66],"generation":[14,78],"of":[15,50,76,79],"angiotensin":[16,21,80,96],"in":[17,40,44,46,81],"plasma,":[19],"and":[20,65],"was":[22],"a":[24,47,92,98,105],"peptide":[25],"hormone":[26],"with":[27],"specific":[28],"target":[29,83],"organs.":[30],"Since":[31],"discovered":[35],"to":[36,71],"occur":[37],"not":[38],"only":[39],"kidney":[42],"but":[43],"addition":[45],"large":[48],"number":[49],"other":[51],"tissues,":[52,84],"e.g.":[53],"salivary":[55],"gland,":[56],"uterus,":[58],"blood":[60],"vessels,":[61],"adrenal":[63],"gland":[64],"brain,":[67],"this":[68],"concept":[69],"had":[70],"be":[72],"revised.":[73],"possibility":[75],"local":[77],"these":[82],"where":[85],"it":[86],"marked":[88],"biological":[89],"effects":[90],"casts":[91],"new":[93],"light":[94],"on":[95],"as":[97],"more":[99],"ubiquitous":[100],"tissue":[101],"factor":[102],"or":[103],"even":[104],"neurohormone.":[106]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}