{"id":"https://openalex.org/W2201816349","doi":"https://doi.org/10.1186/s13256-015-0773-7","title":"Papillon-L\u00e8fevre syndrome with palmoplantar keratoderma and periodontitis, a rare cause of pyrexia of unknown origin: a case report","display_name":"Papillon-L\u00e8fevre syndrome with palmoplantar keratoderma and periodontitis, a rare cause of pyrexia of unknown origin: a case report","publication_year":2015,"publication_date":"2015-12-01","ids":{"openalex":"https://openalex.org/W2201816349","doi":"https://doi.org/10.1186/s13256-015-0773-7","mag":"2201816349","pmid":"https://pubmed.ncbi.nlm.nih.gov/26683691","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4684603"},"language":"en","primary_location":{"id":"doi:10.1186/s13256-015-0773-7","doi":"https://doi.org/10.1186/s13256-015-0773-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13256-015-0773-7","pdf_url":"https://jmedicalcasereports.biomedcentral.com/counter/pdf/10.1186/s13256-015-0773-7","source":{"id":"https://openalex.org/S162052592","display_name":"Journal of Medical Case Reports","issn_l":"1752-1947","issn":["1752-1947"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Case Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jmedicalcasereports.biomedcentral.com/counter/pdf/10.1186/s13256-015-0773-7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074388758","display_name":"Somia Iqtadar","orcid":"https://orcid.org/0000-0002-8482-9355","observed_orcids":["https://orcid.org/0000-0002-8482-9355"]},"institutions":[{"id":"https://openalex.org/I142016965","display_name":"King Edward Medical University","ror":"https://ror.org/02rrbpf42","country_code":"PK","type":"education","lineage":["https://openalex.org/I142016965"]},{"id":"https://openalex.org/I4210145659","display_name":"Mayo Hospital","ror":"https://ror.org/046jyn221","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I4210145659"]}],"countries":["PK"],"is_corresponding":true,"raw_author_name":"Somia Iqtadar","raw_affiliation_strings":["North Medical Ward,Mayo Hospital, King Edward Medical University, Lahore, Pakistan. somia.iqtadar@gmail.com","North Medical Ward,Mayo Hospital, King Edward Medical University, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"North Medical Ward,Mayo Hospital, King Edward Medical University, Lahore, Pakistan. somia.iqtadar@gmail.com","institution_ids":["https://openalex.org/I142016965","https://openalex.org/I4210145659"]},{"raw_affiliation_string":"North Medical Ward,Mayo Hospital, King Edward Medical University, Lahore, Pakistan","institution_ids":["https://openalex.org/I142016965","https://openalex.org/I4210145659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085276659","display_name":"Sami Ullah Mumtaz","orcid":"https://orcid.org/0000-0002-9772-7614","observed_orcids":["https://orcid.org/0000-0002-9772-7614"]},"institutions":[{"id":"https://openalex.org/I142016965","display_name":"King Edward Medical University","ror":"https://ror.org/02rrbpf42","country_code":"PK","type":"education","lineage":["https://openalex.org/I142016965"]},{"id":"https://openalex.org/I4210145659","display_name":"Mayo Hospital","ror":"https://ror.org/046jyn221","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I4210145659"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Sami Ullah Mumtaz","raw_affiliation_strings":["North Medical Ward,Mayo Hospital, King Edward Medical University, Lahore, Pakistan. drsamiullah210@gmail.com","North Medical Ward,Mayo Hospital, King Edward Medical University, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"North Medical Ward,Mayo Hospital, King Edward Medical University, Lahore, Pakistan. drsamiullah210@gmail.com","institution_ids":["https://openalex.org/I142016965","https://openalex.org/I4210145659"]},{"raw_affiliation_string":"North Medical Ward,Mayo Hospital, King Edward Medical University, Lahore, Pakistan","institution_ids":["https://openalex.org/I142016965","https://openalex.org/I4210145659"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064309037","display_name":"Sajid Abaidullah","orcid":"https://orcid.org/0000-0002-1722-1809","observed_orcids":["https://orcid.org/0000-0002-1722-1809"]},"institutions":[{"id":"https://openalex.org/I142016965","display_name":"King Edward Medical University","ror":"https://ror.org/02rrbpf42","country_code":"PK","type":"education","lineage":["https://openalex.org/I142016965"]},{"id":"https://openalex.org/I4210145659","display_name":"Mayo Hospital","ror":"https://ror.org/046jyn221","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I4210145659"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Sajid Abaidullah","raw_affiliation_strings":["North Medical Ward,Mayo Hospital, King Edward Medical University, Lahore, Pakistan. sajidabaidullahemw@hotmail.com","North Medical Ward,Mayo Hospital, King Edward Medical University, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"North Medical Ward,Mayo Hospital, King Edward Medical University, Lahore, Pakistan. sajidabaidullahemw@hotmail.com","institution_ids":["https://openalex.org/I142016965","https://openalex.org/I4210145659"]},{"raw_affiliation_string":"North Medical Ward,Mayo Hospital, King Edward Medical University, Lahore, Pakistan","institution_ids":["https://openalex.org/I142016965","https://openalex.org/I4210145659"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5074388758"],"corresponding_institution_ids":["https://openalex.org/I142016965","https://openalex.org/I4210145659"],"apc_list":{"value":2890,"currency":"USD","value_usd":2890},"apc_paid":{"value":2890,"currency":"USD","value_usd":2890},"fwci":0.2281,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.6207987,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"9","issue":"1","first_page":"288","last_page":"288"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12355","display_name":"Genetic and rare skin diseases.","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12355","display_name":"Genetic and rare skin diseases.","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11787","display_name":"Oral and Maxillofacial Pathology","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11919","display_name":"dental development and anomalies","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/papillon-lefevre-syndrome","display_name":"Papillon-Lef\u00e8vre syndrome","score":0.968999981880188},{"id":"https://openalex.org/keywords/palmoplantar-keratoderma","display_name":"palmoplantar keratoderma","score":0.9940000176429749},{"id":"https://openalex.org/keywords/periodontitis","display_name":"periodontitis","score":0.9589999914169312},{"id":"https://openalex.org/keywords/fever-of-unknown-origin","display_name":"fever of unknown origin","score":0.9779999852180481},{"id":"https://openalex.org/keywords/pyogenic-liver-abscess","display_name":"pyogenic liver abscess","score":0.9929999709129333},{"id":"https://openalex.org/keywords/autosomal-recessive-disorder","display_name":"autosomal recessive disorder","score":0.9419999718666077},{"id":"https://openalex.org/keywords/consanguinity","display_name":"consanguinity","score":0.9200000166893005},{"id":"https://openalex.org/keywords/edentulism","display_name":"edentulism","score":0.753000020980835},{"id":"https://openalex.org/keywords/alveolar-bone-loss","display_name":"alveolar bone loss","score":0.9079999923706055},{"id":"https://openalex.org/keywords/topical-corticosteroids","display_name":"topical corticosteroids","score":0.6840000152587891},{"id":"https://openalex.org/keywords/pyogenic-infection","display_name":"pyogenic infection","score":0.44999998807907104}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9502652883529663},{"id":"https://openalex.org/C2778951404","wikidata":"https://www.wikidata.org/wiki/Q7128426","display_name":"Palmoplantar keratoderma","level":3,"score":0.8353691101074219},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.6904575824737549},{"id":"https://openalex.org/C2779335771","wikidata":"https://www.wikidata.org/wiki/Q1739195","display_name":"Keratoderma","level":3,"score":0.6414445042610168},{"id":"https://openalex.org/C2780385504","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontitis","level":2,"score":0.49889373779296875},{"id":"https://openalex.org/C2781179581","wikidata":"https://www.wikidata.org/wiki/Q2857712","display_name":"Family history","level":2,"score":0.4332357347011566},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.38193050026893616},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3365654945373535},{"id":"https://openalex.org/C2779915019","wikidata":"https://www.wikidata.org/wiki/Q1640998","display_name":"Hyperkeratosis","level":2,"score":0.2527581453323364},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18343374133110046}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005334","descriptor_name":"Fever","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D005334","descriptor_name":"Fever","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D005334","descriptor_name":"Fever","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007645","descriptor_name":"Keratoderma, Palmoplantar","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007645","descriptor_name":"Keratoderma, Palmoplantar","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010214","descriptor_name":"Papillon-Lefevre Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D010214","descriptor_name":"Papillon-Lefevre Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D010214","descriptor_name":"Papillon-Lefevre Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010214","descriptor_name":"Papillon-Lefevre Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010518","descriptor_name":"Periodontitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010518","descriptor_name":"Periodontitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s13256-015-0773-7","doi":"https://doi.org/10.1186/s13256-015-0773-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13256-015-0773-7","pdf_url":"https://jmedicalcasereports.biomedcentral.com/counter/pdf/10.1186/s13256-015-0773-7","source":{"id":"https://openalex.org/S162052592","display_name":"Journal of Medical Case Reports","issn_l":"1752-1947","issn":["1752-1947"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Case Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4684603","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4684603","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Med Case Rep","raw_type":"Text"},{"id":"pmid:26683691","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26683691","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medical case reports","raw_type":"Case Reports"},{"id":"doi:10.60692/4e877-x4949","doi":"https://doi.org/10.60692/4e877-x4949","is_oa":true,"landing_page_url":"https://doi.org/10.60692/4e877-x4949","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/eghr1-kqb74","doi":"https://doi.org/10.60692/eghr1-kqb74","is_oa":true,"landing_page_url":"https://doi.org/10.60692/eghr1-kqb74","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1186/s13256-015-0773-7","doi":"https://doi.org/10.1186/s13256-015-0773-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13256-015-0773-7","pdf_url":"https://jmedicalcasereports.biomedcentral.com/counter/pdf/10.1186/s13256-015-0773-7","source":{"id":"https://openalex.org/S162052592","display_name":"Journal of Medical Case Reports","issn_l":"1752-1947","issn":["1752-1947"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Case Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2201816349.pdf","grobid_xml":"https://content.openalex.org/works/W2201816349.grobid-xml"},"referenced_works_count":7,"referenced_works":["https://openalex.org/W2017537993","https://openalex.org/W2043659186","https://openalex.org/W2044713600","https://openalex.org/W2085168033","https://openalex.org/W2110841437","https://openalex.org/W2111131993","https://openalex.org/W2461468631"],"related_works":["https://openalex.org/W2146627943","https://openalex.org/W2081692013","https://openalex.org/W2409030580","https://openalex.org/W2326292322","https://openalex.org/W1559444789","https://openalex.org/W3119213246","https://openalex.org/W2461468631","https://openalex.org/W4410371020","https://openalex.org/W2017537993","https://openalex.org/W1973301448"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Papillon-Lef\u00e8vre":[1],"Syndrome":[2],"is":[3,35],"a":[4,59,76,181],"rare":[5],"autosomal":[6],"recessive":[7],"disorder":[8],"characterized":[9],"by":[10,86],"diffuse,":[11],"transgradient":[12],"palmoplantar":[13,95],"keratoderma,":[14],"destructive":[15],"periodontitis":[16],"beginning":[17],"in":[18,43],"childhood,":[19],"premature":[20],"loss":[21],"of":[22,39,58,62,67,103,121],"primary":[23],"teeth,":[24],"and":[25,28,88,97,107,114,131,141,158,167,173],"frequent":[26],"cutaneous":[27],"systemic":[29,134],"pyogenic":[30,77],"infections.":[31],"Pyogenic":[32],"liver":[33,78],"abscess":[34,79],"an":[36],"uncommon":[37],"presentation":[38],"the":[40,55,122],"disease":[41],"present":[42],"this":[44],"case.":[45],"CASE":[46],"PRESENTATION:":[47],"A":[48],"16-year-old":[49],"Punjabi,":[50],"Pakistani":[51],"boy":[52],"presented":[53],"to":[54,176],"outpatient":[56],"department":[57],"tertiary-care":[60],"hospital":[61],"Lahore":[63],"with":[64,83,128,163],"high-grade":[65],"fever":[66,156],"2":[68,80],"months":[69],"duration.":[70],"He":[71,90,125,169],"had":[72,91,101,110],"been":[73],"treated":[74,127],"for":[75,133,145,178],"years":[81],"back":[82],"antibiotics":[84],"followed":[85],"incision":[87],"drainage.":[89],"poor":[92],"orodental":[93],"hygiene,":[94],"keratoderma":[96],"periodontitis.":[98],"His":[99,105,155],"parents":[100],"history":[102],"consanguinity.":[104],"brother":[106],"two":[108],"cousins":[109],"similar":[111],"skin":[112,160],"lesions":[113,161],"were":[115,143],"edentulous.":[116],"An":[117],"orthopentogram":[118],"showed":[119],"atrophy":[120],"alveolar":[123],"bone.":[124],"was":[126,152,170,174],"broad-spectrum":[129],"antibiotics,":[130,164],"antipyretics":[132],"infection.":[135],"Multivitamins,":[136],"topical":[137,139,165],"steroids,":[138],"keratolytics":[140],"emollients":[142],"used":[144],"his":[146,159],"dermatological":[147],"issues.":[148],"CONCLUSIONS:":[149],"Our":[150],"patient":[151],"successfully":[153],"treated.":[154],"settled":[157],"improved":[162],"steroids":[166],"keratolytics.":[168],"sent":[171],"home":[172],"asked":[175],"return":[177],"follow-up":[179],"on":[180],"monthly":[182],"basis.":[183]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}