{"id":"https://openalex.org/W2201799447","doi":null,"title":"The bioartificial thyroid: a biotechnological perspective in endocrine organ engineering for transplantation replacement.","display_name":"The bioartificial thyroid: a biotechnological perspective in endocrine organ engineering for transplantation replacement.","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2201799447","mag":"2201799447","pmid":"https://pubmed.ncbi.nlm.nih.gov/17465331"},"language":"en","primary_location":{"id":"pmh:oai:mattioli1885journals.com:article/4617","doi":null,"is_oa":true,"landing_page_url":"https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/4617","pdf_url":"https://www.mattioli1885journals.com/index.php/actabiomedica/article/download/4617/3426","source":{"id":"https://openalex.org/S4393915150","display_name":"Acta bio-medica dell'Ateneo parmense/Acta biomedica","issn_l":"0392-4203","issn":["0392-4203","2531-6745"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","norway-1","poland-20","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"0392-4203","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.mattioli1885journals.com/index.php/actabiomedica/article/download/4617/3426","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011846702","display_name":"Roberto Toni","orcid":"https://orcid.org/0000-0002-5081-4753","observed_orcids":["https://orcid.org/0000-0002-5081-4753"]},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]},{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Roberto Toni","raw_affiliation_strings":["Department of Human Anatomy, University of Parma. rtoni@biocfarm.unibo.it","Departments of Parma;#R##N#Departments of Scientific Foundation and Clinic \u201cG. B. Morgagni\u201d, Catania;#R##N#Academy of Sciences, Bologna, Italy;#R##N#Departments of Medicine, Divisions of Endocrinology, Sloan-Kettering Cancer Center, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Anatomy, University of Parma. rtoni@biocfarm.unibo.it","institution_ids":["https://openalex.org/I124601658"]},{"raw_affiliation_string":"Departments of Parma;#R##N#Departments of Scientific Foundation and Clinic \u201cG. B. Morgagni\u201d, Catania;#R##N#Academy of Sciences, Bologna, Italy;#R##N#Departments of Medicine, Divisions of Endocrinology, Sloan-Kettering Cancer Center, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005086500","display_name":"Claudia Della Casa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Claudia Della Casa","raw_affiliation_strings":["Departments of Parma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Parma","institution_ids":["https://openalex.org/I124601658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045302264","display_name":"Giulia Spaletta","orcid":"https://orcid.org/0000-0002-6871-0864","observed_orcids":["https://orcid.org/0000-0002-6871-0864"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulia Spaletta","raw_affiliation_strings":["Departments of Human Anatomy, Mathematics-CIRAM-Engineering, Bologna"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Human Anatomy, Mathematics-CIRAM-Engineering, Bologna","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Giacomo Marchetti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giacomo Marchetti","raw_affiliation_strings":["Departments of Human Anatomy, Mathematics-CIRAM-Engineering, Bologna"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Human Anatomy, Mathematics-CIRAM-Engineering, Bologna","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089357333","display_name":"Perseo Mazzoni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Perseo Mazzoni","raw_affiliation_strings":["Departments of Human Anatomy, Mathematics-CIRAM-Engineering, Bologna"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Human Anatomy, Mathematics-CIRAM-Engineering, Bologna","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035797784","display_name":"Monica Bodria","orcid":"https://orcid.org/0000-0001-9690-9945","observed_orcids":["https://orcid.org/0000-0001-9690-9945"]},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Monica Bodria","raw_affiliation_strings":["Departments of Parma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Parma","institution_ids":["https://openalex.org/I124601658"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Simone Ravera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Simone Ravera","raw_affiliation_strings":["Departments of Parma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Parma","institution_ids":["https://openalex.org/I124601658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079099400","display_name":"D. Dallatana","orcid":"https://orcid.org/0000-0003-3627-5148","observed_orcids":["https://orcid.org/0000-0003-3627-5148"]},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Davide Dallatana","raw_affiliation_strings":["Departments of Parma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Parma","institution_ids":["https://openalex.org/I124601658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080996267","display_name":"Sergio Castorina","orcid":"https://orcid.org/0000-0002-0745-4107","observed_orcids":["https://orcid.org/0000-0002-0745-4107"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sergio Castorina","raw_affiliation_strings":["Departments of Human Anatomy, Scientific Foundation and Clinic \u201cG. B. Morgagni\u201d, Catania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Human Anatomy, Scientific Foundation and Clinic \u201cG. B. Morgagni\u201d, Catania","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002847203","display_name":"Vincenzo Riccioli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125092","display_name":"Ospedale G.B. Morgagni - L.Pierantoni","ror":"https://ror.org/03jd4q354","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210125092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vincenzo Riccioli","raw_affiliation_strings":["Departments of Scientific Foundation and Clinic \u201cG. B. Morgagni\u201d"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Scientific Foundation and Clinic \u201cG. B. Morgagni\u201d","institution_ids":["https://openalex.org/I4210125092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000662232","display_name":"Emilio Giovanni Castorina","orcid":"https://orcid.org/0000-0002-5805-2140","observed_orcids":["https://orcid.org/0000-0002-5805-2140"]},"institutions":[{"id":"https://openalex.org/I4210125092","display_name":"Ospedale G.B. Morgagni - L.Pierantoni","ror":"https://ror.org/03jd4q354","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210125092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Emilio Giovanni Castorina","raw_affiliation_strings":["Departments of Scientific Foundation and Clinic \u201cG. B. Morgagni\u201d"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Scientific Foundation and Clinic \u201cG. B. Morgagni\u201d","institution_ids":["https://openalex.org/I4210125092"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Salvatore Antoci","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125092","display_name":"Ospedale G.B. Morgagni - L.Pierantoni","ror":"https://ror.org/03jd4q354","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210125092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Salvatore Antoci","raw_affiliation_strings":["Departments of Scientific Foundation and Clinic \u201cG. B. Morgagni\u201d"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Scientific Foundation and Clinic \u201cG. B. Morgagni\u201d","institution_ids":["https://openalex.org/I4210125092"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Enrico Campanile","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125092","display_name":"Ospedale G.B. Morgagni - L.Pierantoni","ror":"https://ror.org/03jd4q354","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210125092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Enrico Campanile","raw_affiliation_strings":["Departments of Scientific Foundation and Clinic \u201cG. B. Morgagni\u201d"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Scientific Foundation and Clinic \u201cG. B. Morgagni\u201d","institution_ids":["https://openalex.org/I4210125092"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Gabriella Raise","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gabriella Raise","raw_affiliation_strings":["Departments of Nuclear Medicine and Sanitary Physics, Universities of Maggiore Hospital, Parma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Nuclear Medicine and Sanitary Physics, Universities of Maggiore Hospital, Parma","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023032143","display_name":"Gabriella Scalise","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gabriella Scalise","raw_affiliation_strings":["Departments of Nuclear Medicine and Sanitary Physics, Universities of Maggiore Hospital, Parma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Nuclear Medicine and Sanitary Physics, Universities of Maggiore Hospital, Parma","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Raffaella Rossi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raffaella Rossi","raw_affiliation_strings":["Departments of Nuclear Medicine and Sanitary Physics, Universities of Maggiore Hospital, Parma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Nuclear Medicine and Sanitary Physics, Universities of Maggiore Hospital, Parma","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Raffaella Rossio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raffaella Rossio","raw_affiliation_strings":["Departments of Departments of Medicine, Divisions of Endocrinology, Sloan-Kettering Cancer Center, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Departments of Medicine, Divisions of Endocrinology, Sloan-Kettering Cancer Center, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084630307","display_name":"Giorgio Ugolotti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giorgio Ugolotti","raw_affiliation_strings":["Departments of Mathematics-CIRAM-Engineering, Bologna"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Mathematics-CIRAM-Engineering, Bologna","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Giorgio Ugolottio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giorgio Ugolottio","raw_affiliation_strings":["Departments of Human Anatomy, Mathematics-CIRAM-Engineering, Bologna"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Human Anatomy, Mathematics-CIRAM-Engineering, Bologna","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Andrew Martorella","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew Martorella","raw_affiliation_strings":["Departments of Endocrinology, Pisa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Endocrinology, Pisa","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112394765","display_name":"Elio Roti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elio Roti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Elio Rot","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elio Rot","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081534186","display_name":"Fiorella Sgallari","orcid":"https://orcid.org/0000-0002-9166-8879","observed_orcids":["https://orcid.org/0000-0002-9166-8879"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fiorella Sgallari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5014279456","display_name":"Aldo Pinchera","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aldo Pinchera","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.746,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.8296793,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"78 Suppl 1","issue":null,"first_page":"129","last_page":"55"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyroid-transplantation","display_name":"thyroid transplantation","score":0.5839999914169312},{"id":"https://openalex.org/keywords/cell-adhesion-molecules","display_name":"adhesion molecules","score":0.7250000238418579},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.996999979019165},{"id":"https://openalex.org/keywords/thyroid-follicular-cells","display_name":"thyroid follicular cells","score":0.6949999928474426},{"id":"https://openalex.org/keywords/endothelial-progenitor-cells","display_name":"endothelial progenitor cells","score":0.9470000267028809},{"id":"https://openalex.org/keywords/vascularization","display_name":"vascularization","score":0.48100000619888306},{"id":"https://openalex.org/keywords/lineage-differentiation","display_name":"lineage differentiation","score":0.5019999742507935}],"concepts":[{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.6057956218719482},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.5453150272369385},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.5080530643463135},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5008969306945801},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.4719879925251007},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4075638949871063},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3975174129009247},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.372683584690094},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33117467164993286},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3002113699913025},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.244637131690979},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22373133897781372},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.18531256914138794}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001704","descriptor_name":"Biopolymers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009924","descriptor_name":"Organ Culture Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D009924","descriptor_name":"Organ Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D010903","descriptor_name":"Pituitary Gland, Anterior","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013959","descriptor_name":"Thyroid Diseases","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D013961","descriptor_name":"Thyroid Gland","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D013961","descriptor_name":"Thyroid Gland","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013961","descriptor_name":"Thyroid Gland","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D013961","descriptor_name":"Thyroid Gland","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":true},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D017709","descriptor_name":"Fractals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021522","descriptor_name":"Bioartificial Organs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:mattioli1885journals.com:article/4617","doi":null,"is_oa":true,"landing_page_url":"https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/4617","pdf_url":"https://www.mattioli1885journals.com/index.php/actabiomedica/article/download/4617/3426","source":{"id":"https://openalex.org/S4393915150","display_name":"Acta bio-medica dell'Ateneo parmense/Acta biomedica","issn_l":"0392-4203","issn":["0392-4203","2531-6745"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","norway-1","poland-20","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"0392-4203","raw_type":"info:eu-repo/semantics/article"},{"id":"pmid:17465331","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17465331","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta bio-medica : Atenei Parmensis","raw_type":"Lecture"},{"id":"mag:2201799447","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17465331","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:mattioli1885journals.com:article/4617","doi":null,"is_oa":true,"landing_page_url":"https://www.mattioli1885journals.com/index.php/actabiomedica/article/view/4617","pdf_url":"https://www.mattioli1885journals.com/index.php/actabiomedica/article/download/4617/3426","source":{"id":"https://openalex.org/S4393915150","display_name":"Acta bio-medica dell'Ateneo parmense/Acta biomedica","issn_l":"0392-4203","issn":["0392-4203","2531-6745"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","norway-1","poland-20","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"0392-4203","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332648","display_name":"Tufts University School of Medicine","ror":"https://ror.org/05wvpxv85"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2201799447.pdf","grobid_xml":"https://content.openalex.org/works/W2201799447.grobid-xml"},"referenced_works_count":164,"referenced_works":["https://openalex.org/W20171346","https://openalex.org/W56529640","https://openalex.org/W75900006","https://openalex.org/W102083435","https://openalex.org/W128393619","https://openalex.org/W165003755","https://openalex.org/W195147176","https://openalex.org/W421135038","https://openalex.org/W572772444","https://openalex.org/W577475803","https://openalex.org/W636242312","https://openalex.org/W647119294","https://openalex.org/W1426595253","https://openalex.org/W1482082078","https://openalex.org/W1499075785","https://openalex.org/W1502870913","https://openalex.org/W1502896205","https://openalex.org/W1591007782","https://openalex.org/W1591912379","https://openalex.org/W1873961654","https://openalex.org/W1915609526","https://openalex.org/W1964596167","https://openalex.org/W1965095299","https://openalex.org/W1965104493","https://openalex.org/W1965933207","https://openalex.org/W1969143900","https://openalex.org/W1969399504","https://openalex.org/W1969413827","https://openalex.org/W1970291858","https://openalex.org/W1971470814","https://openalex.org/W1974529483","https://openalex.org/W1975238653","https://openalex.org/W1976212754","https://openalex.org/W1976254453","https://openalex.org/W1980454773","https://openalex.org/W1983680839","https://openalex.org/W1984206860","https://openalex.org/W1990574061","https://openalex.org/W1991627841","https://openalex.org/W1993566067","https://openalex.org/W1994710495","https://openalex.org/W1997512449","https://openalex.org/W1998950111","https://openalex.org/W1999325890","https://openalex.org/W1999421433","https://openalex.org/W1999750787","https://openalex.org/W2000192039","https://openalex.org/W2002632526","https://openalex.org/W2003243253","https://openalex.org/W2003498399","https://openalex.org/W2004140559","https://openalex.org/W2004583840","https://openalex.org/W2009093637","https://openalex.org/W2009117640","https://openalex.org/W2009981178","https://openalex.org/W2010133282","https://openalex.org/W2012513740","https://openalex.org/W2013046874","https://openalex.org/W2016350172","https://openalex.org/W2016836130","https://openalex.org/W2016872888","https://openalex.org/W2020626596","https://openalex.org/W2020918024","https://openalex.org/W2024021696","https://openalex.org/W2026277609","https://openalex.org/W2026632078","https://openalex.org/W2027369033","https://openalex.org/W2031205668","https://openalex.org/W2033108841","https://openalex.org/W2034301798","https://openalex.org/W2037743714","https://openalex.org/W2039396493","https://openalex.org/W2039493143","https://openalex.org/W2041163464","https://openalex.org/W2041846357","https://openalex.org/W2050476203","https://openalex.org/W2051994179","https://openalex.org/W2052122042","https://openalex.org/W2052530372","https://openalex.org/W2053704719","https://openalex.org/W2054055773","https://openalex.org/W2054171565","https://openalex.org/W2058096164","https://openalex.org/W2059080130","https://openalex.org/W2059100129","https://openalex.org/W2062502773","https://openalex.org/W2063987776","https://openalex.org/W2064753484","https://openalex.org/W2067139290","https://openalex.org/W2067213271","https://openalex.org/W2068783216","https://openalex.org/W2068914494","https://openalex.org/W2069718155","https://openalex.org/W2070431772","https://openalex.org/W2071323720","https://openalex.org/W2073795835","https://openalex.org/W2074528335","https://openalex.org/W2075369109","https://openalex.org/W2077632354","https://openalex.org/W2077656376","https://openalex.org/W2077729437","https://openalex.org/W2080882038","https://openalex.org/W2081479208","https://openalex.org/W2084707443","https://openalex.org/W2085320974","https://openalex.org/W2086600568","https://openalex.org/W2089992526","https://openalex.org/W2091826524","https://openalex.org/W2097488581","https://openalex.org/W2097879134","https://openalex.org/W2098900647","https://openalex.org/W2099927493","https://openalex.org/W2105695271","https://openalex.org/W2107980872","https://openalex.org/W2110820685","https://openalex.org/W2112068069","https://openalex.org/W2113289867","https://openalex.org/W2113396371","https://openalex.org/W2115104498","https://openalex.org/W2116670135","https://openalex.org/W2119908867","https://openalex.org/W2121304556","https://openalex.org/W2122531454","https://openalex.org/W2127366027","https://openalex.org/W2130748121","https://openalex.org/W2132570898","https://openalex.org/W2133185032","https://openalex.org/W2136933332","https://openalex.org/W2138162238","https://openalex.org/W2138559670","https://openalex.org/W2141667977","https://openalex.org/W2141783259","https://openalex.org/W2143359570","https://openalex.org/W2144023435","https://openalex.org/W2152545340","https://openalex.org/W2153028817","https://openalex.org/W2153195754","https://openalex.org/W2162367555","https://openalex.org/W2164579650","https://openalex.org/W2167892440","https://openalex.org/W2167901549","https://openalex.org/W2174603322","https://openalex.org/W2250930445","https://openalex.org/W2286840616","https://openalex.org/W2292032797","https://openalex.org/W2339378878","https://openalex.org/W2405982153","https://openalex.org/W2410244139","https://openalex.org/W2411331384","https://openalex.org/W2411556630","https://openalex.org/W2414262238","https://openalex.org/W2415497563","https://openalex.org/W2415871612","https://openalex.org/W2417728353","https://openalex.org/W2429516608","https://openalex.org/W2471227327","https://openalex.org/W2473883558","https://openalex.org/W2501384800","https://openalex.org/W2768228057","https://openalex.org/W2801688715","https://openalex.org/W2807435963","https://openalex.org/W2883098220","https://openalex.org/W2898631566","https://openalex.org/W3185339336"],"related_works":["https://openalex.org/W7017818227","https://openalex.org/W7047030053","https://openalex.org/W2928515104","https://openalex.org/W2054923785","https://openalex.org/W7135029699","https://openalex.org/W7009808757","https://openalex.org/W16733853","https://openalex.org/W3137856271","https://openalex.org/W2899421406","https://openalex.org/W7119570209"],"abstract_inverted_index":{"A":[0,140],"new":[1,330],"concept":[2],"for":[3,293],"ex":[4,317],"situ":[5],"endocrine":[6,315],"organ":[7,134,138],"bioengineering":[8],"is":[9,22,58,161,278],"presented,":[10],"focused":[11],"on":[12,24,164],"the":[13,25,37,52,74,77,93,97,104,107,110,120,168,189,222,234,270,281,298,325],"realization":[14],"of":[15,36,96,109,142,152,167,188,208,224,267,269],"a":[16,82,129,136,149,153,186,229,285,305,329],"human":[17,154,197,321],"bioartificial":[18,286,314],"thyroid":[19,38,78,155,169,190,271,287],"gland.":[20,98],"It":[21],"based":[23,163],"theoretical":[26],"assumption":[27],"and":[28,69,123,126,157,175,200,206,211,242,249,263,290,312,324,327],"experimental":[29,143],"evidence":[30],"that":[31,76,106,297],"symmetries":[32],"in":[33,51,213,240,243,275],"geometrical":[34],"coordinates":[35],"tissue":[39],"remain":[40],"invariant":[41],"with":[42,218,280],"respect":[43],"to":[44,73,118,147,183,194,221,232,246,283,307,332],"developmental,":[45],"physiological":[46],"or":[47,178],"pathophysiological":[48],"transformations":[49],"occuring":[50],"gland":[53,288],"architecture.":[54],"This":[55],"topological":[56],"arrangement":[57],"dependent":[59],"upon":[60],"physical":[61],"connections":[62],"established":[63],"between":[64],"cells,":[65],"cell":[66],"adhesion":[67],"molecules":[68],"extracellular":[70],"matrix,":[71],"leading":[72],"view":[75],"parenchyma":[79],"behaves":[80],"like":[81],"deformable":[83],"\"putty\",":[84],"moulded":[85],"onto":[86,192],"an":[87,158],"elastic":[88],"stromal/vascular":[89],"scaffold":[90],"(SVS)":[91],"dictating":[92],"final":[94],"morphology":[95],"In":[99,237],"particular,":[100],"we":[101],"have":[102],"raised":[103],"idea":[105],"geometry":[108],"SVS":[111],"per":[112],"se":[113],"provides":[114],"pivotal":[115],"epigenetic":[116],"information":[117],"address":[119],"genetically-programmed,":[121],"thyrocyte":[122,198],"endothelial/vascular":[124,201],"proliferation":[125],"differentiation":[127,252],"towards":[128],"functionally":[130,291],"mature":[131],"gland,":[132],"making":[133],"form":[135],"pre-requirementfor":[137],"function.":[139],"number":[141],"approaches":[144],"are":[145,181,216,253],"explored":[146],"obtain":[148,284],"reliable":[150],"replica":[151],"SVS,":[156,191],"informatic":[159],"simulation":[160],"designed":[162],"fractal":[165],"growth":[166],"intraparenchymal":[170],"arterial":[171],"tree.":[172],"Various":[173],"tissue-compatible":[174],"degradable":[176],"synthetic":[177,235],"biomimetic":[179],"polymers":[180],"discussed":[182],"act":[184],"as":[185,320],"template":[187,306],"which":[193],"co-seed":[195],"autologous":[196],"(TPC)":[199],"(EVPC)":[202],"progenitor":[203],"cells.":[204],"Harvest":[205],"expansion":[207],"both":[209,239],"TPC":[210,248],"EVPC":[212,250],"primary":[214],"culture":[215],"considered,":[217],"specific":[219],"attention":[220],"selection":[223],"normal":[225],"thyrocytes":[226],"growing":[227],"at":[228],"satisfactory":[230],"rate":[231],"colonize":[233],"matrix.":[236],"addition,":[238],"vitro":[241],"vivo":[244],"techniques":[245],"authenticate":[247],"lineage":[251],"reviewed,":[254],"including":[255],"immunocytochemistry,":[256],"reverse":[257],"trascriptase-polymerase":[258],"chain":[259],"reaction,":[260],"flow":[261],"cytomery":[262],"proteomics.":[264],"Finally,":[265],"analysis":[266],"viability":[268],"construct":[272,308],"following":[273],"implantation":[274],"animal":[276],"hosts":[277],"proposed,":[279],"intent":[282],"morphologically":[289],"adequate":[292],"transplantation.":[294],"We":[295],"believe":[296],"biotechnological":[299],"scenario":[300],"proposed":[301],"herein":[302],"may":[303],"provide":[304],"other,":[309],"more":[310],"complex":[311],"clinically-relevant":[313],"organs":[316],"situ,":[318],"such":[319],"pancreatic":[322],"islets":[323],"liver,":[326],"perhaps":[328],"approach":[331],"brain":[333],"bioengineering.":[334]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}