{"id":"https://openalex.org/W2201766790","doi":"https://doi.org/10.1093/ndt/9.5.548","title":"Excellent uricosuric efficacy of benzbromarone in cyclosporin-A-treated renal transplant patients: a prospective study","display_name":"Excellent uricosuric efficacy of benzbromarone in cyclosporin-A-treated renal transplant patients: a prospective study","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W2201766790","doi":"https://doi.org/10.1093/ndt/9.5.548","mag":"2201766790","pmid":"https://pubmed.ncbi.nlm.nih.gov/8090336"},"language":"en","primary_location":{"id":"doi:10.1093/ndt/9.5.548","doi":"https://doi.org/10.1093/ndt/9.5.548","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ndt/9.5.548","pdf_url":null,"source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111944784","display_name":"R. M. Z\u00fcrcher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"R. M. Z\u00fcrcher","raw_affiliation_strings":["Department of Medicine, University Hospital Basel, Switzerland","Division of Nephrology, Department of Medicine, University Hospital BasalSwitzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University Hospital Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]},{"raw_affiliation_string":"Division of Nephrology, Department of Medicine, University Hospital BasalSwitzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111709704","display_name":"H. Andreas Bock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"H. A. Bock","raw_affiliation_strings":["Division of Nephrology, Department of Medicine, University Hospital Basal Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Medicine, University Hospital Basal Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113646921","display_name":"Gilbert T Thiel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"G. Thiel","raw_affiliation_strings":["Division of Nephrology, Department of Medicine, University Hospital Basal Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Medicine, University Hospital Basal Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111944784"],"corresponding_institution_ids":["https://openalex.org/I2802542264"],"apc_list":{"value":3474,"currency":"EUR","value_usd":3926},"apc_paid":null,"fwci":0.3612,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.54500996,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"9","issue":"5","first_page":"548","last_page":"551"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benzbromarone","display_name":"benzbromarone","score":1.0},{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.9639999866485596},{"id":"https://openalex.org/keywords/hyperuricemia","display_name":"hyperuricemia","score":0.8820000290870667},{"id":"https://openalex.org/keywords/gout","display_name":"gout","score":0.7490000128746033},{"id":"https://openalex.org/keywords/kidney-transplant-recipients","display_name":"kidney transplant recipients","score":0.7649999856948853},{"id":"https://openalex.org/keywords/uricosuric-drugs","display_name":"uricosuric drugs","score":0.8529999852180481},{"id":"https://openalex.org/keywords/plasma-uric-acid","display_name":"plasma uric acid","score":0.8309999704360962},{"id":"https://openalex.org/keywords/creatinine-clearance","display_name":"creatinine clearance","score":0.9010000228881836},{"id":"https://openalex.org/keywords/drug-interactions","display_name":"drug interactions","score":0.6380000114440918},{"id":"https://openalex.org/keywords/allopurinol","display_name":"allopurinol","score":0.8489999771118164},{"id":"https://openalex.org/keywords/urinary-uric-acid-excretion","display_name":"urinary uric acid excretion","score":0.7720000147819519}],"concepts":[{"id":"https://openalex.org/C2780274859","wikidata":"https://www.wikidata.org/wiki/Q410435","display_name":"Benzbromarone","level":4,"score":0.9874863624572754},{"id":"https://openalex.org/C2777601384","wikidata":"https://www.wikidata.org/wiki/Q669295","display_name":"Uricosuric","level":4,"score":0.9304357171058655},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8331372141838074},{"id":"https://openalex.org/C2779881121","wikidata":"https://www.wikidata.org/wiki/Q105522","display_name":"Uric acid","level":2,"score":0.7291388511657715},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.6354193091392517},{"id":"https://openalex.org/C2780261098","wikidata":"https://www.wikidata.org/wiki/Q412486","display_name":"Allopurinol","level":2,"score":0.6197654604911804},{"id":"https://openalex.org/C2780402116","wikidata":"https://www.wikidata.org/wiki/Q133087","display_name":"Gout","level":2,"score":0.595963180065155},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5863410234451294},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.5448335409164429},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.5203390121459961},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.49264222383499146},{"id":"https://openalex.org/C2779721657","wikidata":"https://www.wikidata.org/wiki/Q49970","display_name":"Hyperuricemia","level":3,"score":0.36769992113113403}],"mesh":[{"descriptor_ui":"D001553","descriptor_name":"Benzbromarone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001553","descriptor_name":"Benzbromarone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003404","descriptor_name":"Creatinine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006085","descriptor_name":"Graft Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007677","descriptor_name":"Kidney Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014527","descriptor_name":"Uric Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014527","descriptor_name":"Uric Acid","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D016030","descriptor_name":"Kidney Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/ndt/9.5.548","doi":"https://doi.org/10.1093/ndt/9.5.548","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ndt/9.5.548","pdf_url":null,"source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"},{"id":"pmid:8090336","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8090336","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association","raw_type":"Journal Article"},{"id":"pmh:oai:doc.rero.ch:299892","doi":null,"is_oa":false,"landing_page_url":"http://doc.rero.ch/record/299892/files/9-5-548.pdf","pdf_url":"http://doc.rero.ch/record/299892/files/9-5-548.pdf","source":{"id":"https://openalex.org/S4306400148","display_name":"reroDoc Digital Library","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2937966710","https://openalex.org/W2137971591","https://openalex.org/W2090922152","https://openalex.org/W2322167306","https://openalex.org/W3136192465","https://openalex.org/W2016974889","https://openalex.org/W1761780895","https://openalex.org/W2022089959","https://openalex.org/W2332896718","https://openalex.org/W2136728326"],"abstract_inverted_index":{"Patients":[0],"on":[1],"cyclosporin":[2],"A":[3],"(CsA)":[4],"often":[5],"develop":[6],"hyperuricaemia":[7,20,60],"and":[8,59,92,112,225],"gout.":[9],"In":[10,200],"transplant":[11,53,211,240],"patients":[12,54,106,168],"the":[13,28,32,40,115,118,167],"use":[14],"of":[15,27,31,43,100,117,125,143,166,227],"uricosuric":[16,41],"drugs":[17],"for":[18,64,69],"treating":[19],"may":[21],"be":[22,233],"preferable":[23,234],"to":[24,81,133,188,221,232,235],"allopurinol":[25,236],"because":[26],"known":[29],"interaction":[30],"latter":[33],"with":[34,55,149,198,213,242],"azathioprine.":[35],"We":[36],"therefore":[37],"prospectively":[38],"studied":[39],"efficacy":[42,224],"100":[44],"mg":[45],"benzbromarone":[46,202,230],"(Bbr;Desuric)":[47],"daily":[48],"in":[49,98,207,237],"25":[50,101,113,218,247],"CsA-treated":[51,209,238],"renal":[52,210,239],"stable":[56],"graft":[57],"function":[58],"(>":[61],"359":[62],"mumol/l":[63,68,80,85],"females,":[65],">":[66,217],"491":[67],"males).":[70],"Benzbromarone":[71],"decreased":[72],"plasma":[73,95,144,204],"uric":[74,96,126,145,178,205],"acid":[75,97,127,146,179,206],"from":[76,129,182],"579":[77],"+":[78],"18":[79],"313":[82],"+/-":[83,87,131,135,184,190],"24":[84],"(mean":[86],"SEM;":[88],"P":[89,156],"<":[90,138,157],"0.0001)":[91],"thereby":[93],"normalized":[94,203],"21":[99,111],"patients.":[102],"The":[103,140],"remaining":[104],"four":[105],"had":[107],"creatinine":[108,151,215,244],"clearances":[109],"between":[110],"ml/min,":[114],"lowest":[116],"entire":[119],"study":[120],"group.":[121],"Mean":[122],"fractional":[123],"clearance":[124,152,216,245],"increased":[128,181],"5.4":[130],"0.4%":[132],"17.2":[134],"1.0%":[136],"(P":[137],"0.001).":[139,158],"relative":[141],"decrease":[142],"closely":[147],"correlated":[148],"baseline":[150],"(r":[153],"=":[154],"0.67;":[155],"CsA":[159],"trough":[160],"values":[161],"were":[162],"not":[163],"influenced.":[164],"None":[165],"experienced":[169],"any":[170],"significant":[171,228],"side-effects.":[172],"As":[173],"an":[174],"unexpected":[175],"find-ing,":[176],"urinary":[177],"excretion":[180],"2082":[183],"175":[185],"mumol/24":[186,192],"h":[187,193],"3233":[189],"232":[191],"after":[194],"4":[195],"weeks'":[196],"treatment":[197],"benzbromarone.":[199],"conclusion,":[201],"all":[208],"recipients":[212,241],"a":[214,243],"ml/min.":[219,248],"Due":[220],"its":[222],"excellent":[223],"lack":[226],"side-effects,":[229],"appears":[231],"over":[246]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}