{"id":"https://openalex.org/W2201751213","doi":null,"title":"Four-Week Repeated-Dose Toxicity of a Magnolia Ethanol Extract in Rats","display_name":"Four-Week Repeated-Dose Toxicity of a Magnolia Ethanol Extract in Rats","publication_year":2010,"publication_date":"2010-09-01","ids":{"openalex":"https://openalex.org/W2201751213","mag":"2201751213"},"language":"en","primary_location":{"id":"mag:2201751213","doi":null,"is_oa":false,"landing_page_url":"http://www.dbpia.co.kr/Article/2428832","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Biomedical Research","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108240243","display_name":"Yun\u2010Hui Yang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yun\u2010Hui Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051800188","display_name":"Goeun Yang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Goeun Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058553872","display_name":"Dongsun Park","orcid":"https://orcid.org/0000-0001-6042-5949","observed_orcids":["https://orcid.org/0000-0001-6042-5949"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dongsun Park","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6042-5949","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100734965","display_name":"Sun Hee Lee","orcid":"https://orcid.org/0000-0003-2093-3628","observed_orcids":["https://orcid.org/0000-0003-2093-3628"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sun Hee Lee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2093-3628","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057501819","display_name":"Dae\u2010Kwon Bae","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dae\u2010Kwon Bae","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112618230","display_name":"Tae Kyun Kim","orcid":"https://orcid.org/0000-0003-1073-4211","observed_orcids":["https://orcid.org/0000-0003-1073-4211"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tae Kyun Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044229450","display_name":"Young Jin Choi","orcid":"https://orcid.org/0000-0001-5030-0253","observed_orcids":["https://orcid.org/0000-0001-5030-0253"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Young Jin Choi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5030-0253","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030119181","display_name":"Ehn\u2010Kyoung Choi","orcid":"https://orcid.org/0000-0002-6112-6622","observed_orcids":["https://orcid.org/0000-0002-6112-6622"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ehn\u2010Kyoung Choi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6112-6622","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064169551","display_name":"Yun-Bae Kim","orcid":"https://orcid.org/0000-0003-1340-041X","observed_orcids":["https://orcid.org/0000-0003-1340-041X","https://orcid.org/0000-0001-5371-6449"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yun-Bae Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109326152","display_name":"Seock\u2010Yeon Hwang","orcid":"https://orcid.org/0000-0002-9786-7844","observed_orcids":["https://orcid.org/0000-0002-9786-7844"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seock\u2010Yeon Hwang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2099,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.50370719,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":"3","first_page":"175","last_page":"183"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13677","display_name":"Magnolia and Illicium research","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13677","display_name":"Magnolia and Illicium research","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.01640000008046627,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13095","display_name":"Plant-based Medicinal Research","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ethanol-extract","display_name":"ethanol extract","score":0.9620000123977661},{"id":"https://openalex.org/keywords/repeated-dose-toxicity","display_name":"repeated-dose toxicity","score":0.9890000224113464},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.6159999966621399},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.6700000166893005},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.9490000009536743},{"id":"https://openalex.org/keywords/hematological-toxicity","display_name":"hematologic toxicity","score":0.6370000243186951},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.4950000047683716},{"id":"https://openalex.org/keywords/lactate-dehydrogenase","display_name":"lactate dehydrogenase","score":0.7739999890327454},{"id":"https://openalex.org/keywords/creatine-kinase","display_name":"creatine kinase","score":0.9779999852180481},{"id":"https://openalex.org/keywords/safety-assessment","display_name":"safety assessment","score":0.39500001072883606},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.7200446128845215},{"id":"https://openalex.org/C36880943","wikidata":"https://www.wikidata.org/wiki/Q409458","display_name":"Creatine kinase","level":2,"score":0.646191418170929},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6405293345451355},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.5824404954910278},{"id":"https://openalex.org/C2779896295","wikidata":"https://www.wikidata.org/wiki/Q223600","display_name":"Creatine","level":2,"score":0.5280469059944153},{"id":"https://openalex.org/C2777318727","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactate dehydrogenase","level":3,"score":0.48969653248786926},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4469373822212219},{"id":"https://openalex.org/C21613296","wikidata":"https://www.wikidata.org/wiki/Q4925405","display_name":"Coagulative necrosis","level":2,"score":0.43684399127960205},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.41458332538604736},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4039589762687683},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.34335291385650635},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3401520550251007},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.18228361010551453},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11132502555847168},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07199954986572266}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2201751213","doi":null,"is_oa":false,"landing_page_url":"http://www.dbpia.co.kr/Article/2428832","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Biomedical Research","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4220759407","https://openalex.org/W1987349224","https://openalex.org/W2120212604","https://openalex.org/W2040690395","https://openalex.org/W7221266788","https://openalex.org/W6999982897","https://openalex.org/W2613125144","https://openalex.org/W2214082295","https://openalex.org/W3210484041","https://openalex.org/W4312188426"],"abstract_inverted_index":{"This":[0],"study":[1],"was":[2,16,63],"carried":[3],"out":[4],"to":[5,19,163],"investigate":[6],"repeated-dose":[7,114],"toxicities":[8,134],"of":[9,28,40,113,129,160],"Magnolia":[10],"ovobata":[11],"ethanol":[12],"extract":[13],"(MEE).":[14],"MEE":[15,41,161],"orally":[17],"administered":[18],"male":[20,83],"and":[21,53,58,72,79,86,93,103,123,132,139],"female":[22,99],"Sprague-Dawley":[23],"rats":[24],"at":[25,89,107],"dose":[26,112,166],"levels":[27],"0,":[29],"500,":[30],"1,000":[31],"or":[32],"2,000":[33,91,108],"mg/kg":[34,92],"for":[35],"4":[36],"weeks.":[37],"Repeated":[38],"administration":[39,159],"did":[42],"not":[43,143],"induce":[44],"abnormalities":[45],"in":[46,66,98],"general":[47],"signs,":[48],"body":[49],"weight":[50],"gain,":[51],"feed":[52],"water":[54],"consumptions,":[55],"necropsy":[56],"findings":[57,151],"organ":[59],"weights.":[60],"No":[61],"abnormality":[62],"also":[64],"observed":[65],"hematological":[67],"analyses;":[68],"red":[69],"blood":[70,76],"cells":[71],"their":[73],"indices,":[74],"white":[75],"cells,":[77],"platelets":[78],"coagulation":[80],"times.":[81],"In":[82,125,145],"rats,":[84,100],"BUN":[85],"creatinine":[87],"increased":[88],"doses":[90],"500-1,000":[94],"mg/kg,":[95,109],"respectively,":[96],"while":[97],"lactate":[101],"dehydrogenase":[102],"creatine":[104],"phosphokinase":[105],"decreased":[106],"the":[110,130,164],"upper-limit":[111,165],"toxicity":[115],"studies.":[116],"However,":[117],"there":[118],"were":[119,142,152],"no":[120,148],"dose-dependent":[121],"increases":[122],"gender-relationship.":[124],"addition,":[126],"other":[127],"parameters":[128],"hepatic":[131],"muscular":[133],"as":[135,137],"well":[136],"energy":[138],"lipid":[140],"metabolism":[141],"affected.":[144],"microscopic":[146],"examination,":[147],"considerable":[149],"pathological":[150],"observed.":[153],"The":[154],"results":[155],"indicate":[156],"that":[157],"oral":[158],"up":[162],"is":[167],"safe.":[168]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2016-06-24T00:00:00"}
